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All Journal HAYATI Journal of Biosciences Medicina Buletin Veteriner Udayana E-Jurnal Medika Udayana Indonesian Journal of Biotechnology ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Patologi Indonesia Neurologico Spinale Medico Chirurgico Babali Nursing Research Journal of Global Pharma Technology Cermin Dunia Kedokteran

I Wayan Juli Sumadi

Bagian Patologi Anatomi, Fakultas Kedokteran, Universitas Udayana, Bali, Indonesia

Author-ID : 293261

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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KARAKTERISTIK PASIEN KANKER KOLOREKTAL DI RUMAH SAKIT UMUM PUSAT SANGLAH TAHUN 2017 Anak Agung Ngurah Satya Pranata; Ni Nyoman Ayu Dewi; I Wayan Surudarma; I Wayan Juli Sumadi
E-Jurnal Medika Udayana Vol 10 No 3 (2021): Vol 10 No 03(2021): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2021.V10.i3.P09

ABSTRAK Kanker kolorektal (Colorectal Cancer/CRC) menempati urutan ketiga kanker dengan prevalensi tertinggi. Studi ini bertujuan memahami karakteristik pasien kanker kolorektal di Rumah Sakit Umum Pusat (RSUP) Sanglah Tahun 2017. Penelitian ini menggunakan rancangan penelitian deskriptif potong lintang. Data yang digunakan diambil dari rekam medis pasien kanker kolorektal yang tersimpan di Instalasi Patologi Anatomi RSUP Sanglah. Kasus CRC yang didapatkan sebanyak 44 kasus; dari 44 kasus tersebut didapatkan data usia termuda yang menderita CRC adalah 23 tahun dan tertua adalah 80 tahun, dengan persentase lebih besar terjadi pada kelompok usia >50 tahun dibandingkan dengan kelompok usia <50 tahun ((n=32 (73%) vs. n=12 (27%)). Penderita CRC lebih banyak pada laki-laki dibandingkan dengan perempuan dengan rasio 25:19. Berdasarkan diferensiasi sel diperoleh 1 sampel (2%) dengan well-differentiated, 29 sampel (66%) dengan moderate-differentiated dan 5 sampel (11%) dengan poorly-differentiated CRC. Lokasi tumor yang paling banyak ditemukan adalah pada rektosigmoid sebanyak 11 sampel (25%) yang diikuti pada rektum sebanyak 9 sampel (20,5%). Penelitian ini diharapkan dapat memberikan kontribusi terhadap data dasar CRC di Bali. Penelitian lebih lanjut dibutuhkan untuk menganalisis hubungan antara variabel karakteristik dengan respon terapi dan prognosis sehingga dapat membantu dalam manajemen CRC. Kata kunci : Kanker Kolorektal, Usia, Jenis kelamin, Diferensiasi Sel

Efek pemberian ekstrak ethanol ubi jalar ungu (Ipomoea batatas L) terhadap ketebalan dan diferensiasi sel epitel vagina tikus betina yang mengalami ovariektomi di Laboratorium Histologi Fakultas Kedokteran Universitas Udayana periode Oktober-Desember 2017 Jessica Yuwono; Wayan Sugiritama; Gusti Ngurah Mayun; Wayan Juli Sumadi
E-Jurnal Medika Udayana Vol 7 No 5 (2018): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2205.798 KB)

