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All Journal Jurnal Natur Indonesia BIOTROPIA - The Southeast Asian Journal of Tropical Biology e-Journal Pustaka Kesehatan BERKALA SAINSTEK Alchemy : Journal of Chemistry Pharmaciana: Jurnal Kefarmasian Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY The Indonesian Biomedical Journal JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Nusantara Science and Technology Proceedings Makara Journal of Science Jurnal Katalisator Jurnal Pengabdian Masyarakat dan Riset Pendidikan IJSS Borneo Journal of Pharmacy Jurnal Kefarmasian Indonesia Journal of Pharmascience
Ari Satia Nugraha
Drug Utilisation And Discovery Research Group, Faculty Of Pharmacy, University Of Jember, Jember, Indonesia 68121
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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In Silico Study of Histo-aspartic Protease (HAP) Inhibitor from Indonesian Medicinal Plants: Anti-malarial Discovery Dinar Mutia Rani; Muhammad Habiburrohman; Yoshinta Debby; Bawon Triatmoko; Ari Satia Nugraha
Nusantara Science and Technology Proceedings International Conference on Life Sciences and Biotechnology (ICOLIB)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2021.0803

Abstract

Malaria is an infectious disease caused by Plasmodium sp with the highest clinical incidence of 12.07% in Indonesia. New anti-malaria compounds are needed to replace antimalarial drugs that are already resistant nowadays. One of the efforts to find a new anti-malaria drug is through research on traditional medicinal plants used by Indonesian tribes from the ethnopharmacology database. In silico studies provide saving solutions in the process of computer-aided drug design. Histo-aspartic protease (HAP) is essential for the growth of Plasmodium falciparum and has been validated as an antimalarial drug target. Therefore, molecular docking was used to provide new insights into the development of drugs by targeting HAP protease. There are 238 compounds from 43 medicinal plants used as targeting ligand in this study prepared by Autodock Vina for an automated docking tool. The comprehensive docking protocol was valid showed by the RMSD value of 1,275 Å. The result obtained that AM50 (borrasosides A) from Borassus flabellifer was found to have the least affinity score of -10.1 kcal/mol higher compared to the native ligand. In conclusion, we are assuming that the mechanism of borrasosides A compound might get involved with HAP. Further protocols are required to prove the HAP inhibition towards Plasmodium falciparum.
Skrining Fitokimia dan Uji Aktivitas Antibakteri Ekstrak dan Fraksi Daun Senggugu (Rotheca serrata (L.) Steane & Mabb.) terhadap Staphylococcus aureus Nimas Ayu Amanda Putri; Bawon Triatmoko; Ari Satia Nugraha
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.4809

Abstract

Indonesia merupakan salah satu negara berkembang yang masih memiliki banyak permasalahan di bidang kesehatan, salah satu diantaranya adalah penyakit infeksi. Pencarian atau penelusuran agen antibakteri baru perlu dilakukan untuk mendapatkan alternatif antibiotik yang memiliki aktivitas terhadap mikroorganisme patogen. Salah satu cara untuk mendapatkan antibiotik baru adalah dengan memanfaatkan agen antibakteri yang bersumber dari tanaman seperti senggugu (Rotheca serrata (L.) Steane & Mabb.). Penelitian ini dilakukan untuk mengetahui kandungan golongan senyawa kimia dan aktivitas anibakteri yang ada pada daun senggugu. Daun senggugu diekstraksi dengan menggunakan metanol. Ekstrak dari daun senggugu kemudian difraksinasi dengan metode fraksinasi bertingkat menggunakan pelarut heksana, diklorometana dan etil asetat. Skrining fitokimia dilakukan dengan menggunakan metode KLT (Kromatografi Lapis Tipis) untuk melihat secara kualitatif adanya kandungan alkaloid, terpenoid, polifenol dan flavonoid. Uji aktivitas antibakteri dilakukan dengan metode mikrodilusi untuk mendapatkan nilai IC50 ekstrak dan fraksi daun senggugu terhadap Staphylococcus aureus ATCC 25923. Uji aktivitas antibakteri ekstrak dan fraksi daun senggugu menunjukkan bahwa fraksi heksana (323,729±2,025 µg/mL) memiliki aktivitas yang paling besar dengan kandungan senyawa kimia berupa terpenoid.
Global Pharmaceutical Industries, Drugs Exploration and Patenting: Impact On Developing Countries Ari Satia Nugraha
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 05 No. 02 Agustus 2007
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3147.42 KB)

