Articles
Uji Aktivitas Antibakteri Ekstrak Etanol Buah Cabe Jawa (Piper retrofractum Vahl.) Terhadap Bakteri Propionibacterium acnes
Wulansari, I. A. R.;
Yustiantara, P. S.;
Paramita, N. L. P.V.;
Wirasuta, I M.A.G.
Jurnal Farmasi Udayana Vol. 3, No. 2, Tahun 2014
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University
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Jerawat merupakan salah satu penyakit kulit yang dikenal sebagai acne vulgaris. Salah satu bakteri penyebab jerawat adalah bakteri gram positif Propionibacterium acnes yang bersifat anaerob. Cabe jawa (Piper retrofractum Vahl.) telah terbukti secara ilmiah memiliki aktivitas antibakteri terhadap bakteri gram positif Staphylococcus aureus. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak etanol buah cabe jawa (Piper retrofractum Vahl.) terhadap bakteri P. acnes. Uji aktivitas antibakteri dilakukan dengan metode difusi cakram. Sampel adalah 5 variasi konsentrasi dari ekstrak etanol buah cabe jawa dalam CMC-Na 0,5% b/v (1 - 10.000 ppm) dengan kontrol positif Doksisiklin. Media uji adalah Mueller-Hinton Agar. Suspensi bakteri dengan kekeruhan 108 CFU/mL. Hasil penelitian menunjukan bahwa 5 variasi konsentrasi ekstrak etanol buah cabe jawa tidak menghambat pertumbuhan bakteri P. acnes, sehingga dapat disimpulkan bahwa ekstrak etanol buah cabe jawa tidak memiliki aktivitas antibakteri terhadap bakteri P. acnes. Hal ini dapat saja dimungkinkan adanya perbedaan karakter struktur dinding sel dari bakteri P. acnes dan bakteri gram positif lainnya.
PROFIL FITOKIMIA EKSTRAK ETANOL 70% HERBA CENTELLA ASIATICA DENGAN TLC-DENSITOMETRI
Astiti, I.A.G.;
Swastini, D.A;
Wirasuta, I.M.A.G.
Jurnal Farmasi Udayana Vol. 2, No. 3, Tahun 2013
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University
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Telah dilakukan penentuan profil fitokimia ekstrak etanol 70% herba Centella asiatica dengan Thin Layer Chromatography (TLC)-Densitometri. Uji profilling fitokimia ekstrak etanol 70% herba Centella asiatica dilakukan berdasarkan metode standar oleh Reich and Blatter (2004). Identifikasi berdasarkan warna bercak dengan pereaksi pendeteksi menunjukkan bahwa ekstrak etanol 70% herba Centella asiatica mengandung senyawa flavonoid, saponin, tanin, dan triterpenoid. Profil TLC-Densitometri ditampilkan secara naratif berupa nilai Rf, kromatogram, dan spektrum tiap golongan senyawa. Identifikasi flavonoid dengan pereaksi geser NaOMe menunjukkan bahwa ekstrak etanol 70% herba Centella asiatica dari daerah Tabanan Bali diduga mengandung flavonoid golongan flavon atau flavonol.
