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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Entropi Sainstek Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Global Medical and Health Communication Jurnal Tadris Kimiya Jurnal Kartika Kimia Ensiklopedia of Journal Jambura FIsh Processing Journal Jambura Journal of Educational Chemistry Jambura Journal of Chemistry JOURNAL HEALTH AND NUTRITIONS Jurnal Abdi Insani Hydrogen: Jurnal Kependidikan Kimia Experiment: Journal of Science Education Jambura Journal of Husbandry and Agriculture Community Serve Pentagon: Jurnal Matematika dan Ilmu Pengetahuan Alam Algoritma: Jurnal Matematika, Ilmu Pengetahuan Alam, Kebumian dan Angkasa Jurnal Sains dan Kesehatan Damhil: Jurnal Pengabdian kepada Masyarakat Jurnal Pendidikan Kimia, Fisika dan Biologi
Netty Ino Ischak
Universitas Negeri Gorontalo
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Studi Molecular Docking dan Prediksi ADME Senyawa Metabolit Sekunder Tumbuhan Obat Tradisional Gorontalo Terhadap Reseptor HER-2 Sebagai Antikanker Payudara Ischak, Netty Ino; Musa, Weny J.A; Aman, La Ode; Alio, La; Kilo, Akram La; Saleh, Sri Deltalia
Jambura Journal of Chemistry Vol 5, No 2 (2023): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v5i2.20544

Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas dan interaksi senyawa uji dari 12 tumbuhan obat tradisional Gorontalo dengan reseptor HER-2 yang merupakan protein yang terkait dengan sel kanker payudara secara in silico melalui molecular docking. Molekul dengan hasil docking terbaik akan diprediksi menggunakan program Absobsi, Distribusi, Metabolisme, dan Eliminasi (ADME) menggunakan program SwissADME secara online. Hasil validasi situs ikatan dengan menerapkan protokol penambatan ulang (redocking) menunjukkan nilai Root Mean Square Deviation konformasi ligan standar (2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridine-3-yl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5yl]ethoxy}ethanol) menggunakan Autodock Tools dengan nilai energi bebas ikatan yang terbentuk sebesar -6,32 kkal/mol. Sedangkan nilai Root Mean Square Deviation ligan standar menggunakan Autodock Vina memiliki energi bebas ikatan sebesar -11,3 kkal/mol. Hasil energi bebas ikatan ligan uji Palmarumycin CP1 sebesar -9,2 kkal/mol. Interaksi residu aktif HER-2 pada Palmarumycin CP1 dengan kontribusi terbesar terdapat pada residu Tyr 735. Hasil prediksi ADME menunjukkan bahwa hanya ada lima senyawa yang termasuk aturan Lipinski Rule of Five yaitu senyawa Tembetarine, Palmarumycin CP1, Curcumin, Cepharadione A, dan Hexahydrocurcumin. Oleh karena itu, hasil ADME menunjukkan bahwa hanya ada satu senyawa yang memenuhi aturan Lipinski Rule of Five dan sesuai dengan hasil Molecular Docking yang memiliki energi bebas ikatan sebesar -9,2 kkal/mol adalah senyawa Palmarumycin CP1.
KORELASI FAKTOR DEMOGRAFI TERHADAP KEJADIAN STUNTING Yulita, Hendra; Nurhidayati, Siti; Ischak, Netty Ino; Noorma, Nilam; Hayati, Zahratul
Ensiklopedia of Journal Vol 6, No 4 (2024): Vol. 6 No. 4 Edisi 3 Juli 2024
Publisher : Lembaga Penelitian dan Penerbitan Hasil Penelitian Ensiklopedia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33559/eoj.v6i4.2435

