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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Ilmu Dasar Jurnal Kedokteran Syiah Kuala Majalah Kedokteran Bandung AL KAUNIYAH e-Journal Pustaka Kesehatan Jurnal Sains dan Teknologi Althea Medical Journal Jurnal Kesehatan Andalas Research Journal of Life Science Indonesian Journal of Biotechnology Journal of Agromedicine and Medical Sciences Mutiara Medika: Jurnal Kedokteran dan Kesehatan Elkawnie UNEJ e-Proceeding MNJ (Malang Neurology Journal) Medical Laboratory Technology Journal Health Notions Jurnal Pengabdian Pada Masyarakat Warta Pengabdian Multidiciplinary Journal Al-sihah: The Public Health Science Journal Manuju : Malahayati Nursing Journal Majalah Kedokteran Andalas Jurnal Inovasi Teknik Kimia Jurnal ABDINUS : Jurnal Pengabdian Nusantara JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH AloHA International Journal of Health Advancement (AIJHA) Jurnal Kesehatan dr. Soebandi Strada Jurnal Ilmiah Kesehatan (SJIK)
Erma Sulistyaningsih
Department Of Parasitology, Faculty Of Medicine, University Of Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Other

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The Effect of Food Intake on the Incidence of Malnutrition in Toddlers in the Work Area of the Kertosari Health Center, Banyuwangi Regency Endang Sri Purwanti Wulandari; Erma Sulistyaningsih; Ancah Caesarina Novi Marchianti
STRADA : Jurnal Ilmiah Kesehatan Vol. 9 No. 2 (2020): November
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v9i2.530

Abstract

This study aims to determine the effect of food intake patterns on malnutrition incidence in toddlers in the working area of Kertosari Health Care. This study used a cross-sectional method with a research population of 30 toddlers. The data were obtained from validated questionnaires and food intake measurements using a 24 hours food recall form. Samples in this study as many as 30 malnourished toddlers and spread in the Kertosari Health Care working area. The data were analyzed using descriptive analysis techniques and ordinal logistic regression influence tests. The results of the study showed that energy intake patterns (p = 0.032), protein intake patterns (p = 0.026), fat intake patterns (p = 0.026), carbohydrate intake patterns (p = 0.014), zinc intake patterns (p = 0.043) and calcium intake patterns (p = 0.026) with the incidence of malnutrition in toddlers
Risk Factors for Contamination of Pesticide Residues in Women's Breast Milk Farmers in Agricultural Ar-eas Intan Rachmawati; Sri Hernawati; Erma Sulistyaningsih; Aldi Cahya Muhammad
STRADA : Jurnal Ilmiah Kesehatan Vol. 10 No. 1 (2021): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v10i1.675

Abstract

Pesticides are all chemicals, serve as controls for pests and weeds' growth. This study aimed to identify the pesticide residue contamination in women farmers' breast milk in agricultural areas and analyze the risk factors. Quantitative descriptive research method with cross-sectional approach. A sample of 10 female farmers was selected using the purposive sampling technique. Data on risk factors were obtained by interview using a questionnaire, and pesticide residues in breast milk were measured by GC-MS/MS and LC-MS/MS. Spearman rank correlation tests and ordinal logistic regression are used to analyze data. The results showed that all of the respondents' breast milk was contaminated with organochlorine pesticide p'p DDE (> 0.001 mg/kg). Statistical test results prove that nutritional status / BMI with pesticide residue concentration has a significant relationship (p-value = 0.000). In conclusion, excess body mass index is a risk factor for pesticide residue contamination in female farmers in agricultural areas.
Differential Leukocyte Count Responses Post Injection of Duffy-binding-like Domain-2β of PfEMP1 Recombinant Protein in Wistar Rat Zahniar, Zahniar; Sulistyaningsih, Erma; Rachmania, Sheilla; Dewi, Rosita; Kusuma, Irawan Fajar
Medical Laboratory Technology Journal Vol. 11 No. 1 (2025): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i1.628

