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All Journal ACTA VETERINARIA INDONESIANA Jurnal Sain Veteriner Jurnal Veteriner Media Kedokteran Hewan Veterinary Biomedical and Clinical Journal Jurnal Layanan Masyarakat (Journal of Public Service) Ovozoa: Journal of Animal Reproduction Bantara Journal of Animal Science

Muhammad Thohawi Elziyad Purnama

Departemen Ilmu Kedokteran Hewan, Fakultas Kedokteran Hewan, Universitas Airlangga

Author-ID : 2938447

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences Veterinary Other

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Aluminosilikat Berpotensi Menekan Gangguan Reproduksi Mikotoksin Zearalenon Berdasarkan Pengamatan Jumlah Folikel dan Ekspresi Caspase-9 Ovarium Muhammad Thohawi Elziyad Purnama; Imam Mustofa; Tri Wahyu Suprayogi; Abdul Samik; Ragil Angga Prastiya; Amung Logam Saputro
Jurnal Veteriner Vol 18 No 2 (2017)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Zearalenone is a resorcylic acid lactone produced by fungal Fusarium graminearum in contaminated edible grains and can cause reproduction disorder in animals by binding to estrogen receptors on target cells. The aim of this study was to assess the potential use of aluminosilicates as mycotoxin binders to eliminate the adverse effect of zearalenone by examining the number of follicles and caspase-9 expression in the ovary of mice. The study adopted a completely randomized simple design using 20 mices which were randomly divided into five group each of which consisted of four mices. Five treatment groups consisted of K+ (without zearalenone and aluminosilicates); K- (treated with zearalenone 0.1 mg/mice/day); P1 (treated with zearalenone 0.1 mg/mice/day and aluminosilicates 0.5 mg/mice/day); P2 (treated with zearalenone 0.1 mg/mice/day and aluminosilicates 1 mg/mice/day); and P3 were treated with zearalenone 0,1 mg/mice/day and aluminosilicates 2 mg/mice/day) with gastric tube daily for 10 days. The data obtained from this study were analyzed by analysis of variance and proceeded with Duncan test. The result showed that the primary follicles, secondary follicles, tertiary follicles and de Graaf follicles increased significantly on P3 treatment group. Caspase-9 expressions decreased significantly in all of aluminosilicates groups as compared to positive control. The treatment of mice with zearalenone and aluminosilicates increases the number of follicles and decreased caspase-9 expression in the ovary of mice. ABSTRAK Zearalenon merupakan senyawa resorcylic acid lactone yang diproduksi oleh jamur Fusarium graminearum dan dapat mengakibatkan gangguan reproduksi pada ternak dengan membentuk ikatan pada reseptor estrogen. Penelitian ini bertujuan untuk menguji potensi aluminosilikat terhadap mencit yang telah dipapar zearalenon pada aspek jumlah folikel dan ekspresi caspase-9 organ ovarium. Penelitian ini menggunakan 20 ekor mencit yang dibagi menjadi lima kelompok perlakuan dengan masing-masing empat ulangan, yakni K+ tanpa dipapar zearalenon dan aluminosilikat; K- dosis zearalenon 0,1 mg/ekor/hari; P1 dosis zearalenon 0,1 mg/ekor/hari dan aluminosilikat 0,5 mg/ekor/hari; P2 dosis zearalenon 0,1 mg/ekor/hari dan aluminosilikat 1 mg/ekor/hari; P3 dosis zearalenon 0,1 mg/ekor/hari dan aluminosilikat 2 mg/ekor/hari dengan sonde lambung selama sepuluh hari. Data hasil skoring dan perhitungan dianalisis dengan sidik ragam dan dilanjutkan dengan uji Duncan. Hasil penelitian menunjukkan bahwa jumlah folikel primer, sekunder, tersier dan de Graaf pada P3 terjadi peningkatan yang signifikan. Ekspresi caspase-9 ovarium menunjukkan penurunan pada semua perlakuan aluminosilikat. Simpulan penelitian ini adalah mencit yang dipapar zearalenon dan kemudian diberi aluminosilikat mengalami peningkatan jumlah folikel dan penurunan ekspresi caspase-9 pada organ ovarium.

