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All Journal Jurnal Natur Indonesia BIOTROPIA - The Southeast Asian Journal of Tropical Biology e-Journal Pustaka Kesehatan BERKALA SAINSTEK Alchemy : Journal of Chemistry Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY Pharmascience The Indonesian Biomedical Journal JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Nusantara Science and Technology Proceedings Jurnal Katalisator IJSS Borneo Journal of Pharmacy Jurnal Kefarmasian Indonesia
Ari Satia Nugraha
Drug Utilisation And Discovery Research Group, Faculty Of Pharmacy, University Of Jember, Jember, Indonesia 68121
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LICHEN SPECIES DIVERSITY AS BIOINDICATOR OF AIR QUALITY IN THE GUNUNG BIBI FOREST, MOUNT MERAPI NATIONAL PARK Nugroho, Irfan Agus; Romadhona, Ananda Briliana; Septianingtyas, Christabel Reviana; Ilma, Laila Nurul; Nugraha, Ari Satia; Pairah, Pairah; Untari, Ludmilla Fitri; Nugroho, Andhika Puspito
BIOTROPIA Vol. 32 No. 2 (2025): BIOTROPIA Vol. 32 No. 2 August 2025
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2025.32.2.2470

Abstract

ARTICLE HIGLIGHTS- The study identified 36 lichen species from 14 different families.- The lichen composition differed between stations, indicating disparities in air quality.- Station II (1600-1700 masl) had better air quality than Station I (1600-1700 masl), which had a higher diversity index value and more lichen coverage. - Nitrogen emissions from farming may reduce the non-nitrophilic lichen diversity and abundance.- The diversity and abundance of lichen is affected by air temperature, humidity, light intensity, and the type of bark.ABSTRACTThe Mount Merapi ecosystem is distinguished by its considerable biodiversity potential, which has led to its designation as a national park and the protection of its unique ecological characteristics. A notable example of the Mount Merapi ecosystem is the Gunung Bibi forest, which has been designated as a Sanctuary Zone within the Mount Merapi National Park, with the primary objectives of biodiversity conservation, habitat preservation, and ecosystem protection. However, the Gunung Bibi forest is susceptible to the repercussions of volcanic eruptions and the pressure of agricultural activities from the surrounding area, which may potentially impact its air quality. Given the geographical area of the forest, the most efficient method for air quality monitoring is the use of lichens diversity as bio-indicators. This study aims to analyze the relationship between lichen species diversity and air quality in the Gunung Bibi forest area of Mount Merapi National Park, and the factors that influence it. Data collection was carried out by dividing the area into two research stations based on altitude. Data collection was carried out using a purposive sampling method with analysis including lichen abundance, lichen thallus cover area, and Shannon-Wiener Diversity Index measurement. Based on the research conducted, the results of lichen species diversity found at the research site include 36 species from 13 different families. The lichen composition at the two stations differs, indicative of disparities in air quality. Station II (1600-1700 masl) exhibited indications of better air quality in comparison to Station I (1500-1600 masl), which was distinguished by a higher diversity index value, as well as a greater lichen thallus covering area. The difference in air quality between the two research stations is probably due to nitrogen emissions from agricultural activities, which limit the diversity and abundance of non-nitrophilic lichen species Environmental factors affecting lichen species diversity and abundance are air temperature, humidity, light intensity, and bark type of lichen substrate.
Structure Modification of Cinnamic Acid to (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one and Antioxidant Activity Test by DPPH Method Pangaribowo, Dian Agung; Fathunnisa, Fathunnisa; Nugraha, Ari Satia; Puspaningtyas, Ayik Rosita; Sary, Indah Purnama
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6163

Abstract

Antioxidants can protect cells from free radical damage by stabilizing them. One of the compounds that has antioxidant activity is cinnamic acid. Cinnamic acid and its derivatives have several activities: antibacterial, anticancer, and antioxidant. However, the ability of cinnamic acid to capture free radicals is still relatively low. One of the efforts that can be made to increase the antioxidant activity of cinnamic acid is to modify its structure. Structure modification is an effort to improve the pharmacological activity of a compound through chemical synthesis reactions. The cinnamic acid structure can be modified by changing the carboxylic -OH group into an amine group through an N-atom acylation reaction. This study was conducted by reacting cinnamoyl chloride (1a), which is a cinnamic acid derivative with 1,2,3,4-tetrahydroisoquinoline (2b) which is a compound of isoquinoline group to produce (E)-1-(3,4-dihydroisoquinoline-2(1H)-yl)-3-phenylprop-2-en-1-one (3b) and then tested for antioxidant activity using DPPH method. The resulting product compound was yellow crystals with a yield of 81.56%. The antioxidant activity produced by the product is more significant than that of cinnamic acid compounds at the same concentration.
Cytotoxic Potential of Flavonoid from Nicotiana tabacum Leaves on MCF-7 Human Breast Cancer Cells Kusumawardani, Banun; Febi, Qonita Nafilah; Rosidah, Malihatul; Azis, Deri Abdul; Puspitasari, Endah; Nugraha, Ari Satia
Indonesian Journal of Cancer Chemoprevention Vol 11, No 2 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss2pp97-10