Abstract

Globalization has contributed to the development of pharmaceutical industries in terms of medical exploration and trade among countries araund the world. A number of pharmaceutical companies have been established throughout the world and become international businesses. Nowadays, pharmaceutical businesses in developed countries are more likely to embrace global agreement on intellectual properties and trade designed to keep competition fair. Multinational Pharmaceutical Companies (most of them are from developed countries) play a large role in both drug development and supply. According to ABPI in 2004, more than 60% of the world’s drugs consumption is supplied by only 20 big pharmaceutical corporations. Can it be argued that multinational pharmaceutical companies give benefit for pharmaceutical companies and people in developing countries around the world? This article will focus on several negative impacts occurred on developing countries.
Skrining Fitokimia dan Uji Aktivitas Antibakteri Tumbuhan Jelutong Pipit (Kibatalia arborea (Blume) G.Don) terhadap Escherichia coli Ita Husnul Chotimah; Bawon Triatmoko; Ari Satia Nugraha
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.4806

Abstract

Infeksi menjadi masalah kesehatan yang serius terutama di negara berkembang seperti di Indonesia.Sejumlah agen antibakteri baru yang berasal dari metabolit sekunder tumbuhan telah banyak diteliti salah satunya adalah Kibatalia arborea (Bl) G.Don.Penelitian ini dilakukan untuk mengetahui aktivitas dan kandungan golongan senyawa yang ada pada daun K. arborea. Daun K. arborea diekstraksi dengan menggunakan metanol. Ekstrak dari daun K. arborea kemudian difraksinasi dengan metode fraksinasi bertingkat menggunakan pelarut n- heksana, diklorometana dan etil asetat. Uji aktivitas antibakteri dilakukan dengan metode mikrodilusi untuk mendapatkan nilai IC50 ekstrak dan fraksi daun K. arborea terhadap Escherichia coli ATCC 25922. Skrining fitokimia dilakukan untuk melihat adanya kandungan golongan senyawa alkaloid, terpenoid, polifenol dan flavonoid. Uji aktivitas antibakteri ekstrak dan fraksi daun K. arborea terhadap E. coli menunjukkan bahwa fraksi etil asetat (516,458±12,073 µg/ml) memiliki aktivitas yang paling besar, diikuti ekstrak (590,665±24,157 µg/ml) dan dua fraksi dengan nilai IC50 yang tidak berbeda secara signifikan yaitu fraksi n-heksana (880,667±22,587 µg/ml) dan fraksi diklorometana (848,616±37,029 µg/ml). Hasil skrining fitokimia ekstrak metanol daun K. arborea menunjukkan bahwa ekstrak mengandung senyawa dari golongan flavonoid, polifenol, terpenoid. Fraksi heksana mengandung alkaloid dan terpenoid. Fraksi diklorometana mengandung alkaloid, terpenoid dan polifenol. Fraksi etil asetat mengandung terpenoid, polifenol dan flavonoid. Sedangkan residu tidak mengandung golongan senyawa flavonoid, polifenol, terpenoid dan alkaloid.
Pengembangan Indikator Bromofenol Biru dan Metil Merah pada Label Pintar sebagai Sensor Kematangan Buah Tomat Rofiko Nuning Rahayu; Indah Purnamasary; Ari Satia Nugraha
Pustaka Kesehatan Vol 10 No 1 (2022): Volume 10 No.1, 2022
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v10i1.18817

