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All Journal Jurnal Natur Indonesia e-Journal Pustaka Kesehatan BERKALA SAINSTEK Alchemy : Journal of Chemistry Pharmaciana: Jurnal Kefarmasian Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY The Indonesian Biomedical Journal JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Nusantara Science and Technology Proceedings Makara Journal of Science Jurnal Katalisator Journal of Multidisciplinary Science: MIKAILALSYS IJSS Borneo Journal of Pharmacy Jurnal Kefarmasian Indonesia Journal of Pharmascience
Ari Satia Nugraha
Drug Utilisation And Discovery Research Group, Faculty Of Pharmacy, University Of Jember, Jember, Indonesia 68121
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Pengembangan Pembalut Pintar untuk Deteksi Dini Kondisi Hiperurisemia dan Hiperkolesterolemia Dewi, Itut Septiana; Kuswandi, Bambang; Nugraha, Ari Satia
Pustaka Kesehatan Vol 12 No 2 (2024): Volume 10 No.2, 2024
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v12i2.22412

Abstract

Hyperuricemia and hypercholesterolemia’s cases are increasing. Noninvasive early detection method should be develope. Development of smart sanitary napkins based on paper chip biosensors using “Whatman” filter paper through screen printing and immobilized with pH 6 citrate buffer and iron (III)-actress- (1,10-phenanthroline) complex reagent for detection of uric acid and cholesterol oxidase enzymes and reagent 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid (ABTS)) for cholesterol detection. The analysis of the paper chip biosensor has a response time of 10 minutes for uric acid detection and 25 minutes for cholesterol detection. Uric acid linearity 2 - 20 mg / dL and cholesterol 50 - 500 mg / dL. The LOD and LOQ detection areas for uric acid were 0.322 mg / dL and 0.965 mg / dL, respectively, while the cholesterol detection areas were 8.740 mg / dL and 26.221 mg / dL, respectively. NaCl interference interfering with the detection of uric acid and cholesterol was 5.746% and 6.388%, respectively and creatinine interference interfering with the detection of uric acid and cholesterol was 5.868% and 5.583%, respectively. The precision for uric acid detection was 1.252% (RSD <3.7%) and cholesterol detection was 0.059% (RSD <2.7%). The accuracy (% recovery) for uric acid detection was 100.333% and for cholesterol, the detection was 100.016%. Smart bandages can be used to analyze the initial conditions of hyperuricemia and hypercholesterolemia.
Virtual Screening of Inhibitor Compounds for HL-60 Cell Line Using QSAR and Molecular Docking Approaches Putri Handayani, Maulina Surindri; Sudarko, Sudarko; Nugraha, Ari Satia
BERKALA SAINSTEK Vol 12 No 1 (2024)
Publisher : Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bst.v12i1.42341

Abstract

Leukaemia is a type of heterogeneous malignancy disease in which the number of immature white blood cells in the bone marrow is increased or poorly differentiated. Inhibitors of HL-60 cell line are important drugs in the treatment of leukaemia. This study aims to identify potential inhibitors for HL-60 leukaemia cells using virtual screening with QSAR and molecular docking approaches. The best QSAR model obtained was the model with R2 testing value of 0.72. The best model was applied to the Enamine database, obtained 3,841,278 compounds with pIC50 above 9 were clustered to end up with 50 inhibitor candidate compounds. The compounds were further studied through molecular docking against CDK- 2 and BCL-2 target proteins with binding free energy analysis. Screened compounds have high inhibitory potential against CDK-2 and BCL-2 target proteins in HL-60 cells which can be proposed as potential inhibitors of HL-60 cells. These compounds can be further tested for the development of more effective antileukaemia drugs.
Isolasi dan Skrining Aktivitas Antibakteri Fungi Tanah Muara Desa Katialada Gorontalo Lokasi Satu terhadap Staphylococcus aureus Rohmatillah, Wilda Nur; Arifin, Muhammad Zainul; Tauladani, Saeful Akhmad; Muharam, Gani Asri; Asia, Asia; Pratoko, Dwi Koko; Nugraha, Ari Satia
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5978

