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All Journal Medical Journal of Indonesia Journal of Dentistry Indonesia Paediatrica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS) Alami Journal (Alauddin Islamic Medical) Journal Majalah Kedokteran Andalas Majalah Patologi Indonesia Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Ening Krisnuhoni
Department Of Anatomic Pathology, Faculty Of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Extragastrointestinal Stromal Tumor (EGIST) in 59 Years Old Male: A Rare Case Report Mahendra Dewi, I Gusti Ayu Sri; Ekawati, Ni Putu; Gotra, I Made; Krisnuhoni, Ening; Paskarani, Putu Erika; Hutapea, Yuliance Nurhawati
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1237

Abstract

Introduction: GISTs usually occur in older adults with a median age of about 60–65 years. The incidence rate between men and women is equal (1:1). The most common location of GISTs is the stomach which accounts for 60%, followed by the jejunum and ileum around 30%, duodenum 5%, and colorectal 5% and a small percentage of cases occur in the esophagus, appendix, gallbladder, and extraintestinal areas such as the mesentery, omentum, and retroperitoneum. Case Presentation: A 59-year-old male, suffered from a lump under the umbilicus 3 months before admission to the hospital. The results of the ultrasound examination showed a mass in the superior area of the bladder, and the mass did not appear to infiltrate the intestines, bladder, umbilicus, and surrounding organs. The biopsy tissues showed spindles and round-to-oval morphology with eosinophilic cytoplasm. Mitoses 65/50 High Power Field In addition, immunohistochemistry examination showed positive stains in DOG 1, CD117, SMA, CD 34, and negative for S100.Conclusion: Extragastrointestinal stromal tumor is a rare tumor. Based on, clinical, imaging, histopathological, and immunohistochemical examination, this case was diagnosed as an extragastrointestinal stromal tumor, spindle cell type.
Relationship between Clinicopathological Profile and Tumor Budding Status in Colorectal Adenocarcinoma at Dr. Cipto Mangunkusumo General National Hospital: A Retrospective Study Dhuhani, Ika; Handjari, Diah Rini; Rahadiani, Nur; Krisnuhoni, Ening; Stephanie, Marini
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 3 (2022): VOLUME 23, NUMBER 3, December 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2332022193-199

Abstract

Background: Colorectal adenocarcinoma (CA) is one of the most common malignancies. Tumor budding (TB) status is associated with poor prognosis in patients. Prognosis is influenced by the clinicopathological profile. This study aims to determine the relationship between the clinicopathological profile with TB status in CA at Dr. Cipto Mangunkusumo General National Hospital.Method: A cross-sectional retrospective analytic study using secondary data in the form of cases in large bowel malignancy resection preparations at the Department of Anatomical Pathology in 2019-2021. A total of 213 samples were taken from all cases according to the inclusion and exclusion criteria. Chi square statistical analysis was performed to see the clinicopathological relationship with TB status.Results: Most common TB status were low grade with 92 cases. Most cases were ≥ 50 years old (64.3%), male (50.7%), located in the left colon (77.5%), histopathological degree low grade (85.9%), depth of invasion on pT3 (61.5%), lymphovascular invasion (LVI) (50.2%), lymph node metastasis (52.6%), stage 3 American Joint Committee on Cancer (AJCC (42.3%), without perineural invasion (PNI) (79.3%) and without distant metastases (82.6%). Statistical analysis test showed that there was a significant relationship between the degree of histopathology, depth of invasion, LVI, lymph node metastasis, and AJCC stage (p 0.001) and tumor location (p = 0.036).Conclusion: TB status was significantly related histopathological degree, LVI, lymph node metastasis, depth of invasion, AJCC stage, and tumor location. TB status was not associated with PNI and distant organ metastases. 
Strategy for Diagnosing Breast Cancer in Indonesia during the COVID-19 Pandemic: Switching to Ultrasound-Guided Percutaneous Core Needle Biopsy Sobri, Farida Briani; Bachtiar, Adang; Panigoro, Sonar Soni; Rahmaania, Juwita Cresti; Yuswar, Patria Wardana; Krisnuhoni, Ening; Tandiari, Nelly
Kesmas Vol. 16, No. 3
Publisher : UI Scholars Hub

