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All Journal HAYATI Journal of Biosciences Medicina Buletin Veteriner Udayana E-Jurnal Medika Udayana Indonesian Journal of Biotechnology ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Patologi Indonesia Neurologico Spinale Medico Chirurgico Babali Nursing Research Journal of Global Pharma Technology Cermin Dunia Kedokteran
I Wayan Juli Sumadi
Bagian Patologi Anatomi, Fakultas Kedokteran, Universitas Udayana, Bali, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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PROFIL KLINIKOPATOLOGI PASIEN LESI PRAKANKER SERVIKS YANG MENJALANI LOOP ELECTROSURGICAL EXCISION PROCEDURE (LEEP) DI RSUP SANGLAH TAHUN 2016 – 2020 Jayakusuma, I Putu Prabawa; Ekawati, Ni Putu; Sumadi, I Wayan Juli; Saputra, Herman
E-Jurnal Medika Udayana Vol 11 No 7 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i7.P12

Abstract

Loop Electrosurgical Excision Procedure (LEEP) adalah tindakan pemotongan sel abnormal pada serviks menggunakan wire loop yang dialiri aliran listrik. LEEP merupakan salah satu penatalaksanaan pasien lesi prakanker serviks. Penelitian ini bertujuan untuk mengetahui gambaran profil klinikopatologi pasien lesi prakanker serviks yang menjalani Loop Electrosurgical Excision Procedure (LEEP) di RSUP Sanglah tahun 2016 – 2020. Penelitian ini merupakan penelitian deskriptif cross-sectional. Sampel dipilih berdasarkan kriteria inklusi dan eksklusi. Data diolah menggunakan software SPSS ver. 26 untuk mendapatkan karakteristik profil pasien lesi prakanker yang menjalani prosedur Loop Electrosurgical Excision Procedure (LEEP) yang terdiri dari usia, diagnosis klinis, dan diagnosis histopatologis. Hasil penelitian menunjukkan bahwa pasien lesi prakanker yang menjalani prosedur Loop Electrosurgical Excision Procedure (LEEP) di RSUP Sanglah Denpsar Bali pada tahun 2016-2020 sebanyak 37% dari kelompok umur 31-40 tahun. Diantara pasien lesi prakanker yang menjalani prosedur Loop Electrosurgical Excision Procedure (LEEP) 37% diagnosis klinis adalah ASCUS. Hasil diagnosis histopatologis terbanyak adalah HSIL (33,3%) dan non lesi prakanker (33,3%).
KARAKTERISTIK KLINIKOPATOLOGI KANKER LAMBUNG Erawan, I Putu Putra; Ekawati, Ni Putu; Sumadi, I Wayan Juli; Saputra, Herman
E-Jurnal Medika Udayana Vol 12 No 8 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i08.P14

Abstract

ABSTRACT Gastric cancer is a malignant neoplasm of the stomach and can invade and spread to other organs. Cases of gastric cancer are still common throughout the world and tend to be potentially deadly, especially among older men. Based on data obtained through GLOBOCAN in 2018, gastric cancer is a neoplasm with the 5th most common occurrence in the world and the 3rd deadliest cancer in the world, with an estimated 783,000 deaths in 2018. The purpose of this study is to determine the profile of gastric cancer patients at Sanglah Hospital from 2010 to 2020. This research is classified as a descriptive study using a cross-sectional method. The sample used was selected based on inclusion and exclusion criteria. The subjects of the study were 21 gastric cancer patients at Sanglah Hospital in 2010-2020. Data retrieval from medical records was then analyzed with SPSS version 22 software. The results of the study showed that the profile of gastric cancer patients at Sanglah Hospital in 2010-2020 varied greatly, with the most occurring in the age group above 50 years. By gender, the majority of cases are women. For clinical diagnosis, the most frequently found is dyspepsia. Keywords: Characteristics, Gastric Cancer, Sanglah General Hospital
KARAKTERISTIK KLINIKOPATOLOGI TUMOR-TUMOR TULANG RAWAN DI RSUP SANGLAH TAHUN 2016-2020 Suryaningmara, I Wayan Bagus; Sumadi, I Wayan Juli; Saputra, Herman; Ekawati, Ni Putu
E-Jurnal Medika Udayana Vol 12 No 1 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i01.P05