Abstract

The emergence of antibiotic resistance becomes a barrier in controlling infectious diseases, so it is necessary to find new alternative antibiotics. This study aimed to explore the potential of estuarine soil fungals secondary metabolites isolated from Katialada Village Gorontalo Location One and test their antibacterial activity against Staphylococcus aureus. The antibacterial parameter observed was the percent inhibition of ethyl acetate extracts against Staphylococcus aureus. The estuarine soil samples were cultured in PDA media producing five single fungal isolates differentiated based on color morphology, texture, and shape coded IS2-BTG-4.1.1, IS2-BTG-4.1.2, IS1-BTG-4.2, IS2-BTG4.3.1, and IS2-BTG-4.3.2. Those five samples were fermented using PDB media and the fermented products were extracted with ethyl acetate. The extracts were screened for its compound using a TLC plate and antibacterial testing with a single concentration of 100 g/mL in the microdilution method. The screening results showed that the five ethyl acetate extracts contained terpenoid compounds and code IS2-BTG-4.3.2 also had alkaloids. Based on the antibacterial test results, the five ethyl acetate extracts had growth inhibitory activity on the Staphylococcus aureus, with the percentage showed by IS2-BTG-4.1.1 50,2% ± 14,8%, IS2-BTG-4.1.2 35,6% ± 12,9%, IS1-BTG-4.2 13,0% ± 7,3%, IS2-BTG-4.3.1 13,6% ± 6,0%, and IS2-BTG-4.3.2 by 12,4% ± 9,2%.
Penentuan Aktivitas Antioksidan dan Antidiabetes Ekstrak Daun Kepundung (Baccaurea racemosa Muell.Arg.) secara In Vitro Wulandari, Lestyo; Nugraha, Ari Satia; Azhari, Nuri Putri
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 1 (2020): J Sains Farm Klin 7(1), April 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.1.60-66.2020

Abstract

 Kepundung (Baccaurea racemosa Muell.Arg.) merupakan salah satu tanaman berkhasiat di Indonesia yang mengandung flavonoid, polifenol, tanin, dan terpenoid yang dapat berfungsi sebagai antioksidan. Kandungan senyawa dengan aktivitas antioksidan dapat dikaitkan dengan potensi aktivitas antidiabetes dari tanaman ini. Penelitian dilakukan untuk mengetahui aktivitas antioksidan dan antidiabetes ekstrak metanol, etanol, dan etil asetat dari daun kepundung. Ekstraksi dilakukan dengan metode ultrasonik. Pengujian aktivitas antioksidan dilakukan secara kuantitatif dengan metode DPPH, sedangkan pengujian aktivitas antidiabetes menggunakan metode penghambatan enzim α-amilase. Nilai IC50 pada penentuan aktivitas antioksidan dan antidiabetes ditentukan dengan menggunakan spektrofotometer UV-Vis pada panjang gelombang maksimum. Hasil penentuan antioksidan menunjukkan bahwa nilai IC50 ekstrak metanol, etanol, dan etil asetat masing-masing adalah 9,38 ± 0,15; 10,55 ± 0,09; dan 946,70 ± 2,31 ppm. Ini menunjukkan ekstrak metanol dan etanol memberikan hasil terbaik dalam aktivitas antioksidan. Nilai IC50 aktivitas antidiabetes in vitro ekstrak metanol, etanol, dan etil asetat masing-masing adalah 67,63 ± 0,36; 67,46 ± 0,23; dan 841,04 ± 1,52 ppm. Hasil ini juga menunjukkan bahwa ekstrak metanol dan etanol daun kepundung memiliki aktivitas antidiabetes yang hampir sama
Budaya Kewirausahaan Masyarakat Kawasan Wisata: Studi Kasus Komunitas Pedagang/UMKM di Wilayah Pantai Sayang Heulang Garut Mardani Eka Ningrum; Iyan Setiawan; Sri Dinarwati; Yandy Noviandri; Hari Satia Nugraha
Indonesian Journal of Social Science Vol. 3 No. 2 (2025): JULY- IJSS
Publisher : PDPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58818/ijss.v3i2.124

