Articles
<![CDATA[Influence of Fucoidan in Mucus Thickness of Gastric Mucosa in Patients with Chronic Gastritis ]]>
<![CDATA[Kaka Renaldi]]>;
<![CDATA[Marcellus Simadibrata]]>;
<![CDATA[Ari Fahrial Syam]]>;
<![CDATA[Abdul Aziz Rani]]>;
<![CDATA[Ening Krisnuhoni]]>
<![CDATA[ The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 2, August 2011 ]]>
Publisher : <![CDATA[The Indonesian Society for Digestive Endoscopy ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (574.172 KB)
|
DOI: 10.24871/122201179-84
<![CDATA[Background: Chronic gastritis is commonly found with complains of dyspepsia, which may decrease work productivity. Imbalance between agressive and defensive factors is the cause of chronic gastritis. Therapy is mostly directed to the agressive factors, particularly gastric acid and very few studies are directed on defensive factors. Mucus is the first defense mechanism of gastric mucosa. Fucoidan is a phytopharmaca, which is thought to increase the thickness of gastric mucosa. The objective of this study was to know the thickness of gastric mucosa in patients with chronic gastritis and to evaluate the effect of fucoidan to the gastric mucosa thickness in patients with chronic gastritis. Method: In this double-blinded randomized clinical trial study, 41 patients in the Endoscopy Unit Cipto Mangunkusumo Hospital between October 2009 and October 2010 were enrolled consecutively. Selected patients were divided into 2 groups: a group was given fucoidan and another group was given placebo. Statistical analysis was done using T-test. Results: Of 41 chronic gastritis patients, only 34 patients completed this study. There was difference of mucus thickness of gastric mucosa in patients with chronic gastritis; in the antrum 42.59 µ m (± 8.67) and in the corpus 44.28 µ m (± 9.64). This study also showed that fucoidan administration increased the mucus thickness in the antrum by 7.42 µ m and in the corpus by 7.74 µ m compared to placebo significantly. Conclusion: Fucoidan increased the mucus thickness of gastric mucosa in patients with chronic gastritis. Keywords: mucus thickness, chronic gastritis, fucoidan]]>
<![CDATA[Clinical, Molecular, and Histopathological Aspect of Primary Biliary Cholangitis ]]>
<![CDATA[Flora Dameria]]>;
<![CDATA[Marini Stephanie]]>;
<![CDATA[Ria Kodariah]]>;
<![CDATA[Diah Rini Handjari]]>;
<![CDATA[Ening Krisnuhoni]]>;
<![CDATA[Nur Rahadiani]]>
<![CDATA[ The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 20, No 3 (2019): VOLUME 20, NUMBER 3, December 2019 ]]>
Publisher : <![CDATA[The Indonesian Society for Digestive Endoscopy ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (783.778 KB)
|
DOI: 10.24871/2032019177-183
<![CDATA[Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease which tends to be chronic and progressive in nature that is marked by the presence of cholangitis and small size biliary duct destruction which may cause cirrhosis or even liver failure. PBC incidence increases because PBC can now be diagnosed earlier and is due to the increasing survival rate of PBC patients. Diagnosis of PBC can be confirmed in asymptomatic state if in the indirect immunofluorescence (IIF) examination revealed AMA positive, and there is an abnormal liver function. Etiopathogenesis of PBC is multifactorial which involves genetic and environmental factors. Genetic factors which contribute to the incidence of PBC are HLA and non-HLA genes, while in the environmental factors, the triggering factors of PBC are bacterial infection and xenobiotic. Interaction of these factors causes the development of E2 subunit pyruvate dehydrogenase complex (PDC-E2) and antimitochondrial antibody (AMA) as the causing autoantigen of biliary duct desctruction in PBC, mediated by the immune system. PBC stage is divided into minimal, mild, moderate and severe. Ursodeoxycholic acid (UDCA) is the first line therapy for PBC, while obeticholic acid (OCA) and fibrate is used as the second line. Liver transplantation is the definitive therapy for PBC where disease progresses into the advanced stage, although the patients have received medical treatment.]]>
<![CDATA[Association between HBV DNA Level and Intrahepatic HBcAg Protein Expression of Hepatocytes in Patients with Chronic Hepatitis B ]]>
<![CDATA[Devy Serevina]]>;
<![CDATA[Ening Krisnuhoni]]>;
<![CDATA[Rino Alvani Gani]]>
<![CDATA[ The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 2, August 2010 ]]>
Publisher : <![CDATA[The Indonesian Society for Digestive Endoscopy ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.24871/112201079-82
