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All Journal Medicina WMJ (Warmadewa Medical Journal) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Meditory : The Journal of Medical Laboratory Majalah Patologi Indonesia Jurnal Sewaka Bhakti MAHESA : Malahayati Health Student Journal Aesculapius Medical Journal Warmadewa Minesterium Medical Journal Indonesian Journal of Cancer Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Ni Wayan Armerinayanti, Ni Wayan
Universitas Warmadewa
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Nursing Public Health Other

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Ekspresi Matriks Metaloproteinase 9 pada Infiltrasi Karsinoma Tiroid Papiler Klasik dan Varian Folikuler Ni Wayan Armerinayanti; I Ketut Mulyadi; Luh Putu Iin Indrayani Maker
Majalah Patologi Indonesia Volume 26 No. 2, Mei 2017
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakangKarsinoma tiroid papiler (KTP) merupakan 80% dari seluruh karsinoma tiroid berdiferensiasi baik dengan 2 tipe paling sering yaitu KTP klasik dan KTP varian folikuler (KTPVF). Agresivitas antara kedua tipe KTP ini masih kontroversi dalam berbagai aspek klinikopatologik. Matriks metaloproteinase 9 (MMP-9) merupakan marka relevan dalam memprediksi agresivitas tumor karena mempengaruhi proses invasi dan metastasis. Tujuan penelitian ini adalah untuk mengetahui ekspresi MMP-9 dalam mempengaruhi luas infiltrasi KTP sehingga berkaitan dengan agresivitas KTP.MetodePenelitian ini menggunakan metode analitik potong lintang dengan jumlah sampel sebanyak 40 sediaan blok parafin pasien KTP Klasik dan KTPVF yang diperiksa secara histopatologi di Bagian Patologi Anatomi Fakultas Kedokteran Universitas Udayana/RSUP Sanglah Denpasar sejak tanggal 1 Januari 2011 sampai 30 Juni 2014. Sampel terdiri dari 10 KTP klasik intrakompartemen, 10 KTP klasik ekstrakompartemen, 10 KTPVF intra-kompartemen dan 10 KTPVF ekstrakompartemen. Selanjutnya dilakukan pulasan imunohistokimia MMP-9 pada seluruh sampel. Hasil penelitian dianalisis dengan uji one way anova dan regresi multipel ANCOVA dengan kemaknaan p<0,05.HasilTerdapat perbedaan rerata skor ekspresi MMP-9 antar keempat kelompok, di mana rerata skor ekspresi MMP-9 KTP klasik intrakompartemen 2,60±1,77; KTP klasik ekstrakompartemen 7,80 ±1,54; KTPVF intra-kompartemen 3,70±1,74 dan KTPVF ekstrakompartemen 7,00±1,80. Melalui uji one way anova terdapat perbedaan yang bermakna antara KTP intrakompartemen dengan KTP ekstrakompartemen (p<0,001). Uji regresi ANCOVA menunjukkan tidak terdapat pengaruh usia, jenis kelamin dan ukuran tumor terhadap skor ekspresi MMP-9 (p>0,05).KesimpulanPeningkatan maupun penurunan ekspresi MMP-9 mempengaruhi luas infiltrasi KTP sehingga ekspresi MMP-9 berkaitan dengan agresivitas KTP.
Karakteristik Pasien Pasca-Apendektomi di Rumah Sakit Umum Daerah Tabanan I Komang Ardhika Gunawan; Ni Putu Diah Witari; Ni Wayan Rusni; Ni Wayan Armerinayanti; Gde Candra Yogiswara; Ade Dwi Mahendra; I Gusti Ngurah Fajar Viwakananda; Made Bramastya Nugraha Teja Kusuma Mulyawan
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 2 (2026): Mei: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i2.6473