Abstract

Malaria due to Plasmodium falciparum causes a high mortality rate, and vaccination is a valuable approach to control it. One malaria vaccine candidate is Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1), specifically Duffy binding-like 2β (DBL2β) domain (DBL2β-PfEMP1), which has a vital role in severe malaria pathogenesis. The DBL2β-PfEMP1 recombinant protein is immunogenic. This study aimed to investigate the immune response of DBL2β-PfEMP1 protein by analyzing the differential leukocyte count. Twenty-three rats were randomly divided into control and five treatment groups. Rats were injected on days 0, 21, and 42 with a physiological solution of 0.9% NaCl, adjuvant, DBL2β-PfEMP1 protein, and each mixture of DBL2β-PfEMP1 protein with doses of 150, 300, and 450 µg/200gBW and adjuvant. Blood was collected on day 56 and prepared for differential leukocyte count examination with a visual microscopic examination by two expert observers. The results showed that DBL2β-PfEMP1 recombinant protein and adjuvant increased the eosinophils and neutrophils but decreased monocytes and lymphocytes and did not affect the basophils. Statistical analysis showed significant differences between groups for eosinophils (between control and DBL groups; Adj and DBL groups; DBL and other groups except DBL150+adj) and monocytes (between control and all doşe groups with adjuvant; DBL and all doşe groups with aduvant), but not for basophils, neutrophils, and lymphocytes. In conclusion, the serial injection of DBL2β-PfEMP1 recombinant protein showed different responses in each leukocyte cell type. Further analysis by time-series differential leukocyte count examination will be essential to determine the responses of each type of leukocyte to support the research on malaria vaccine development.
Optimasi Transformasi Gen CIDR1α-PfEMP1 pada Eschericia coli BL21(DE3) dengan Metode Heat-shock Dewantoro, Dicky; Sulistyaningsih, Erma; Dewi, Rosita
JST (Jurnal Sains dan Teknologi) Vol. 12 No. 1 (2023): April
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jstundiksha.v12i1.53704

Abstract

Malaria masih menjadi masalah kesehatan dunia terutama di negara-negara berkembang. Data World Malaria Report 2020, kasus malaria di dunia tahun 2019 mencapai 229 juta kasus dengan total kematian mencapai 409.000 jiwa. Kematian tertinggi terjadi pada pasien usia balita yang mencapai 272.000 jiwa.  Angka kematian akibat malaria berat di dunia sangat tinggi sehingga perlu berbagai pendekatan penanganan termasuk vaksin malaria. Domain Cysteine-rich Interdomain Regions 1α-Plasmodium falciparum Erythrocyte Membrane Protein 1 (CIDR1α-PfEMP1) merupakan kandidat vaksin malaria karena berperan penting dalam pathogenesis malaria. Pengembangan vaksin malaria berbasis CIDR1α-PfEMP1 dilakukan melalui teknologi rekombinan DNA dimana tahapan yang sangat penting adalah transformasi. Tujuan penelitian ini untuk mengoptimasi kondisi transformasi gen CIDR1α-PfEMP1 pada Escherichia coli BL21(DE3) menggunakan metode heat shock guna mendapatkan efisiensi transformasi tertinggi. Variable yang dianalisis adalah durasi heat shock selama 30, 50, dan 70 detik dan volume plating 100 µL dan 200 µL. Hasil penelitian menunjukkan efisiensi transformasi tertinggi sebesar 1,9 x 102 CFU/µg dicapai pada kondisi heat shock selama 50 detik dan volume plating 200 µL. Ini adalah kondisi optimum transfomasi gen CIDR1α-PfEMP1 yang dapat digunakan untuk penelitian lanjutan guna mengembangkan vaksin malaria.
Analysis of Microglia Morphology and Number in Wistar Rats Brain After CIDR1α-PfEMP1 Recombinant Protein Injection Sulistyaningsih, Erma; Putri, Izza Amalia; Rachmania, Sheilla
Al-Kauniyah: Jurnal Biologi Vol. 18 No. 1 (2025): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v1i1.38242