Abstract

Penelitian ini bertujuan untuk mengkaji budaya kewirausahaan yang berkembang di kalangan pelaku Usaha Mikro, Kecil, dan Menengah (UMKM) di kawasan wisata Pantai Sayang Heulang, Kabupaten Garut. Fokus utama kajian ini adalah memahami nilai-nilai, sikap, dan praktik kewirausahaan yang diterapkan oleh masyarakat lokal dalam menjalankan usahanya di sektor pariwisata. Metode yang digunakan adalah pendekatan kualitatif dengan teknik observasi, wawancara mendalam, dan dokumentasi terhadap sejumlah pelaku UMKM. Hasil penelitian menunjukkan bahwa masyarakat memiliki semangat kewirausahaan yang tinggi, tercermin dari kemandirian usaha, kemampuan beradaptasi terhadap kebutuhan wisatawan, serta budaya gotong royong yang masih kuat. Namun demikian, pelaku usaha masih menghadapi berbagai kendala, seperti keterbatasan akses teknologi, pemasaran digital, dan ketergantungan pada musim wisata. Oleh karena itu, diperlukan dukungan berkelanjutan dari pemerintah dan lembaga terkait untuk memperkuat kapasitas wirausaha masyarakat lokal, melalui pelatihan, pendampingan, serta penguatan ekosistem usaha berbasis potensi lokal.
Structure Modification of Cinnamic Acid to (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one and Antioxidant Activity Test by DPPH Method Pangaribowo, Dian Agung; Fathunnisa, Fathunnisa; Nugraha, Ari Satia; Puspaningtyas, Ayik Rosita; Sary, Indah Purnama
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6163

Abstract

Antioxidants can protect cells from free radical damage by stabilizing them. One of the compounds that has antioxidant activity is cinnamic acid. Cinnamic acid and its derivatives have several activities: antibacterial, anticancer, and antioxidant. However, the ability of cinnamic acid to capture free radicals is still relatively low. One of the efforts that can be made to increase the antioxidant activity of cinnamic acid is to modify its structure. Structure modification is an effort to improve the pharmacological activity of a compound through chemical synthesis reactions. The cinnamic acid structure can be modified by changing the carboxylic -OH group into an amine group through an N-atom acylation reaction. This study was conducted by reacting cinnamoyl chloride (1a), which is a cinnamic acid derivative with 1,2,3,4-tetrahydroisoquinoline (2b) which is a compound of isoquinoline group to produce (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one (3b) and then tested for antioxidant activity using DPPH method. The resulting product compound was yellow crystals with a yield of 81.56%. The antioxidant activity produced by the product is more significant than that of cinnamic acid compounds at the same concentration.
Cytotoxic Potential of Flavonoid from Nicotiana tabacum Leaves on MCF-7 Human Breast Cancer Cells Kusumawardani, Banun; Febi, Qonita Nafilah; Rosidah, Malihatul; Azis, Deri Abdul; Puspitasari, Endah; Nugraha, Ari Satia
Indonesian Journal of Cancer Chemoprevention Vol 11, No 2 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss2pp97-10

Abstract

Flavonoid has potential bioactivity as anticancer agents. The flavonoid of cultivated tobacco (Nicotiana tabacum), locally known as “Kasturi”, leaves was screened for its cytotoxicity against MCF-7 human breast cancer cells and non-transformed Vero cells (African normal cell kidney line) in different concentrations. This study aimed to examine the cytotoxic potential of the flavonoid of Kasturi tobacco leaves against MCF-7 human breast cancer cells. Flavonoid obtained from methanolic extracts of Kasturi tobacco leaves, which have been purified from nicotine. The flavonoid of Kasturi tobacco leaves with concentrations of 20 to 640 μg/mL were exposed to MCF-7 and Vero cells for 24 h. Cell viability was evaluated by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Flavonoid of Kasturi tobacco leaves with concentrations of 160 μg/mL decreased the MCF-7 cell viability more than 50%, with an inhibitory concentration 50 (IC50) value of 148.41 μg/mL. Meanwhile, it inhibited 50% of Vero cell viability at 255.35 μg/mL. The flavonoid of Kasturi tobacco leaves has cytotoxic activity on MCF-7 cells, and might be a potential alternative agent for human breast cancer therapy.Keywords: flavonoid, tobacco leaves, human breast cancer cells, anticancer activity
ANTIOXIDANT POTENTIAL OF EXTRACT OF BLACK RICE, BAJAKAH WOOD ROOT AND KEBIUL SEED Yesti, Yulia; Kintoko, Kintoko; Nugraha, Ari Satia; Putra, Billy Harnaldo; Gusriyani, Sri; Saputra, Harry Ade; Alfarisyi, Muhammad Iqbal
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3457

