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All Journal Jurnal Natur Indonesia BIOTROPIA - The Southeast Asian Journal of Tropical Biology e-Journal Pustaka Kesehatan BERKALA SAINSTEK Alchemy : Journal of Chemistry Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY Pharmascience The Indonesian Biomedical Journal JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Nusantara Science and Technology Proceedings IJSS Borneo Journal of Pharmacy Jurnal Kefarmasian Indonesia
Ari Satia Nugraha
Drug Utilisation And Discovery Research Group, Faculty Of Pharmacy, University Of Jember, Jember, Indonesia 68121
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Anti-proliferative and Apoptotic Activities of Kasturi Tobacco (Nicotiana tabacum L.) Leaf Resinoid on Cervical Cancer Cell Banun Kusumawardani; Larissa Tania; Ari Satia Nugraha
The Indonesian Biomedical Journal Vol 14, No 4 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i4.2027

Abstract

BACKGROUND: Cervical cancer has a high rate of morbidity and mortality in women with cancer. Recent studies have found that tobacco (Nicotiana tabacum L.) is a potential source of anti-cancer agents. Hence, this study was conducted to determine the potential of Kasturi tobacco leaf resinoids as apoptotic agents against cervical cell malignancies, since it has not been fully elucidated before.METHODS: The phytochemical diversity of Kasturi tobacco resinoids was generated by gas chromatography-mass spectrometry (GC-MS) analysis followed by spectral similarity to National Institute of Standards and Technology (NIST) database. Cytotoxicity and proliferative activity of HeLa cells treated with Kasturi tobacco resinoids at various concentrations were evaluated by MTT assay. The expression of Caspase-3, cyclooxygenase-2 (COX-2) and heat shock protein 90 (HSP-90) in HeLa cells was analyzed by immunocytochemistry. Next, the migration ability of HeLa cells was observed by the scratch method.RESULTS: Kasturi tobacco resin contains 4,8,13-cyclotetradecatriene-1,3-diol, 1,5,9-trim with α-2,7,11-cembratriene-4,6-diol (α-CBD) structure in the form of a diterpenoid compound with the chemical formula C20H34O2 and a molecular weight of 306 Da. Kasturi tobacco resinoid with IC50 value of 2500 μg/mL inhibited proliferative activity during 72 hours. At a concentration of 1¼ IC50 and incubation for 48 hours, Caspase-3 expression increased by 74.1%, while COX-2 and HSP-90 expression decreased by 28.3% and 26.1%, respectively. HeLa cell migration was inhibited by Kasturi tobacco resinoid at 24 hours incubation.CONCLUSION: Kasturi tobacco resinoids with a concentration of 1¼ IC50 have potential as cervical anti-cancer agents by increasing Caspase-3 expression and decreasing COX-2 and HSP-90 expression within 48 hours.KEYWORDS: Kasturi tobacco resinoids, cervical cancer, anti-cancer agent, proliferative activity 
In silico study to predicting Apyrase-ADP binding affinity from salivary gland of Aedes aegypti in inhibition of platelet aggregation by molecular docking Rike Oktarianti; Silvya Fitri Nur Azizah; Ari Satia Nugraha; Syubbanul Wathon; Kartika Senjarini
Biogenesis: Jurnal Ilmiah Biologi Vol 10 No 2 (2022)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v10i2.33227

Abstract

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Isolasi Fungi Tanah Muara Sungai Desa Kalinaun Sulawesi Utara serta Skrining Antibakteri terhadap Pseudomonas aeruginosa Muhammad Habiburrohman; Nafa Rosyida Zanuba; Muhammad Zainul Arifin; Saeful Akhmad Tauladani; Gani Asri Muharam; Asia Asia; Dwi Koko Pratoko; Bawon Triatmoko; Ari Satia Nugraha
Jurnal Pharmascience Vol 10, No 1 (2023): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i1.13825