Abstract

AbstractOne malaria vaccine candidate is Cysteine-rich Interdomain Region 1α (CIDR1α) of Plasmodium falciparumErythrocyte Membrane Protein 1 (PfEMP1), an essential protein involved in the pathogenesis of cerebral malaria. Microglia in the brain act as the first line of defense against brain pathological changes. The study aimed to evaluate the response of brain microglia to the CIDR1α-PfEMP1 recombinant protein injection by observing microglia morphology and number in rat’s cerebral cortex. 12 Wistar rats were divided into the control group, which was injected with normal saline solution, and the treatment group, which was injected with 150 µg CIDR1α-PfEMP1 recombinant protein combined with adjuvants. Injection was conducted thrice within three-week intervals (day 1, 21, and 42). Wistar rats were euthanized on day 56, and histological slides were prepared with Hematoxylin-Eosin staining. Examination using a microscope, 400x, and Fiji Image J software showed microglia morphology of ramified and rod cells in both the control and treatment groups. The microglia number in the control group was 93.00 ± 5.77, and the treatment group was 105.75 ± 15.62. Statistical analysis using an independent t-test showed no significant differences between groups (p= 0.15). The result indicated that the injection of CIDR1α-PfEMP1 recombinant protein did not provoke pathological changes in brain tissue, which induced a microglia response. This study strengthens the potential of the CIDR1α-PfEMP1 recombinant protein as a peptide-based malaria vaccine candidate.AbstrakSalah satu kandidat vaksin malaria adalah Cysteine-rich Interdomain Region 1α (CIDR1α) dari Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1), protein penting dalam patogenesis malaria serebral. Mikroglia di otak berperan sebagai pertahanan lini pertama terhadap perubahan di otak. Penelitian ini bertujuan mengevaluasi respon mikroglia otak terhadap pemberian protein rekombinan CIDR1α-PfEMP1 dengan mengamati morfologi dan jumlah mikrolia pada korteks serebri otak tikus. 12 tikus Wistar dibagi dalam kelompok kontrol yang diinjeksi normal saline dan  kelompok perlakuan diinjeksi 150 µg protein rekombinan CIDR1α-PfEMP1 yang dikombinasikan dengan adjuvant. Injeksi dilakukan tiga kali dengan interval tiga minggu (hari 1, 21, dan 42). Tikus dieuthanasia pada hari ke-56 dan preparat histologi otak disiapkan dengan pengecatan Hematoxyline-Eosin. Pengamatan menggunakan mikroskop 400x dan Fiji Image J software menunjukkan morfologi ramified dan rod cell pada kelompok kontrol maupun perlakuan. Jumlah mikroglia pada kelompok kontrol 93,00 ± 5,7 sedangkan kelompok perlakuan 105,75 ± 15,62). Analisis statistik menggunakan independent-t test menunjukkan tidak terdapat perbedaan yang bermakna antara 2 kelompok (p= 0,15). Hasil ini mengindikasikan bahwa pemberian protein rekombinan CIDR1α-PfEMP1 tidak menimbulkan patologi pada jaringan otak yang memicu respon mikroglia. Hal ini menguatkan potensi protein rekombinan CIDR1α-PfEMP1 sebagai kandidat vaksin malaria berbasis peptida.
The Relationship between Sanitation and Personal Hygiene with Seroprevalence of Toxoplasmosis in Pregnant Women at Kaliwates and Banjarsengon Community Health Centers Nabila Putri Anissa; Yunita Armiyanti; Eny Nurmaida; Bagus Hermansyah; Erma Sulistyaningsih; Wiwien Sugih Utami
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Toxoplasmosis is an infectious disease in animals that can be transmitted to humans. Sanitation and personal hygiene are risk factors for toxoplasmosis. Toxoplasmosis can be transmitted from pregnant women to their fetuses. Toxoplasmosis in pregnancy can cause pregnancy, premature birth, and congenital toxoplasmosis. According to the Jember District Health Office in 2023, access to proper sanitation and good hygienic behavior is still low. The purpose of this study was to analyze the relationship between sanitation and individual hygiene with toxoplasmosis seroprevalence in pregnant women at the Kaliwates and Banjarsengon Health Centers. This study used a crosssectional study type. The subjects of the study were 65 pregnant women at the Kaliwates and Banjarsengon Health Centers who were taken using the accidental sampling technique. The serological examination used the Toxoplasma IgM and IgG ELISA kit from Calbiotech®. The results of this study showed that 77% of pregnantwomen were detected positive for toxoplasmosis. The majority of pregnant women have good sanitation and personal hygiene categories of 87.7% and 90.8%, respectively. Based on the results of Fisher's exact test, sanitation and personal hygiene are not related to toxoplasmosis seroprevalence (p>0.05). This study concludes that sanitation and personal hygiene of pregnant women at the Kaliwates and Banjarsengon Health Centers are not significantly related to toxoplasmosis seroprevalence.  
High Toxoplasmosis Seroprevalence and Anemia Among Early-Mid Pregnant Women in Jember, Indonesia Wulandari, Lindi Priyantika Tri; Armiyanti, Yunita; Aziz, Ayu Munawaroh; Hermansyah, Bagus; Sulistyaningsih, Erma; Utami, Wiwien Sugih
Journal of Community Medicine and Public Health Research Vol. 6 No. 2 (2025): Journal Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jcmphr.v6i2.68484