Abstract

Tumor tulang adalah pertumbuhan sel abnormal pada tulang. Saat tumor tumbuh, jaringan abnormal dapat menggantikan jaringan sehat. Adapun jenis tumor pada tulang rawan yang umum terjadi yaitu Osteochondroma, Chondrosarcoma, dan Enchondroma. Penelitian ini merupakan penelitian deskriptif dengan metode penelitian (cross-sectional) untuk mengetahui gambaran karakteristik klinikopatologi tumor tulang rawan di RSUP Sanglah Denpasar tahun 2016 – 2020. Pengumpulan sampel dilakukan dengan menggunakan teknik total sampling. Pasien dengan tumor tulang rawan di RSUP Sanglah Denpasar tahun 2016 – 2020 terbanyak terjadi pada rentang usia >40 tahun yaitu 13 (36,1%) orang. Lokasi tumor tulang rawan di RSUP Sanglah Denpasar tahun 2016 – 2020 paling banyak ditemukan pada pelvis dengan jumlah 9 (25%) kasus. Tipe histologi pada pasien dengan tumor tulang rawan di RSUP Sanglah Denpasar tahun 2016 – 2020 yang paling banyak ditemukan yaitu Conventional Chondrosarcoma dengan jumlah 19 (52,8%) kasus. Tumor tulang rawan pada pasien di RSUP Sanglah Denpasar tahun 2016 – 2020 tersering yaitu tumor ganas dengan jumlah 20 (55,6%) kasus sedangkan tumor jinak dengan jumlah 16 (44,4%) kasus. Apabila dijumpai pasien berusia tua > 40 tahun dengan tumor tulang di pelvis maka perlu dipikirkan tumor tulang rawan sebagai salah satu diferensial diagnosis. Kata kunci : Tumor Tulang Rawan, Karakteristik, Chondrosarcoma
Karakteristik Klinikopatologi Psoriasis di RSUP Prof. Dr. I G. N. G. Ngoerah Denpasar Periode Tahun 2011-2021 -, Jerry; Saputra, Herman; Ekawati, Ni Putu; Sumadi, I Wayan Juli
E-Jurnal Medika Udayana Vol 13 No 3 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i03.P02

Abstract

Psoriasis is a skin disease that can affect all ages. Many people think that skin diseases do not endanger human life, but psoriasis can be complicated into a more serious disease. This study aims to determine the clinicopathological characteristics of psoriasis at Prof. Dr. I G. N. G. Ngoerah Central Hospital Denpasar in 2011-2021. This study used a cross-sectional design with total sampling from secondary data at the Anatomical Pathology Installation of Prof. Dr. I G. N. G. Ngoerah Denpasar. Of the 75 samples obtained, the most cases of psoriasis were psoriasis vulgaris (54.7%) which was dominated by male patients (70.7%), where most cases occurred in the age group of 31-40 years (24.0%). Most of the lesions were found locally, especially on the body area (54.7%). Of all medical record data that included family history (21.3%), all cases stated that there was no family history of psoriasis. Most of patients’ main complaints were red spots (57.3%). The majority of patients had a match between the clinical diagnosis and the clinicopathological diagnosis (73.3%). These findings can provide insight into the clinicopathological characteristics of psoriasis so that it can be detected as early as possible and given appropriate treatment. It is necessary to carry out further analytical research to look for the relationship between various variables.
PROFIL KLINIKOPATOLOGI LESI PRE KURSOR KARSINOMA KOLOREKTAL (KKR) DI RSUP SANGLAH DENPASAR PERIODE TAHUN 2018-2020 I Wayan, Oka Semara Jaya; Saputra, Herman; Ekawati, Ni Putu; Juli Sumadi, I Wayan
E-Jurnal Medika Udayana Vol 11 No 7 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i7.P07