Potensi Toksin Binders untuk Mengurangi Efek Mikotoksin Zearalenon terhadap Panjang, Bobot, dan Jumlah Fetus Mencit (TOXIN BINDERS HAS THE POTENTIAL TO DECREASE ZEARALENONE MYCOTOXIN ON FETAL LENGTH, WEIGHT AND LITTER SIZE OF PREGNANT MICE) Muhammad Thohawi Elziyad Purnama; Amung Logam Saputro; Ragil Angga Prastiya
Jurnal Veteriner Vol 19 No 3 (2018)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Corn is a source of feed with protein content to increase livestock production. Zearalenone is a mycotoxin produced by Fusarium graminearum obligate in corn. The mycotoxins allegedly can cause pregnancy disorders to fetal malformations. Using toxin binders to inhibit zearalenone mycotoxins. The purpose of this study was to determine the potential of toxin binders in reducing the effect of zearalenon on the length, weight and fetal litter size of pregnant mice (Mus musculus). This study used 20 balb/c mice divided into control group (C-) without toxin binders and zearalenone; (C+) was given only zearalenone 0.1 mg / mice / day; and treatment groups T1; T2; T3 was given zearalenone 0.1 mg / mice / day and toxin binders 0.5; 1; 2 mg / mice / day. The toxin binders and zearalenone was done with orally for 14 days. The data were analyzed using Analysis of variance test and continued by Duncan test. The results showed that C-, C+, T1 were significantly different (p<0.05) with T2 and T3 on the fetal length. The fetal weight showed C-, T1, T2, T3 was significantly different (p<0.05) with C+. The result of fetal litter size showed that were not significantly different (p>0.05) between treatment groups. It was concluded that toxin binders could decrease the effect of zearalenon thus increasing the length and weight of the fetus but not affecting the fetal litter size of pregnant mice (M. musculus).

Aktivitas Antibakteri Ekstrak Daun Sirsak (Annona muricata L.) Terhadap Pertumbuhan Bakteri Pseudomonas aeruginosa Secara In Vitro (ANTIBACTERIAL ACTIVITY OF SOURSOP (ANNONA MURICATA) LEAF EXTRACT ON GROWTH OF BACTERIA PSEUDOMONAS AERUGINOSA IN VITRO) Faisal Fikri; Imas Hapsari Rahmaningtyas; Ragil Angga Prastiya; Muhammad Thohawi Elziyad Purnama
Jurnal Veteriner Vol 20 No 3 (2019)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

The aim of this study was to measure antibacterial activity of soursop leaf extract (Annona muricata L.) on bacterial growth inhibition of Pseudomonas aeruginosa by diffuse disc method. The result of the inhibition zone was analyzed using Analysis of Variance and followed using Duncan test, to show highly significantly different (p<0.01). The inhibition number of negative control (C-) was 0.00e±0.00 and the positive control (C+) was 31.31a±0.57. The result of concentration 1 (T1) was 14.49b±4.96; concentration 2 (T2) 8.98c±1.29; concentration 3 (T3) 5.84cd±1.85; concentration 4 (T4) 5.56cd±1.58; concentration 5 (T5) 2.85de±0.28; concentration 6 (T6) 2.98de±0.53; concentration 7 (T7) 2.82de±1.59; concentration 8 (T8) 2.41de±1.10; concentration 9 (T9) 2.20de±0.34; concentration 10 (T10) 1.10e±0.19; and concentration 11 (T11) 0.00e±0.00. The increase of soursop leaf extract concentration showed high inhibition diameter of bacterial growth. It concluded that soursop leaf extract have an antibacterial activity to inhibit P. aeruginosa growth with Minimal Inhibitory Concentration (MIC) 125 ppm.

Ekstrak Etanol Kulit Buah Naga Menurunkan Indikasi Neoplasia Mammae Tikus Putih Berdasarkan Histopatologi dan Inhibitor Siklooksigenase-2 Muhammad Thohawi Elziyad Purnama; Ragil Angga Prastiya; Faisal Fikri; Amung Logam Saputro; Bodhi Agustono
Jurnal Veteriner Vol 19 No 1 (2018)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Cancer caused uncontrolled cell proliferation and triggered by changes on cell information that regulate growth function. Each cell has different potential so many cancer prevalence such as endometrial cancer, lymph node cancer, lung cancer, skin and mammary gland cancer. The aims of this study were to assess the potential of dragon fruit skin ethanolic extract on white rats (Rattus norvegicus) exposed 7,12- Dimethylbenz(á)antrasena (DMBA) on mammary gland based on histopathological features and cyclooxygenase-2 (Cox-2) intensity. This study were used 20 of rats randomly divided into five group and each groups consisted of four rats, i.e: K+ weren’t treated DMBA and extract; K- were treated with DMBA; P1 were treated with DMBA and extract 10 mg/kg BW; P2 were treated with DMBA and extract 15 mg/kg BW; P3 were treated with DMBA and extract 20 mg/kg BW. The DMBA was given by intra dermal injection during twice a week for five weeks and the extracts with gastric tube everyday till 14 days. The data was analyzed by Anova test and continued with Duncan test. The result showed that the histopathological features were decrease significantly on P3. The variables of Cox-2 intensity were decrease significantly on P1, P2 and P3. Conclusion of this study was ethanol extract of dragon fruit skin can decrease neoplastic indication of mammary gland on white rats (R. norvegicus) based on histopathological features and Cox-2 inhibitors.

