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All Journal Medical Journal of Indonesia Universa Medicina Paediatrica Indonesiana Majalah Kedokteran Andalas Cermin Dunia Kedokteran eJournal Kedokteran Indonesia Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal Jurnal Kedokteran Meditek Ophthalmologica Indonesiana Cermin Dunia Kedokteran
Wresti Indriatmi B. Makes
Division Of Venereology, Department Of Dermatology And Venereology, Faculty Of Medicine, Universitas Indonesia-dr. Cipto Mangunkusumo Hospital
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Kegel exercises with a guidebook for stress urinary incontinence treatment Hakim, Surahman; Santoso, Budi Iman; Rahardjo, Harrina Erlianti; Setiati, Siti; Kusumaningsih, Widjajalaksmi; Prihartono, Joedo; Ibrahim, Nurhadi; Indriatmi, Wresti; Erwinanto
Medical Journal of Indonesia Vol. 33 No. 2 (2024): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247142

Abstract

BACKGROUND Stress urinary incontinence (SUI) is uncontrollable urine leakage when intra-abdominal pressure increases. Behavioral therapy with Kegel exercise is currently the best conservative management recommendation for treating SUI patients. This study aimed to investigate the success of supervised Kegel exercises using the Kegel exercises guidebook in women with SUI. METHODS This quasi-experimental study involved both groups being taught the same regiment of Kegel exercises, but the intervention group was given the Kegel exercises guidebook. After 12 weeks, the compliance, subjective, and objective success rates were evaluated through the patient’s notes, Urinary Distress Inventory-6, Incontinence Impact Questionnaire-7, perineometer, and pad test. RESULTS Patients with a higher level of education had lower compliance to Kegel exercises (p = 0.01; odds ratio [OR] 0.38; 0.18–0.79). No significant difference was observed in the subjective symptom improvement between the two groups. The intervention group had a significantly higher success rate based on objective success by analyzing the 1-hour pad test results. The intervention group was also more adherent (p<0.001; OR 4.78; 2.51–9.0). CONCLUSIONS Patients who received the Kegel exercises guidebook were more compliant and more objectively successful than those who did not receive the manuals.
DNA quality and quantity in adipose tissue: a comparison of the effects of bomb explosion Leonardo; Sugiharto, Ade Firmansyah; Indriatmi, Wresti; Atmadja, Djaja Surya; Yudianto, Ahmad; Herkutanto; Widodo, Wahyu
Medical Journal of Indonesia Vol. 32 No. 4 (2023): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247206

Abstract

BACKGROUND Adipose tissue is often overlooked in DNA testing due to misconceptions about its DNA content. However, its shock-absorbing qualities may be useful for high-pressure scenarios like bomb blasts. This study aimed to evaluate DNA quality and quantity in adipose tissue affected by blasts compared to that in unaffected tissue. METHODS 10 adipose tissue samples were taken from regions near and far from the blast, representing the blast-exposed and non-blast-exposed groups. The adipose tissue was stored at a low temperature for 5 days, after which an organic extraction method was applied. The purity of the DNA extract was assessed using a NanoDrop spectrophotometer, and its integrity was evaluated using 0.8% concentration gel electrophoresis at 60 V for 90 min. DNA typing was conducted using the GlobalFiler™ kit, and DNA quantity was determined with the Quantifiler™ Trio DNA Quantification kit. RESULTS Of 20 DNA extracts from adipose tissue, all samples demonstrated purity, integrity, and complete typing results. Adequate integrity was found in 90% of samples in both groups. A 50% incidence of allele shifting was observed at the D7S820 locus within the blast-exposed group. CONCLUSIONS DNA from blast-exposed adipose tissue exhibited no significant quality or quantity differences from non-blast-exposed tissue. This suggested adipose tissue’s potential as an alternative DNA source in a bomb explosion.
Psoriasis Genomics: A Review Hutasuhut, Magna; Budianti, Windy Keumala; Indriatmi, Wresti; Setyorini, Mirawati
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Psoriasis is a dermatological condition influenced by genetic and epigenetic factors, environmental triggers, as well as immune responses. Genomics refers to the study of individual genes (genomes) and their interactions with environmental influences. In the context of psoriasis genomics, the interplay between genetic predisposition and environmental factors contributes to the manifestation and variations of the disease. With advancements in molecular genotyping technology and genome-wide association studies (GWASs), researchers have identified 50 genetic markers linked to psoriasis. Discussion: Several genetic loci associated with psoriasis have been identified, including PSORS 1-15. The genetics of psoriasis is also linked to its onset, precipitating factors, associated comorbidities, and clinical variations. Advances in psoriasis genomics are leading to more targeted and innovative treatment approaches. The latest therapeutic developments for psoriasis mainly focus on the interleukin-23 (IL-23)/T-helper 17 (Th17) pathways. Conclusion: The development of GWASs provides new knowledge about psoriasis, including its pathogenesis and specific treatments.
Hubungan Konsumsi Coklat dengan Perburukan Akne Vulgaris pada Remaja dan Dewasa Muda dengan Akne Vulgaris: Laporan Kasus Berbasis Bukti Shelly; Ningrum, Rizki Irianti Rakasiwi; Indriatmi, Wresti
Cermin Dunia Kedokteran Vol 50 No 10 (2023): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i10.808

