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All Journal Martabe : Jurnal Pengabdian Kepada Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Indonesian Journal of Pharmaceutical Education Jurnal Kolaboratif Sains Jurnal Ilmiah Bakti Farmasi Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jurnal Kesehatan Farmasi Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products
Hiola, Faramita
Universitas Negeri Gorontalo
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Pengaruh SLM_2026 Terhadap Stabilitas Fisik dan Laju Pelepasan Krim Niosom Antosianin Secara In Vitro Tungadi, Robert; Abdulkadir, Widy Susanti; Hiola, Faramita; Paneo, Mohamad Aprianto; Ayu Maloho, Sity Nur Rahayu Maloho
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 2 No. 2 (2025): Volume 2 Nomor 2 Tahun 2025
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v2i2.65

Abstract

Antosianin merupakan salah satu zat aktif yang dapat diformulasikan dalam sediaan krim. Namun antosianin memiliki kestabilan yang sering berubah ubah. Untuk itu antosianin diformulasikan ke dalam bentuk niosom untuk meningkatkan kestabilan antosianin di dalam stratum korneum serta dibuatlah dalam sediaan krim dengan penambahan skin lipid matriks_2026 yang digunakan sebagai basis krim serta memiliki aktivitas sebagai emulgator. Penelitian ini bertujuan untuk mengetahui pengaruh Skin lipid matriks_2026 terhadap stabilitas fisik dan laju pelepasan krim niosom antosianin secara in vitro. Metode penelitian ini diawali dengan pembuatan niosom menggunakan metode injeksi pelarut etanol kemudian dilakukan karakterisasi meliputi ukuran partikel menggunakan Particle Size Analyzer (PSA) dan persen efisiensi penjerapan (%EP). Niosom Antosianin diformulasikan ke dalam bentuk krim dan dilakukan evaluasi fisik serta uji penetrasi menggunakan metode difusi franz. Hasil penelitian menunjukkan karakterisasi F1, F2, dan F3 secara berturut-turut yaitu persen efisiensi penjerapan sebesar 67,16%, 93,66%, dan 100% dengan ukuran partikel sebesar 205,5 nm, 157 nm, 257 nm serta indeks polidispersitas sebesar 0,235, 0,195, dan 0,355. Ketiga formula krim memenuhi persyaratan evaluasi fisik sediaan krim yang baik. Hasil uji penetrasi menunjukkan jumlah kumulatif antosianin yang terpenetrasi selama 24 jam untuk F1, F2, dan F3 secara berturut-turut adalah 199,835 μg/cm2, 306,0784 μg/cm2, dan 209,2437 μg/cm2. Tidak terdapat pengaruh yang signifikan dari variasi konsentrasi antosianin yang digunakan dalam formula terhadap penetrasi krim niosom antosianin.
Karakterisasi Senyawa Minyak Atsiri Ekstrak Etil Asetat Bawang Putih (allium sativum l.) Taupik, Muhammad; Andy Suryadi, A. Mu’thi; Hiola, Faramita; Rannu, Jumriani
Indonesian Journal of Pharmaceutical Education Vol 1, No 2 (2021): Mei-Agustus 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i2.11767

Abstract

Garlic (Allium sativum L.) is one of tuber vegetable crops that is widely grown in various countries in the word and is often used as food spices and medicines. The purpose of this study was to characterize the volatile oil compound ethyl acetate extract of garlic (Allium sativum L.) using Uv-Vis and IR spectrophotometric metods. Several methods used in this research included extraction, identification of compounds, fractionation, thin layer chromatography, prepative thin layer chromatography, and characterization of compounds using Uv-Vis spectrophotometry and IR spectrophotometry. A total of 3000 grams od garlic was macerated using 70% ethanol, then evaporated and obtained a thick extract of 421.5 grams. The results of thin layer chromatography used an eluent ratio of Methanol : Ethyl Acetate (4:2) obtained stains with an Rf value of 0,55. The optimizion result of maximum wavelength of garlic isolated (Allium sativum L.) is 232 nm wich indicated  the presence of an electron transition  n→σ*.The results of IR  spectrophotometry had fuctional groups at wave numbers 3231.530 cm-1 (N-H), 1637.48 cm-1 (C=O), 1014.65 cm-1(C-N). 
Interaksi Obat Pada Pasien Diabetes Melitus Tipe 2 Dengan Penyakit Penyerta Di Rumah Sakit Otanaha Kota Gorontalo Rasdianah, Nur; Hiola, Faramita; Andy Suryadi, A. Mu’thi; Gani, Athira Sri Wahyuni
Indonesian Journal of Pharmaceutical Education Vol 1, No 1 (2021): Januari-April 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i1.9953