Tingkat Kesepahaman Masalah terkait Obat antara Dokter dan Apoteker di Apotek
Fauna Herawati;
Ni Nyoman Yuni Astrini;
I Made Agus Gelgel Wirasuta
MPI (Media Pharmaceutica Indonesiana) Vol. 1 No. 2 (2016): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya
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DOI: 10.24123/mpi.v1i2.190
Kolaborasi antar tenaga kesehatan diperlukan untuk meningkatkan pelayanan kesehatankepada pasien. Kolaborasi antar tenaga kesehatan didefinisikan sebagai profesional tenaga kesehatandengan peran yang saling melengkapi dan kooperatif bekerja sama, berbagi tanggung jawab untukpemecahan masalah dan pengambilan keputusan untuk merumuskan dan melaksanakan rencanaperawatan pasien; demikian pula dalam kolaborasi dokter dan apoteker, diperlukan kesepahamantentang masalah terkait obat. Penelitian ini bertujuan untuk mengukur tingkat kesepahaman dokter-apoteker di klinik pada periode September-Oktober 2013. Penelitian ini menggunakan metodedeskriptif observasional dan dilakukan di salah satu apotek di Bali yang bekerja sama dengan dokterspesialis penyakit dalam. Sampel penelitian adalah resep dokter spesialis penyakit dalam untukpasien diabetes mellitus (DM) dan pengambilan resep dilakukan secara consecutive sampling. Jumlahsampel yang berhasil diperoleh berjumlah 102 lembar resep pasien diabetes melitus rawat jalanyang akan dianalisis melalui 3 tahap dengan menggunakan elemen medication therapy management(MTM), daftar periksa the Pharmaceutical Care Network Europe (PCNE) versi 6.2, dan kappa agreement.Hasil analisis menunjukkan tingkat kesepahaman (κ) sebesar 0,84. Kesepahaman antara dokterdan apoteker tentang masalah terkait obat sangat baik (95% sepaham); ketidaksepahaman terutamaterkait pertimbangan klinis penggunaan obat dan kepatuhan pasien, oleh karena itu apotekerperlu meningkatkan pengetahuan agar dapat berkontribusi dalam kolaborasi tersebut. Apotekerdalam kolaborasi interprofesional dapat berperan dalam pengaturan dosis, identifikasi efek samping,rekonsiliasi pengobatan, dan memberikan rekomendasi terapi berbasis bukti.
STUDI TINGKAT PENYALAHGUNAAN NARKOBA PADA MAHASISWA DI DENPASAR DAN BADUNG
Ni Putu Citra Anggryni Sugitha;
I Ngengah Wirajana;
I Made Agus Gelgel Wirasuta
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 2 (2012): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana
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The level of knowledge and their abuses of drugs among students in some university in Denpasar and Badung regency have been assessed. Eight hundred students have been integrated on survey of knowledge-risk - effects survey and 2085 students were screened for drugs abused. Aim of this study was to assets the drugs knowledge level of students and determine their abuser level uncorrelated to their risk. We found out that, all students have ever attended sort course on drugs abuses and 85 % of student’s active searched drugs information through internet. On the contrary was obtained the low level (28-36%) of knowledge-risk-effect on drugs. About the 34% of 800 respondents presented high risk to abused drugs. Surprisingly it was found out just one among 2085 students positive consume codeine after screening and determinations tests.
KASUS KEMATIAN AKIBAT DICHLORVOS DAN PHENTHOAT
Putu Nandya Nandita;
Ni Made Widi Astuti;
IMA Gelgel Wirasuta;
Pande Made Nova Armita Sari
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 9 No 1 (2019): Indonesian Journal Of Legal And Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana
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DOI: 10.24843/IJLFS.2019.v09.i01.p05
Dichlorvos and phenthoat are organophosphate group pesticides which have toxic effects on humans and can cause fatal deaths. Suicide cases using organophosphate pesticides (dichlorvos and phenthoat) are one of the postmortem toxicology analysis studies. As a forensic toxicologist, competency is needed to be able to handle suicide deaths that are thought to be caused by dichlorvos and phenthoat. Handling suicides due to dichlorvos and phenthoate is done from sample preparation, screening tests, assurance tests, determination, and data interpretation. Forensic toxicology analysis in the case showed that high concentrations of dichlorvos and phenthoate were found to have toxic effects on the victim's body. Based on the toxicological analysis, it can be concluded that it is true that the victim died from organophosphate poisoning (dichlorvos and phenthoat).
TOC INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES Volume 1 tahun 2017
gelgel Wirasuta
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 7 (2017): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana
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INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCESVolume 1 tahun 2017
PROFILING KIMIA SAMPEL KOKAIN SITAAN DI BALI DENGAN KROMATOGRAFI LAPIS TIPIS – SPEKTROFOTODENSITOMETRI
I Made Agus Gelgel Wirasuta;
Kusuma Hidayatullah;
Emmy Sahara;
Roedy Aris Tavip
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 2 (2012): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana
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The seized cocaine samples by Narcotic Police in Denpasar have been carried out profiling. Cocaine’s were eluted on Al-TLC Si GF254 and spot scanned on Spectrophotodensitometric-method. Eight seized cocaine’s were presented relative peaks pattern, with chromatograms similarity of 99.81%. Based on the similarity, all of cocaine’s, could be classified into one group or same origin.