Post menopause woman experiencing estrogen hormone deficiency causing vaginal atrophy leading decrease in vaginal epithelial thickness. Hormone replacement therapy (HRT) was the first choice to overcome those problems. Meanwhile, HRT has so much adverse effect in long term use such as increase risk of breast cancer, and cardiovascular disease. Phytoestrogen is an estrogen compound derived from plant particullary in purple yam, containing antosianin that could be an alternative for estrogen replacement therapy. Study design is post-test only control group with animal model using wistar mice divided into four groups intervention. Control group recieving placebo, intervention group 1 (I1) recieving 1 cc of purple yam ethanol extract, I2 and I3 recieving 2cc and 4 cc of yam ethanol extract respectively. Oovorectomy was done before intervention and intervention was done for one months. Histophatological structure of vaginal epithelial and assesment of vaginal epithelial maturation was observed. There are significant difference between the average number of parabasal cell, intermediate cell, and superficial cell in four groups intervention (p=0.000). The highest number of parabasal cell was found in control group (151.63±34.13), the highest number of intermediate cell was found in I3 group, and the highest number of superficial cell was found in I3 group. There are significant different between thickness of epithelial cell layer in four groups intervention (p=0.004) and I3 group with the thickest layer of ephitel (54.24 ± 7.782). The best maturation degree was found in I3 group with much squamous epithelium with thick layer of glicogen on the surface of epithelial layer. Meanwhile, control group was found with poor maturation, superficial epithelial layer undergoes keratinization with predominant of parabasal cell layer and only a few number of superficial squamous epithelial cell was found. Intervention of purple yam ethanol extract enhance epithelial maturation and differentiation, increase epithelial thickness in rats undergoes oovorectomy. Keywords: purple yam extract, vagina epithelial, thickness of epithelial, maturation degree, phytoestrogen.

AKURASI SITOLOGI IMPRIN PADA TUMOR TULANG DI RSUP SANGLAH DENPASAR I Putu Gede Putra Darmawan; I Wayan Juli Sumadi; I Made Gotra; Ni Made Mahastuti
E-Jurnal Medika Udayana Vol 8 No 12 (2019): Vol 8 No 12 (2019): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.133 KB)

Tumor tulang termasuk tumor dengan insiden yang relatif jarang namun memiliki angka mortalitas yang tinggi. Diagnosis tumor tulang umumnya menggunakan pemeriksaan histopatologi rutin namun memerlukan proses yang lama. Pemeriksaan sitologi imprin merupakan salah satu metode pemeriksaan yang cepat dan murah. Sitologi imprin telah dibuktikan memiliki akurasi yang tinggi dalam mendiagnosis berbagai jenis tumor. Penelitian ini bertujuan untuk mengetahui akurasi pemeriksaan sitologi imprin pada kasus tumor tulang. Jenis penelitian merupakan uji diagnostik untuk menganalisis tingkat akurasi pemeriksan sitologi imprin pada kasus tumor tulang, yang dilakukan core biopsy dan dari pemeriksaan potong beku di RSUP Sanglah Denpasar selama periode Januari 2013 hingga Agustus 2018. Menggunakan metode consecutive sampling dengan melakukan pencatatan nomor data sekuder yang berisi hasil diagnosis sitologi imprin dan histopatologi tumor tulang. Pada penelitian ini didapatkan 23 kasus tumor tulang yang memenuhi kriteria, yang terdiri dari 11 sampel frozen section dan 12 sampel core biopsy. Pemeriksaan sitologi imprint tersebut memiliki akurasi sebesar 91,3%, dengan sensitivitas 93,3%, spesifisitas 87,5%, nilai prediktif positif 93,3%, nilai prediktif negatif 87,5%, likehood ratio positif 7,4 dan likehood ratio negatif 0,07. Sehingga pemeriksaan sitologi imprin dari spesimen core biopsy dan pemeriksaan potong beku pada kasus tumor tulang dengan menggunakan pemeriksaan histopatologi rutin sebagai baku emas di RSUP Sanglah Denpasar memiliki akurasi yang tinggi. Kata Kunci : Akurasi, Sitologi Imprin, Tumor Tulang, RSUP Sanglah

Posterior Spinal Surgery for Extradural Spinal Metastasis of Round Cell Tumor in the Lower Thoracal Region Marleen Marleen; Tjokorda GB Mahadewa; I Wayan Juli Sumadi
Neurologico Spinale Medico Chirurgico Vol 3 No 3 (2020)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v3i3.104

Spinal cord dysfunction caused by a spinal tumor is not always easy to treat since the tumor itself possesses variably etiology and low ability of nerve impairment to recover. The most common extradural tumor is derived from metastases, followed by other pathology such as plasmacytoma, lymphoma, etc. Since histopathologically they may present as round cell tumors, pre-operative data and intraoperative findings may help the clinician to establish appropriate diagnosis. This case report aims to describe the role of posterior spinal surgery and the reasoning of the selected approach in the treatment of spinal metastasis mimicking plasmacytoma in the lower thoracal region. We report 56 years old male who has myelopathy symptoms caused by lower thoracal extradural mass lesion, which histopathological study shows round cell tumor findings. Laminectomy and posterior stabilization were undertaken, and additional rotational flap was made to close sacral decubitus ulcer defect. Axial pain was improved and the patient discharged from the hospital with improved quality of life.