Abstract

The novel on-package color indicator label has been fabricated based on bromophenol blue and a mixture between bromophenol blue and methyl red, and tests have been conducted to assess the ripeness of tomatoes (Lycopersicum commune). Bromophenol blue (BPB) and a mixture between bromophenol blue and methyl red (MM) were immobilized onto the Whatman paper membrane via the adsorption method. The BPB and mixture between BPB and MM/ Whatman paper membrane as color indicator work based on pH decrease as the volatile organic compounds. They are produced gradually in the package headspace during the development of tomato fruit. Subsequently, the combination indicator between bromophenol blue and methyl red changes from purple to red foul conditions, while the bromophenol blue indicator changes from blue to yellow foul conditions that can be seen visually. The results showed the color indicator can be used to determine the maturity conditions of tomatoes (Lycopersicum commune) at room temperature and chiller temperature. Furthermore, there are also changes in several parameters (pH, texture, weight loss, sensory evaluation) that are commonly used for the ripeness characteristics of tomatoes (Lycopersicum commune). Therefore, this indicator can be used for visual monitoring of the maturing of the tomatoes in packaging.
Isolasi Fungi Tanah Muara Desa Pasir Putih Kabupaten Situbondo serta Penapisan Aktivitas Antibakteri terhadap Staphylococcus aureus Ziyan Nihlatul Millah; Bawon Triatmoko; Ari Satia Nugraha
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1077

Abstract

Healthcare-Associated Infections (HAIs) is a bacterial infections in Indonesia caused by Staphylococcus aureus. According to the World Health Organization (WHO), the prevalence of HAIs in developing countries varies between 5.7% and 19.1% with a combined prevalence of 10.1%. The prevalence of HAIs in Indonesia is 7.1%. Infections caused by bacteria are a life-threatening disease, which needs to be treated immediately by administering antibacterial agents. One of the natural products with potential as new antibacterial agents, such as soil fungi. This research aims to discover the Antibacterial activity of fungi on estuary land at Pasir Putih village, Situbondo, East Java. This research was initiated by growing the soil on the PDA media to isolate six fungi which were labeled as IS-B1-A1, IS-B1-A2, IS-B1-T1, IS-B1-T2, IS-B1-B1, and IS-B1-B2. All the isolated fungi were separately fermented for 14 d and extracted using ethyl acetate before the microdilution test. The result of antibacterial testing showed all extracts from isolated fungi with code IS-B1-A1, IS-B1-A2, IS-B1-T1, IS-B1-T2, IS-B1-B1, and IS-B1-B2 possessed antibacterial activity against Staphylococcus aureus with percentage inhibition of 51.1±2.6%; 84.6±3.1%; 72.7±7.9%; 82.9±7.6%; 65.6±0.8%; 88.2±2.8% at a concentration of 100 μg/mL.
Anti-proliferative and Apoptotic Activities of Kasturi Tobacco (Nicotiana tabacum L.) Leaf Resinoid on Cervical Cancer Cell Banun Kusumawardani; Larissa Tania; Ari Satia Nugraha
The Indonesian Biomedical Journal Vol 14, No 4 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i4.2027

