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All Journal International Journal of Public Health Science (IJPHS) ACTA VETERINARIA INDONESIANA Jurnal Sain Veteriner Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kesehatan Lingkungan indonesia Jurnal Ilmu Dasar e-Journal Pustaka Kesehatan Jurnal Kesehatan Masyarakat Althea Medical Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Geografi Indonesia Jurnal Kesehatan Jurnal Kesehatan Andalas Damianus Journal of Medicine Journal of Agromedicine and Medical Sciences Jurnal Media Gizi Indonesia (MGI) JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Majalah Kedokteran Sriwijaya Universa Medicina Jurnal Bioteknologi & Biosains Indonesia (JBBI) Journal Of Vocational Health Studies Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Window of Health : Jurnal Kesehatan Al-sihah: The Public Health Science Journal Jurnal Medik Veteriner SRIWIJAYA JOURNAL OF MEDICINE Journal of Health Sciences JHECDs: Journal of Health Epidemiology and Communicable Diseases JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Kedokteran Masyarakat JEBIMAN: Jurnal Ekonomi, Bisnis, Manajemen dan Akuntansi Jember Medical Journal (JMJ) Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) ASPIRATOR - Journal of Vector-Borne Diseases Studies Folia Medica Indonesiana
Bagus Hermansyah
Departemen Parasitologi, Fakultas Kedokteran Universitas Jember, Jalan Kalimantan 37 Kampus Tegal Boto, Jember, Jawa Timur 68121
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : e-Journal Pustaka Kesehatan

 1 
Kadar IL-10 Mencit Balb/C Terinfeksi Plasmodium berghei dengan Pemberian Fraksi Metanol Bangle (Zingiber cassumunar Roxb.) sebagai Terapi Komplementer (The IL-10 level of Plasmodium berghei-infected Balb/C Mice after Methanolic Fraction of Bangle (Zingib Asis Fitriana; Bagus Hermansyah; Muhammad Afiful Jauhani; Wiwien Sugih Utami
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6791

Abstract

Malaria is an infectious disease caused by Plasmodium spp. The cause of mortality in malaria is the parasite’s resistance to malaria drugs and immune system problem. Interleukin-10 is an anti-inflammatory cytokine during plasmodium infection. Bangle is a herbal remedy that contains high amount of curcumin showing immunostimulant activity. The purpose of this study was to determine the difference of IL-10 level in Plasmodium berghei-infected Balb/C mice given with methanolic fraction of bangle (Zingiber cassumunar Roxb.) as a complementary therapy. This study was a true experimental with posttest control group design using 25 mice Balb/c which divided into 5 groups (A, B, C, D and E). All groups except group A were infected with P. berghei. After positively infected, group B was not treated, C was treated with artemisinin, group D was given with artemisinin and methanolic fraction bangle 0,017 mg/gBW, group E was treated with methanolic fraction bangle 0,017 mg/gBW. The result showed that group D had the highest-level of IL-10 among the treatment groups. The Post Hoc LSD test showed p value ≥ 0,05. In conclusion, there was no significant difference of IL-10 serum level in P. berghei-infected Balb/C mice given with methanolic fraction of bangle (Z. cassumunar Roxb.) as complementary therapy. Keywords: Interleukin-10, Plasmodium berghei, Bangle (Zingiber cassumunar Roxb.)
Efek Minuman Keras Oplosan terhadap Perubahan Histopatologi Organ Renal Tikus Wistar Jantan Made Masagung Kawiartha; Rena Normasari; Bagus Hermansyah
Pustaka Kesehatan Vol 6 No 3 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i3.9777