<![CDATA[Background: Correlation between serum Hepatitis B viral deoxyribonucleic acid (HBV DNA) and hepatitis B core antigen (HBcAg) protein expression in the liver regarding hepatitis B e-antigen (HBeAg) status have not been well studied. This study was aimed to demonstrate association between serum HBV DNA and HBeAg levels with HBcAg expressions in the liver. Method: A total of 55 naive chronic hepatitis B (CHB) patients were enrolled. All samples were tested for HBeAg serum by serological test enzyme-linked immunosorbent assay (ELISA) and HBV DNA was determined by polymerase chain reaction (PCR) HBsAg and HBcAg were evaluated immunohistochemically in the liver tissue Results: Of 55 patients, 44 (80%) were HBeAg positive and 11 (20%) were HBeAg negative. There was a positive correlation between serum HBV DNA and HBcAg expression in the nuclei (r: 0.383; p = 0.004). There was association between HBcAg expression in the nucleus and qualitative HBeAg (p = 0.017). Conclusion: In the patient with chronic HBV, there is a very significant positive correlation between the level of viral replication and HBcAg expression in the nucleus of hepatocytes. Moreover, there is association between HBcAg expression in the hepatocytes nucleus and HBeAg serum level. These finding lead to the proposition that nucleus localization of HBcAg protein function to amplify the pool of cccDNA in the replication cycle of HBV.. Keywords: HBV DNA, Imunohistochemistry, HBcAg]]>
<![CDATA[Hepatocellular Carcinoma in an Infant due to HBV Vertical Transmission ]]>
<![CDATA[Nunung Ainur Rahmah]]>;
<![CDATA[Wirasmi Marwoto]]>;
<![CDATA[Vera Yuwono]]>;
<![CDATA[Ening Krisnuhoni]]>;
<![CDATA[Diah Rini Handjari]]>;
<![CDATA[Darmawan Kartono]]>;
<![CDATA[David Handojo Muljono]]>
<![CDATA[ The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 10, ISSUE 1, April 2009 ]]>
Publisher : <![CDATA[The Indonesian Society for Digestive Endoscopy ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.24871/101200929-32
<![CDATA[Hepatocellular carcinoma (HCC) is one of the common tumors in the world. The incidence of HCC generally increases with age in all population but there is a tendency of decreasing incidence in the elderly and it is very rare in children. This is a case report of HCC in a 9-month-old boy, who was admitted to the hospital with palpable abdominal mass in the right upper quadrant. Imaging modality by ultrasonography could not adequately demonstrate definite findings demonstrating that the tumor was derived from liver, and the diagnosis was neuroblastoma. Intra-operatively, the tumor mass appeared to be derived from the surface of the posterior edge of the liver, so it was a pedunculated tumor. The histopathological examination revealed a pedunculatedhepatocellular carcinoma grade 3. The Victorian blue staining and immunohistochemical staining were done afterward, which showed HBsAg positive result as found in non-tumor lesion as well as inneoplastic lesion of liver tissue.Keywords: hepatocellular carcinoma, pedunculated HCC, infant HCC, occult hepatitis B virus infection]]>
<![CDATA[CD4+ and CD8+ Counts in Liver and Their Correlation with Necroinflammatory and Fibrosis Grades in Chronic Hepatitis C ]]>
<![CDATA[Chyntia Olivia Maurine]]>;
<![CDATA[Rino Alvani Gani]]>;
<![CDATA[Ening Krisnuhoni]]>;
<![CDATA[Kuntjoro Harimurti]]>
<![CDATA[ The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 3, Desember 2012 ]]>
Publisher : <![CDATA[The Indonesian Society for Digestive Endoscopy ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (364.96 KB)
|
DOI: 10.24871/1332012145-150
<![CDATA[ABSTRACTBackground: Studies on the characteristics CD4+ and CD8+ in hepatitis C and their correlation with the severity of the disease have been rarely conducted. This study was aimed to obtain the mean difference between CD4+ and CD8+ count in liver to evaluate their correlation with fibrosis and necroinflammatory grades in chronic hepatitis C. Method: A cross-sectional study was conducted between March and July 2010 with 30 liver biopsies obtained from patients with non-B and non-HIV chronic hepatitis C who visited the Outpatient Clinic of Hepatology Unit at Cipto Mangunkusumo Hospital in January 2008–February 2010. Fibrosis and necroinflammatory grades were determined using METAVIR methods on liver biopsies. The mean values of CD4+ and CD8+ in portal tracts and hepatic lobules in liver biopsy specimens were evaluated. Statistical analysis was performed by using independent T-test and Spearman test. Results: There was a difference in mean CD4+ counts between portal tracts and the lobules (95% CI = 4.3-17.9; p = 0.002) and also differences in mean CD8+ counts in portal tracts and hepatic lobules (95% CI = 15.4-35.6; p 0.001). There was no correlation between CD4+ and CD8+ counts, either in portal tracts or the lobules, and inflammatory grades as well as the liver fibrosis. Conclusion: CD4+ and CD8+ counts are greater in portal area compared to the hepatic lobules, with greater CD8+ counts than CD4+. However, both CD4+ and CD8+ counts are not correlated to the severity of liver damage. Keywords: CD4+, CD8+, intrahepatic, chronic hepatitis C, METAVIR]]>
