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All Journal Hemera Zoa POROS TEKNIK The Indonesian Biomedical Journal Sari Pediatri Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Al Qalam: Jurnal Ilmiah Keagamaan dan Kemasyarakatan Jurnal Kreativitas PKM Bioscientia Medicina : Journal of Biomedicine and Translational Research JURNAL KESEHATAN BHAKTI HUSADA Bioscientia Medicina : Journal of Biomedicine and Translational Research COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat eJournal Kedokteran Indonesia Makara Journal of Health Research Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Folia Medica Indonesiana
Ahmad Aulia
Department Of Histology, Faculty Of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Thermally Oxidized Cooking Palm Oil-Induced Histopathological Alterations in Brain, Heart, Liver, and Kidney: A Systematic Review of Lipid Peroxidation and Inflammatory Mechanisms Nimas Ayu Nirwanti; Ahmad Aulia Jusuf
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1273

Abstract

Background: Repeated heating of cooking palm oils at high temperatures generates various toxic compounds, including lipid peroxidation products. These compounds are implicated in various diseases through oxidative stress and inflammation. This systematic review aims to evaluate the histopathological effects of thermally oxidized cooking oil (TOCO) consumption on the brain, heart, liver, and kidney, focusing on the roles of lipid peroxidation and inflammation. Methods: A systematic search was conducted in PubMed, Scopus, and Web of Science databases using predefined keywords and inclusion/exclusion criteria. Studies published between 2013 and 2024 investigating the histopathological effects of TOCO on the specified organs were included. Data on histopathological changes, markers of lipid peroxidation (malondialdehyde [MDA], 4-hydroxynonenal [4-HNE]), and inflammatory markers (TNF-α, IL-1β, IL-6) were extracted. Results: Seven studies met the inclusion criteria. The data revealed consistent histopathological changes across all four organs. In the brain, neuronal degeneration, astrogliosis, and microglial activation were observed. The heart exhibited cardiomyocyte hypertrophy, fibrosis, and inflammatory cell infiltration. The liver showed hepatocyte necrosis, steatosis, and inflammation. The kidneys presented with tubular necrosis, glomerular damage, and interstitial fibrosis. Elevated levels of MDA and 4-HNE were consistently reported in all affected tissues, along with increased expression of TNF-α, IL-1β, and IL-6. Conclusion: Consumption of TOCO induces significant histopathological damage in the brain, heart, liver, and kidney. The observed damage is strongly associated with increased lipid peroxidation and inflammatory responses. These findings highlight the potential health risks associated with consuming repeatedly heated cooking oils and underscore the need for public health awareness and strategies to mitigate these risks.
Kajian Yuridis Atas Penegakan Hukum terhadap Mantan Karyawan Waralaba Terkenal yang Membocorkan Resep Rahasia Perusahaan Aulia, Ahmad; Amirulloh , Muhamad; Sudaryat , Sudaryat
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 3 No. 09 (2024): COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v3i09.1146