Abstract

ABSTRACT CRC precursor lesions are abnormal tissue growths in the colon and rectum that are not controlled but do not have the capacity to invade surrounding tissues. Good management if delayed in the long term causes the lesion to develop into colorectal carcinoma, a malignant condition that occurs in the colon and rectum. The purpose of this study was to determine the clinicopathological description of pre-cursor colorectal carcinoma lesions at Sanglah Hospital Denpasar in 2018- 2020. The study used secondary data by cross sectional (cross sectional) with a total sampling technique using data from the patient's medical record at the Anatomical Pathology Installation at Sanglah Hospital Denpasar. The number of data obtained during the study period as patients diagnosed as precursor TRC lesions were 55 samples which were then processed using SPSS ver 26 software. The results of the study obtained a profile of the clinicopathological characteristics of pre-cursor TRC lesions at Sanglah Hospital Denpasar in 2018- 2020 the most findings were adenoma low grade dysplasia as many as 26 cases (47.3%), occurring in the age group 60-69 as many as 15 cases (27.3%), experiencing clinical manifestations of blood during defecation with a total of 18 cases (26.9%), and most commonly found in the rectum as many as 29 cases (52.7%). This finding is useful because it can provide insight into the profile of the clinicopathological characteristics of pre-cursor TRC lesions at Sanglah Hospital Denpasar in 2018-2020. Further analytical research is needed to find the relationship between various variables. Keywords: profile, precursor lesion, colorectal carcinoma
Intra-adrenal Paraganglioma and Paraaortic Paraganglioma in 15 Years Old Boys Butarbutar, Christine Rosalina; Maker, Luh Putu Iin Indrayani; Sumadi, I Wayan Juli; Winarti, Ni Wayan; Ariyanta, Kadek Deddy; Asih, Made Widhi
Majalah Patologi Indonesia Vol. 33 No. 1 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i1.631

Abstract

Intra-adrenal paraganglioma (also called pheochromocytoma) is a chromaffin cell tumor that arises in the adrenal medulla and produces excess catecholamines. Paraganglioma can also be located in the extra-adrenal area. The incidence rate of intra-adrenal and extra-adrenal paraganglioma is about 1 case per 2.500-6.500 population, highest incidence at 40-50 years old, and distribution is the same in males and females. Intra-adrenal paraganglioma in pediatrics is more familial, bilateral, multifocal, and malignant. In children, the incidence rate of these tumors was 8.86%, the ratio of boys to girls was 2:1, and the average age of 11. This article reports a case, of a 15 years old boy with severe headaches, recurrent seizures, and a hypertension crisis (143/103-220/110 mmHg). MSCT scan of abdominal showed solid mass heterogeneous with central necrotic multiple in the supero-anterior of the left and right kidneys and on the right anterolateral aorta as high as CV L2, impressive adrenal gland mass and extra-adrenal, suspect pheochromocytoma. Performed surgery, routine histopathological examination, and Immunohistochemistry. Macroscopic examination showed an oval round shape mass of left and right adrenal tumors as well as the paraaortic, a smooth outer surface of the capsular, with yellowish brown color mass tumor at cut surface, supple consistency. Microscopic examination showing adrenal gland and paraaortic tissue with fibrous capsule contains proliferation of neoplastic cells forming a nested alveolar (Zellballen) pattern with a round oval to polygonal cells, granular eosinophilic cytoplasm, round oval nuclei, surrounded by sustentacular cells. Chromogranin A and S-100 are positive. The case was concluded by clinical findings, histopathological, and immunohistochemistry as intra-adrenal paraganglioma and paraganglioma of paraaortic.
Profile Clinico Patological of Leprosy at Prof. Dr. I. G. N. G. Ngoerah Central Hospital Denpasar During 2017 – 2022 Wikaputri, Anak Agung Ayu Mutiara; Saputra, Herman; Ekawati, Ni Putu; Sumadi, I Wayan Juli
Babali Nursing Research Vol. 5 No. 1 (2024): January
Publisher : Babali Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37363/bnr.2024.51334