Abstract

Introduction: Acne vulgaris (AV) is a common dermatological problem. AV can occur in all age groups, especially in the adolescent. Chocolate is one of the most consumed foods by teenagers, its relationship with AV has not been established. Objective: To determine whether chocolate consumption is associated with worsening AV in adolescents and young adults with AV. Methods: Article searches used the PubMed, EMBASE, Proquest, and Scopus databases using the keywords adolescent and young adult, chocolate, acne. Search for relevant studies was also carried out from the reference list. Results: Three articles met the eligibility criteria. Critical reviews demonstrated that white chocolate is associated with an increase in total, non-inflammatory, and inflammatory acne lesions in adolescents and young adults with AV. There is still no agreement regarding the association of dark chocolate with worsening AV in adolescents and young adults with AV. Conclusion: White chocolate is associated with worsening AV in adolescents and young adults with AV, whereas the relationship of dark chocolate with worsening of AV in adolescents and young adults with AV is still inconclusive.
Co-Authors Adisasmito, Ayutika Saraswati Ahmad Yudianto Aldri Frinaldi Andi Yasmon Anggraini, Ika Anissa, Lidwina Aria Kekalih Arlha Aporia Debinta Badriul Hegar Benny Nelson Budi Iman Santoso Caroline Oktarina Christa Desire Gracia Christine Lieana Djaja Surya Atmadja Efendi, Ida Effendi, Ida Emma Rusmayani Endi Novianto Erwinanto Evita Halim Effendi Evita Halim Effendi Evita Karianni Bermanshah Fathan, Hafiza Fauziah, Siti Nurani Fourina, Peppy Githa Rahmayunita Gultom, Desy A. Hafiza Fathan Halim, Melissa Hanny Nilasari Harrina E. Rahardjo Hartono Gunardi Haswinzky, Rose Amalia Heri Wibowo Herkutanto Hutabarat, Hernayati Hutasuhut, Magna I Putu G Kayika Ika Anggraini Indina Sastrini Inge Ade Krisanti Irawan, Yudo Irene Dorthy Santoso Jacoeb, Tjut N.A. Jhauharina Rizki Fadhilla Joedo Prihartono Kemal N. Siregar Krisanti, Inge Ade Kuraga, Rahmaniar Desianti Kurniawan, Kristian Kusmarinah Bramono Larisa Paramitha Leonardo Lesmana, Elvira Lidwina Anissa Lili Legiawati Manalu, Patricsia Marissa, Melani Martinus Tarina Martinus, Martinus Mawardi, Prasetya Melani Marissa Melani Marissa Nadjib Advani Nelson, Benny Ningrum, Rizki Irianti Rakasiwi Nur Azizah, Anggita Nurhadi Ibrahim Patricsia Manalu Peppy Fourina Pusponegoro, Erdina H.D. Rahadi Rihamadja Rahadi Rihatmadja Rahadi Rihatmadja Rahmaniar Desianti Kuraga Rinadewi Astriningrum Rinawati Rohsiswatmo Rizki Irianti Rakasiwi Ningrum Roro Inge Ade Krisanti Saleha Sungkar Santoso, Dewi Irawati Soeria Santoso, Irene Dorthy Sastrini, Indina Satya Wydya Yenny Setyorini, Mirawati Shannaz Nadia Yusharyahya Shelly Shelly Sirait, Sondang Panjaitan Siti Nurani Fauziah Siti Setiati Sondang Pandjaitan Sirait Sri L. Menaldi Sugiharto, Ade Firmansyah Surahman Hakim Suyatna, Fransiscus Dhyanagiri Tetty Yuniarti Tiara Aninditha Valdi Ven Japranata Wahyu Widodo Widjajalaksmi Kusumaningsih, Widjajalaksmi Widya Artini Windy Keumala Budianti Yeva Rosana Yudo Irawan Yudo Irawan Yvan Vandenplas Zainal Hakim