Abstract

Acute appendicitis is one of the most common abdominal surgical emergencies, primarily managed through appendectomy. Post-appendectomy patients require further hospitalization, where indicators such as length of stay, leukocyte levels, and pain intensity are essential to evaluate clinical outcomes. This study aims to describe the characteristics of post-appendectomy patients at Tabanan General Hospital (BRSU Tabanan) in 2023–2024. This research used a descriptive observational design with a cross-sectional approach, and data were collected retrospectively from medical records. Samples were selected using consecutive sampling, with a total of 120 patients who met the inclusion and exclusion criteria. Data were analyzed univariately and presented in frequency distributions and mean values.The results showed that the mean age of patients was 34.73 ± 13.62 years, with a higher proportion of females (56.7%) compared to males (43.3%). The mean leukocyte count was 12.65 ± 4.22 ×10³/µL, with most patients (56.7%) categorized as mild leukocytosis. The mean length of stay was 2.83 ± 1.54 days, with 93.3% of patients classified as having a short hospitalization period (≤5 days). Most patients had no comorbidities (85%), while hypertension was the most common comorbid disease (61.1%). The mean Visual Analog Scale (VAS) score before appendectomy was 5.34 ± 0.96 (moderate pain), which decreased to 2.42 ± 0.63 (mild pain) after surgery.
HIGH MATRIX METALLOPROTEINASE 9 EXPRESSION AS A RISK FACTOR OF LYMPHOVASCULAR INVASION IN CERVICAL CARCINOMA Ni Wayan Armerinayanti
Meditory : The Journal of Medical Laboratory Vol. 13 No. 2 (2025): Meditory, Volume 13 No. 2 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i2.4204

Abstract

Background: Cervical carcinoma is an epithelial cancer with the highest mortality among female genital malignancies. Its poor prognosis is largely related to metastasis, which begins early through lymphovascular space invasion (LVSI). LVSI occurs when cancer cells invade surrounding tissue via proteolytic enzymes, but early prediction remains difficult. Although several molecular markers have been studied, none is definitive, and the role of matrix metalloproteinase-9 (MMP-9) in LVSI remains controversial.Objective: This study will prove MMP-9 as a risk factor for LVSI in cervical carcinomaMethods: This case–control study analyzed 40 archived paraffin-embedded tissue blocks from cervical carcinoma patients at BaliMed Denpasar Hospital. Immunohistochemical staining was performed to assess MMP-9 expression, while hematoxylin and eosin (H&E) staining was used to evaluate lymphovascular space invasion (LVSI). Statistical analysis was conducted using the chi-square test in SPSS version 25.Results: The study showed that 85,7% of cervical carcinomas with LVSI have high MMP-9 expression, with a significant result compared to cervical cancer without LVSI (p=0.001, OR= 13.5).Conclusions: The MMP-9 expression was significantly associated with the risk of LVSI in cervical carcinoma 
EFFICACY AND SAFETY OF CHIMERIC ANTIGEN RECEPTOR-MODIFIED T CELL (CAR-T) THERAPY IN LYMPHOMA: AN UPDATED SYSTEMATIC REVIEW AND META-ANALYSIS I Gede Krisna Arim Sadeva; I Gede Wikania Wira Wiguna; Ni Wayan Armerinayanti; Putu Mirah Wahyu Subagia Putri; Christo Timothy Mamangdean; Putu Ari Shanti Dewi; Kadek Meryndha Kumala Tungga; I Komang Raditya Putra Pratama; Agung Brahmanthya Nadine Kepakisan; Komang Indra Parama  Arta
Meditory : The Journal of Medical Laboratory Vol. 14 No. 1 (2026): Meditory, Volume 14 No. 1 Tahun 2026
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v14i1.5125