Karakteristik klinikopatologi osteosarkoma berdasarkan usia, jenis kelamin, lokasi, dan tipe histopatologi di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar tahun 2012 -2016 Putu Agus Aryanda Putra; Anak Agung Ngurah Susraini; I Wayan Juli Sumadi
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Background: Osteosarcoma was the most common primary bone tumor, and there are only a few studies discussed the clinicopathological characteristics of Osteosarcoma.Aim: This study aimed to determine the clinicopathological features of Osteosarcoma based on age, sex, type, and the location in Anatomical Pathology Laboratories Sanglah Hospital Denpasar in 2012 â€“ 2016.Method: This research was a cross sectional descriptive study which obtains data from the medical record in Anatomical Pathology laboratories Sanglah Hospital Denpasar in 2012 â€“ 2016. The total sample is 44 cases by total sampling technique. The data were processed using SPSS version 20.Result: In this study, the majority of Osteosarcoma patients were in age group 0 â€“ 24 years as many as 30 cases (68.2%) and rarely found in the age group 49 -72 years for 2 cases (4.5%). Osteosarcoma was slightly higher in a male about 23 cases (52.3%) and 21 cases in female (47.7%).Conclusion: the Histopathological type that mostly found was Conventional Osteosarcoma as many as 41 cases (93.2%) and the most common site of Osteosarcoma was in femur about 24 cases (52.2%).Â Osteosarkoma merupakan tumor primer pada tulang yang paling sering ditemukan, namun tidak banyak penelitian yang hanya membahas karakteristik klinikopatologi Osteosarkoma.Tujuan: Tujuan penelitian ini adalah untuk mengetahui karakteristik klinikopatologi Osteosarkoma berdasarkan usia, jenis kelamin, tipe, dan lokasi di Laboratorium Patologi Anatomi RSUP Sanglah RSUP Sanglah Denpasar pada tahun 2012 â€“ 2016.Metode: Penelitian ini merupakan studi deskriptif cross sectional yang dilaksanakan di Laboratorium Patologi Anatomi RSUP Sanglah Denpasar menggunakan catatan rekam medis periode tahun 2012 -2016. Teknik pengambilan sampel menggunakan total sampling, dengan total jumlah sampel sebanyak 44 orang. Data diolah menggunakan SPSS versi 20. PenderitaHasil: Osteosarkoma pada penelitian ini paling sering ditemukan pada kelompok usia 0 â€“ 24 tahun sebanyak 30 kasus (68,2%) dan paling sedikit pada kelompok usia 49 â€“ 72 tahun terdapat 2 kasus (4,5%). Jumlah kasus Osteosarkoma sedikit lebih tinggi kasusnya pada pria yaitu, sebanyak 23 kasus (52,3%) sedangkan pada wanita ditemukan sebanyak 21 kasus (47,7%).Simpulan: Tipe histopatologi yang paling sering ditemukan adalah Conventional Osteosarcoma sebanyak 41 kasus (93,2%) dan lokasi tersering pada tulang femur sebanyak 24 kasus (52,2%).