Abstract

Exposure to free radicals and oxidative stress are major factors in various degenerative diseases, such as cardiovascular disease, diabetes, cancer, and neurodegenerative diseases. Therefore, the use of natural antioxidant sources is important to reduce the negative effects of free radicals. This study compares the natural antioxidant potential of black rice, bajakah root, and kebiul seeds, whereas previous studies have only identified the antioxidant potential of a single natural ingredient. This study aims to measure the antioxidant potential, such as total polyphenols, total flavonoids, and antioxidant activity, of these three natural materials using distilled water, 70% ethanol, and 96% ethanol as solvents. The experimental research method involved testing antioxidant activity and measuring total phenolics and flavonoids. The results showed that the 70% ethanol extract of black rice had the highest total polyphenol content at 6.83±0.28 mgGAE/g (0.007±0.00%), the 70% ethanol extract of bajakah wood root had the highest flavonoid content at 8.77±0.02 mgQE/g (0.009±0.00%), and the distilled water extract of kebiul seeds showed the strongest antioxidant activity based on an IC50 value of 5.96 ± 0.01 ppm. This study concluded that black rice has potential as a primary source of phenolics and anthocyanins, while bajakah wood root and kebiul seeds are sources of flavonoids with strong antioxidant activity.
Anti-inflammatory and antioxidant activity correlation with total phenolic, flavonoids, and alkaloids of best-selling Indonesian jamu Endah Puspitasari; Ari Satia Nugraha; Nuri Nuri; Ramadhan Bagus Cahyono; Putri Dwi Apriliani
Pharmaciana Vol. 16 No. 1 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i1.30626