Abstract

BACKGROUND: Cervical cancer has a high rate of morbidity and mortality in women with cancer. Recent studies have found that tobacco (Nicotiana tabacum L.) is a potential source of anti-cancer agents. Hence, this study was conducted to determine the potential of Kasturi tobacco leaf resinoids as apoptotic agents against cervical cell malignancies, since it has not been fully elucidated before.METHODS: The phytochemical diversity of Kasturi tobacco resinoids was generated by gas chromatography-mass spectrometry (GC-MS) analysis followed by spectral similarity to National Institute of Standards and Technology (NIST) database. Cytotoxicity and proliferative activity of HeLa cells treated with Kasturi tobacco resinoids at various concentrations were evaluated by MTT assay. The expression of Caspase-3, cyclooxygenase-2 (COX-2) and heat shock protein 90 (HSP-90) in HeLa cells was analyzed by immunocytochemistry. Next, the migration ability of HeLa cells was observed by the scratch method.RESULTS: Kasturi tobacco resin contains 4,8,13-cyclotetradecatriene-1,3-diol, 1,5,9-trim with α-2,7,11-cembratriene-4,6-diol (α-CBD) structure in the form of a diterpenoid compound with the chemical formula C20H34O2 and a molecular weight of 306 Da. Kasturi tobacco resinoid with IC50 value of 2500 μg/mL inhibited proliferative activity during 72 hours. At a concentration of 1¼ IC50 and incubation for 48 hours, Caspase-3 expression increased by 74.1%, while COX-2 and HSP-90 expression decreased by 28.3% and 26.1%, respectively. HeLa cell migration was inhibited by Kasturi tobacco resinoid at 24 hours incubation.CONCLUSION: Kasturi tobacco resinoids with a concentration of 1¼ IC50 have potential as cervical anti-cancer agents by increasing Caspase-3 expression and decreasing COX-2 and HSP-90 expression within 48 hours.KEYWORDS: Kasturi tobacco resinoids, cervical cancer, anti-cancer agent, proliferative activity 
In silico study to predicting Apyrase-ADP binding affinity from salivary gland of Aedes aegypti in inhibition of platelet aggregation by molecular docking Rike Oktarianti; Silvya Fitri Nur Azizah; Ari Satia Nugraha; Syubbanul Wathon; Kartika Senjarini
Biogenesis: Jurnal Ilmiah Biologi Vol 10 No 2 (2022)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v10i2.33227

Abstract

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Isolasi Fungi Tanah Muara Mangrove Desa Katialada Gorontalo dan Skrining Aktivitas Antibakteri terhadap Pseudomonas aeruginosa Arthur Hariyanto Prakoso; Muhammad Zainul Arifin; Saeful Akhmad Tauladani; Gani Asri Muharam; Asia Asia; Ari Satia Nugraha
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.15738

Abstract

Pseudomonas aeruginosa is a bacterial pathogen that causes various kinds of infections. The use of antibiotics is usually done to treat the infection. However, Pseudomonas aeruginosa has various resistance abilities that can avoid the efficacy of antibiotics. The emergence of drug resistance events encourages the need for the discovery of new antibiotic drugs, one of which comes from fungals secondary metabolite. Soil fungi from mangrove ecosystems have not been studied much. Interestingly, these soil fungi have unique adaptive responses. This response also affects the secondary metabolites it contains. Knowing this information, mangrove soil samples were cultured on fungi media which were then tested against Pseudomonas aeruginosa through antagonist test and microdilution test. Three fungal cultures with yeast characteristics were obtained and each of the secondary metabolite ethyl acetate extracts of these three fungi had antibacterial activity. The antibacterial activity was indicated by the % inhibition parameter. The terpenoid content in fungal cultures may be responsible for the antibacterial activity against Pseudomonas aeruginosa. This research is an initial screening of the search for new antibiotic candidates, so further research study such as isolation and species determination needs to be done. 
Isolasi Fungi Tanah Muara Mangrove Desa Katialada Gorontalo dan Skrining Aktivitas Antibakteri terhadap Pseudomonas aeruginosa Prakoso, Arthur Hariyanto; Arifin, Muhammad Zainul; Tauladani, Saeful Akhmad; Muharam, Gani Asri; Asia, Asia; Nugraha, Ari Satia
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.15738