Clinicopathological patterns of cervical carcinoma in pathological anatomy laboratory at RSUP Sanglah Denpasar, Bali since 2012-2016 Shameni Subramaniam; I Wayan Juli Sumadi; I.G.A. Sri Mahendra Dewi
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: Carcinoma of the cervix is the second most common cancer in women worldwide, Cervical cancer is the most common cancer in women in developing countries. Cervical cancer is the fourth most common cancer in women overall, with an estimated 528,000 new cases in 2012. According to the data clinicopathology of cervical cancer in Bali its still in a small amount.Aims: To obtain information about clinicopathology of cervical carcinoma from the year 2012 â€“ 2016.Methods: A descriptive design study is conducted to determine the clinical pathology profile of cervical carcinoma among patients in Sanglah Hospital, Denpasar, Bali in the year 2012 â€“ 2016. Medical records of the patients were used as the secondary data for this research. This research used the histopathologic document that available in Pathological Anatomy at RSUP Sanglah which mainly reports about patient condition starting from the early anamnesis period until the exact diagnosis of the patient which is due to the laboratory examination or other.Result and Conclusion: As of 2012 to 2016, there were 142 cases of cervical cancer patients in RSUP Sanglah.The age group of 41-50 years has the highest number of patients in the year 2012 â€“ 2016 which is about 52 patients. Abnormal vaginal bleeding is the most common clinical finding of cervical cancer patients from the year 2012- 2016 and carries 53% in 142 cases. It is found out that the most common histopathologic type of cervical cancer from the year 2012 â€“ 2016 is squamous cell followed by adenocarcinoma in the list.

Karakteristik klinikopatologi karsinoma kolorektal di RSUP Sanglah, Bali, Indonesia tahun 2013-2017 Venosha Gunasekaran; Ni Putu Ekawati; I Wayan Juli Sumadi
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: Colorectal cancer is the third most common cancer in the world and the fourth leading cause of cancer death. The etiology of colorectal carcinoma is an unhealthy lifestyle and a poor diet such as excessive consumption of fat. This study aims to determine the characteristic of the clinicoopatological on colorectal carcinoma patients at Sanglah Hospital Denpasar 2013-2017.Methods: A cross-sectional study was conducted with a purposive sampling technique, on all patients who met the inclusion criteria. The tools used in data collection are medical records and their complaints that are found in the Anatomy Department of Sanglah Hospital. Data recorded includes age, grade, stage, and histopathology. The data analysis method uses SPSS version 17 for Windows.Results: A total of 121 cases were collected where most were in the age range of 50-60 years, as many as 48 cases (39.7%). In addition, Grade 2 was 98 cases (81.0%), followed by histopathological type with adenocarcinoma not otherwise specified as many as 118 cases (97.5%). Stadium 2 cases were 65 cases (53.7%), and 72 cases (59.5%) were males.Conclusion: Most cases are in the range of 50-60 years of age which is followed by Grade 2, histopathological type of adenocarcinoma not otherwise specified, stage 2 and male sex