Abstract

Oxidative stress and inflammation are closely linked pathological processes. Although non-steroidal anti-inflammatory drugs (NSAIDs) are effective, their use is associated with gastrointestinal, cardiovascular, and renal side effects, highlighting the need for safer alternatives. Jamu, an Indonesian traditional medicine, is widely used, yet scientific evidence supporting its efficacy and safety remains limited. The objective of this study was to investigate the anti-inflammatory and antioxidant activities of four different Indonesian jamu brands available for purchase on e-commerce platforms in Indonesia, and examine their correlation with the total phenolics, flavonoids, and alkaloids content in those jamu. The anti-inflammatory activity of jamu was assessed in vitro by evaluating its ability to stabilize red blood cell membranes and inhibit protein denaturation, using diclofenac sodium as a positive control. The antioxidant activity was evaluated using the 1-diphenyl-2-picrylhydrazyl (DPPH) assay, with ascorbic acid as the standard antioxidant. Total phenolics, flavonoids, and alkaloids contents were determined spectrophotometrically and expressed as gallic acid equivalents (GAE), rutin equivalents (RE), and berberine equivalents (BE) per gram of jamu extract, respectively. The correlations were evaluated based on multiple regression and Pearson correlation analysis using 99% confidence level. The aqueous extracts of Jamu A, B, C, and D were able to stabilize red blood cell membranes, inhibit protein denaturation, and exhibit free radical scavenging activity. Among the extracts, Jamu B demonstrated the lowest IC50 value, indicating the most effective anti-inflammatory and antioxidant properties followed by Jamu A, Jamu D, and Jamu C. These activities were significantly correlated with their total phenolics, flavonoids, and alkaloids content (p < 0.01).
Liparis condylobulbon Reichb. f. from Gumitir, Indonesia: Morphology, Molecular, and Phytochemical Profile Ulum, Fuad Bahrul; Arum, Asyifa Yasmin; Sa’adah, Kurnia; Setyati, Dwi; Dwinianti, Edia Fitria; Rajamani, Ranjithkumar; Nugraha, Ari Satia; Su’udi, Mukhamad
Makara Journal of Science Vol. 30, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Liparis condylobulbon Rchb.f. is an epiphytic orchid across South and Southeast Asia, which holds notable ethnomedicinal and pharmacological significance. This study aims to characterize Indonesian Liparis condylobulbon using integrated morphological, molecular (matK, rbcL, ITS2), and phytochemical (LC-MS, DPPH) analyses of specimens from Mount Gumitir, providing the first comprehensive taxonomic and pharmacological profile to support species authentication and future bioprospecting. The L. condylobulbon specimen displays diagnostic epiphytic morpho-logy, including fusiform pseudobulbs, two elongate leaves, and an erect inflorescence bearing ~123 flowers. Molecular barcoding using matK, rbcL, and ITS2 confirmed its identity, with phylogenetic analyses consistently clustering it with L. condylobulbon, supporting taxonomic placement despite minor ITS2-based variation. Metabolomic analysis revealed 58 distinct secondary metabolites, including 30 flavonoids, 22 terpenoids, and 6 phenolic compounds, with key bioactives such as diosmin, picrasinoside B, and 6-gingerol exhibiting known anti-inflammatory, antioxidant, and anticancer properties. Although the crude extract showed relatively low antioxidant capacity (IC₅₀ = 650 µg/mL), the chemical diversity and presence of pharmacologically active constituents underscore the species' potential for future phytotherapeutic applications.
Co-Authors Adinda Kusuma Pertiwi Afrian Rosyadi Aissa Dinar Yanuariski Alfarisyi, Muhammad Iqbal Amrina Rosyada Fajriyanti Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arum, Asyifa Yasmin Asia Asia Asia Asia Asia Asia Asia, Asia Ayik Rosita Puspaningtyas1 Azhari, Nuri Putri Azis, Deri Abdul Bambang Kuswandi Bambang Kuswandi Banun Kusumawardani Bawon Triatmoko Billy Harnaldo Putra, Dini Fatmi, Dede Irma Rahmawati Dewi, Itut Septiana Dian Agung Pangaribowo Dinar Mutia Rani Dinarwati, Sri Dwi Koko Pratoko Dwi Setyati Dwinianti, Edia Fitria Endah Puspitasari Fathunnisa, Fathunnisa Fawwas Batio Putra Pamungkas Febi, Qonita Nafilah Fuad Bahrul Ulum Gani Asri Muharam Gani Asri Muharam Gusriyani, Sri Harry Ade Saputra Herlina Ifan Arif Maulana Indah Purnama Sary, Indah Purnama Indah Purnamasary Ita Husnul Chotimah Iyan Setiawan Kartika Senjarini Kintoko Kintoko Larissa Tania Lestyo Wulandari Lestyo Wulandari Luh Putu Ratna Sundari Mardani Eka Ningrum Mariatul Kibthiyyah Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Zainul Arifin Muhammad Zainul Arifin Muhammad Zainul Arifin Muhammad Zainul Arifin Muharam, Gani Asri Nafa Rosyida Zanuba Naura Bathari Winarto Nimas Ayu Amanda Putri Ninisita Sri Hadi Nuri Nuri Nuri Putri Azhari Prakoso, Arthur Hariyanto Putri Dwi Apriliani Putri Handayani, Maulina Surindri Rajamani, Ranjithkumar Ramadhan Bagus Cahyono Rike Oktarianti Rofiko Nuning Rahayu Rohmatillah, Wilda Nur Rosidah, Malihatul S. Sudarko Saeful Akhmad Tauladani Savitri, Ganevi Resta Sa’adah, Kurnia Silvya Fitri Nur Azizah Sri Untari Siwi Su’udi, Mukhamad Tauladani, Saeful Akhmad Wathon, Syubbanul Wilda Nur Rohmatilah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Yandy Noviandri Yashinta Nirmala Siswanti Yoshinta Debby Yulia Yesti, Yulia Ziyan Nihlatul Millah