<![CDATA[Demographic Characteristic of Fundic Gland Polyp and Its Association with Gastritis in Pathology Anatomy Department, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital ]]>
<![CDATA[Liza Handayani]]>;
<![CDATA[Ening Krisnuhoni]]>
<![CDATA[ The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 1 (2017): VOLUME 18, NUMBER 1, April 2017 ]]>
Publisher : <![CDATA[The Indonesian Society for Digestive Endoscopy ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (1653.011 KB)
|
DOI: 10.24871/181201725-29
<![CDATA[Background: Fundic gland polyp (FGP) is the most common polyp found in the stomach with the incidence of 47% from all stomach polyps. FGP is more common to be found in female with the ratio of 5:1 and occurs in the average age of 53-year-old. Gastrin is a hormone produced by G cell, which function is to facilitate epithelial cell proliferation. Gastritis is a frequently found digestive tract disturbance. Torbenson et al showed the presence of chronic gastritis in FGP patients. The aim of this study is to observe the demographic characteristics of FGP and to identify the association between number of polyps with morphologic appearances of gastritis in Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital in year 2012-2014.Method: This retrospective study was a descriptive analytical study. This study was performed by reviewing the slides of FGP cases and evaluating the severity of gastritis based on visual analog scale from Sydney System (SS).Results: Study of FGP demographic obtained 44 cases with predominantly female aged 30 (68.2%), patients’ average age was 55.4 year old with dominant age group in age group 51-60 year old which accounted for 16 (36.4%). This study was performed in 38 cases. The frequency of single polyp was 18 and multiple polyp was 20. Most cases were chronic inflammation which accounted for 21 (55.3%) and mild atrophy 18 (47.4%). Mild intestinal metaplasia was found in 1 case. There was no case of neutrophil infiltration, H. pylori infection or dysplasia. Chi-square test revealed that there was no significant association between number of polyps with gastritis.Conclusion: Chi-square test which was performed in this study showed there is no significant association between number of polyps with gastritis.]]>
<![CDATA[Specimen Adequacy and Clinicopathological Evaluation of Inflammatory Bowel Disease Colorectal Biopsies in Cipto Mangunkusumo Hospital Jakarta ]]>
<![CDATA[Lydia Kencana]]>;
<![CDATA[Nur Rahadiani]]>;
<![CDATA[Marini Stephanie]]>;
<![CDATA[Diah Rini Handjari]]>;
<![CDATA[Ening Krisnuhoni]]>
<![CDATA[ The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 22, No 2 (2021): VOLUME 22, NUMBER 2, August 2021 ]]>
Publisher : <![CDATA[The Indonesian Society for Digestive Endoscopy ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (2043.947 KB)
|
DOI: 10.24871/2222021100-105
<![CDATA[Background: Colorectal mucosal biopsies account for majority of daily practice specimens in the field of gastrointestinal pathology. Most of them were sent for inflammatory bowel disease (IBD) evaluation. Due to broad spectrum of histologic findings and different stage of disease, pathologists often find difficulties on calling out diagnosis of IBD. This study aims to evaluate the adequacy of specimen, clinical characteristics, endoscopy and histologic findings of colorectal biopsies from IBD and non-IBD patients.Method: This cross-sectional study included 49 IBD and 49 non-IBD cases registered in the archives of Anatomical Pathology Department, Cipto Mangunkusumo National Referral Hospital Jakarta in 2019. The samples were evaluated for adequacy of specimen, clinical, endoscopy and histologic findings.Results: Most samples were adult with a slight female predominance. All request forms contained the clinical working diagnosis but only 26.5% and 20.4% of them provided clinical