Abstract

Toxoplasmosis is an infection caused by the parasite Toxoplasma gondii, which can be transmitted through various routes. Toxoplasmosis in pregnant women may cause abortion and fetal disabilities. Decreased body immunity due to anemia can increase the risk of toxoplasmosis during pregnancy. The purpose of this study was to identify the characteristics of pregnant women and their association with anemia, determine the prevalence of anemia and toxoplasmosis infection in pregnant women, and investigate whether anemia is a risk factor for toxoplasmosis in pregnant women. This research is an analytical, observational study using a cross-sectional laboratory examination. The sample in this study consisted of blood collected from first- and second-trimester pregnant women at the Kaliwates and Banjarsengon Public Health Centers for hemoglobin analysis and toxoplasmosis serology. Accidental sampling was conducted from July to December 2024. The research data were presented in tabular form and analyzed using the Chi-square test. This study was conducted on 65 pregnant women. The number of pregnant women with anemia was 43% and the number of pregnant women who were positive for toxoplasmosis was 66%. A significant association exists between gestational age and anemia (p-value = 0,041). Bivariate analysis between anemia and T. gondii infection showed no significant association (p-value = 0.182). This study concludes that anemia is not proven to be a risk factor for toxoplasmosis infection in pregnant women. However, the cases of anemia and toxoplasmosis were high and require specific attention.
Pembentukan Model Keluarga Sadar Gizi (KADARZI) dan Kader Siaga Stunting sebagai Upaya Pemberdayaan Masyarakat Desa Sukogidri-Jember dalam Mengatasi Stunting Sulistyaningsih, Erma; Dewanti, Parawita; Pralampita, Pulong Wijang
Jurnal ABDINUS : Jurnal Pengabdian Nusantara Vol 5 No 2 (2021): Volume 5 Nomor 2 Tahun 2021
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/ja.v5i2.15364

Abstract

Stunting is a major health problem in Indonesia. Sukogidri Village is one of the villages that contribute to stunting in Jember Regency. There are 18 stunting children under five from 353 total children under five in the village. The effort to solve the stunting problem should involve community participation through empowerment. This community service aimed to increase community empowerment to solve the stunting by forming the nutritionally-aware family (Keluarga Sadar Gizi = KADARZI) model and the stunting-alert cadres. KADARZI model was chosen in selected families and trained on the definition of KADARZI, the efforts and steps undertaken as a model for KADARZI in selected families. The stunting-alert cadres were formed from health cadres who were provided with intensive education and training materials on the stunting, its dangers and how to prevent it. After going through serial training, 10 KADARZI models and 10 stunting-alert cadres were formed in Sukogidri Village, Jember. It is hoped that the KADARZI model and stunting alert cadres will play an active role in overcoming stunting in the village.
Pengaruh PENGARUH BIOINSEKTISIDA GRANULA CAMPURAN EKSTRAK BIJI SRIKAYA (Annonae squamosa) DAN DAUN SIRIH (Piper betle) TERHADAP MORFOLOGI TELUR Aedes aegypti Firdha Novitasari; Dwi Wahyuni; Erma Sulistyaningsih
Jurnal Kesehatan dr. Soebandi Vol 9 No 1 (2021): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v9i1.265

Abstract

Introduction: Dengue hemorrhagic fever (DHF) is an important public health problem in Indonesia because its morbidity and mortality are quite high. Prevention by vector control methods with chemical insecticides adversely affects the environment. Research on granular bioinsectide mixture of betel leaf extract and sugar apple seeds against Aedes aegypti is expected to be used to break the chain of Aedes aegypti mosquitoes starting from the juvenile stage (eggs) as an effort to control the vector population naturally. Objective: This study aims to analyze the effect of granule bioinsecticide mixture of sugar apple seed extract and betel leaf on changes in the morphology of Aedes aegypti eggs. Methods: This study is a true-experimental study with a Post test Only Control Group Design design. The treatment group will be given a granular bioinsecticide, a mixture of sugar apple seed extract and betel leaf, positive control will be given abate while negative control will be given aquades. Each group uses 25 eggs with 3 repetitions. On day 3, all eggs will be observed using a stereo microscope to determine morphological changes. The data obtained will be analyzed using ordinal regression test. Results: the ordinal regression test got the value of ρ in the Wald test between (0.012 - 0.955)> α = 0.01. Conclusion: there is no effect of mixed granules of betel leaf and sugar apple seeds on the mortality of Aedes aegypti eggs. Further research is needed on new formulations using other natural ingredients to increase the effect of ovicides on Aedes aegypti.
Immunoglobulin M Response Post DBL2Β-PFEMP1 Recombinant Protein Injection in Wistar Rats: Study for Malaria Vaccine Development Erma Sulistyaningsih; Achmad Faza Abdillah; Rosita Dewi; Sheilla Rachmania
Al-Kauniyah: Jurnal Biologi Vol. 19 No. 2 (2026): AL-KAUNIYAH: JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v19i2.44265