Abstract

Penyakit infeksi merupakan salah satu penyakit yang menyebabkan mortalitas dan morbiditas di dunia yang dapat diterapi menggunakan antibotik. Adanya resistensi dapat mengancam efektivitas antibiotik. Penelitian ini bertujuan untuk mencari kandidat antibiotik yang bersumber dari fungi tanah muara yang diuji aktivitasnya terhadap bakteri Pseudomonas aeruginosa. Ekosistem tanah muara  mangrove memiliki kondisi ekstrem sehingga menuntut mikroorganisme untuk bertahan hidup dengan memproduksi senyawa antibiotik untuk bersaing dengan mikroorganisme lain. Sampel tanah diambil dari Muara Sungai Desa Kalinaun, Kecamatan Likupang Timur, Kabupaten Minahasa Utara, Provinsi Sulawesi Utara. Sampel tanah yang didapat sebanyak empat isolat fungi berpotensi dalam menghambat bakteri uji, yaitu IS2-BTG11-1-1, IS2-BTG11-2-1, IS2-BTG11-2-2, IS2-BTG11-2-3. Keempat isolat tersebut dilakukan fermentasi selama 14 hari lalu diekstraksi dengan pelarut etil asetat. Setelah didapatkan ekstrak etil asetat, dilakukan skrining fitokimia dan didapatkan hasil bahwa keempat ekstrak mengandung senyawa golongan terpenoid. Setelah dilakukan skrining fitokimia, dilakukan uji aktivitas antibakteri menggunakan metode mikrodilusi. Uji mikrodilusi dilakukan dengan konsentrasi tunggal 50 µg/mL. Berdasarkan uji mikrodilusi, keempat ekstrak fungi tanah muara memberikan aktivitas penghambatan berturut-turut dari terbesar ke terkecil : IS2-BTG11-2-3 (50,9% ± 7,6); IS2-BTG11-2-1 (49,8% ± 13,5); IS2-BTG11-1-1 (34,4% ± 2,4); IS2-BTG11-2-2 (37,2% ± 7,7). Pada penelitian ini senyawa yang berperan sebagai antibakteri belum bisa dipastikan, sehingga membutuhkan penelitian lebih lanjut. Kata Kunci: Antibakteri, Pseudomonas aeruginosa, Fungi Tanah Muara, Mikrodilusi, Desa Kalinaun  Infectious diseases are one of the leading causes of mortality and morbidity in the world that  can be treated with antibiotics. The existence of resistance can threaten the effectiveness of antibiotics. This study aims to find new antibiotic candidates from fungi in estuary soils and tested the activity against Pseudomonas aeruginosa bacteria. Estuary soil ecosystems have extreme conditions that require microorganisms to be able to survive Soil samples were taken from the Estuary of the Kalinaun Village, East Likupang District, North Minahasa Regency, North Sulawesi Province. Soil samples obtained were 4 isolates of fungi that had the potential bacteria inhibition, namely IS2-BTG11-1-1, IS2-BTG11-2-1, IS2-BTG11-2-2, IS2-BTG11-2-3. Four isolates were fermented for 14 days and extracted with ethyl acetate solvent. Phytochemical screening of the extract was carried out and the results showed that the four extracts contained terpenoid compounds. Antibacterial activity was tested using the microdilution methods with a single concentration of 50 µg/mL. Based on the microdilution test, four estuary soil fungal extracts gave inhibitory activity from the largest to the smallest: IS2-BTG11-2-3 (50.9% ± 7.6); IS2-BTG11-2-1 (49.8% ± 13.5); IS2-BTG11-1-1 (34.4% ± 2.4); IS2-BTG11-2-2 (37.2% ± 7.7). In this study, the compound that acts as an antibacterial has not been determined, so it requires further research.
Isolasi Fungi Tanah Muara Mangrove Desa Katialada Gorontalo dan Skrining Aktivitas Antibakteri terhadap Pseudomonas aeruginosa Arthur Hariyanto Prakoso; Muhammad Zainul Arifin; Saeful Akhmad Tauladani; Gani Asri Muharam; Asia Asia; Ari Satia Nugraha
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.15738

Abstract

Pseudomonas aeruginosa is a bacterial pathogen that causes various kinds of infections. The use of antibiotics is usually done to treat the infection. However, Pseudomonas aeruginosa has various resistance abilities that can avoid the efficacy of antibiotics. The emergence of drug resistance events encourages the need for the discovery of new antibiotic drugs, one of which comes from fungals secondary metabolite. Soil fungi from mangrove ecosystems have not been studied much. Interestingly, these soil fungi have unique adaptive responses. This response also affects the secondary metabolites it contains. Knowing this information, mangrove soil samples were cultured on fungi media which were then tested against Pseudomonas aeruginosa through antagonist test and microdilution test. Three fungal cultures with yeast characteristics were obtained and each of the secondary metabolite ethyl acetate extracts of these three fungi had antibacterial activity. The antibacterial activity was indicated by the % inhibition parameter. The terpenoid content in fungal cultures may be responsible for the antibacterial activity against Pseudomonas aeruginosa. This research is an initial screening of the search for new antibiotic candidates, so further research study such as isolation and species determination needs to be done. 
Isolasi Fungi Tanah Muara Mangrove Desa Katialada Gorontalo dan Skrining Aktivitas Antibakteri terhadap Pseudomonas aeruginosa Prakoso, Arthur Hariyanto; Arifin, Muhammad Zainul; Tauladani, Saeful Akhmad; Muharam, Gani Asri; Asia, Asia; Nugraha, Ari Satia
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.15738