Abstract

Flavonoid has potential bioactivity as anticancer agents. The flavonoid of cultivated tobacco (Nicotiana tabacum), locally known as “Kasturi”, leaves was screened for its cytotoxicity against MCF-7 human breast cancer cells and non-transformed Vero cells (African normal cell kidney line) in different concentrations. This study aimed to examine the cytotoxic potential of the flavonoid of Kasturi tobacco leaves against MCF-7 human breast cancer cells. Flavonoid obtained from methanolic extracts of Kasturi tobacco leaves, which have been purified from nicotine. The flavonoid of Kasturi tobacco leaves with concentrations of 20 to 640 μg/mL were exposed to MCF-7 and Vero cells for 24 h. Cell viability was evaluated by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Flavonoid of Kasturi tobacco leaves with concentrations of 160 μg/mL decreased the MCF-7 cell viability more than 50%, with an inhibitory concentration 50 (IC50) value of 148.41 μg/mL. Meanwhile, it inhibited 50% of Vero cell viability at 255.35 μg/mL. The flavonoid of Kasturi tobacco leaves has cytotoxic activity on MCF-7 cells, and might be a potential alternative agent for human breast cancer therapy.Keywords: flavonoid, tobacco leaves, human breast cancer cells, anticancer activity
ANTIOXIDANT POTENTIAL OF EXTRACT OF BLACK RICE, BAJAKAH WOOD ROOT AND KEBIUL SEED Yesti, Yulia; Kintoko, Kintoko; Nugraha, Ari Satia; Putra, Billy Harnaldo; Gusriyani, Sri; Saputra, Harry Ade; Alfarisyi, Muhammad Iqbal
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3457

Abstract

Exposure to free radicals and oxidative stress are major factors in various degenerative diseases, such as cardiovascular disease, diabetes, cancer, and neurodegenerative diseases. Therefore, the use of natural antioxidant sources is important to reduce the negative effects of free radicals. This study compares the natural antioxidant potential of black rice, bajakah root, and kebiul seeds, whereas previous studies have only identified the antioxidant potential of a single natural ingredient. This study aims to measure the antioxidant potential, such as total polyphenols, total flavonoids, and antioxidant activity, of these three natural materials using distilled water, 70% ethanol, and 96% ethanol as solvents. The experimental research method involved testing antioxidant activity and measuring total phenolics and flavonoids. The results showed that the 70% ethanol extract of black rice had the highest total polyphenol content at 6.83±0.28 mgGAE/g (0.007±0.00%), the 70% ethanol extract of bajakah wood root had the highest flavonoid content at 8.77±0.02 mgQE/g (0.009±0.00%), and the distilled water extract of kebiul seeds showed the strongest antioxidant activity based on an IC50 value of 5.96 ± 0.01 ppm. This study concluded that black rice has potential as a primary source of phenolics and anthocyanins, while bajakah wood root and kebiul seeds are sources of flavonoids with strong antioxidant activity.
Co-Authors Adinda Kusuma Pertiwi Afrian Rosyadi Aissa Dinar Yanuariski Alfarisyi, Muhammad Iqbal Amrina Rosyada Fajriyanti Andhika Puspito Nugroho Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Asia Asia Asia Asia Asia Asia Asia, Asia Ayik Rosita Puspaningtyas1 Azhari, Nuri Putri Azis, Deri Abdul Bambang Kuswandi Bambang Kuswandi Banun Kusumawardani Bawon Triatmoko Billy Harnaldo Putra, Dini Fatmi, Dewi, Itut Septiana Dian Agung Pangaribowo Dinar Mutia Rani Dinarwati, Sri Dwi Koko Pratoko Endah Puspitasari Fathunnisa, Fathunnisa Fawwas Batio Putra Pamungkas Febi, Qonita Nafilah Gani Asri Muharam Gani Asri Muharam Gusriyani, Sri Harry Ade Saputra Ifan Arif Maulana Ilma, Laila Nurul Indah Purnama Sary, Indah Purnama Indah Purnamasary Ita Husnul Chotimah Iyan Setiawan Kartika Senjarini Kintoko Kintoko Larissa Tania Lestyo Wulandari Lestyo Wulandari Luh Putu Ratna Sundari Mardani Eka Ningrum Mariatul Kibthiyyah Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Zainul Arifin Muhammad Zainul Arifin Muhammad Zainul Arifin Muhammad Zainul Arifin Muharam, Gani Asri Nafa Rosyida Zanuba Naura Bathari Winarto Nimas Ayu Amanda Putri Ninisita Sri Hadi Nugroho, Irfan Agus Nuri Putri Azhari Pairah, Pairah Prakoso, Arthur Hariyanto Putri Handayani, Maulina Surindri Rike Oktarianti Rofiko Nuning Rahayu Rohmatillah, Wilda Nur Romadhona, Ananda Briliana Rosidah, Malihatul Saeful Akhmad Tauladani Savitri, Ganevi Resta Septianingtyas, Christabel Reviana Silvya Fitri Nur Azizah Sri Untari Siwi Sudarko Sudarko Syubbanul Wathon, Syubbanul Tauladani, Saeful Akhmad Untari, Ludmilla Fitri Wilda Nur Rohmatilah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Yandy Noviandri Yashinta Nirmala Siswanti Yoshinta Debby Yulia Yesti, Yulia Ziyan Nihlatul Millah