Peranan p53 dalam perkembangan dan prognosis osteosarkoma: tinjauan pustaka I Wayan Juli Sumadi; Nyoman Adiputra
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: Osteosarcoma is the most common non hematopoietic primary malignant tumor in the bone. Several factors have been related through the development and prognosis of osteosarcoma. One of them is the mutation of p53 gene that encodes p53 protein. This literature review aims to evaluate the role p53 in the progressiveness and prognosis of osteosarcoma.Methods: A review of relevant literature was performed to elaborate p53 involvement in osetosarcoma. A total of 22 qualified published literature from 2006 until 2017 were collected from several electronic database as well as manual search and included in this review.Results: P53 has an important role in maintaining genome integrity through its ability to induce genes involved in senescence process, DNA repair and apoptosis. Loss of P53 induces progenitor cells to proliferate and experience differentiation disturbances thereby increasing the potential malignant transformation to osteosarcoma. Loss of p53 also increases osteosarcoma progression by increasing proliferation and providing a good microenvironment for tumor cells. P53 causes inhibition to other tumor suppressor proteins such as BMP-2 and CD137L. Loss of P53 has a role in providing a good microenvironment for osteosarcoma cells to invade surrounding tissue, metastasis and suppressed immune response through increased activity of SDF-1, HIF-1Î±, VEGF, and NO. High mutant p53 expression has a positive association with short-term survival but does not have a strong association to predict long-term survival.Conclusion: A p53 gene has a pivotal role in the progressiveness and prognosis of osteosarcoma through increasing proliferation and providing a good microenvironment for tumor cellsÂ Latar Belakang: Osteosarkoma merupakan tumor ganas primer non hematopoietik tersering pada tulang. Berbagai faktor telah dikaitkan dengan perkembangan dan prognosis pasien osteosarkoma, Salah satunya adalah mutasi gen p53 yang menyandi protein p53. Tinjauan pustaka ini bertujuan untuk mengevaluasi peran p53 dalam progresif dan prognosis osteosarkoma.Metode: Tinjauan pustaka yang relevan dilakukan untuk menguraikan keterlibatan p53 dalam osetosarcoma. Sebanyak 22 literatur yang diterbitkan berkualitas dari 2006 hingga 2017 dikumpulkan dari beberapa basis data elektronik serta pencarian manual dan dimasukkan dalam ulasan ini.Hasil: P53 mempunyai peranan yang sangat penting dalam menjaga integritas genom melalui kemampuannya untuk menginduksi gen-gen yang terlibat dalam proses penuaan sel, perbaikan DNA maupun apoptosis. Hilangnya p53 menginduksi sel-sel progenitor osteosarkoma untuk berproliferasi dan mengalami gangguan diferensiasi sehingga meningkatkan potensi transformasi keganasan menjadi osteosarkoma. Kehilangan p53 juga meningkatkan progresivitas osteosarkoma melalui peningkatan proliferasi dan penyediaan lingkungan mikro yang baik bagi sel tumor. P53 menyebabkan hambatan fungsi protein penekan tumor lainnya yaitu BMP-2 dan CD137L. Kehilangan p53 berperan dalam menyediakan lingkungan mikro yang baik untuk sel-sel osteosarkoma untuk menginvasi jaringan sekitar, bermetastasis dan menghambat aktivitas sistem imun melalui peningkatan aktivitas SDF-1, HIF-1Î±, VEGF, dan NO. Ekspresi p53 mutan yang tinggi memiliki hubungan positif dengan angka harapan hidup jangka pendek namun tidak memiliki hubungan yang kuat untuk memprediksi harapan hidup jangka panjang.Kesimpulan: Gen p53 memiliki peran penting dalam progresivitas dan prognosis osteosarkoma melalui peningkatan proliferasi dan menyediakan lingkungan mikro yang baik untuk sel tumor.

Karakteristik klinikopatologi osteokondroma di Rumah Sakit Umum Pusat Sanglah Denpasar periode tahun 2013 - 2018 I Gusti Ngurah Pratama Yuda Atmaja; I Wayan Juli Sumadi; Ni Putu Sriwidyani
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Background: Osteochondroma is a benign cartilage tumor which is quite a number of events with a clinical picture and quite varied pathology. The cause of osteochondroma is still not known with certainty. Data from osteocondroma cases in Indonesia especially in Bali are still very rarely found, even histopathological data registered at hospitals in Bali are still very rare. Aim: The study aims to determine the clinicopathological characteristics of osteochondroma patients in the Sanglah Hospital Denpasar for 5 years.Method: This research is a cross-sectional descriptive study conducted at the Sanglah Hospital using the histological data archive for the period 2013 - 2018. The sampling technique used total sampling, with a total sample of 32 people.Results: Most of the osteochondroma sufferers in this study were 59.4% male, while female sufferers were around 40.6%, with the most age range being 10 - 20 years (62.5%) and at least those aged > 20 years (15.6%). The most tumor location is the distal femur bone (37.5%). Most tumor size is at the size of 1-5 cm (78.1%). Most cases of osteochondroma based on the thickness of the hyaline cartilage cap are 1-3 mm (59.4%).Conclusion: The clinicopathological characteristics of osteochondroma patients by using histopathological data in the Sanglah Hospital shows that osteochondroma is more common in men. Osteokondroma merupakan salah satu tumor tulang rawan jinak yang angka kejadiannya cukup banyak dengan gambaran klinis dan gambaran patologinya cukup bervariasi. Penyebab osteokondroma masih belum dapat diketahui dengan pasti. Data dari kasus osteokondroma di Indonesia khususnya di Bali masih sangat jarang ditemukan, bahkan data histopatologi yang teregristasi di rumah sakit di Bali masih sangat jarang terjadi. Tujuan: Untuk mengetahui karakteristik klinikopatologi pasien osteokondroma di Rumah Sakit Umum Pusat (RSUP) Sanglah Denpasar selama 5 tahun.Metode: Penelitian ini merupakan penelitian deskriptif cross-sectional yang dilaksanakan di RSUP Sanglah menggunakan arsip data histologi periode tahun 2013 – 2018. Teknik pengambilan sampel menggunakan total sampling, dengan total jumlah sampel sebanyak 32 orang.Hasil: Sebagian besar penderita osteokondroma pada penelitian ini adalah laki – laki selitar 59,4%, sedangkan penderita perempuan sekitar 40,6%, dengan rentang usia terbanyak adalah 10 – 20 tahun (62,5%) dan paling sedikit pada usia > 20 tahun (15,6%). Lokasi tumor paling banyak adalah tulang distal femur (37,5%). Ukuran tumor paling banyak adalah pada ukuran 1 – 5 cm (78,1%). Kasus osteokondroma berdasarkan ketebalan tutup tulang rawan hialin terbanyak adalah pada ukuran 1 – 3 mm (59,4%).Simpulan: Karakteristik klinikopatologi pasien osteokondroma dengan menggunakan data histopatologi di RSUP Sanglah menunjukkan osteokondroma lebih banyak diderita oleh laki – laki.