Abstract

Pseudomonas aeruginosa is a bacterial pathogen that causes various kinds of infections. The use of antibiotics is usually done to treat the infection. However, Pseudomonas aeruginosa has various resistance abilities that can avoid the efficacy of antibiotics. The emergence of drug resistance events encourages the need for the discovery of new antibiotic drugs, one of which comes from fungals secondary metabolite. Soil fungi from mangrove ecosystems have not been studied much. Interestingly, these soil fungi have unique adaptive responses. This response also affects the secondary metabolites it contains. Knowing this information, mangrove soil samples were cultured on fungi media which were then tested against Pseudomonas aeruginosa through antagonist test and microdilution test. Three fungal cultures with yeast characteristics were obtained and each of the secondary metabolite ethyl acetate extracts of these three fungi had antibacterial activity. The antibacterial activity was indicated by the % inhibition parameter. The terpenoid content in fungal cultures may be responsible for the antibacterial activity against Pseudomonas aeruginosa. This research is an initial indohoki77 juga dikenal karena layanan pelanggannya yang responsif dan profesional. Tim dukungan pelanggan tersedia 24/7 untuk membantu para pemain dengan segala pertanyaan atau masalah yang mereka hadapi screening of the search for new antibiotic candidates, so further research study such as isolation and species determination needs to be done. 
Pengembangan Pembalut Pintar untuk Deteksi Dini Kondisi Hiperurisemia dan Hiperkolesterolemia Dewi, Itut Septiana; Kuswandi, Bambang; Nugraha, Ari Satia
Pustaka Kesehatan Vol 12 No 2 (2024): Volume 10 No.2, 2024
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v12i2.22412

Abstract

Hyperuricemia and hypercholesterolemia’s cases are increasing. Noninvasive early detection method should be develope. Development of smart sanitary napkins based on paper chip biosensors using “Whatman” filter paper through screen printing and immobilized with pH 6 citrate buffer and iron (III)-actress- (1,10-phenanthroline) complex reagent for detection of uric acid and cholesterol oxidase enzymes and reagent 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid (ABTS)) for cholesterol detection. The analysis of the paper chip biosensor has a response time of 10 minutes for uric acid detection and 25 minutes for cholesterol detection. Uric acid linearity 2 - 20 mg / dL and cholesterol 50 - 500 mg / dL. The LOD and LOQ detection areas for uric acid were 0.322 mg / dL and 0.965 mg / dL, respectively, while the cholesterol detection areas were 8.740 mg / dL and 26.221 mg / dL, respectively. NaCl interference interfering with the detection of uric acid and cholesterol was 5.746% and 6.388%, respectively and creatinine interference interfering with the detection of uric acid and cholesterol was 5.868% and 5.583%, respectively. The precision for uric acid detection was 1.252% (RSD <3.7%) and cholesterol detection was 0.059% (RSD <2.7%). The accuracy (% recovery) for uric acid detection was 100.333% and for cholesterol, the detection was 100.016%. Smart bandages can be used to analyze the initial conditions of hyperuricemia and hypercholesterolemia.
Virtual Screening of Inhibitor Compounds for HL-60 Cell Line Using QSAR and Molecular Docking Approaches Putri Handayani, Maulina Surindri; Sudarko, Sudarko; Nugraha, Ari Satia
BERKALA SAINSTEK Vol 12 No 1 (2024)
Publisher : Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bst.v12i1.42341