history and endoscopy findings. During histology evaluation, 59.2% of the specimen was considered sub-optimal. The most common histologic findings in both IBD and non-IBD groups were diffuse lymphoplasmacytic infiltration in the lamina propria and crypt distortion. Fibrosis/collagen deposition was found in 38.8% of IBD population compared to 12.2% of non-IBD population (p=0.003). Most IBD cases (55.1%) were categorized as active phase IBD.Conclusion: Since the most common histologic findings in IBD patients were also found in non-IBD patients, IBD diagnosis based on histopathology alone is highly inadvisable. However, there were also lack of clinical data and endoscopy findings in most of colorectal biopsies sent for IBD evaluation. Along with overlapping and unspecific morphology and suboptimal events during histological evaluation, all of this complicated the diagnosis of IBD. Hence multidisciplinary approach is required for a better IBD diagnosis and treatment.]]>
<![CDATA[Prevalence of Hepatitis Virus Infection in Prisoners ]]>
<![CDATA[Ening Krisnuhoni]]>
<![CDATA[ The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 20, No 1 (2019): VOLUME 20, NUMBER 1, April 2019 ]]>
Publisher : <![CDATA[The Indonesian Society for Digestive Endoscopy ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (65.26 KB)
|
DOI: 10.24871/20120191
<![CDATA[Conformance Level of Histopathological Examination in BiopsyPre Colonoscopy Compared to Histopathological Examinationin Surgery with Tumors in the Colon at The Endoscopy andGastrointestinal Centre of RSCM ]]>
<![CDATA[Fuadi, Ifransyah]]>;
<![CDATA[Makmun, Dadang]]>;
<![CDATA[Krisnuhoni, Ening]]>
<![CDATA[ Jurnal Penyakit Dalam Indonesia Vol. 4, No. 3 ]]>
Publisher : <![CDATA[UI Scholars Hub ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
<![CDATA[Introduction. Level of agreement comparison between biopsy per colonoscopy examination is used to measure of the quality of a colonoscopy examination and needed to be identified. This study aims to identify level of agreement comparison between histopathologic examination of biopsy per colonoscopy and histopathologic examination per surgical. Methods. A cross sectional study was conducted by using medical records from patients with colon tumor who had undergone histopathologic examination with biopsy per colonoscopy and then confirmed by surgical procedure in PESC RSPUN dr. Cipto Mangunkusumo between 1st January, 2006 31st December, 2015. Level of agreement calculated using comparative agreement category test in order to obtain the value of kappa. Results. A total of 48 subjects were included in this study. Analysis result showed that level of real agreement, level of agreement by chance, and level of agreement not by chance was 79%, 77%, and 23%, respectively. The kappa value was 0,134. Conclusion. The level of agreement comparison between histopathologic examination of biopsy per colonoscopy compared with histopathologic examination per surgical at PESC RSCM between 2006-2015 period was not good.]]>
<![CDATA[Systemic amyloidosis following inflammatory bowel disease, follicular lymphoma, and diffuse large B-cell lymphoma: a case report ]]>
<![CDATA[Sukrisman, Lugyanti]]>;
<![CDATA[Makmun, Dadang]]>;
<![CDATA[Krisnuhoni, Ening]]>
<![CDATA[ Medical Journal of Indonesia Vol. 33 No. 3 (2024): September ]]>
Publisher : <![CDATA[Faculty of Medicine Universitas Indonesia ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.13181/mji.cr.247428
<![CDATA[Systemic amyloidosis is a rare disorder characterized by the widespread deposition of misfolded amyloid proteins in several organs, leading to organ failure and potentially death if not promptly recognized. The occurrence of inflammatory bowel disease (IBD), follicular lymphoma, and diffuse large B-cell lymphoma (DLBCL) developing into systemic amyloidosis is uncommon. Here is a case of a 55-year-old Asian woman with a history of IBD, follicular lymphoma, and abdominal DLBCL who developed systemic amyloidosis affecting her gastrointestinal, cardiac, and renal organs. Gastrointestinal symptoms (abdominal pain and melena) initially manifested in this patient with systemic amyloidosis. She underwent treatment with three cycles of rituximab and bendamustine. However, she passed away after 2 months of hospitalization due to multiple organ failure. Hence, physicians must be vigilant in recognizing amyloidosis as a potential complication of lymphoma or other inflammatory diseases, as early recognition can contribute to improved clinical outcomes.]]>