Aktivitas Superoxide Dismutase pada Serum Darah Babi Landrace yang Disembelih dengan Metode Electrical Stunning Shabrina Fauzia Prayoga; Kuncoro Puguh Santoso; Nove Hidajati; Faisal Fikri; Maya Nurwartanti Yunita; Muhammad Thohawi Elziyad Purnama
Jurnal Veteriner Vol 22 No 2 (2021)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Tujuan penelitian ini untuk menentukan aktivitas Superoxide Dismutase (SOD) pada babi Landrace yang disembelih dengan metode stunning dan non-stunning. Sebanyak 18 ekor babi Landrace jantan dewasa yang telah dikebiri dengan masing-masing bobot 115±20 kg dibagi menjadi dua kelompok, yakni stunning dan non-stunning dengan pengujian serum pada pre dan post treatment. Electrical stunning dilakukan dengan aliran listrik pada dua elektroda sebesar 220 volt dan 1,3 ampere. Sampel darah diambil sebanyak 3 mL, kemudian diuji aktivitas SODnya.. Hasil aktivitas SOD dianalisis dengan uji T berpasangan untuk membandingkan aktivitas SOD serum antara stunning dan non-stunning pada fase pre dan post treatment. Hasil stunning menunjukkan penurunan signifikan (p<0,05) aktivitas SOD sebesar 56,12±54,47 dibandingkan non-stunning sebesar 137,84±66,63. Aktivitas SOD yang rendah tampak signifikan (p<0,05) juga pada pre-treatment dibandingkan dengan post-treatment. Dapat disimpulkan bahwa penyembelihan dengan metode electrical stunning menurunkan aktivitas SOD pada serum babi Landrace.

Perbandingan Susunan Jantan dan Betina Memengaruhi Performa Ayam Pedaging Galur Lohman Broder Mb202 Nadiya Listyasari; Soeharsono Soeharsono; Muhammad Thohawi Elziyad Purnama
Jurnal Veteriner Vol 23 No 2 (2022)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Penelitian ini bertujuan untuk mengevaluasi perbandingan komposisi jantan dan betina ayam broiler strain Lohman Broder MB202 dalam satu kandang terhadap konsumsi pakan, bobot badan, dan konversi pakan. Sebanyak 40 ekor ayam broiler masing-masing 20 jantan dan 20 betina digunakan dalam penelitian kali ini selanjutnya dibagi menjadi lima kelompok (P1, P2, P3, P4, P5). Semua kelompok perlakuan dipelihara secara intensif, diberi pakan, minum ad libitum dan vaksin terjadwal selama 35 hari. Data dianalisis dengan univariate ANOVA dan dilanjutkan dengan uji Post Hoc Tukey dengan nilai signifikansi 95%. Konsumsi dan konversi pakan menunjukkan perbedaan nyata pada kelompok P1 dan P4 dibandingkan kelompok P2, P3 dan P5. Pertambahan bobot badan juga tampak signifikan pada kelompok P1 dan P4 hari ke 5–6 atau hari ke 25–30 dan hari ke 1–35. Dapat disimpulkan bahwa perbandingan jumlah pengaturan broiler jantan dan betina dalam satu kandang berpengaruh terhadap performa ayam broiler. Perbandingan terbaik ditunjukkan pada rasio jantan dan betina P1 (8:0) atau P4 (6:2).

Co-Authors Abdul Samik Agus Purnomo Agus Purnomo Agustono, Bodhi Alifia, Annisa Aliyyah Revinda Bima Putri Arimbi Audina Putri Geraldine BUDI UTOMO Citra Kurnia Putri Dayanti, Efin Windi Dina Deviana Dwi Retna Kumalaningrum Fahlevi Lailiyah Faisal Fikri Fransiska Okta Zania Hani Plumeriastuti Hidajati, Nove Ichi Arum Galerani Imam Mustofa Imas Hapsari Rahmaningtyas Iwan Sahrial Hamid Kenconojati, Hapsari Khairani, Shafia Kuncoro Puguh Santoso Nadiya Listyasari Nove Hidajati Nur Prabowo Dwi Cahyo Praja, Ratih Novita Prastiya, Ragil Angga Santoso, Kuncoro Puguh Saputro, Amung Logam Shabrina Fauzia Prayoga Shabrina Fauzia Prayoga Soeharsono Soeharsono Soeharsono Soeharsono Sri Agus Sudjarwo Sri Mulyati Tatik Hernawati Tri Wahyu Suprayogi Wibawati, Prima Ayu Widya Ayu Kusuma Wisudawati, Feby Dwi Wurlina, W Yudhana, Aditya Yunita, Maya Nurwartanti

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