UJI KONFIRMASI DAN PENETAPAN KADAR MORFIN DENGAN KLT-SPEKTROFOTODENSITOMETRI
I Made Agus Gelgel Wirasuta;
Ida Ayu Shanti Primaningrum;
Ketut Widyani Astuti
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 4 (2014): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana
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Screening and determination test of morphine using TLC-Spectrophotodensitometry method have been studied. Screening test based on the hRfc – value and the correlation value between detected spectrum and reference. The analysis results were improved by using the shift of spectrum reaction. The maximal result of screening test was obtained when determinate the hRfc-value with error window of three and the spectrum correlation above 0.90. The reaction of spectrum shift showed that morphine spectrum was not significantly changed after plates sprayed with HCL 10% and KOH 0.1 M so that could be used to increasing the analysis result of substance identity determination. Validation of method showed precision of method was 1.69%, the limit of detection 93.1 ng/spot and the limit of quantitation was 310,3 ng, percentage recovery of morphine from plasma was 106.34 ng ±10.79 (10.1%). TLC Spectrophotodensitometry could be used as simple and cheap method for screening and determination test of the morphine.
KASUS AGITASI AKIBAT PEMAKAIAN MEPHEDRONE
Ni Made Widi Astuti;
Dewa Ayu Sri Kusuma Dewi;
Pande Made Nova Armita Sari;
IMA Gelgel Wirasuta
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 9 No 1 (2019): Indonesian Journal Of Legal And Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana
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DOI: 10.24843/IJLFS.2019.v09.i01.p06
Mephedrone or 4-Methylmethcathinone is one type of NPS (New Psychoactive Substance) which is included in the katinon derivative. Mephedrone has been banned in Indonesia and in other countries such as the Netherlands. Mephedrone is used as a recrerational drug that can increase enthusiasm for its users. Misuse of mephedrone can cause toxicity to death for its users. In reviewing this article we will summarize the cases of mephedrone abuse in Indonesia, the pathway for mephedrone synthesis, the pharmacological, pharmacokinetic and pharmacodynamic effects of mephedrone and forensic toxicology analysis on cases of misuse of mephedrone compounds.
Pelaksanaan Standar Pelayanan Kefarmasian Aspek Visite Di Rumah Sakit X Sesuai Peraturan Perundangan
I Made Sasmita Dwidhananta;
I Made Agus Gelgel Wirasuta
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 10 No 2 (2020): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana
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DOI: 10.24843/IJLFS.2020.v10.i02.p01
One of the pharmacists practice in the implementation of pharmacy services for patients is through visite. This study is to determine the implementation of the visite of pharmaceutical services standards at X Hospital with applicable laws and regulations. This research is observational descriptive study. Accidental sampling technique and in-depth interview are used to obtain observation and interview data. The implementation of pharmacy service standards for visite aspects at X Hospital has been in accordance with the laws and regulations of visite. Evaluation results that show patient evaluation and assessment of patient drug regimens by pharmacists have been carried out well, while the current patient planning consultation and administration of drug consultations for returning patients are sufficient. Factors that become obstacles in the implementation of visite at X Hospital are the limited of pharmacists, overload tasks, limited time, lack of motivation, and the not effective of hospital management system. Pelaksanaan pelayanan kefarmasian pada pasien salah satunya berupa praktik apoteker ruang rawat melalui kegiatan visite. Penelitian ini bertujuan untuk mengetahui pelaksanaan standar pelayanan kefarmasian aspek visite di RS X sesuai peraturan perundangan yang berlaku. Penelitian ini bersifat deskriptif observasional. Teknik accidental sampling dengan indepth interview digunakan untuk memperoleh data observasi dan wawancara. Pelaksanaan standar pelayanan kefarmasian aspek visite di RS X telah sesuai dengan peraturan perundangan serta pedoman visite. Hasil evaluasi menunjukkan akurasi riwayat pengobatan pasien dan pengkajian rejimen obat pasien oleh apoteker telah dilakukan dengan baik, sedangkan penilaian perencanaan pengobatan pasien saat ini dan pemberian konsultasi obat kepada pasien pulang tergolong cukup. Faktor-faktor yang menjadi kendala dalam pelaksanaan visite di RS X adalah jumlah apoteker yang terbatas, banyaknya tugas apoteker, waktu pelaksanaan yang terbatas, motivasi apoteker rendah, serta sistem manajemen rumah sakit yang belum efektif.