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All Journal Journal of Mathematical and Fundamental Sciences MPI (Media Pharmaceutica Indonesiana) Pharmascience Jurnal Kajian Ilmiah Kesehatan Dan Teknologi (JKIKT) Jurnal Biomedika CERATA Jurnal Ilmu Farmasi Jurnal Pengabdian Kepada Masyarakat (Mediteg) Budimas : Jurnal Pengabdian Masyarakat International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Borneo Journal Of Pharmascientech Jurnal Pengabdian UNDIKMA Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Kesehatan (JIKA) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Ilung (Inovasi Lahan Basah Unggul) Jurnal Bakti Untuk Negeri Sinteza CERATA Jurnal Pengabdian Masyarakat Panacea Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia Jurnal Sains dan Kesehatan Jurnal Kesehatan Qamarul Huda
Normaidah, Normaidah
Program Studi Pendidikan Profesi Apoteker, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat, Banjarbaru, Indonesia
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Journal : Pharmascience

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Studi In Silico Senyawa Hylocereus polyrhizus dan Allium sativum terhadap Enzim HMG-CoA Reduktase Normaidah Normaidah; Dian Nurmansyah
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.11639

Abstract

Ekstrak buah naga merah (Hylocereus polyrhizus) dan ekstrak bawang putih (Allium sativum) diketahui mampu menurunkan kadar kolesterol total darah dalam studi in vivo. Penambatan molekul dapat dilakukan dalam memprediksi senyawa yang bertanggung jawab berdasarkan nilai docking. Tujuan dari penelitian ini adalah mengetahui zat aktif potensial dari H. polyrhizus dan A. sativum yang berperan penting dalam penurunan kadar kolesterol darah melalui jalur inhibisi enzim HMG-CoA reduktase dalam uji in silico. Reseptor yang digunakan adalah enzim HMG-CoA reduktase (PDB ID: 1HW9) dengan ligan natif simvastatin yang dipreparasi menggunakan YASARA. Struktur senyawa aktif sebanyak 19 senyawa dari buah H. polyrhizus 17 dari A. sativum digambar menggunakan MarvinSketch pada pH 7,4 dengan 10 bentuk konformasi. Proses penambatan molekul dilakukan menggunakan program PLANTS dan divisualisasi dengan Discovery Studio Visualizer. Ligan natif menunjukkan nilai RMSD sebesar 1,5265 Å dengan nilai docking -79,1320. Senyawa 4, dan 17 pada buah H. polyrhizus serta senyawa 36 pada A. sativum menunjukkan kedekatan relative dengan ligan natif lebih dari 95%. Senyawa ini diprediksi mampu menurunkan kadar kolesterol total darah dengan penghambatan enzim HMG-CoA reduktase secara penambatan molekul. Kata Kunci: Buah Naga Merah, Bawang Putih, Vitamin E, Antilipidemia, Kolesterol Total  The red dragon fruit extract (Hylocereus polyrhizus) and garlic extract (Allium sativum) are able to decrease the total blood cholesterol levels in in vivo study. The molecular docking can predict the responsible compound based on the docking value. The purpose of this study is to determine the potential active substances of H. polyrhizus and A. sativum which play an important role in reducing blood cholesterol levels through the HMG-CoA reductase enzyme inhibition pathway in the in silico study. The receptor in this study was the enzyme HMG-CoA reductase (PDB ID: 1HW9) with the native ligand simvastatin and prepared using YASARA. The structure of the active compound (19 compounds from H. polyrhizus and 17 compouns from A. sativum) were drawn using MarvinSketch at pH 7.4 with 10 conformations. The molecular docking process was carried out using the PLANTS program and visualized with the Discovery Studio Visualizer. The native ligand showed RMSD value of 1.5265 Å with a docking value of -79.1320. The compounds 4 and 17 in H. polyrhizus fruit and compounds 36 in A. sativum showed relative closeness with native ligands of more than 95% of the docking score. Based on molecular docking, these compounds are to be able to decrease the total blood cholesterol levels by inhibiting the HMG-CoA reductase enzyme.
Uji Sun Protection Factor (SPF) Ekstrak Etanol Daun Mitragyna speciosa Korth. Normaidah Normaidah; Maulidya Najahidin; Maslia Rahmah; Fadlilaturrahmah Fadlilaturrahmah; Hayatun Izma
Jurnal Pharmascience Vol 10, No 2 (2023): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i2.17038