Abstract

Rahasia Dagang atau bisnisnya sangat rentan mengalami risiko terjadinya pembocoran atau pencurian terhadap antara lain resep makanan maupun minuman sebagaimana yang telah disepakati untuk tidak boleh dibocorkan. Dari uraian ini sebagai latar belakang masalah diidentifikasi masalah untuk dijadikan kajian secara yuridis yakni terkait perlindungan dan tindakan hukum apa saja yang dapat dilakukan dalam upaya penegakan hukumnya ditinjau menurut Menurut Undang Undang No. 30 Tahun 2000 Tentang Rahasia Dagang. Penelitian ini meneliti atau membahas perlindungan dan tindakan hukum apa saja yang dapat dilakukan dalam upaya penegakan hukum Rahasia Dagang dalam perjanjian waralaba (franchise).  Penelitian ini menggunakan metode penelitian kepustakaan dengan data sekunder sebagai sumber datanya. Dalam penelitian  ini menunjukkan bahwa rahasia dagang sangat penting dilindungi dalam bisnis waralaba, karena dalam suatu bisnis waralaba dapat diketahui rahasia dagang pemilik hak (pemberi waralaba), sehingga potensi terungkapnya rahasia dagang dalam suatu bisnis waralaba menjadi besar. Mengingat pentingnya perlindungan Rahasia Dagang dalam perjanjian waralaba, maka perjanjian  waralaba haruslah dibuat secara komprenhensif. Perjanjian tersebut tidak hanya harus dapat menjamin perlindungan Rahasia Dagang pada saat berlangsungnya perjanjian namun juga pada saat setelah perjanjian tersebut berakhir. Selanjutnya dalam penelitian ini juga untuk mengkaji tindakan hukum apa saja yang dapat dilakukan dalam upaya  penegakan hukum bagi pihak yang melakukan pelanggaran Rahasia Dagang dalam usaha waralaba. Hasil penelitian atau kajian ini menunjukkan bahwa Rahasia Dagang dalam usaha di bidang makanan dan minuman mendapatkan perlindungan yang resepnya tidak boleh diketahui oleh umum tanpa adanya perjanjian lisensi didalamnya. Tindakan hukum yang dapat dilakukan dalam Upaya penegakan hukum dan atau sanksi hukum bagi pihak yang telah membocorkan Rahasia Dagang adalah dapat dikenakan sanksi administrasi dan sanksi pidana yang diatur dalam UU No 30 Tahun 2000 tentang rahasia dagang serta Kitab Undang – Undang Hukum Perdata dan Kitab Undang – Undang Hukum Pidana.
Peripheral Serum AMH Level Reflects the Size of the Follicle Pool in a Mouse Model Study Suratih, Ni Made Desy; Wiweko, Budi; Maidarti, Mila; Wuyung, Puspita Eka; Jusuf, Ahmad Aulia; Louisa, Melva; Kekalih, Aria
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 3 Jully 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i3.2220

Abstract

Objective: This is to compare peripheral and central serum levels of Anti-Mullerian hormone (AMH) in experimental animals for predicting ovarian reserve. Methods: This is an experimental study involving 20 female Sprague-Dawley rats aged 8–10 weeks with normal estrus cycles as the young control group and 5 female rats aged 28–30 weeks as the old control group (n = 5/group): the young control group, the old control group, the 1x cisplatin group, the 2x cisplatin group, and the 3x cisplatin group. After treatment, tissue collection, histological staining, and blood collection through the retro-orbital bleeding (ROB) and heart were performed. Subsequently, measurements of ovarian weight, follicle counting, and levels of AMH and Follicle-stimulating hormone (FSH) were conducted.Results: The serum AMH levels from ROB in the young control, 1x cisplatin, 2x cisplatin, 3x cisplatin, and the old control groups were 1151, 1818, 2782.96, 1381.352, and 1544 ng/mL, respectively. Cisplatin 2x group was significantly (p<0.005) higher compared to the young control. The average concentrations of serum AMH in the ROB and heart were higher in the 2x cisplatin group compared to the other groups. Meanwhile, cisplatin 3x group decreased in level due to the burn out phenomenon. Conclusion: AMH is a preferred marker compared to FSH. Blood collection through the ROB is considered a less invasive alternative technique in the treatment group, requiring serial observation. Keywords: AMH, follicle pool, ovarian aging, ROB
Effect of the High-Intensity Interval Training on BDNF Level in Ischemic Stroke Rat Model on the Recovery of Motor Function Yani, Sri; Harris, Salim; Jusuf, Ahmad Aulia; Goenarjo, Roman; Makkiyah, Feda Anisah; Sabita, Rifqi; Ibrahim, Nurhadi
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2911