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Abstract

In this era of COVID-19, suspected breast cancer patients experience delay in diagnosis due to the fear of contracting the virus and reduction of non-COVID-19 health services. Furthermore, it may lead to potential increase in the incidence of advanced cancers in the future. Ultrasound-guided (US-guided) percutaneous core needle biopsy (CNB) is a great option for the diagnosis of cancer but it is poorly utilized. This study aimed to prove that the US-guided CNBis accurate when performed in a local setting and a potential solution for diagnosing breast cancer patients in this pandemic. In addition, it was a single health center cross-sectional study, and the participants were all breast cancer patients that had US-guided CNB from 2013-2019. The pathology results from US-guided CNB were compared to specimens from post-CNB surgeries. The data were collected from medical records and the immunohistochemistry (IHC) examinations were carried out for malignancy. There were 163 patients who were included in this study, 86 had malignancies and 77 had benign tumor reported in their CNB results. The US-guided CNB had 100% sensitivity and specificity compared to surgery. With its lower cost, time usage, and patient exposure to the hospital environment, US-guided CNB should replace open surgery biopsy for diagnosing suspicious breast cancers during the pandemic in Indonesia.
Reoperasi dan Non Reoperasi Penyakit Hirschsprung Dikaitkan dengan Profil Klinikopatologik Ujung Proksimal Reseksi di Departemen Patologi Anatomik FKUI/RSCM Tahun 2015 sampai 2019 Permata Warastridewi, Arie; Krisnuhoni, Ening
Majalah Patologi Indonesia Vol. 32 No. 2, Mei 2023
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v32i2.615

Abstract

Background Hirschsprung’s disease (HD) is a developmental disorder of the enteric nervous system, which is characterized by the absence of ganglion cells in the submucosal and myenteric plexuses. The success of surgery is influenced by many factors, one of which is the presence of histopathological abnormalities in the proximal part of the HD rectosigmoid resection. The aim of this study is to determine whether there are any histological characteristics associated with Hirschsprung's disease that would necessitate reoperation at the Department of Anatomical Pathology Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital (FMUI/CMH). Methods This was an analytical study using a cross-sectional design and secondary data from the Department of Anatomical Pathology Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital (FMUI/CMH) archives between 2015 and 2019. At the proximal end, histopathological examinations were performed to determine mature ganglion, nerve thickening, normal ganglion number, perineural inflammation, and serositis. The patient's age at the time of surgery, gender, the type of surgery, and the patient's age at the time of reoperation were all recorded. Results From the 64 resection cases, 15 reoperation resection cases and 49 non-reoperation resection cases were obtained. Of the 15 reoperation cases, the histopathological investigation revealed fifteen cases of mature ganglion, ten cases of nerve thickening, and fourteen cases of normal ganglion. There was no perineural inflammation in fifteen cases, and no serositis in fourteen cases. A p value of 0.026 was obtained for the patient's age at the time of the operation. Conclusion There are several factors that determine pasients with Hirschsprung disease who undergo reoperation after resection. The age of the patient at the time of resection is one of the factors that can affect the occurence of reoperation in patients with Hirschsprung disease.
Perbedaan Profil Histomorfologik Jaringan Hati Resipien dan Donor Pascatransplantasi Hati Anak antara Kelompok Pasien Rejeksi dan Tidak Rejeksi di Departemen Patologi Anatomik FKUI/RSCM Periode 2010-2019 Perkasa, Alif Gilang; Stephanie, Marini; Rahadiani, Nur; Handjari, Diah Rini; Krisnuhoni, Ening; Oswari, Hanifah
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.487