Abstract

Abstract: Based on the profile data of the Deli Serdang Regency Health Office, Labuhan Deli Health Center is one of the locations where there are stunting cases in Deli Serdang Regency with a prevalence of stunting cases of 0.48% in 2021 and an increase to 1.46% in 2022. The purpose of the study was to determine the correlation of demographic factors with the incidence of stunting. This type of research is quantitative with a case control approach. The sample consisted of 88 case samples and 88 control samples. The sampling technique used purposive sampling. The results showed that there was a relationship between maternal education (p value: 0.000) and family economic status (p value: 0.023) on the incidence of stunting. It is recommended that the Puskesmas foster posyandu / nutrition cadres to provide education or counseling on stunting, parenting, nutritional knowledge and parenting patterns of mothers and take regular measurements at posyandu activities.Keywords: Family Economy, Maternal Education, Stunting 
HUBUNGAN AKTIVITAS FISIK DAN POLA MAKAN TERHADAP KADAR GULA DARAH PASIEN DIABETES MELITUS Ischak, Netty Ino; Handayani, Sekar; Rofiqoh, Rofiqoh; Mu'awanah, Mu'awanah; Widhi, Anisa Sekar
Ensiklopedia of Journal Vol 6, No 3 (2024): Vol. 6 No. 3 Edisi 2 April 2024
Publisher : Lembaga Penelitian dan Penerbitan Hasil Penelitian Ensiklopedia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33559/eoj.v6i3.2326

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Hyperglycemia is a medical condition where there is an increase in blood glucose levels that exceed normal limits. Unhealthy diet and lack of physical activity are one of the causes of uncontrolled blood sugar levels. This study aims to determine the relationship of physical activity and diet to blood sugar levels of patients with diabetes mellitus in the Internal Medicine Polyclinic of Selasih Regional General Hospital, Pelalawan Regency. Research is quantitative with a cross sectional approach. The total sample of 84 respondents was taken using accidental sampling technique. Data analysis was performed univariate and bivariate with chi square test. The results showed that the majority of low physical activity were 49 respondents (58.3%), poor diet were 59 respondents (70.2%) and uncontrolled blood sugar levels were 64 respondents (76.2%). There is a relationship between physical activity (0.030) and diet (0.011) on blood sugar levels of diabetes mellitus patients at the Internal Medicine Polyclinic of Selasih Regional General Hospital, Pelalawan Regency. It is recommended to respondents to be able to do physical activities such as and adjust their diet so that the respondent's blood sugar levels are controlled and prevent worse conditions due to complications.Keywords: Diabetes mellitus, blood sugar, physical activity, diet
Computational Study of Phytopharmaceutical Antidiabetes Potential of Gorontalo Traditional Medicine Plants La Kilo, Akram; Aman, La Ode; Asisah, Asisah; Ischak, Netty Ino; Paputungan, Mardjan; Alio, La
Jurnal Kartika Kimia Vol 6 No 1 (2023): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v6i1.202

Abstract

Diabetes Mellitus (DM) was a disease characterized by the occurrence of hyperglycemia. This study aimed to analyze the activity of compounds in traditional medicinal plants as potential anti-diabetic candidates using the MM method and to analyze the interactions of compounds contained in traditional medicinal plants that could be used as anti-diabetic drugs. The methods used were Molecular docking and Molecular dynamics, with the Aldose reductase 2HV5 receptor and the ligand ZST. Based on the research findings, the active compounds identified as potential anti-diabetic drugs were Calebin_A and alpha_tocotrienol. Docking method validation on Protein 2HV5 using the natural ligand ZST showed an RMSD of 0.66 Å. The best results from molecular docking were obtained with Calebin_A, which had a binding affinity of -11.3 kcal/mol, and alpha_tocotrienol, which had a binding affinity of -11.2 kcal/mol. The results of the molecular dynamics method on the best complexes were evaluated by considering the changes in system energy, system temperature, pressure, RMSD, RMSF, and binding free energy (∆G). The standard ligand ZST had a value of -30.43 kcal/mol, the test ligand calebin_A had a value of -34.48 kcal/mol, and alpha_tocotrienol had a value of -39.46 kcal/mol.
Molecular Docking of Secondary Metabolite Compounds of Andrographis Paniculata Plant as Potential Covid-19 Drug Candidate Netty Ino Ishak; Akram La Kilo; Dandi Saputra Halidi; La Ode Aman; Jafar La Kilo; Weny J.A. Musa
Jurnal Sains dan Kesehatan Vol. 5 No. 3 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i3.1845