Abstract

Abstract Background: Lymphoma (Hodgkin and non-Hodgkin) is a malignancy of the lymphatic system, with global prevalence reaching 2.8% and mortality rates reaching 248,700 cases each year. Therefore, Chimeric Antigen Receptor-Modified T cell therapy (CAR-T) was developed as a new approach to improve survival rates in lymphoma patients. Objective: This study aimed to evaluate the efficacy and safety of CAR-T cell therapy in lymphoma. Methods: PRISMA 2020 was used in the literature search and systematic review with the keywords "CAR-T Cell Therapy" and "Lymphoma". All statistical analyses were performed with R statistical software version 3.3 and MedCalc software version 22. A p-value ≤ 0.05 was considered statistically significant. Results: There were 16 studies involving 440 patients with lymphoma. The complete response rate was 62% (95% CI 55%-65%, I² = 40%). Meanwhile, cytokine release syndrome (CRS) occurred in 73% of cases (95% CI 49%-88%, I² = 80%). The overall Immune effector cell-associated neurotoxicity syndrome (ICANS) rate was 17% (95% CI 9%-30%, I² = 66%). There is no significant publication bias in all analyses (p-value>0.05). However, these results need to be interpreted with caution, considering the high heterogeneity in the pooled analysis results (I² > 50%).
ASSOCIATION BETWEEN MID-UPPER ARM CIRCUMFERENCE AND HEMOGLOBIN CONCENTRATION IN ADOLESCENT GIRLS: A CROSS-SECTIONAL STUDY Luh Putri Wulandari dewi; Sri Ratna Dewi; Ni Wayan Armerinayanti dewi; Desak Putu Oki Lestari dewi; Putu Indah Budi Apsari dewi; Kadek Agus Kurniawan; Dewa Ayu Agung Alit Suka Astini
Meditory : The Journal of Medical Laboratory Vol. 14 No. 1 (2026): Meditory, Volume 14 No. 1 Tahun 2026
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v14i1.5203

Abstract

Background: Anemia remains a relevant nutritional concern among adolescent girls. Mid-upper arm circumference (MUAC) is a practical anthropometric measurement that may be associated with hemoglobin concentration and may help identify adolescents with limited nutritional reserves. Objective: This study aimed to examine the association between MUAC length and hemoglobin concentration in adolescent girls at SMA N 1 Tegalalang, Gianyar Regency. Methods: This analytical observational study used a cross-sectional design. A total of 147 female students were recruited using consecutive sampling. MUAC was the independent variable, and hemoglobin concentration was the dependent variable. Hemoglobin was measured using a point-of-care testing device. Data were analyzed using ANCOVA in IBM SPSS Statistics version 27, with the control of age and menstrual duration. Results: Most participants had a MUAC of ≥23.5 cm (50.34%) and normal hemoglobin concentration (≥12 g/dL; 93.9%). After adjustment for age and menstrual duration, MUAC was significantly associated with hemoglobin concentration (F = 5.257, p = 0.024, partial η² = 0.047). Conclusions: A significant association was observed between MUAC and hemoglobin concentration among female adolescents. MUAC may be considered a practical anthropometric measure for identifying adolescents who could benefit from further nutritional assessment and hemoglobin testing.
Karakteristik Pasien Otitis Media Supuratif Kronis di Rumah Sakit Mangusada Ni Putu Eka Widiantari; Agus Santosa; Ni Wayan Armerinayanti; Saraswati Laksmi Dewi
MAHESA : Malahayati Health Student Journal Vol 6, No 9 (2026): Volume 6 Nomor 9 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i9.24576