Hubungan antara ekspresi Vascular Endothelial Growth Factor (VEGF) dengan karakteristik klinikopatologi osteosarkoma di RSUP Sanglah Denpasar, Bali Johanes Prasetyo Harjanto; I Wayan Juli Sumadi; I Made Gotra; Ni Putu Ekawati
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Background: Osteosarcoma is the most common malignant primary bone tumor. Although osteosarcoma cases are relatively rare compare to carcinoma, the mortality rate is quite high. Osteosarcoma prognosis can be seen from conventional pathology and biological markers, such as Vascular Endothelial Growth Factor (VEGF). In various studies, the presence of VEGF expression has been associated with the worsening prognosis of osteosarcoma. This study aims to determine the relationship between VEGF expression and osteosarcoma's clinicopathological characteristics at Sanglah General Hospital, Denpasar, 2015-2019.Method: This research is a cross-sectional analytic study. The sampling technique used all affordable populations that were included in the inclusion criteria, with a total sample of 30 samples. The research data used secondary data obtained from the archive of histopathological examination reports at the Anatomical Pathology Laboratory at Sanglah General Hospital and paraffin blocks from all available samples for immunohistochemical examination. Data were analyzed using SPSS version 22 for Windows.Results: The clinicopathological characteristics of the osteosarcoma studied were age, tumor location, histological type, and grading. Patients with osteosarcoma in this study were predominantly found in the age group <20 years (66.67%), femur locations (60.00%), mixed type osteosarcoma (53.33%), and high grade (100.00%). A total of 26 samples (86.67%) had high VEGF expression and 4 samples had low VEGF expression (13.30%). There was no significant relationship between age (p=0.241), location of the tumor (p=0.739), and histological type (p=1.000) to the VEGF expression.Conclusion: The relation between each osteosarcoma clinicopathological characteristic associated with VEGF expression showed insignificant results in age, location, and histological type. Further research is needed with a more significant number of samples to get better results. Latar Belakang: Osteosarkoma adalah tumor tulang primer ganas yang paling umum. Meskipun kasus osteosarkoma relatif jarang dibandingkan dengan karsinoma, angka kematiannya cukup tinggi. Prognosis osteosarkoma dapat dilihat dari patologi konvensional dan penanda biologis, salah satunya adalah Vascular Endothelial Growth Factor (VEGF). Dalam berbagai penelitian, kehadiran ekspresi VEGF telah dikaitkan dengan prognosis yang memburuk dari osteosarcoma. Penelitian ini bertujuan untuk mengetahui hubungan ekspresi VEGF dengan karakteristik klinikopatologi osteosarkoma di RSUP Sanglah Denpasar tahun 2015-2019.Metode: Penelitian ini merupakan penelitian analitik potong lintang. Teknik pengambilan sampel menggunakan semua populasi terjangkau yang termasuk dalam kriteria inklusi, dengan jumlah sampel sebanyak 30 sampel. Data penelitian menggunakan data sekunder yang diperoleh dari arsip laporan pemeriksaan histopatologi di Laboratorium Patologi Anatomi RSUP Sanglah dan blok parafin dari semua sampel yang tersedia untuk pemeriksaan imunohistokimia. Data dianalisis dengan SPSS versi 22 untuk Windows.Hasil: Karakteristik klinikopatologi dari osteosarkoma yang diteliti adalah usia, lokasi tumor, tipe histologis, dan grading. Penderita osteosarkoma pada penelitian ini paling banyak ditemukan pada kelompok usia <20 tahun (66,67%), lokasi femur (60%), tipe campuran osteosarkoma (53,33%) dan High-Grade (100.00%). Sebanyak 26 sampel (86,67%) memiliki ekspresi VEGF tinggi dan 4 sampel memiliki ekspresi VEGF rendah (13,30%). Tidak terdapat hubungan yang bermakna antara usia (p=0,241), lokasi (p=0,739), dan tipe histologis (p=1,000).Kesimpulan: Hubungan antara masing-masing karakteristik klinikopatologi osteosarkoma yang terkait dengan ekspresi VEGF menunjukkan hasil yang tidak bermakna pada usia, lokasi, dan tipe histologis. Diperlukan penelitian lebih lanjut dengan jumlah sampel yang lebih banyak untuk mendapatkan hasil yang lebih baik.