Abstract

The aim of this research was to investigate the interaction between secondary metabolite compounds and the Mpro receptor, which was the main protein in Covid-19. Ligand-receptor interactions were studied using the Molecular Docking method. The validation results indicated that the test ligand Andrographolide had a higher affinity value compared to the standard ligand, with a value of -6.6 kcal/mol compared to the standard ligand's -7.5 kcal/mol. Additionally, the compound 14-Acetyl-3,19-isopropylideneandrographolide, 5,4 dihydroxy-7,8,2',3'-tetramethoxyflavone-5-glucoside had an affinity of -7.5 kcal/mol, Andrographidin A had -7.6 kcal/mol, Andrographiside had -7.7 kcal/mol, Skullcapflavone I had 7.7 kcal/mol, 5-Hydroxy-7,8,2'-trimethoxyflavone-5-glucoside had -7.7 kcal/mol, Apigenin had 7.7 kcal/mol, 5-Hydroxy-7,8-dimethoxyflavone-5-glucoside had -7.8 kcal/mol, Neoandrographolide had -7.8 kcal/mol, Andropanoside had -7.9 kcal/mol, Wogonin-5 glucoside had -8.1 kcal/mol, 5,2',3'-Trihydroxy-7,8-dimethoxyflavone-3'-glucoside had -8.4 kcal/mol, and Bisandrographolide had -8.5 kcal/mol. From the molecular docking results, the secondary metabolite compounds from the Andrographis paniculata plant exhibited significant interactions surpassing the standard ligand N3. Active residue interactions observed included Phe140, Leu141, Asn142, Gly143, His163, Glu166, Gln189, and Thr190. Keywords: Andrographis paniculata; Covid-19 drug; Mpro receptor; molecular docking
Analisis Kadar Logam Berat Timbal (Pb), Kadmium (Cd), dan Merkuri (Hg) pada Sayuran Selada (Lactuca Satiya L.) yang Beredar di Pasar Sentral Kota Gorontalo Merlin Darise; Ishak Isa; Mardjan Paputungan; Netty Ino Ischak; Erni Mohamad; Nita Suleman
Algoritma : Jurnal Matematika, Ilmu pengetahuan Alam, Kebumian dan Angkasa Vol. 3 No. 1 (2025): Algoritma : Jurnal Matematika, Ilmu pengetahuan Alam, Kebumian dan Angkasa
Publisher : Asosiasi Riset Ilmu Matematika dan Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/algoritma.v3i1.348

Abstract

The purpose of this study was to determine the results of the analysis of heavy metal levels of Pb, Cd, Hg found in lettuce in the Central market of Gorontalo city. In this study, the object of research was the roots, stems and leaves of lettuce. The method used was wet deconstruction method using a mixture of HNO3 and HCl. After that the solution was cooled, then filtered. The sample solution that has been deconstructed is analysed by UV-Vis Spectrophotometry. The results of the analysis showed that there was heavy metal Pb in the root, stem and leaf lettuce samples of 2.54 mg / kg, 1.58 mg / kg, 2.28 mg / kg / respectively. Cd heavy metal levels of 0.07 mg/kg, 0.60 mg/kg, 0.65 mg/kg. Hg heavy metal levels of 2.09 mg/kg, 0.21 mg/kg, 0.44 mg/kg. Based on the 2018 Food and Drug Administration regulations, the value of Pb metal content is 0.20 mg/kg, the value of Cd content is 0.05 mg/kg, and the value of Hg content is 0.03 mg/kg.
Inhibis Enzim α-Glukosidase dan α-Amilase dari Ekstrak Metanol Daun Buhu (Garuga floribunda Decne) Sebagai Antidiabetes Nurvita Abdullah; Netty Ino Ischak; La Alio; Yuszda K. Salimi; La Ode Aman; Ahmad Kadir Kilo
Algoritma : Jurnal Matematika, Ilmu pengetahuan Alam, Kebumian dan Angkasa Vol. 3 No. 1 (2025): Algoritma : Jurnal Matematika, Ilmu pengetahuan Alam, Kebumian dan Angkasa
Publisher : Asosiasi Riset Ilmu Matematika dan Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/algoritma.v3i1.360

