Article Per Year (5 Year)
p-Index From 2021 - 2026
3.519
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Farmasi Indonesian Journal of Pharmaceutical Science and Technology Acta Pharmaceutica Indonesia The Indonesian Biomedical Journal Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ Majalah Farmasetika Jurnal Ilmiah Farmasi Farmasyifa Jurnal Kefarmasian AKFARINDO Science Midwifery Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Sciences of Pharmacy Jurnal Farmasi Indonesia Jurnal Pengabdian Masyarakat (Jupemas) International Journal Multidisciplinary Jurnal Medika Farmaka Jurnal Kesehatan Bakti Tunas Husada Indonesian Journal of Community Development Medical Sains : Jurnal Ilmiah Kefarmasian International Journal of Health, Medicine, and Sports Kimia Padjadjaran Journal of Pharmascience
Marita Kaniawati
Bhakti Kencana University
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

Published : 32 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 32 Documents
Search

 1   2   3   4 
Efek Kombinasi Ekstrak Etanol Rimpang Kunyit (Curcuma longa L.) dan Daun Pegagan (Centella asiatica (L.) Urb) terhadap Ekspresi Gen eNOS pada Jaringan Hati Tikus Obes Agus Sulaeman; Salim Agustian; Elis Susilawati; Soni Muhsinin; Marita Kaniawati; Marita Feliana
Journal of Pharmascience Vol. 12 No. 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.23813

Abstract

Obesitas adalah kondisi patologis akibat akumulasi lemak berlebih yang meningkatkan risiko gangguan metabolik, termasuk disfungsi endotel yang ditandai oleh penurunan produksi Nitric Oxide (NO) sintesis oleh enzim Endothelial Nitric Oxide Synthase (eNOS). Penelitian ini bertujuan mengevaluasi efek kombinasi ekstrak etanol rimpang kunyit (Curcuma longa L.) dan daun pegagan (Centella asiatica (L.) Urb) terhadap kadar NO serum dan ekspresi gen eNOS pada jaringan hati tikus obesitas. Penelitian eksperimental ini menggunakan tikus jantan yang diinduksi obesitas dengan pakan tinggi lemak dan karbohidrat selama 60 hari. Tikus dibagi enam kelompok: normal (kontrol negative), obesitas (kontrol positif), pembanding orlistat 10,8 mg/kgBB, ekstrak kunyit 200 mg/kgBB, ekstrak pegagan 20 mg/kgBB, dan kombinasi kunyit-pegagan 200:100 mg/kgBB. Parameter yang diukur meliputi berat badan, kadar NO serum (metode Griess), ekspresi gen eNOS (qPCR), kadar SGOT dan  SGPT. Hasil menunjukkan kombinasi ekstrak secara signifikan menurunkan berat badan dan meningkatkan kadar NO dibandingkan kelompok obesitas (p < 0,05), meningkatkan ekspresi gen eNOS serta secara (p< 0,05) signifikan menurunkan kadar SGOT dan SGPT . Penelitian ini mengindikasikan potensi kombinasi ekstrak kunyit dan pegagan sebagai agen preventif disfungsi endotel pada obesitas melalui peningkatan produksi NO dan regulasi ekspresi gen eNOS serta berperan sebagai hepatoprotektor. Kata Kunci: Ekstrak Kunyit, Ekstrak Pegagan, Ekspresi Gen eNOS, Jaringan Hati, Obesitas  Obesity is a pathological condition caused by excessive fat accumulation that increases the risk of metabolic disorders, including endothelial dysfunction characterized by decreased Nitric Oxide (NO) synthesis by the enzyme Endothelial Nitric Oxide Synthase (eNOS). This study aims to evaluate the effects of a combination of ethanol extracts of turmeric rhizome (Curcuma longa L.) and gotu kola leaves (Centella asiatica (L.) Urb) on serum NO levels and eNOS gene expression in the liver tissue of obese rats. This experimental study used male rats induced to become obese with a high-fat and high-carbohydrate diet for 60 days. The rats were divided into six groups: normal (negative control), obese (positive control), orlistat 10.8 mg/kgBW, turmeric extract 200 mg/kgBW, gotu kola extract 20 mg/kgBW, and turmeric-gotu kola combination 200:100 mg/kgBW. The measured parameters included body weight, serum NO levels (Griess method), eNOS gene expression (qPCR), SGOT and SGPT levels. The results showed that the combination of extracts significantly reduced body weight and increased NO levels compared to the obesity group (p < 0.05), increased eNOS gene expression, and significantly (p < 0.05) decreased SGOT and SGPT levels. This study indicates the potential of the combination of turmeric and pegagan extracts as a preventive agent for endothelial dysfunction in obesity through the enhancement of NO production and regulation of eNOS gene expression as well as acting as a hepatoprotector.
POTENSI KOMBINASI EKSTRAK ETANOL DAUN DADAP SEREP (Erythrina subumbrans) DAN PEGAGAN (Centella asiatica) DALAM MENURUNKAN RISIKO DISFUNGSI ENDOTEL PADA TIKUS DENGAN DIET TINGGI FRUKTOSA Marita Kaniawati; Agus Sulaeman; Aulia Nurfazri Istiqomah; Kevin Efraim Lian
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2875