Co-Authors -, Jerry Agus Eka Darwinata Anak Agung Ayu Ngurah Susraini Anak Agung Gde Oka Anak Agung Ngurah Satya Pranata Anak Agung Ngurah Satya Pranata Andreliano Yosua Rompis Arimbawa, I Wayan Gede Bandem Ariyanta, Kadek Deddy Ayu Dewi Ni Nyoman Ayu Dewi, Ni Nyoman Butarbutar, Christine Rosalina Eka Wiratnaya Elysanti Dwi Martadiani Erawan, I Putu Putra Febrina, Jessica Gunawan, I Wayan Nico Fajar Gusti Ngurah Mayun Herman Saputra Herman Saputra Herman Saputra I Gde Haryo Ganesha I Gde Raka Widiana I Gusti Ayu Artini I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Sri Mahendra Dewi I Gusti Bagus Lulut Premana Mulia I Gusti Bagus Mulia Agung Pradnyaandara I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Pratama Yuda Atmaja I Gusti Nyoman Sri Wiryawan I Kadek Adi Purnama Sandhi I Ketut Bawantika Adi Putra I Ketut Mulyadi I Made Gotra I MADE MULIARTA . I Made Wirya Sastra I Nyoman Adi Putra I Putu Gede Putra Darmawan I Wayan Sugiritama I Wayan Surudarma I Wayan Wirata I Wayan, Oka Semara Jaya Ida Ayu Ika Wahyuniari Ida Sri Iswari Ivana Juliarty Sitanggang Jayakusuma, I Putu Prabawa Jessica Harlan Jessica Yuwono Johanes Prasetyo Harjanto John Nolan Ketut Mulyadi Luh Made Sudimantini Luh Made Sudimartini Luh Putu Iin Indrayani Maker Luh Yeni Laksmini M. Arif Perdana Ariyansyah Made Agus Kusumadjaja Made Widhi Asih Maker, Luh Putu Iin Indrayani Mark, Antony Marleen Marleen Meiske Margaretha Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Ni Made Linawati Ni Made Maharini Rahayu Ni Made Mahastuti Ni Made Pramita Widya Suksmarini Ni Nyoman Ayu Dewi Ni Nyoman Margiani Ni Putu Ekawati Ni Putu Mariati Ni Putu Sriwidyani Ni Wayan Armerinayanti, Ni Wayan Ni Wayan Winarti Nur Silfiah, Nur Pande Putu Bagus Premana Pranata, I Putu Yogi Putu Agus Aryanda Putra Putu Ayu Widya Pramesti Putu Dessy Wilantari Putu Eka Buana Sari Putu Oka Samirana Putu Yuliawati Saraswati, Ni Ketut Rake Putri Shameni Subramaniam Silvester Kristian Taopan Surudarma, I Wayan Suryaningmara, I Wayan Bagus Tessa Saputri Marmanto Tjokorda Gde Bagus Mahadewa Venosha Gunasekaran Wikaputri, Anak Agung Ayu Mutiara

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