Abstract

Leukaemia is a type of heterogeneous malignancy disease in which the number of immature white blood cells in the bone marrow is increased or poorly differentiated. Inhibitors of HL-60 cell line are important drugs in the treatment of leukaemia. This study aims to identify potential inhibitors for HL-60 leukaemia cells using virtual screening with QSAR and molecular docking approaches. The best QSAR model obtained was the model with R2 testing value of 0.72. The best model was applied to the Enamine database, obtained 3,841,278 compounds with pIC50 above 9 were clustered to end up with 50 inhibitor candidate compounds. The compounds were further studied through molecular docking against CDK- 2 and BCL-2 target proteins with binding free energy analysis. Screened compounds have high inhibitory potential against CDK-2 and BCL-2 target proteins in HL-60 cells which can be proposed as potential inhibitors of HL-60 cells. These compounds can be further tested for the development of more effective antileukaemia drugs.
Isolasi dan Skrining Aktivitas Antibakteri Fungi Tanah Muara Desa Katialada Gorontalo Lokasi Satu terhadap Staphylococcus aureus Rohmatillah, Wilda Nur; Arifin, Muhammad Zainul; Tauladani, Saeful Akhmad; Muharam, Gani Asri; Asia, Asia; Pratoko, Dwi Koko; Nugraha, Ari Satia
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5978

Abstract

The emergence of antibiotic resistance becomes a barrier in controlling infectious diseases, so it is necessary to find new alternative antibiotics. This study aimed to explore the potential of estuarine soil fungals secondary metabolites isolated from Katialada Village Gorontalo Location One and test their antibacterial activity against Staphylococcus aureus. The antibacterial parameter observed was the percent inhibition of ethyl acetate extracts against Staphylococcus aureus. The estuarine soil samples were cultured in PDA media producing five single fungal isolates differentiated based on color morphology, texture, and shape coded IS2-BTG-4.1.1, IS2-BTG-4.1.2, IS1-BTG-4.2, IS2-BTG4.3.1, and IS2-BTG-4.3.2. Those five samples were fermented using PDB media and the fermented products were extracted with ethyl acetate. The extracts were screened for its compound using a TLC plate and antibacterial testing with a single concentration of 100 g/mL in the microdilution method. The screening results showed that the five ethyl acetate extracts contained terpenoid compounds and code IS2-BTG-4.3.2 also had alkaloids. Based on the antibacterial test results, the five ethyl acetate extracts had growth inhibitory activity on the Staphylococcus aureus, with the percentage showed by IS2-BTG-4.1.1 50,2% ± 14,8%, IS2-BTG-4.1.2 35,6% ± 12,9%, IS1-BTG-4.2 13,0% ± 7,3%, IS2-BTG-4.3.1 13,6% ± 6,0%, and IS2-BTG-4.3.2 by 12,4% ± 9,2%.
Penentuan Aktivitas Antioksidan dan Antidiabetes Ekstrak Daun Kepundung (Baccaurea racemosa Muell.Arg.) secara In Vitro Wulandari, Lestyo; Nugraha, Ari Satia; Azhari, Nuri Putri
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 1 (2020): J Sains Farm Klin 7(1), April 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.1.60-66.2020

Abstract

 Kepundung (Baccaurea racemosa Muell.Arg.) merupakan salah satu tanaman berkhasiat di Indonesia yang mengandung flavonoid, polifenol, tanin, dan terpenoid yang dapat berfungsi sebagai antioksidan. Kandungan senyawa dengan aktivitas antioksidan dapat dikaitkan dengan potensi aktivitas antidiabetes dari tanaman ini. Penelitian dilakukan untuk mengetahui aktivitas antioksidan dan antidiabetes ekstrak metanol, etanol, dan etil asetat dari daun kepundung. Ekstraksi dilakukan dengan metode ultrasonik. Pengujian aktivitas antioksidan dilakukan secara kuantitatif dengan metode DPPH, sedangkan pengujian aktivitas antidiabetes menggunakan metode penghambatan enzim α-amilase. Nilai IC50 pada penentuan aktivitas antioksidan dan antidiabetes ditentukan dengan menggunakan spektrofotometer UV-Vis pada panjang gelombang maksimum. Hasil penentuan antioksidan menunjukkan bahwa nilai IC50 ekstrak metanol, etanol, dan etil asetat masing-masing adalah 9,38 ± 0,15; 10,55 ± 0,09; dan 946,70 ± 2,31 ppm. Ini menunjukkan ekstrak metanol dan etanol memberikan hasil terbaik dalam aktivitas antioksidan. Nilai IC50 aktivitas antidiabetes in vitro ekstrak metanol, etanol, dan etil asetat masing-masing adalah 67,63 ± 0,36; 67,46 ± 0,23; dan 841,04 ± 1,52 ppm. Hasil ini juga menunjukkan bahwa ekstrak metanol dan etanol daun kepundung memiliki aktivitas antidiabetes yang hampir sama
Budaya Kewirausahaan Masyarakat Kawasan Wisata: Studi Kasus Komunitas Pedagang/UMKM di Wilayah Pantai Sayang Heulang Garut Mardani Eka Ningrum; Iyan Setiawan; Sri Dinarwati; Yandy Noviandri; Hari Satia Nugraha
Indonesian Journal of Social Science Vol. 3 No. 2 (2025): JULY- IJSS
Publisher : PDPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58818/ijss.v3i2.124