Abstract

Fructose has long been known as a sugar additive or sweetener, commonly found in soft drinks, pastries, and other processed foods. High levels of added sugar in the daily diet increase the risk of various metabolic disorders, including insulin resistance. Insulin resistance can lead to impaired endothelial function (endothelial dysfunction), which can lead to impaired vasodilation responses. Endothelial dysfunction can lead to an increased risk of cardiovascular diseases such as atherosclerosis, coronary heart disease (CHD), hypertension, and other vascular diseases. The aim of this study was to identify the potential of a combination of dadap serep (Erythrina subumbrans) and pegagan (Centella asiatica) to reduce the risk of endothelial dysfunction (as measured by nitric oxide (NO) levels) triggered by high fructose consumption. This research method is an in vivo experimental preventive using 36 rats divided into normal group, induction group, comparison group of curcumin 9 mg/kgBW, test group 1 EEPDS 50:100 mg/kgBW, test group 2 EEPDS 100:100 mg/kgBW and test group 3 EEPDS 100:50 mg/kgBW. Measurement of NO levels using the Griess method, while insulin resistance examination was carried out using the insulin tolerance test method. The results showed that the combination group of EEPDS 100:50 mg/kgBW was the group that showed the most optimal effect in maintaining endothelial function and had the best insulin sensitivity. The conclusion of this study shows that the combination of EEPDS 100:50 mg/kgBW is effective in maintaining insulin sensitivity and maintaining endothelial function in rats.
Co-Authors Agus Sulaeman Agus Sulaeman agustian, dudy Agustian, Salim Agustina Aligita, Widhya Amelia, Ferda Andi Wijaya Anwar Santoso Anwar Susanto Auliyaa, Millata Azzah Wulandari, Yulinda Cintiya Dewi , Silvy Deni Hendra Alamsyah Dila Anggraeni Dimas Alamanda, Vidiana Dodit Rinaldi, Muhammad Dwi Fatma, Ira Efraim Lian, Kevin Elis Susilawati Emmy F Harefa Fajeri, Nur Iman Feliana, Marita Gabriela Da Costa Soares, Fidelia s Garnadi Jafar, Garnadi Idar, Idar Ilhamjaya Patellongi Ilhamjaya Patellongi Indri Nuraeni Pratiwi Irawan Yusuf Irene Welmince Bokotei, Martini Irviansyah, Cepy Okta Istiqomah, Aulia Nurfazri Jajang Japar Sodik Jefry Jefry Kambu, Jenita Kartadarma, Supriyatni Kartawinata, Tutus Gusdinar Kasihtheisya, Naida Kevin Efraim Lian Kharina Septi Lestari Kusmiati, Meti Languwila, Indrawati Linda Rofiasari Maharani, Ilmi Intan Maia de Fatima Freitas, Floriana Marita Feliana Marliani, Lia Meti Kusmiati Mia N. A. Fatin Nugraha, Eka Rahmat Nurfazri, Aulia Pratama, Reza Priana, Eka Puput Novriana Safari, Alit Rian Reladi Yanuar Salim Agustian Saputra, Erwin Yuliana Septri Rahmawati, Nabila Solihah, Nurlaella Soni Muhsinin Sri Lestari Kartikawati Subakti, Nanda Supriyatini Kartadarma Susilawati, Elis Sutrisno, Entris Syakib Bakri Syihabbudin, Nazar Taofiq Putra Pratama, Muhamad Tri Nevita Margareth Panjaitan Tutus Gusdinar Kartawinata Valiani, Cici Wahyudi, Vierly Stephany Putri Widhya Aligita Yani Mulyani Yani Mulyani Yusita, Intan Zinan, Daula Zahra