Abstract

Mixed liquor is a liquor mixed with other substances, mainly ethanol and methanol. Mixed liquor can cause kidney destruction. The aim of this study was to investigate the effect of mixed liquor toward kidney's microscopic and macroscopically changes. This study used 24 rats which were divided into 4 groups consist of 1 control group and 3 experimental groups. The first, second, and third experimental groups were given ethanol 1,296ml/2 days; methanol 0,2592ml/2days and aquades 1,4448ml/2 days for 5 days; 11 days and 17 days, respectively. Afterward rats were terminated and the right kidney mass was measured. The kidney tissue was prepared for histological examination and the number of necrotic cell was calculated. According to Kruskal Wallis test, kidney mass was not significantly different (p>α) while total necrotic cells was significantly different (p<α). This study showed that rats induced with mixed liquor for 5 , 11, and 17 days resulted in kidney microscopically change.
Uji Aktivitas Fraksi N-Heksana Ekstrak Metanol Bangle (Zingiber cassumunar Roxb.) sebagai Terapi Komplementer Malaria secara In Vivo (The Activity Test of N-Hexane Fraction of Bangle (Zingiber cassumunar Roxb.) Methanolic Extract as Complementary Thera Sarah Andriani; Bagus Hermansyah; Sugiyanta Sugiyanta
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Malaria is one of endemic disease in Indonesia that caused many deaths. Immune system plays important rules in preventing malaria severity. Bangle has been proven as an immunostimulant and could reduce parasitaemia in malaria infection. This study aimed to determine the activity of n-hexane fraction of bangle methanolic extract as complementary therapy of malaria. This study used 28 mice, divided into one positive control group, one negative control group, and five treatment groups. Bangle stimulation before induction was given to five treatment groups with dose: 0,005625mg/grbw, 0,01125mg/grbw, 0,0225mg/grbw, 0,045mg/grbw, and 0,09mg/grbw for 14 days. Plasmodium berghei induction was given to all groups, and then treatment groups were given ACT and bangle fraction, and positive control group was given ACT without fraction for three days. Parasitaemia was observed everyday, then plasmodium growth inhibition percentation was counted. Bangle fraction stimulation gave lower parasitaemia at the begining and Pearson correlation test showed strong positive correlation between dose of bangle fraction and plasmodium growth inhibition percentation (p<0,01). We can conclude that n-hexane fraction of bangle methanolic extract was active as complementary therapy of malaria (IC50=0,013 mg/grbb). Keywords: malaria, bangle, n-hexane, complementary therapy
Respon Imunogenitas Protein Permukaan 19 kDa Streptococcus pneumoniae (Immunogenicity Response of Streptococcus pneumoniae 19 kDa Surface Protein) Muhammad Dimas Arya Candra Permana; Dini Agustina; Bagus Hermansyah
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Pneumonia is the main common cause of children death in the world. Microbiological studies found the major causes of pneumonia is Streptococcus pneumoniae. Infection of S.pneumoniae influenced by several virulence factors, one of which is surface protein. The purpose of this study was to determine the immunogenicity of 19 kDa S.pneumoniae surface protein through hemagglutination inhibition and adhesion inhibition test. Adhesion inhibition test used antibodies that is formed from surface protein, to inhibit bacterial adhesion to the enterocytes. Hemagglutination inhibition test also used antibodies that formed from surface protein, to inhibit the agglutination of erythrocytes caused by S.pneumoniae. The results showed that antibodies, which was formed from 19 kDa S.pneumoniae surface protein, were able to inhibit hemagglutination process up to 1X dilution. Adhesion inhibition test showed that the higher antibody dilution, the greater the adhesion index. Pearson correlation analysis of the adhesion test showed that there was a significant correlation between antibody dilution with bacterial adhesion index (R= -0,787; p=0,036). It can be concluded that the 19 kDa surface protein of S.pneumoniae was immunogenic.   Keywords: Streptococcus pneumoniae, surface protein, antibody
Keberhasilan Terapi Konservatif pada Persalinan Preterm Disertai dan Tanpa Disertai Ketuban Pecah Dini di RSD dr. Soebandi, Jember Nurul Furqooniyah; Yonas Hadisubroto; Bagus Hermansyah
Pustaka Kesehatan Vol 7 No 1 (2019): Volume 7 No. 1, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i1.17587

Abstract

Preterm delivery is the greatest cause of neonatal morbidity and mortality. Preterm delivery can be accompanied by premature rupture of membranes. Preterm delivery with and without premature rupture of membranes are managed by conservative therapy to delay birth. Rupture of membranes causes inadequate protection of the fetus. This study aimed to determine the success of conservative therapy in preterm delivery with and without premature rupture of membranes at Regional Hospital (RSD) dr. Soebandi Jember. The study used secondary data from medical records of pregnant women with spontaneous single preterm delivery that has been given conservative treatment from January 2015-January 2017 period. As many as 149 samples were included for the study, which is collected using total sampling technique. This research used cross sectional research design. Chi-Square statistical test results showed a significance of (p = 0.001 <0.05). It can be concluded that there was a significant difference of the success of conservative therapy between the preterm delivery with and without premature rupture of membranes.
Uji Aktivitas Fraksi Diklorometana Ekstrak Metanol Bangle (Zingiber cassumunar Roxb.) sebagai Terapi Komplementer Malaria secara In Vivo (The Activity Test of Dichloromethane Fraction of Bangle (Zingiber cassumunar Roxb.) Methanolic Extract as Complement Edda Rachmadenawanti; Bagus Hermansyah; Yuli Hermansyah
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