Abstract

Pseudomonas aeruginosa is a bacterial pathogen that causes various kinds of infections. The use of antibiotics is usually done to treat the infection. However, Pseudomonas aeruginosa has various resistance abilities that can avoid the efficacy of antibiotics. The emergence of drug resistance events encourages the need for the discovery of new antibiotic drugs, one of which comes from fungals secondary metabolite. Soil fungi from mangrove ecosystems have not been studied much. Interestingly, these soil fungi have unique adaptive responses. This response also affects the secondary metabolites it contains. Knowing this information, mangrove soil samples were cultured on fungi media which were then tested against Pseudomonas aeruginosa through antagonist test and microdilution test. Three fungal cultures with yeast characteristics were obtained and each of the secondary metabolite ethyl acetate extracts of these three fungi had antibacterial activity. The antibacterial activity was indicated by the % inhibition parameter. The terpenoid content in fungal cultures may be responsible for the antibacterial activity against Pseudomonas aeruginosa. This research is an initial indohoki77 juga dikenal karena layanan pelanggannya yang responsif dan profesional. Tim dukungan pelanggan tersedia 24/7 untuk membantu para pemain dengan segala pertanyaan atau masalah yang mereka hadapi screening of the search for new antibiotic candidates, so further research study such as isolation and species determination needs to be done. 
Co-Authors Adinda Kusuma Pertiwi Afrian Rosyadi Aissa Dinar Yanuariski Alfarisyi, Muhammad Iqbal Amrina Rosyada Fajriyanti Andhika Puspito Nugroho Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arum, Asyifa Yasmin Asia Asia Asia Asia Asia Asia Asia, Asia Ayik Rosita Puspaningtyas1 Azhari, Nuri Putri Azis, Deri Abdul Bambang Kuswandi Bambang Kuswandi Banun Kusumawardani Bawon Triatmoko Billy Harnaldo Putra, Dini Fatmi, Dewi, Itut Septiana Dian Agung Pangaribowo Dinar Mutia Rani Dinarwati, Sri Dwi Koko Pratoko Dwi Setyati Dwinianti, Edia Fitria Eko Cahyo Mayndarto Endah Puspitasari Fathunnisa, Fathunnisa Fawwas Batio Putra Pamungkas Febi, Qonita Nafilah Fuad Bahrul Ulum Gani Asri Muharam Gani Asri Muharam Gusriyani, Sri Harry Ade Saputra Ifan Arif Maulana Ilma, Laila Nurul Indah Purnama Sary, Indah Purnama Indah Purnamasary Ita Husnul Chotimah Iyan Setiawan Kartika Senjarini Kintoko Kintoko Larissa Tania Lestyo Wulandari Lestyo Wulandari Luh Putu Ratna Sundari Mardani Eka Ningrum Mariatul Kibthiyyah Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Zainul Arifin Muhammad Zainul Arifin Muhammad Zainul Arifin Muhammad Zainul Arifin Muharam, Gani Asri Muharram, Gani Asri Nafa Rosyida Zanuba Naura Bathari Winarto Nimas Ayu Amanda Putri Ninisita Sri Hadi Nita Laila Asyifa Nugroho, Irfan Agus Nuri Nuri Nuri Putri Azhari Pairah, Pairah Prakoso, Arthur Hariyanto Putri Dwi Apriliani Putri Handayani, Maulina Surindri Rajamani, Ranjithkumar Ramadhan Bagus Cahyono Rike Oktarianti Rofiko Nuning Rahayu Rohmatillah, Wilda Nur Romadhona, Ananda Briliana Rosidah, Malihatul S. Sudarko Saeful Akhmad Tauladani Savitri, Ganevi Resta Sa’adah, Kurnia Septianingtyas, Christabel Reviana Silvya Fitri Nur Azizah Sri Untari Siwi Su’udi, Mukhamad Tauladani, Saeful Akhmad Untari, Ludmilla Fitri Waluy Wathon, Syubbanul Wilda Nur Rohmatilah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Yandy Noviandri Yashinta Nirmala Siswanti Yoshinta Debby Yulia Yesti, Yulia Zanuba, Nafa Rosyida Ziyan Nihlatul Millah