Abstract

BACKGROUND: Stroke is one of the major causes of disability in the world. High-intensity interval training (HIIT) is known as a novel treatment to promote stroke recovery. However, the results differ in their effects on irisin, which is a regulator of brain-delivered neurotrophic factor (BDNF). Therefore, this study was conducted to investigate the effect of HIIT on BDNF and irisin levels in a rat model of ischemic stroke with middle cerebral artery occlusion (MCAO) induction on recovery motor function.METHODS: Rats were categorized into 4 groups: sham, MCAO, MCAO+moderate-intensity interval training (MIIT), and MCAO+HIIT. MCAO induction was performed to create the ischemic stroke rats model. The motor function was assessed through rotarod and footprint tests. Blood samples were obtained 6 days before MCAO and 14 days after MCAO to examine BDNF and irisin levels with enzyme-linked immunosorbent assay (ELISA). Brain tissue samples were collected 14 days after MCAO for histopathological examination of cortical tissue with hematoxylin-eosin (HE) staining.RESULTS: Rats in the MCAO+HIIT group exhibited an enhanced ability to walk on the rotarod (p=0.016). The stride-length hind paw right in the MCAO+HIIT group demonstrated a noteworthy increase in comparison to baseline value (p=0.036), and the stride-length fore paw right showed a significant increase in both the MCAO+HIIT (p=0.036) and MCAO groups (p=0.034). BDNF significantly improved in the MCAO+MIIT (p=0.043) and MCAO+HIIT groups (p=0.018). The irisin level only showed a significant enhancement in the MCAO+HIIT group (p=0.018).CONCLUSION: HIIT increased motor function, while BDNF level increased with HIIT and MIIT intervention. This preclinical research is useful for supporting the recovery of stroke patients by HIIT intervention.KEYWORDS: BDNF, HIIT, MIIT, irisin, ischemic stroke, MCAO
Asuhan Mandiri Akupresur untuk Meningkatkan Produksi ASI pada Ibu Balita Stunting di Kampung Lio, Kecamatan Pancoran Mas, Kota Depok Jusuf, Ahmad Aulia; Mihardja, Hasan; Srilestari, Adiningsih; Simadibrata, Christina Lanny; Viventius, Yoshua; Chandra, Inria; Widyaprastuti, Hermin; Natalia, Zellah Fransisca; Fitriani, Elies
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 12 (2025): Volume 8 No 12 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i12.23037