Abstract

As the numbers of cases continue to soar, diabetes mellitus or DM is one the most common disease in Indonesia. The WHO predicts that in 2030, numbers of diabetics in Indonesia will rise up to 21.3 million people, compared to 8.4 million people in 2000. Regarding the treatment, most of diabetes cases are commonly treated with pharmacological therapy. In this regard, polypharmacy and medications-related problems might occur during the treatment to control blood glucose level that is concurrent with the treatment of other diseases. Drug Interaction is a common medication-related problem. The present study is aimed to investigate the cases of drug interaction in patients with type-2 DM with comorbid diseases during the period of January-December 2019 in Otanaha Hospital, Gorontalo. As based on the inclusion criteria, the study involved 92 patients with type-2 DM and comorbid disease involved combination of metformin-glimepiride (47%), insulin (19%), metformin (14%), and glimepiride (9%). Moreover, based on the observation, minor interaction occurred the most (47%), followed by moderat interaction (31%) and major interaction. To sum up, the cases of drug interaction in patients with type-2 DM and comorbid disease in Otanaha Hospital, Gorontalo are relatively high. It is further concluded that the pharmacist's role is influential to supervise and monitor the patients medication intake.
Formulasi Sediaan Emulgel Ekstrak Daun Kelor (Moringa oleifera Lam) Dan Uji Aktivitas Antioksidan Menggunakan Metode DPPh Nurrohwinta Djuwarno, Endah; Hiola, Faramita; Isa, Ishak
Indonesian Journal of Pharmaceutical Education Vol 1, No 1 (2021): Januari-April 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i1.9947

Abstract

Moringa (Moringa oleifera Lam) is one of the plants that has high antioxidant activity, especially in the leaves. Emulgel is one of the topical dosage which dermatologically has several beneficial properties, namely thixotropic, not oily, easy to spread, easy to clean, soft, easy to wash, long lasting, transparent and comfortable when used. The purpose of this research was to formulate moringa (Moringa oleifera Lam) leaves extract into emulgel dosage forms and determine the antioxidant activity of the dosage using DPPH method.The research began with extraction of moringa leaves and optimization of the base by varying the concentration of carbopol 940 as gelling consisting of F1 0.5%, F2 1%, F3 1.5% and F4 2%. The base that met the requirements of good physical stability was F2.  The F2 base was then made into emulgel dosage with 3 concentration variations of the extract, namely F2a 4%, F2b 5% and F2c 6%. The physical stability test result of each formula met the organoleptic test,the pH test, the dispersion test, the adhesion test, the viscosity test, and the freeze-thaw test. The One way ANOVA statistical test result showed that the p value was greater than 0.05, which meant that the emulgel dosage had good physical stability. The IC50values of each antioxidant activity result were F2a (t0 = 120.464 g/mL; t28 = 144.887 g/mL), F2b (t0 = 113.642 g/mL; t28 = 128.407g/mL), F2c (t0 = 74.745 g/mL; t28 = 90.618 g/mL). The statistical results of the t-test showed thep value = 0,027, (less than 0.05), This indicated that there were significant difference results of the antioxidant activity test between the three formulas on the first day (t0) and on the 28th day (t28).
Peningkatan Pengetahuan Ibu Balita tentang Gizi Seimbang dan Pencegahan Stunting: The Improvement of Knowledge of Mothers with Toddlers about Balanced Nutrition and Stunting Prevention Hiola, Faramita; Putri Ayuningtias Mahdang; Nanang R. Paramata
Jurnal Kolaboratif Sains Vol. 8 No. 9: September 2025
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v8i9.8448