World Malaria Report reported that Malaria threats 40% of world population in six regions and ninety seven endemic countries. This study aimed to investigate the activity of dichloromethane fraction of Bangle as a complementary therapy of malaria in vivo. This was true experimental laboratories study using 28 mice of Balb/c, divided into seven groups. Five treatment groups were given five dose of dichloromethane fraction of Bangle methanolic extracts as imunostimulant before malaria infection and during malaria therapy by combining with malaria standard therapy. K(+) group was given malaria standard therapy. K(-) group was not given any therapy after infection. Inhibition percentage of malaria parasite in K(-) was 0 and K(+) was 24,74%. The treatment group of 0,09 mg/grBW had the highest inhibition percentage, as many as 88,19%. It declined by decreasing dose of fraction. The result of pearson correlation showed very strong correlation (r=0,880). The Ic50 value of dichloromethane fraction of Bangle methanolic extract as a complementary therapy was 0,008 mg/grBW. In conclusion, dichloromethane fraction of Bangle methanolic extract had immunostimulant effect and antimalarial activity in vivo.   Key words: bangle, complementary therapy, inhibition percentage, malaria
Co-Authors Achmad Maududie Achmad Nazalal Furqon Adilah Julinar Irianti Afifatun Hasanah Agustina Tri Endharti Ahmad Hasbi Al-Muzaky Angga Mardro Raharjo Ardyansyah, Rizky Robeth Arifin, Mochammad Samsul Asis Fitriana Ayundasari, Asti Azham Purwandhono Azham Purwandhono Aziz, Ayu Munawaroh Billy Jusup Kurniawan Brillian Adexa Yudinda Burhan, Niniek Cholis Abrori, Cholis Cicih Komariyah Desi Dwi Cahyani Diana Chusna Mufida Dicky Setiawan Didi Candradikusuma Didi Candradikusuma Dimas Aji Bimantara Dina Helianti Dinda Ayu Wanodya Supriatiningsih Dini Agustina Drajad, Rahadinda Mutia Dhamar Dwita Aryadina Dwita Aryadina Rachmawati Dwita Sakuntala Edda Rachmadenawanti El Milla, Kardiana Izza Ellen Ocktavironita Elvia Rahmi Marga Putri Enny Suswanti ENNY SUSWATI Eny Nurmaida Epafroditus Sanjaya Adiguna Erfan Efendi Erma Sulistyaningsih Erma Sulistyaningsih Febrianti, Zahrah Fitri, Nadya Eka Ghaiska Najma Amnur Habib Mustofa Habibi, Ali Hanu Neda Septian Heni Fatmawati Hidayat Sujuti Ida Srisurani Wiji Astuti Ika Rahmawati Sutejo Indra Samudra Rahmat Irawan Fajar Kusuma Ivan Iqbal Baidowi Jauhani, M. Afiful Jauhar Firdaus Josef Sem Berth Tuda Kesy Sasta Handani Kristianningrum Dian Sofiana Kusiyanto Taslim, Fitranda Lailatis Shofia Laili, Nikmatul Laily Nurhayati Laksmi Indreswari Laksmi Indreswari Leersia Yusi Ratnawati Loeki Enggar Fitri M. Ali Shodikin M.S. Irham Rozaq Made Masagung Kawiartha Mash’ab Zirrun Al-Qomah Muhammad Afiful Jauhani Muhammad Alif Taryafi Muhammad Dimas Arya Candra Permana Muhammad Ryznar Faisal Nur Luqmani Nabila Putri Anissa Nexia Nevarachell Onny Amirsyah Nidya Husna Kholidah Niniek Burhan Nita Alfianti Nugraha, Bima Setia Sandya Nurmaida, Eny Nurul Furqooniyah Pangestu, Ahmad Yudho Hadi Pralampita, Pulong Wijang Primadana, Aditya Putra, Muhamad Dwi Eka Putri, Elvia Rahmi Marga Qintar Layallia Faza Rahardjo, Angga Mardro Rahmadhan, Adiz Dwiputra Rahmi, Aulya Raissa Puan Andrina Ramadanti, Novi Awalia Ramadhani, Rafindra Rena Normasari Rezza Putri Mahartika Risyanto, Chusnul Aulia Arisny Putri Rozaq, M.S. Irham Sa'bani, Begawan Sakinah, Elly N Salsabila, Yuna Annisa Salsabilla, Safira Putri Nur Samsul Arifin Saputra, Antonius Dwi Sarah Andriani Selly Silfana Liensa septa surya wahyudi, septa surya Shabri, Hammam Arif Shodikin, M Ali Shodikin, M. Ali Shofia, Lailatis Siti Zulaikha Sri Rahmanita Sugiyanta Sugiyanta Supangat Supangat Syamsuddin, Alif Fazduani Tiara Ajeng Dewita Tristianti, Farmitalia Nisa Tuda, Josef Sem Berth Tutiana Bayati Umar Zein Wiwien Sugih Utami Wiwin Sugih Utami Wulandari, Lindi Priyantika Tri Yoga Setyo Yonas Hadisubroto Yudha Nurdian Yuli Hermansyah Yuli Hermansyah Yuli Rahmantia, Vania Yuna Annisa Salsabila Yunita Armianti Yunita Armiyanti Zahrah Febianti Zulaikha Rizqina Rahmawati