Abstract

The Garuga floribunda (Garuga floribunda Decne) plant is one of the species known for its various medicinal properties. This research aims to investigate the inhibitory activity of α- glucosidase and α-amylase enzymes and to determine the optimum concentration of the methanol extract of Garuga floribunda leaves as an antidiabetic agent. The leaves extraction is obtained through an extraction process using methanol as the solvent and tested for itsinhibitory activity against the α-glucosidase enzyme using the p-nitrophenyl-α-D- glucopyranoside (p-NPG) substrate and the α-amylase enzyme using the DNS (3,5- dinitrosalicylic acid) substrate. The method is UV-Vis spectrophotometry. The Phytochemical tests of this plant reveal the presence of flavonoids, alkaloids, saponins, tannins, steroids, and terpenoids. The inhibition test results show that the methanol extract of Garuga floribundaleaves exhibited significant inhibitory activity against both enzymes. The highest inhibition percentage against the α-glucosidase enzyme is 91.09%, indicating very high antidiabetic activity. Meanwhile, the inhibition against the α-amylase enzyme is 7.56%, showing no significant antidiabetic activity. The optimum concentration for inhibiting both enzymes is 1000 ppm.
Uji Organoleptik & Karakteristik Fisikokimia Serta Aktivitas Antioksidan Produk Susu Berbasis Kacang Sacha Inchi (Plukenetia volubilis L.) Nurfadilah M. Kasim; Netty Ino Ischak; Yuszda K. Salimi; Nurhayati Bialangi; La Ode Aman; Erni Mohamad
Pentagon : Jurnal Matematika dan Ilmu Pengetahuan Alam Vol. 3 No. 1 (2025): Maret : Pentagon : Jurnal Matematika dan Ilmu Pengetahuan Alam
Publisher : Asosiasi Riset Ilmu Matematika dan Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/pentagon.v3i1.412

Abstract

This research aims to formulate and examine the physicochemical characteristics and antioxidant activity of sacha inchi (Plukenetia volubilis L.) as a plant-based milk. Moreover, this research also aims to conduct organoleptic tests on the products. The sacha inchi milk is formulated with five ratios: SI1 (sacha inchi 1:10 parts water), SI2 (sacha inchi 2:10 parts water), SI3 (sacha inchi 3:10 parts water), SI4 (sacha inchi 4:10 parts water), and SI5 (sacha inchi 5:10 parts water). Organoleptic tests are carried out by assessing the aspects of taste, color and aroma of the product with a score range of 1 (least preferred) - 5 (most preferred). The results of the organoleptic test showed that the most preferred sacha inchi peanut milk formulation was SI5 with a preference level reaching a score of 4.48. The SI5 formulation is more dominantly preferred because it is richer in taste, color and aroma. Then continued with physicochemical testing which includes water content, ash content, fat content, protein content, carbohydrate content, calcium content, pH, and viscosity and IC50 antioxidant activity test using UV-Vis Spectrophotometer instrument. The results of physicochemical tests and IC50 antioxidant activity conducted in this study were respectively: water content (74.10%), ash content (0.65%), fat content (19.15%), protein content (4.29%), carbohydrate content (1.82%), calcium content (0.043%), pH (6.01), viscosity (209 mPa∙S), and IC50 antioxidant activity (429.10 ppm).
Identifikasi Senyawa Metabolit Sekunder Ekstrak Etanol Cangkang Sacha Inchi (Plukenetia volubilis L.) Astria Endesei; Yuszda K. Salimi; Netty Ino Ischak; Ahmad Kadir Kilo; Hendri Iyabu; La Ode Aman
Jurnal Pendidikan Kimia, Fisika dan Biologi Vol. 1 No. 3 (2025): Mei : Jurnal Pendidikan Kimia, Fisika dan Biologi
Publisher : Asosiasi Riset Ilmu Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/jupenkifb.v1i3.281