Abstract

ABSTRAK Stunting merupakan kondisi gagal tumbuh yang ditandai dengan rasio TB/U atau PB/U kurang dari -2 SD. Penyebab stunting multifaktorial. Selain faktor fasilitas kesehatan, kesehatan ibu dan bayi, juga faktor sosial ekonomi dan tingkat pendidikan. Selain penyebab di atas, faktor penyebab stunting lainnya yaitu tidak diberikannya ASI eksklusif pada bayi. Pengendalian stunting memerlukan kolaborasi berbagai pihak baik dari stakeholder pemerintah setempat, praktisi medis dan kesehatan, kader yang terjun secara langsung ke masyarakat, bahkan orang tua Balita terdampak stunting. Akupresur adalah teknik penekanan mekanik berdasarkan titik akupunktur. Teknik ini mempunyai keunggulan sederhana, murah, non invasif, mudah dilakukan, serta telah terbukti efektif pada banyak kondisi medis berdasarkan studi literatur beberapa penelitian yang telah dilakukan sebelumnya. Beberapa studi telah membuktikan efek akupresur dalam meningkatkan produksi ASI pada Ibu menyusui. Akupresur diharapkan dapat menjadi solusi dalam mengatasi masalah stunting di Kota Depok, khususnya lokus stunting di Kampung Lio, Kecamatan Pancoran Mas. Penyuluhan dan workshop akupresur mandiri bagi ibu menyusui Balita stunting diadakan secara hybrid online melalui zoom dan offline di Aula Kantor Kelurahan Depok, dengan jumlah peserta 35 orang offline dan online sebanyak 160 peserta. Dilakukan pretest dan postest untuk mengukur peningkatan pengetahuan sebelum dan sesudah diberikan penyuluhan. Kata Kunci: Akupresur, Balita, Produksi ASI, Stunting  ABSTRACT Stunting is a condition of growth failure characterized by a ratio of height/age or height/age of less than -2 SD. The causes of stunting are multifactorial. In addition to health facilities, maternal and infant health, there are also socioeconomic factors and education levels. Another factor causing stunting is the lack of exclusive breastfeeding for infants. Controlling stunting requires collaboration between various parties, including local government stakeholders, medical and health practitioners, community cadres, and even parents of toddlers affected by stunting. Acupressure is a mechanical pressure technique based on acupuncture points. This technique has the advantages simple, affordable, non-invasive, yet easy to perform, and has been proven effective in many medical conditions based on several previous studies. Several studies have proven the effect of acupressure in increasing breast milk production in breastfeeding mothers. Acupressure is expected to be a solution to overcome the problem of stunting in Depok City, especially the stunting locus in Kampung Lio, Pancoran Mas District. Counseling and a self-directed acupressure workshop for breastfeeding mothers of stunted toddlers were held as a hybrid online (via Zoom) and offline (via Zoom) session at the Depok Village Office Hall. There were 35 participants (via offline) and 160 participants (via online). A pre- and post-test were conducted to measure knowledge gains before and after the counseling session. Keywords: Acupressure, Toddlers, Breast Milk Production, Stunting
Impact on the Kidney of Pancreas Damage due to Streptozotocin-Induced Hyperglycemia Prathita, Yana Aurora; Jusuf, Ahmad Aulia; Simadibrata, Christina; Djaali, Wahyuningsih; Viventius, Yoshua
Folia Medica Indonesiana Vol. 59, No. 2
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: • This study observed the histology of pancreatic β-cell damage without any intervention to the kidneys of the animal models. • The histological analysis of the kidneys shows that STZ-induced animal models can be used for assessing kidney abnormalities due to hyperglycemia. • A scoring system for the histological analysis was developed to evaluate the changes in the kidney cells. Abstract The kidneys are one of the organs affected by microvascular complications due to diabetes mellitus. Hyperglycemia plays an important role in glomerular, mesangial cell, and tubular damage in the kidneys. Metabolic dysregulation, including hyperglycemia, initiates cellular damage in the kidneys. Streptozotocin (STZ) is a chemical compound that is known to damage pancreatic cells and cause hyperglycemia. This study aimed to examine the effects of hyperglycemia on the morphology of the kidneys. Kidney tissues were observed histologically using a light microscope. Samples were taken from the kidneys of experimental animals administered with STZ to induce hyperglycemia. Observation was performed afterwards to investigate any damage to pancreatic cells. A total of 12 kidney samples were divided into two groups: the control group and the STZ-induced group. The samples were prepared before staining with hematoxylin-eosin and Masson's trichrome. The endothelium, podocytes, mesangial cells, and basement membrane of the glomerulus were examined. The tubules of the kidneys were also examined, and the presence or absence of connective tissue formation in both groups was statistically tested. The results suggested a significant difference in tubular damage (p<0.05) and an insignificant difference in an increase in the damage of other components of the kidneys (p>0.05) in the STZ-induced group. Significant morphological changes were observed in the hyperglycemic renal tubules due to the administration of STZ. In conclusion, STZ-induced hyperglycemia caused damage to the kidney components but overall had no significant impact on the kidney.
Platelet-Rich Plasma as a Pharmacopuncture Agent in Cervical Myofascial Pain Nareswari, Irma; Kamal, Achmad Fauzi; Mihardja, Hasan; Yunus, Reyhan Eddy; Jusuf, Ahmad Aulia; Harahap, Alida Roswita; Wahyuni, Luh Karunia; Werdhani, Retno Asti; Handayani, Selfi; Rukmindar, Dion
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.310