Abstract

Penelitian ini bertujuan untuk mengkaji budaya kewirausahaan yang berkembang di kalangan pelaku Usaha Mikro, Kecil, dan Menengah (UMKM) di kawasan wisata Pantai Sayang Heulang, Kabupaten Garut. Fokus utama kajian ini adalah memahami nilai-nilai, sikap, dan praktik kewirausahaan yang diterapkan oleh masyarakat lokal dalam menjalankan usahanya di sektor pariwisata. Metode yang digunakan adalah pendekatan kualitatif dengan teknik observasi, wawancara mendalam, dan dokumentasi terhadap sejumlah pelaku UMKM. Hasil penelitian menunjukkan bahwa masyarakat memiliki semangat kewirausahaan yang tinggi, tercermin dari kemandirian usaha, kemampuan beradaptasi terhadap kebutuhan wisatawan, serta budaya gotong royong yang masih kuat. Namun demikian, pelaku usaha masih menghadapi berbagai kendala, seperti keterbatasan akses teknologi, pemasaran digital, dan ketergantungan pada musim wisata. Oleh karena itu, diperlukan dukungan berkelanjutan dari pemerintah dan lembaga terkait untuk memperkuat kapasitas wirausaha masyarakat lokal, melalui pelatihan, pendampingan, serta penguatan ekosistem usaha berbasis potensi lokal.
Co-Authors Adinda Kusuma Pertiwi Afrian Rosyadi Aissa Dinar Yanuariski Amrina Rosyada Fajriyanti Andhika Puspito Nugroho Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Asia Asia Asia Asia Asia Asia Asia, Asia Ayik Rosita Puspaningtyas1 Azhari, Nuri Putri Azis, Deri Abdul Bambang Kuswandi Bambang Kuswandi Banun Kusumawardani Bawon Triatmoko Dewi, Itut Septiana Dian Agung Pangaribowo Dinar Mutia Rani Dinarwati, Sri Dwi Koko Pratoko Endah Puspitasari Fathunnisa, Fathunnisa Fawwas Batio Putra Pamungkas Febi, Qonita Nafilah Gani Asri Muharam Gani Asri Muharam Ifan Arif Maulana Ilma, Laila Nurul Indah Purnama Sary, Indah Purnama Indah Purnamasary Ita Husnul Chotimah Iyan Setiawan Kartika Senjarini Larissa Tania Lestyo Wulandari Lestyo Wulandari Luh Putu Ratna Sundari Mardani Eka Ningrum Mariatul Kibthiyyah Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Zainul Arifin Muhammad Zainul Arifin Muhammad Zainul Arifin Muhammad Zainul Arifin Muharam, Gani Asri Nafa Rosyida Zanuba Naura Bathari Winarto Nimas Ayu Amanda Putri Ninisita Sri Hadi Nugroho, Irfan Agus Nuri Putri Azhari Pairah, Pairah Prakoso, Arthur Hariyanto Putri Handayani, Maulina Surindri Rike Oktarianti Rofiko Nuning Rahayu Rohmatillah, Wilda Nur Romadhona, Ananda Briliana Rosidah, Malihatul Saeful Akhmad Tauladani Savitri, Ganevi Resta Septianingtyas, Christabel Reviana Silvya Fitri Nur Azizah Sri Untari Siwi Sudarko Sudarko Syubbanul Wathon, Syubbanul Tauladani, Saeful Akhmad Untari, Ludmilla Fitri Wilda Nur Rohmatilah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Yandy Noviandri Yashinta Nirmala Siswanti Yoshinta Debby Ziyan Nihlatul Millah