Abstract

This study aimed to identify the secondary metabolite compounds present in the ethanol extract of Plukenetia volubilis L. (sacha inchi) shells through phytochemical screening and LC-MS analysis. The extraction was performed using the maceration method with 95% ethanol as solvent, resulting in a yield of 47.33%. Qualitative phytochemical tests revealed the presence of alkaloids, flavonoids, tannins, terpenoids, saponins, and glycosides in the extract. Further LC-MS analysis tentatively identified several phenolic and flavonoid compounds with known biological activities, including sinapinic acid, 1-o-sinapoylglucose, and azelaic acid from the dicarboxylic acid group. The presence of these compounds highlights the potential of sacha inchi shell extract as a natural antioxidant and antidiabetic agent. These findings support the valorization of sacha inchi agricultural waste as a promising raw material for pharmaceutical and nutraceutical applications.
Pengaruh Model Pembelajaran Problem Based Learning terhadap Kemampuan Pemecahan Masalah Siswa pada Materi Laju Reaksi di SMA Negeri 7 Gorontalo Fitria Lamalani; Netty Ino Ischak; Masrid Pikoli
Jurnal Pendidikan Kimia, Fisika dan Biologi Vol. 1 No. 3 (2025): Mei : Jurnal Pendidikan Kimia, Fisika dan Biologi
Publisher : Asosiasi Riset Ilmu Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/jupenkifb.v1i3.306

Abstract

This study aims to determine the effect of the Problem Based Learning (PBL) model on students’ problem-solving abilities in the reaction rate material at SMA Negeri 07 Gorontalo. The research employed a quasi-experimental method with a pretest-posttest control group design. The subjects consisted of two classes: class XI1 as the experimental group (using the PBL model) and class XI2 as the control group (using conventional learning). The instrument used was an essay test based on problem-solving indicators. The results showed a significant improvement in problem-solving ability in the experimental class compared to the control class. The average posttest score of the experimental class was 74 (categorized as good), while the control class scored 52 (categorized as fair). The t-test results indicated a significant difference between the two groups (p < 0.05), suggesting that the PBL model is more effective in enhancing students' problem-solving abilities than conventional learning methods.
Co-Authors Agustian A Maridji Ahmad Kadir Kilo Akram La Kilo Arviani, Arviani Asisah, Asisah Astria Endesei Badu, Ririn Bambang, Rita Daaliwa, Neva Dandi Saputra Halidi Deasy N Botutihe Deasy Natalia Botutihe Dewi Budi Purwati Dian Saraswati Domu, Siti Afdianti Dwi Fazriani Eka Anggraini Odja Eka Puspita Sari Erni Mohamad Fahia Datau Fihrina Mohamad Fitri, Farah Alifia Fitria Lamalani Frida M Yusuf Frida M. Yusuf Frimawaty H Djafar Handayani, Sekar Haris Munandar Hayati, Zahratul Hendri Iyabu Hendri Iyabu Ibrahim, Yusni Ika Riyana Tungkagi Ishak Isa Ishak, Siti Amalisa Jafar La Kilo Jumarni Kamarudin Karim, Fadila La Alio La Alio La Ode Aman Laliyo, Lukman A.R Liputo, Aprila Perdana Eka Citra Lukman A. R. Laliyo Lumuru, Feyske Youke Malae, Ismail Mangara Sihaloho Mardjan Paputungan Masrid Pikoli Merlin Darise Mohamad Taufik Iriawan Sutaji Mu'awanah, Mu'awanah Najmah, Najmah Nibras K. Laya Nita Suleman Noorma, Nilam Nurfadilah M. Kasim Nurhayati Bialangi Nurlaela Abd. Kadir Nurvita Abdullah Ode, Nur Mei Yulianty Opir Rumape Polontalo, Widya Cahyaningsih Pomuato, Sasmita Pore, Syarifah R Tulie, Wina Zulviana Rahman, Sapriyaty rofiqoh rofiqoh Safriyanto Dako Said, Sriyanti S Saleh, Sri Deltalia Selvian Idrus Siti Nurhidayati Suchi Wulandari Dai Suleman Daima Suleman Duengo Suparmin Fathan Supriadin, Yogi Tri Handayani Wa Ode Santi Mekar Weny J.A. Musa Widhi, Anisa Sekar Wiwin Rewini Kunusa Yayurulia Hadju Yulita, Hendra Yusni Ibrahim Yusuf, Andriyana Yusuf, Kartika Endarwaty Yuszda K Salimi Yuszda K. Salimi Zaenul Wathoni