Abstract

Introduction: Leprosy is a chronic disease caused by Mycobacterium Leprae. According to the WHO, leprosy is one of the communicable diseases that affect the skin, peripheral nerves, and upper mucosa, and it can cause physical disabilities, if not properly handled. This study aims to determine the clinical and pathological profile of leprosy at Prof. dr. I. G. N. G. Ngoerah Central Hospital Denpasar, in 2017 - 2022. Metods: The study used a descriptive research design with total sampling from secondary data obtained from the Pathology Anatomy Laboratory of Prof. dr. I. G. N. G. Ngoerah Central Hospital Denpasar. The sample collected during the study period included 63 samples of patients diagnosed with leprosy, which were then processed using SPSS software version 26. Result: The highest number of cases was found in patients age group of 19-64 years, accounting for 55 cases (87.3%), predominantly in male patients with 36 cases (57.1%). The most common main complaint was red patches, with 43 cases (72.8%) presenting erythematous skin lesions, specifically plaques, in 24 cases (42.8%). Conclusion: Based on classification, leprosy was more frequently grouped into two classifications: WHO classification and Ridley Jopling classification. According to the WHO classification, the majority of patients were found to have the PB type, accounting for 35 cases (55.6%), while based on the Ridley Jopling classification, the BT type was more prevalent, with 21 cases (33.3%). This study is beneficial as it provides insights into the clinical and pathological profile of leprosy. Further analytical research is needed to explore the relationships between various variables
Efek Anti-hiperkolesterolemik Ekstrak Etanol Daun Cnidosculus aconitifolius terhadap Pembentukan Lesi Aterosklerosis Arteri Koroner pada Tikus Wistar Jantan yang Diberi Diet Aterogenik (Rattus norvegicus): Hasil Penelitian Saraswati, Ni Ketut Rake Putri; Iswari, Ida Sri; Sumadi, I Wayan Juli
Cermin Dunia Kedokteran Vol 52 No 5 (2025): Kardiologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i5.1336

Abstract

Introduction: Foods high in cholesterol increase the production of free radicals and inflammation, and may also trigger the formation of atherosclerotic lesions. Cnidosculus aconitifolius or tree spinach leaves were known to have antioxidant and anti-inflammatory activities. This study was to determine the effect of Cnidosculus aconitifolius on blood cholesterol level and coronary artery atherosclerotic lesions formation using a rat model. Methods: A randomized post-test-only control group of 30 male Wistar rats (Rattus norvegicus), aged 2-3 months, randomly divided into 3 groups: standard control was given regular food; negative control was given an atherogenic diet; and the treatment group was given an atherogenic diet + Cnidosculus aconitifolius leaf ethanol extracts. The treatment lasted 44 days. Data was analyzed with OneWay ANOVA and Kruskal-Wallis test. Results: The total cholesterol and LDL levels were significantly lower in the treatment group compared to the control group (p<0.001). A decrease of atherosclerotic lesion scores in the treatment group compared to the control (p=0.010) was also observed. Conclusion: Cnidosculus aconitifolius leaf ethanol extracts have an anti-hypercholesterolemic effect, hence the potential to prevent the formation of atherosclerotic lesions in the coronary arteries of hypercholesterolemic Wistar rats.
The Effect of Stevia (Stevia rebaudiana Bertoni) Leaf Extract Cream on Transforming Growth Factor-β1 Levels and Collagen Amount in the Skin of Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B Febrina, Jessica; Muliarta, I Made; Wahyuniari, Ida Ayu Ika; Sumadi, I Wayan Juli; Linawati, Ni Made; Artini, I Gusti Ayu
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.435-444