Abstract

Kratom (Mitragyna speciosa Korth.) merupakan tanaman tropis yang memiliki kemampuan melindungi kulit dari paparan sinar matahari. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas tabir surya ekstrak etanol daun M. speciosa kuantitatif menggunakan spektrometri UV-Vis. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Kandungan metabolit sekunder secara kualitatif dilakukan menggunakan skrining fitokimia. Aktivitas tabir surya diuji menggunakan lambda 290-320 nm dengan interval 5 nm. Ekstrak etanol daun M. speciosa diperoleh sebesar 86,09 gram (17,218%) dan pada konsentrasi 250 ppm menunjukkan adanya aktivitas tabir surya dengan nilai SPF sebesar 8,433. Daun kratom asal Kalimantan Selatan berpotensi sebagai produk kosmetik tabir surya. Kata Kunci: Kratom, Spektrofotometri UV-Vis, Tabir Surya, Flavonoid Kratom (Mitragyna speciosa Korth.) is a tropical plant that has the ability to protect the skin from sun exposure due to the presence of flavonoids. The purpose of this study was to determine the sunscreen activity of the M. speciosa leaves ethanolic extract, quantitatively by UV-Vis spectrometry. Extraction was carried out by maceration method in 96% ethanol. The content of secondary metabolites were qualitatively determined using the phytochemistry screening study. The sunscreen activity was tested using 290-320 nm (5 nm intervals). The ethanol extract of M. speciosa leaves was obtained by 86.09 grams (17.218%) and with a concentration of 250 ppm showed sunscreen activity with an SPF value of 8.433. Kratom leaves from South Kalimantan have potential as a sunscreen.
Co-Authors Adinda Dwina Hadiastuti Agung Sriyono Agustina, Ni Kadek Ayu Akbar, Nabila Hadiah Akhirullah, Muhammad Maulana Aldiana Astuti Alfisyahr, Nurul Hikmah Amalia Khairunnisa Amalia Khairunnisa Amalia Khairunnisa, Amalia Amalia Khirunnisa Amalia Risna Anna Khumaira Sari Anna Khumaira Sari Arnida Arnida Asa, Raudatul Jannah Audya Rahmah Bayu Bakti Angga Santoso Buih, Putri Helena Junjung Chatarina Umbul Wahyuni DENI SETIAWAN Dewi Kartika Dewi Kartika Dewi Ramadhani Difa Intannia DINA HARDIYANTI Dina Noor Kamali Edy Meiyanto Elma Stasya Endang Wahyuningsih Erika Nur Aisyah Fadlilaturrahmah Fadlilaturrahmah Fadlilaturrahmah, Fadlilaturrahmah Fhirda Azhari Fitri Apriliany, Fitri Gema Yulan Dahnis Hayatun Izma Henni Selvina Henny Maryani Herningtyas Nautika Lingga Humairah Humairah Ikhwan Rizki, Muhammad Indah Hairunisa Izma, Hayatun Jauhar Latifah Khairunnisa Khoirunnisa Muslimawati Khumaira Sari, Anna Kurniasari, Winda Tri Laura Sarwo Liling Triyasmono Linda Permata Sari Malahayati, Siti Maslia Rahmah Maulidya Najahidin Melindawati, Vina Mia Fitriana Muhammad Ikhwan Rizki Muhammad Irfan Rosyadi Muhammad Itqan Mazdadi Muhammad Rasyid Ridha Muthi Ikawati Mutia Mawaddah Normilawati Nur Mahdi Nurramadhani A. Sida Nurul huda Nurul Mardiati Pratiwi, Endah Agustia Qory Rahmat Nazri Rahmah, Indah Noor Rahmah, Maslia Rahmat Ramadhani Rahmatullah, Satrio Wibowo Rahmawati, Nanda Hesti Ramadhani, Muhammad Irfan Ratna Asmah Susidarti Ratnapuri, Prima Happy Rezka Fajar Ramadhan Ricky Desrianto Risye Hendry Ronalisa Ronalisa Rosiana Aryani Rusdiana Rusdiana Samsul Hadi Samsul Hadi Saputra, Adryan Maulana Sholikhah Deti Andasari Silviana, Mega Sindwi Rinanda Sari Siti Nur Oktavia Sofia Sutomo Sutomo Sutomo Sutomo Syifa Auliani Syifa Auliani Sylvan Septian Ressandy Tangkas, Hansel Hens Viogenta, Pratika Wasilah Winsa Wira Wijaya Yopie Kusuma Kurniawan