Abstract

Vaccination is vital in malaria prevention strategies. The DBL2β-PfEMP1 recombinant protein is a malaria vaccine candidate due to its essential role in severe pathogenesis. This study analyzed the IgM levels after DBL2β-PfEMP1 recombinant protein injection. This study used nineteen male Wistar rats, aged 2–3 months, and was divided into a control group, which was injected with NaCl 0.9%, and four treatment groups, which were injected with DBL2β-PfEMP1 protein in doses of 150 μg without adjuvant, and 150, 300, and 450 μg with adjuvant. Rats were injected subcutaneously twice at a 6-week interval. Blood samples were collected two weeks after injection. IgM was measured using the ELISA. There was an increasing trend in IgM levels after the DBL2β-PfEMP1 protein injection with a dose-dependent effect in the primary injection. The One-way ANOVA test showed a significant difference between groups (p = 0.037), and the post-hoc Bonferroni test showed a significant difference only between a control and treatment group of 450 μg + adjuvant (p= 0.046). A trend of increasing IgM in secondary injection was only observed in the 150 μg + adjuvant group, which is suggested as an optimum dose. Further analysis of other immune indicators is needed to draw a comprehensive immune response in developing a malaria vaccine candidate.
Co-Authors Achmad Faza Abdillah Agustina Tri Endharti Al Munawir Alami, Eqiel Navadz Akthar Aldi Cahya Muhammad Alfi Kamalia Aliyatul Farida Anas Bakhtiar Diyansah Ancah Caesarina Novi Marchianti Aprilia, Annisa Nadya Ardyansyah, Rizky Robeth Arifin, Mochammad Samsul Ayundasari, Asti Aziz, Ayu Munawaroh Bagus Hermansyah Burhan, Niniek Cholis Abrori, Cholis Cicih Komariah Denaneer Rahmadatu Devita Prima Nurmasari Dewantoro, Dicky Didi Candradikusuma Didi Candradikusuma Dini Agustina Dion Krismashogi Darmawan Dwi Wahyuni Dwita Aryadina Rachmawati Elly Nurus Sakinah, Elly Nurus Endang Sri Purwanti Wulandari Eny Nurmaida Erfan Efendi Eva Sulawati Arum Fathul Hidayatul Hasanah, Fathul Hidayatul Febrina Sylva Fridayanti, Febrina Sylva Firdha Novitasari Fitri Dika Maharani FX Ady Soesetijo, FX Ady Ghani Silahudin Hadi Prayitno Heni Fatmawati Hidayat Sujuti I Ketut Suada Ida Srisurani Wiji Astuti Ika Rahmawati Sutejo Intan Rachmawati Irawan Fajar Kusuma Iza Billa Fahmi Jarot Subandono Jauhar Firdaus Josef Sem Berth Tuda Kahfi Karunia Ilahi Laeli Kurniasari Laili, Elisa Fadia Laily Rahmawati Loeki Enggar Fitri Luh Putu Ratna Sundari Muhammad Hasan Nabila Putri Anissa Nafisa, Tsabita Ngurah Agung Reza Satria Nugraha Putra Nicole Berens-Riha Nicole Berens-Riha, Nicole Niniek Burhan Nur Aqmarina Kusumawardani Nurmaida, Eny Parawita Dewanti Pralampita, Pulong Wijang Pungky Setya Arini Putri, Izza Amalia Rahma, Nafisah Hani Asyifah Rina Fitriana Rina Fitriana Ristya Widi Endah Yani Rosita Dewi Rosita Dewi Sahrir Sillehu Salim Salim Samsul Arifin Sari, Leny Yulia Widia Setyoadji, Winnie Almira Sheilla Rachmania Sheilla Rachmania, Sheilla Silvi Ahmada Chasya Sinta Ariyani Sri Hernawati Sugiyanta Sugiyanta Sukarti Moeljopawiro Sukarti Moeljopawiro Thomas Loescher Thomas Loescher, Thomas Tri Agus Siswoyo Tristira Urvina Tuda, Josef Sem Berth Umar Zein Warda Ayu Nadira Wayan T. Artama Wayan T. Artama Widhi Dyah Sawitri Wiji Utami Wiwien Sugih Utami Wulandari, Lindi Priyantika Tri Yunita Armiyanti Zahniar, Zahniar