Abstract

Ultraviolet B (UVB) exposure is a major cause of skin aging, leading to collagen degradation and wrinkles due to free radical damage. Stevia (Stevia rebaudiana Bertoni) has antioxidant properties that may counteract this by preserving Transforming Growth Factor-β1 (TGF-β1), essential for collagen synthesis. This study evaluated the effects of stevia leaf extract cream on TGF-β1 and collagen levels in male Wistar rats. Thirty rats were divided into five groups: K0 (no UVB, no cream), K1 (base cream), P1 (2.5% stevia cream), P2 (5% stevia cream), and P3 (10% stevia cream). Groups K1, P1, P2, and P3 were exposed to a cumulative UVB exposure of 840 mJ/cm2 over four weeks. However, TGF-β1 levels measured by ELISA did not differ significantly among groups (p>0.05). However, collagen levels, assessed using Picro Sirius Red staining, varied significantly (p<0.05). The K1 exhibited significantly lower collagen compared to K0 (p=0.003), whereas the P2 group effectively prevented collagen degradation compared to K1 (K1: 65.87% vs. P2: 77.92%; p = 0.005). While stevia leaf extract cream did not prevent TGF-β1 reduction, it demonstrated a clear protective effect against UVB-induced collagen loss. Among the tested concentrations, 5% stevia leaf extract cream was the most effective in preserving dermal Collagen, highlighting its potential as a topical agent for preventing photoaging and maintaining skin structural integrity.
Co-Authors -, Jerry Agus Eka Darwinata Anak Agung Ayu Ngurah Susraini Anak Agung Gde Oka Anak Agung Ngurah Satya Pranata Anak Agung Ngurah Satya Pranata Andreliano Yosua Rompis Arimbawa, I Wayan Gede Bandem Ariyanta, Kadek Deddy Ayu Dewi Ni Nyoman Ayu Dewi, Ni Nyoman Butarbutar, Christine Rosalina Eka Wiratnaya Elysanti Dwi Martadiani Erawan, I Putu Putra Febrina, Jessica Gunawan, I Wayan Nico Fajar Gusti Ngurah Mayun Herman Saputra Herman Saputra Herman Saputra I Gde Haryo Ganesha I Gde Raka Widiana I Gusti Ayu Artini I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Sri Mahendra Dewi I Gusti Bagus Lulut Premana Mulia I Gusti Bagus Mulia Agung Pradnyaandara I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Pratama Yuda Atmaja I Gusti Nyoman Sri Wiryawan I Kadek Adi Purnama Sandhi I Ketut Bawantika Adi Putra I Ketut Mulyadi I Made Gotra I MADE MULIARTA . I Made Wirya Sastra I Nyoman Adi Putra I Putu Gede Putra Darmawan I Wayan Sugiritama I Wayan Surudarma I Wayan Wirata I Wayan, Oka Semara Jaya Ida Ayu Ika Wahyuniari Ida Sri Iswari Ivana Juliarty Sitanggang Jayakusuma, I Putu Prabawa Jessica Harlan Jessica Yuwono Johanes Prasetyo Harjanto John Nolan Ketut Mulyadi Luh Made Sudimantini Luh Made Sudimartini Luh Putu Iin Indrayani Maker Luh Yeni Laksmini M. Arif Perdana Ariyansyah Made Agus Kusumadjaja Made Widhi Asih Maker, Luh Putu Iin Indrayani Mark, Antony Marleen Marleen Meiske Margaretha Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Ni Made Linawati Ni Made Maharini Rahayu Ni Made Mahastuti Ni Made Pramita Widya Suksmarini Ni Nyoman Ayu Dewi Ni Nyoman Margiani Ni Putu Ekawati Ni Putu Mariati Ni Putu Sriwidyani Ni Wayan Armerinayanti, Ni Wayan Ni Wayan Winarti Nur Silfiah, Nur Pande Putu Bagus Premana Pranata, I Putu Yogi Putu Agus Aryanda Putra Putu Ayu Widya Pramesti Putu Dessy Wilantari Putu Eka Buana Sari Putu Oka Samirana Putu Yuliawati Saraswati, Ni Ketut Rake Putri Shameni Subramaniam Silvester Kristian Taopan Surudarma, I Wayan Suryaningmara, I Wayan Bagus Tessa Saputri Marmanto Tjokorda Gde Bagus Mahadewa Venosha Gunasekaran Wikaputri, Anak Agung Ayu Mutiara