Abstract

BackgroundLiver rejection is an immune system response of recipient in which attacking the antigen originating from a donor that can causedamage to the transplanted organ. Although the prevalence of liver rejection has decreased due to the use of immunosuppressivedrugs, it is estimated that 20-40% of recipients still experience rejection and are at risk of re-transplantation and even death. Thisstudy aims to investigating histomorphological characteristics that can play a role as risk factors for rejection by assessing thedifferences in histomorphological characteristics before transplantation between recipient groups with rejection and non-rejection inpediatric liver transplant recipients in the Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr.Cipto Mangunkusumo (PA-FKUI/RSCM)MethodsThis study was an analytical study with a cross sectional design, using secondary data from the archives of the Department ofAnatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo 2010-2019. The clinical andhistopathologic data obtained were analyzed using comparative statistical tests.ResultsRejection were found in 25% of recipients. Rejection were more common in the group of recipients aged >1 (75%), male (58%),cirrhosis 4C (92%) and mild portal inflammation (56%). Rejection were more common in the group of donor with male (66%) andsteatosis ≤10% (92%). There were no significant differences in the histomorphological profiles of recipients and donors with orwithout rejection.ConclusionThe histomorphologic profiles of both recipients and donors were known to be descriptively associated with complications of posttransplant liver rejection. However, in terms of analysis, there was not any significant differences
Hubungan Imunoekspresi β-Catenin antara Karsinoma Sel Skuamosa Oral Derajat Rendah dan Derajat Tinggi Berdasarkan Sistem Grading Bryne. Welly Hartono Ruslim; Ening Krisnuhoni; Kusmardi Suid
Majalah Patologi Indonesia Vol. 23 No. 3, September 2014
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

Background β-catenin is an important protein in cellular adhesion and signal transduction. In unstimulated condition, β-catenin only appears on the cellular membrane. Altered expression of β-catenin has been associated with progressiveness and metastatic process of malignancy in human. The aim of this study was to evaluate the expression of β-catenin on oral squamous cell carcinoma (OSCC) and also to assess its different expression in low grade and high grade lesions based on Bryne grading system. Methods This study was conducted on 2 groups of OSCC which included 20 cases of low grade and 20 cases of high grade. Immunohistochemistry staining of β-catenin was used to identify the difference of its expression in cell membrane, cytoplasm, and nuclei on invasive tumor front. Results The expression of β-catenin on cell membrane, cytoplasm, and nuclei showed significant difference between low and high grade OSCC (p=0.000; p=0.005; and p=0.035, respectively). There has not been any significant association between β-catenin expression with age, sex, and tumor location. Conclusion Expression of β-catenin could showed morphological change the OSCC. Key words : β-catenin, Bryne grading, oral squamous cell carcinoma (OSCC).
Analisis Peran p53 pada Astrositoma Difus dan Astrositosis: Studi Diagnostik Eka Susanto; Esti DS Soetrisno; Nurjati C Siregar; Ening Krisnuhoni; Primariadewi Rustamadji
Majalah Patologi Indonesia Volume 26 No. 1, Januari 2017
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