Abstract

Chronic cervical myofascial pain (CMP) is a prevalent musculoskeletal disorder characterized by persistent neck pain, inflammation, functional impairment, and altered pain processing. Conventional treatments, including pharmacological therapy and physical rehabilitation, often provide limited and temporary relief. Increasing evidence suggests that chronic CMP involves not only peripheral nociceptive input but also nociplastic pain mechanisms driven by sustained neuroimmune dysregulation and central sensitization. Pharmacopuncture, combining acupuncture point stimulation with localized injection of therapeutic agents, has evolved with the introduction of regenerative biologics such as platelet-rich plasma (PRP). PRP contains concentrated platelets and bioactive growth factors, including VEGF, PDGF, and TGF-β, which exert anti-inflammatory and tissue-reparative effects. Emerging data indicate that PRP pharmacopuncture may reduce pro-inflammatory cytokines (e.g., IL-1β and TNF-α), modulate regulated cell death pathways (e.g., apoptosis and pyroptosis), and promote the restoration of myofascial tissue homeostasis. These mechanisms may contribute to both peripheral tissue repair and attenuation of nociplastic pain processing. This narrative review synthesizes current clinical and experimental evidence on the biological mechanisms and therapeutic potential of PRP pharmacopuncture in chronic CMP. Available studies report meaningful improvements in pain intensity and functional outcomes compared with conventional acupuncture or pharmacotherapy alone. However, substantial methodological heterogeneity may arise from PRP preparation protocols, acupoint selection, and outcome measures, limiting the ability to draw definitive conclusions. High-quality randomized controlled trials incorporating standardized protocols and mechanistic biomarkers are required to establish PRP pharmacopuncture as an evidence-based integrative treatment for chronic CMP.
Hyperbaric Oxygen Therapy for Traumatic Brain Injury: A Review Of History, Development, Current Techniques, and Future Directions Wiwoho, Yudi Yuwono; Sadikin, Abdul Halim; Jusuf, Ahmad Aulia; Mulyawan, Wawan; Mudjihartini, Ninik; Ibrahim, Nurhadi; Jusman, Sri Widia A.; Sadikin, Mohamad
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.321

Abstract

Hyperbaric oxygen therapy (HBOT) has gained increasing attention as a potential adjunctive treatment for traumatic brain injury (TBI) patients. This narrative review discusses the historical background, current preclinical and clinical studies, and explores its underlying mechanisms from biomolecular, histological, and clinical perspectives. HBOT promotes neural recovery by improving oxygenation, preserving mitochondrial integrity, enhancing neurotrophic support and synaptic connectivity, mitigating secondary injury pathways (including oxidative stress, inflammation, and apoptosis), and promoting angiogenesis and vascular stability. These mechanisms have demonstrated improvements of motor, cognitive, and memory functions both in preclinical and clinical studies, although outcomes and treatment protocols vary. However, challenges remain regarding optimal protocols, patient selection, and adverse effects. Further high-quality clinical trials are required to define the optimal HBOT regimen are required.
Co-Authors . Iskandarsyah Achmad Fauzi Kamal Adiningsih Srilestari Ahani, Ardhi Rahman Amirulloh , Muhamad Ari Fahrial Syam Aria Kekalih Asrinda, Indria Bambang Pontjo Priosoeryanto Banifade, Fadlil Malik Barasila, Atikah Chalida Budi Wiweko Chandra, Inria Christina Simadibrata Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Cosphiadi Irawan Fasha, Iqbal Fitriani, Elies Goenarjo, Roman Hakim, Al Rasyid Maulana Harahap, Alida Roswita Hasan Mihardja Imelda Rosalyn Sianipar Irena Ujianti Jeanne Adiwinata Pawitan Jusman, Sri Widia Azraki Lailan Safina Nasution Lestari, Novi Lina Marlina Luh Karunia Wahyuni, Luh Karunia Makkiyah, Feda Anisah Melva Louisa Mila Maidarti Mohamad Sadikin Murti Andriastuti, Murti Murti, Krishna Aditya Nareswari, Irma Natalia, Zellah Fransisca Neng Tine Kartinah Almuktabar Ni Ken Ritchie, Ni Ken Nimas Ayu Nirwanti Ninik Mudjihartini Nur Aditya, Robby Nurhadi Ibrahim Patwa Amani, Patwa Prathita, Yana Aurora Puspita Eka Wuyung Radiana Dhewayani Antarianto Retno Asti Werdhani Reyhan Eddy Yunus Rukmindar, Dion Sabita, Rifqi Sadikin, Abdul Halim Salim Harris, Salim Santoso, Dewi Irawati Soeria Sarifudin sarifudin, Sarifudin Selfi Handayani Simadibrata, Christina Lanny Sophie Yolanda Sudaryat , Sudaryat Suratih, Ni Made Desy Tena Djuartina, Tena Tri Isyani Tungga Dewi Tyas, Nike Estu Renaning Viventius, Yoshua Wahyunia Likhayati Septiana Wahyuningsih Djaali Wawan Mulyawan Widyaprastuti, Hermin Wiwoho, Yudi Yuwono Yani, Sri