Abstract

ABSTRACT Chronic suppurative otitis media (CSOM) remains a significant health problem as it contributes to hearing impairment and serious complications, particularly in developing countries. Although the number of CSOM cases at Mangusada Hospital has increased in recent years, local data on the characteristics of CSOM patients at this hospital remain limited. This study aimed to describe the characteristics of CSOM patients at Mangusada Hospital, including age, sex, clinical symptoms, history of infection, and comorbidities. This study used a cross-sectional design with a descriptive observational approach. Data were obtained from the medical records of CSOM patients who met the inclusion and exclusion criteria. A total of 141 patients were included using consecutive sampling. The results showed that most CSOM patients were in the adult age group (18–59 years), with a higher proportion of females than males. The most common clinical symptom was otorrhea, and the majority of patients experienced only one clinical symptom. More than half of the patients had no documented history of infection or comorbidities in their medical records. Middle-aged females need to improve ear hygiene to prevent the incidence of suppurative media otitis. Keywords: Characteristics, Chronic, Hearing, Otitis Media, Suppurative.  ABSTRAK Otitis media supuratif kronis (OMSK) masih menjadi masalah kesehatan yang signifikan karena berkontribusi terhadap gangguan pendengaran dan komplikasi serius, terutama di negara berkembang. Meskipun jumlah kasus OMSK di Rumah Sakit Mangusada menunjukkan peningkatan dalam beberapa tahun terakhir, hingga saat ini belum tersedia data lokal yang menggambarkan karakteristik pasien OMSK secara komprehensif. Penelitian ini bertujuan untuk menggambarkan karakteristik pasien OMSK di Rumah Sakit Mangusada berdasarkan usia, jenis kelamin, gejala klinis, riwayat infeksi, dan penyakit penyerta. Penelitian ini menggunakan desain cross-sectional dengan pendekatan deskriptif observasional. Data diperoleh dari rekam medis pasien OMSK yang memenuhi kriteria inklusi dan eksklusi, dengan jumlah sampel sebanyak 141 pasien yang diambil menggunakan metode consecutive sampling. Hasil penelitian menunjukkan bahwa sebagian besar pasien OMSK berada pada kelompok usia dewasa (18–59 tahun) sebesar 60,2%, dengan proporsi perempuan (55,3%) lebih banyak dibandingkan laki-laki (44,7%). Gejala klinis yang paling sering ditemukan adalah telinga keluar cairan (otorrhea) pada 71,6% pasien, diikuti nyeri telinga (24,8%), tinnitus (17,7%), gangguan pendengaran (17,0%), dan rasa penuh pada telinga (13,5%). Sebagian besar pasien (59,6%) hanya mengalami satu gejala klinis. Lebih dari setengah pasien (56,7%) tidak memiliki riwayat infeksi yang tercatat dalam rekam medis, sementara 21,3% memiliki riwayat infeksi telinga dan 19,1% memiliki riwayat infeksi saluran pernapasan atas. Sebagian besar pasien (54,6%) tidak memiliki penyakit penyerta. Pasien wanita dengan usia pertengahan perlu menjaga kebersihan telinga sehingga penyakit otitis media supuratif dapat dicegah. Kata Kunci: Karakteristik, Kronis, Otitis Media, Pendengaran, Supuratif.
Co-Authors Ade Dwi Mahendra Agung Brahmanthya Nadine Kepakisan Agus Santosa Anak Agung Oka Lely Analysa - Artha, I Gusti Alit Asri Lestarini Astuti, Ni Luh Putu Vina Juni Cahyawati, Putu Nita Christo Timothy Mamangdean Desak Putu Oki Lestari Gde Candra Yogiswara Gede Bagus Gita Pranata Gede Khrisnanda Arya Dharma Gede Khrisnanda Arya Dharma I Gde Sastra Winata I Gede Krisna Arim Sadeva I Gede Wikania Wira Wiguna I Gusti Ngurah Fajar Viwakananda I Ketut Mulyadi I Komang Ardhika Gunawan I Komang Raditya Putra Pratama I Putu Agung Dhrestaketu Sumedang I Wayan Juli Sumadi I Wayan Suwarna Kadek Agus Kurniawan Kadek Berliantara Kadek Berliantara Kadek Meryndha Kumala Tungga Ketut Mulyadi Komang Indra Parama  Arta Komang Yasmika Utami Komang Yasmika Utami Luh Gde Evayanti Luh Putri Wulandari dewi Luh Putu Iin Indrayani Maker Made Bramastya Nugraha Teja Kusuma Mulyawan Made Intan Ryani Putri Made Intan Ryani Putri Ni Ketut Santhiyogi Visnu Wardani Ni Ketut Santhiyogi Visnu Wardani Ni Luh Putu Eka Kartika Sari Ni Luh Putu Eka Kartika Sari Ni Putu Diah Witari, Ni Putu Ni Putu Eka Widiantari Pande Made Ngurah Geriawan Perdana, I Gede Sukma Okta Putu Ari Shanti Dewi Putu Asih Primatanti Putu Asih Primatanti Putu Ayu Bunga Aurellia Putu Ayu Bunga Aurellia Putu Indah Budi Apsari dewi Putu Mirah Wahyu Subagia Putri Putu Nita Cahyawati PUTU SARASWATI LAKSMI DEWI Riasa, I Nyoman Putu Romy Windiyanto Rusni, Ni Wayan Sari, Ni Luh Putu Eka Kartika Sri Ratna Dewi Suka Astini, Dewa Ayu Agung Alit Wardana, Ni Komang Sara Kusuma