Latar belakang Astrositoma difus (WHO grade II) merupakan tumor astrositik yang paling sering ditemukan di FKUI/ RSCM. Tumor ini merupakan tumor invasif, potensial agresif, dan dapat bertransformasi menjadi astrositoma derajat tinggi. Pada praktik sehari-hari, diagnosis astrositoma difus kadang-kadang sulit ditegakkan hanya dengan gambaran histopatologik. Hal ini terutama disebabkan karena astrositoma difus sukar dibedakan dengan astrositosis, apalagi bila ukuran spesimen biopsi sangat kecil. Beberapa penelitian menunjukkan bahwa mutasi gen TP53 sering ditemukan pada astrositoma difus. Penelitian ini dilakukan untuk menganalisis pulasan imunohistokimia p53 dalam membedakan astrositoma difus (WHO grade II) dengan astrositosis. Metode Studi diagnostik dilakukan pada 20 kasus astrositoma difus dan 20 kasus lesi astrositosis dengan baku emas pemeriksaan histopatologi. Penilaian histopatologi dan ekspresi p53 dinilai secara tersamar. Pulasan imunohistokimia dinyatakan dalam skor, yaitu positif bila inti astrosit terwarnai coklat tua. Hasil penilaian ekspresi pulasan p53 dimasukkan ke dalam Tabel 2x2 untuk dihitung nilai diagnostiknya. Hasil Protein p53 terekspresi kuat pada 13 kasus astrositoma difus dan 1 kasus astrositosis karena peradangan. Dengan demikian didapatkan sensitivitas 65% dan spesifisitas 95%. Terdapat 2 kasus astrositosis yang positif kuat pada endotel dan makrofag. Ekspresi lemah dan sedang tidak terbatas pada astrositoma difus, namun dijumpai pula pada kasus astrositosis. Kesimpulan Pada penelitian ini di dapatkan spesifisitas yang cukup tinggi, namun sensitivitas masih rendah. Ekspresi p53 tidak terbatas pada astrosit neoplastik, tapi juga dijumpai pada astrosit reaktif dan sel selain astrosit. Oleh karena itu diperlukan kehati-hatian dalam interpretasi ekspresi p53. Kata kunci: astrositoma difus, astrositosis, imunohistokimia, p53.
Gastorintestinal stromal tumor: gambaran klinik, histopatologik dan imunohistokimia Wiwit Ade Fidiawati; Ening Krisnuhoni
Majalah Patologi Indonesia Vol. 19 No. 1 (2010)
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

ABSTRAKLatar BelakangTumor mesenkimal traktus gastrointestinal mempunyai gambaran histopatologik yang sulit untukdibedakan. Tumor tersebut dapat berasal dari otot dan saraf maupun campuran keduanya.Beberapa tahun belakangan ini tumor mesenkimal traktus gastrointestinal dinyatakan berasal dariIntertitial Cells of Cajal (ICC) dan disebut sebagai Gastrointestinal Stromal Tumor (GIST).Bahan dan caradata arsip Departemen Patologi Anatomik selama dua tahun (2006-2007) terdapat 25 kasus yangdidiagnosis sebagai GIST dengan pulasan Hematoxillin & Eosin, CD117, CD34, S100 dan SMA.Langkah berikutnya dilakukan analisis gambaran klinik, histopatologik dan imunohistokimia.HasilDari 25 kasus GIST, 84,9% terdapat pada pria dan usia terbanyak antara 40-49 tahun. Gastermerupakan lokasi GIST tersering (72%), kemudian diikuti oleh usus kecil (16%), usus besar (8%)dan esophagus (4%). Gambaran histopatologik yang terbanyak adalah subtipe sel kumparan(52%), kemudian subtype campuran (28%) dan subtype epiteloid (20%). GIST dengan diferensiasisaraf merupakan jenis diferensiasi terbanyak, kemudian diikuti oleh GIST yang tidakberdiferensiasi, berdiferensiasi otot polos dan GIST berdiferensiasi campuran otot polos dan saraf.KesimpulanPada penelitian ini, kasus GIST lebih banyak terdapat pada pria dan lokasi tersering adalah gaster.Sub tipe histopatologik terbanyak adalah subtipe spindel dan diferensiasi saraf merupakandiferensiasi tersering. Diagnosis GIST dapat ditegakkan bila sel tumor positif dengan pulasanCD117.
Profil ekspresi von Hippel-Lindau (pVHL) pada adenokarsinoma duktal pankreas dan jaringan pankreas non-neoplastik serta hubungannya dengan faktor klinikopatologi Jessica Prisscila; Marini Stephanie; Nur Rahadiani; Amelia Fossetta Manatar; Ening Krisnuhoni
Majalah Patologi Indonesia Vol. 35 No. 1, Januari 2026
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.658