Abstract

Masalah gizi dan stunting pada anak-anak, khususnya di Indonesia, masih menjadi tantangan utama dalam meningkatkan kesehatan masyarakat. Sosialisasi mengenai gizi seimbang dan pencegahan stunting menjadi solusi strategis untuk menurunkan prevalensi stunting, yang masih tinggi di beberapa wilayah. Tujuan dari kegiatan pengabdian ini adalah untuk meningkatkan pengetahuan ibu balita tentang pentingnya pemberian gizi seimbang dan cara pencegahan stunting. Metode yang digunakan meliputi pendekatan partisipatif, sosialisasi interaktif, serta pemberian materi edukasi dengan menggunakan media leaflet dan video. Hasil yang didapat menunjukkan adanya peningkatan signifikan dalam pengetahuan ibu balita mengenai gizi seimbang dan pencegahan stunting, yang tercermin dalam peningkatan hasil pre-test dan post-test. Kegiatan ini dapat memberi kontribusi dalam upaya penurunan angka stunting.
Isolasi Dan Identifikasi Mikroalga Di Danau Limboto Mahdalena Sy. Pakaya; Hiola, Faramita; Juliyanty Akuba; Hutuba, Ariani H.; Lahay, Astiara
Journal of Pharmacology and Natural Products Vol. 2 No. 3 (2025): Volume 2, Nomor 3, Tahun 2025
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jpnp.v2i3.75

Abstract

Penggunaan antibiotik dengan dosis yang tidak tepat secara terus-menerus menyebabkan bakteri patogen menjadi resisten. Penemuan senyawa antibakteri dapat dilakukan dengan cara isolasi pada bahan alam salah satunya mikroalga. Penelitian ini bertujuan untuk mengisolasi dan mengidentifikasi mikroalga pada perairan danau limboto yang berpotensi sebagai antibakteri. Penelitian ini menggunakan metode ekperimental yang dilakukan di Laboratorium Mikrobiologi Farmasi menggunakan teknik mikroskopis, metode difusi cakram serta KLT Bioautografi untuk menguji senyawa aktif yang berperan sebagai antibakteri. Hasil identifikasi didapatkan mikroalga pada titik 2 (MA2 a dan MA2 b) dan titik 3 (MA3 a) termasuk kelompok alga hijau (Chlorophyta). Metode isolasi menggunakan metode pengenceran berseri didapatkan isolat (MA2 a dan MA3 a).
Co-Authors A. Mu’thi Andy Suryadi Akuba, Juliyanti Andy Suryadi, A. Mu’thi Anggai, Rifka Anggraini Anindia Mangulu Ariani H. Hutuba Ayu Maloho, Sity Nur Rahayu Maloho Dewa Ayu Puspita Divia Handayani Mudjidu Dr. Apt. Hamsidar Hasan S.Si.,M.Si Endah Nurrohwinta Djuwarno Fika Nuzul Ramadhani Gani, Athira Sri Wahyuni Gunawan, Selvi Ayu Setiaarini Halada, Ichlasul Oktofandi Hamsidar Hasan Hamzah, Alifiah Ramawaty Hasrita Samudi Iman, Devansyah Ishak Isa Ismail, Ulfatul Magfirah M. Jihan Utari Paputungan Julianty Akuba Kahar, Putri Kartika Adhilia Katili, Ayub H. Khairun nisha Samsi Lahay, Astiara Lia Amalia Liputo, Kartika Vany Lisa Efriani Puluhulawa Madania, Madania Madania, Madania Mahdalena Sy Pakaya mahdalena sy. pakaya Makkulawu, Andi Mohamad Aprianto Paneo Muhammad Taupik Muhammad Taupik Nanang R. Paramata Nanang Roswita Paramata Nur Ain Thomas Nur Rasdianah Pakaya, Meri Isriani Papeo, Dizky Ramadani Putri Putri Ayuningtias Mahdang Putri Ayuningtias Mahdang Rannu, Jumriani Robert Tungadi Sri Nur'ain E. Ahmad Suleman, Ahmad Teti Sutriyati Tuloli Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Yasir Mokodompis