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All Journal Jurnal Kesehatan Masyarakat Indonesia Jurnal Kedokteran Diponegoro Althea Medical Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Biomedicine and Translational Research Jurnal Kesehatan Andalas Biomedical Journal of Indonesia Jurnal Kedokteran dan Kesehatan Jurnal Medika Malahayati Medical and Health Science Journal JURNAL ANALIS LABORATORIUM MEDIK Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS AgriHealth: Journal of Agri-food, Nutrition and Public Health Jurnal Kedokteran Universitas Palangka Raya Jurnal Kesehatan Tambusai Jurnal Kedokteran Raflesia Jurnal PADAMU NEGERI (Pengabdian pada Masyarakat Bidang Eksakta) JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Jurnal Pengabdian Masyarakat As-salam Dikdimas : Jurnal Pengabdian Kepada Masyarakat Proceeding of Bengkulu International Conference on Health Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health
Debie Rizqoh
Departemen Mikrobiologi Dan Imunologi, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Bengkulu
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Journal : Althea Medical Journal

 1 
PPAR-γ, but not KCNJ11, Is Associated with Type 2 Diabetes Mellitus Progression among First-Generation Offspring of Lembak Ethnicity in Bengkulu, Indonesia Dita, Diah Ayu Aguspa; Yunita, Elvira; Rizqoh, Debie; Ashan, Hesty Rhauda; Fahira, Dita
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4448

Abstract

Background: Genetic and environmental factors influence the onset and progression of type 2 diabetes mellitus (T2DM). Variants affecting peroxisome proliferator activated-receptor gamma (PPAR-γ) and potassium, inwardly rectifying channel subfamily J member 11 (KCNJ11) may alter insulin secretion and sensitivity. This study investigated the association between PPAR-γ and KCNJ11 gene expression and the risk of T2DM among first-generation (F1) offspring of T2DM patients of Lembak ethnicity in Bengkulu, Indonesia.Methods: A cross-sectional observational study was conducted from July to September 2024, recruiting 60 unrelated participants aged 18–40 years, all of whom were exposed to the neron tradition (high-sugar consumption). Gene expression of PPAR-γ and KCNJ11 was determined using real-time quantitative PCR (qRT-PCR).Results: F1 offspring of T2DM patients (n=30) had significantly (p<0.05) higher body weight (66.89±15.62 kg; p=0.008), body mass index (BMI) (23.55±3.46 kg/m2), HbA1C (6.55±1.25), random blood glucose levels (median 131 [75–371] mg/dl), and duration of neron consumption (median 3 [1–12] years) compared with controls (n=30). PPAR-γ expression differed significantly between group (1.60±2.91 vs 4.23±8.54; p=0.009), whereas KCNJ11 expression did not (0.79±0.76 vs 1.37±0.89; p=0.124). Multivariate analysis revealed no correlation between gene expression and the patients characteristic (p>0.05). Linear regression showed 30.4% of PPAR-γ and 45.8% of KCNJ11 variability.Conclusions: PPAR-γ expression is associated with T2DM onset among Lembak F1 offspring, whilst KCNJ11 expression is not. Multiple genetic and environmental factors likely contribute to disease progression. Screening for PPAR-γ expression may support interventions targeting insulin sensitivity and lipid metabolism.
Co-Authors Ade Tiur Rumondang Ade Tiur Rumondang Adiansyah Ahmad Fandi Alvi Jalilul Hakim Ambarsarie, Riry Amelia, Aisyah Annelin Kurniati Annelin Kurniati Arifani, Novita Ashan, Hesty Rhauda Athalia , Nabila Wine Atik Prihatiningrum, Atik Atiqah, Rissya Febiona Azella Chika Fauzia Besly Sinuhaji Besly Sinuhaji Besly Sinuhaji Dendrinson Purba Dendrinson Purba Dessy Triana Dessy Triana Dessy Triana Diah Ayu Aguspa Dita Dian Handayani Djatmiko, Ellen Maidia Ellen Maidia Djatmiko Ellen Maidia Djatmiko Elvira Yunita Elvira Yunita Endang, Jusup Enny Nugrahaeni Enny Nugrahaeni Enny Nugraheni Enny Nugraheni Enny Nugraheni Enny, Nugraheni Ety Febrianti Ety Febrianti Fadlika, Rizki Fahira, Dita Fandi, Ahmad Fauzia, Azella Chika Febrianti, Ety Febrina, Olivia Putri Grace Junita Bate'e Gunasari, Lala Foresta Valentine Hakim, Alvi Jalilul Hamka Ismuda Hestina Hestina Iqbal, Maulana Jusup Endang Kumala, Wulan Okta Kurniati, Annelin Laudy, Nabila Putri Mardhatillah Sariyanti Mardhatillah Sariyanti Mardhatillah Sariyanti Mardhatillah Sariyanti Meidiyanti, Prima Mulya Sundari Mulya Sundari Mulya Sundari Mulya Sundari Mulya Sundari Mulya Sundari Nabilah, Putri Syifa Nikki Aldi Massardi Noor Diah Erlinawati Novita Arifani Nugraheni, Enny Nur Fitri Ocktaviani, Risti Dwi Oktavia Salsadillah Putri Oktavia Silalahi Oktoviani Oktoviani, Oktoviani Pratiwi, Ulfa Hanum Putri Maulida Rachmawati, Indah Dwi Ramadhani, Abdah Zhafirah Rizkianti Anggraini Roina Sitanggang Roina Sitanggang Sariyanti, Mardhatillah Sipriyadi Suryani, Utari Hartati Umar, Liya Agustin Utari Hartati Suryani Utari Hartati Suryani Wulan Okta Kumala