Abstract

Introduction Pancreatic malignancy, primarily Pancreatic Ductal Adenocarcinoma (PDAC), presents a significant challenge due to its aggressive nature and late-stage diagnosis. This study explores the role of von Hippel-Lindau gene product (pVHL) in PDAC and non-neoplastic pancreatic tissues, investigating their relationship with PDAC clinicopathological characteristics. Method This research was carried out at the Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital.   The cases analyzed spanned from January 2012 to September 2023. Immunohistochemistry of pVHL was used, and the Histoscore/H-score calculations were utilized to classify pVHL expression as either high or low. Results A total of 54 cases of PDAC and non-neoplastic pancreatic tissue exhibited varying levels of pVHL expression. Cases of PDAC with positive surgical margin, absence of lymphovascular and perineural invasion, pT2, pN0, M0 stage, and survival exceeding 7 months were the profiles in which low pVHL expression was detected. Significant result was found on the correlation between pVHL with pN status. Conclusion The levels of pVHL expression varied between PDAC and non-neoplastic pancreatic tissue. There were no differences in the clinicopathological profile of PDAC tumors, except for pN stage. Further research, with a larger sample size, is needed to determine pVHL's diagnostic value and its expression in different clinicopathological profiles.
Co-Authors Abdul Aziz Rani Abdul Aziz Rani Abdullah, Arman Adel Achmad Fauzi ACHMAD FAUZI Adang Bachtiar Agustina, Yohana Alfa Ahmad Aulia Jusuf Ahmad Soefyani Alan R. Tumbelaka Alif Gilang Perkasa Amelia Fossetta Manatar Ari Fahrial Syam Arman Adel Abdullah Aru W. Sudoyo Ary H. Reksodiputro Arya Govinda Badriul Hegar Bethy Hernowo Chudahman Manan Chudahman Manan Chyntia Olivia Maurine Dadang Makmun Dadang Makmun Daldiyono Daldiyono Daldiyono Daldiyono Daldiyono Hardjodisastro Darmawan Kartono David Handojo Muljono Devy Serevina Dewantoro, Okto Dhuhani, Ika Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Dyonesia Ary Harjanti Eka Susanto Elisabeth Indria Sari Elisabeth Indria Sari Erni Erfan, Erni Esti DS Soetrisno Farida Briani Sobri Fili Sufangga Flora Dameria Handayani, Liza Handjari, Diah R. Hanifah Oswari Hutapea, Yuliance Nurhawati I Gusti Ayu Sri Mahendra Dewi I Made Gotra Iamaroon, Anak Ifransyah Fuadi Ifransyah Fuadi, Ifransyah Indriasti Indah Wardhany Irsan Hasan Irwina Eka Deraya Iskandar, Rizka Puteri Jelita Inayah Sari Jessica Prisscila Juwita Cresti Rahmaania Kaka Renaldi Kharia Utia Kuntjoro Harimurti Kusmardi Lia Mulyani Liem, Isabella Kurnia Liza Handayani Lugyanti Sukrisman Lydia D Simatupang Lydia Kencana Manatar, Amelia Fossetta Marcellus Simadibrata Marcellus Simadibrata Marini Stephanie Marini Stephanie Marini Stephanie Marini Stephanie Marini Stephanie Murdani Abdullah Murdani Abdullah Murdani Abdullah Nafrialdi Nafrialdi Nelly Tandiari Ni Putu Ekawati Nita Afriani Nunung Ainur Rahmah Nur Rahadiani Nurdin, Wildawati Nurjati C Siregar Okto Dewantoro Paskarani, Putu Erika Patria Wardana Yuswar Paulus Kusnanto Perkasa, Alif Gilang Permata Warastridewi, Arie Primariadewi Rustamadji Prisscila, Jessica Puspita Eka Wuyung Rabbinu Rangga Pribadi Rahmaania, Juwita Cresti Reni Oktavina Ria Kodariah Rino A Gani Rizka Puteri Iskandar Santoso Cornain Santoso Cornain Sari, Elisabeth Indria Saut Horas Hatoguan Nababan Seruni Tyas Khairunissa Sobri, Farida Briani Sonar Panigoro Sufangga, Fili Tandiari, Nelly Velma Herwanto Velma Herwanto Vera Yuwono Welly Hartono Ruslim Wildawati Nurdin Wirasmi Marwoto Wirasmi Marwoto Wiwit Ade Fidiawati Yonathan, I Wayan Murna Yuniardini Septorini Wimardhani Yuswar, Patria Wardana Zakiyah Zakiyah