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All Journal Jurnal Natur Indonesia e-Journal Pustaka Kesehatan BERKALA SAINSTEK Alchemy : Journal of Chemistry Pharmaciana: Jurnal Kefarmasian Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY The Indonesian Biomedical Journal JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Nusantara Science and Technology Proceedings Makara Journal of Science Jurnal Katalisator Journal of Multidisciplinary Science: MIKAILALSYS IJSS Borneo Journal of Pharmacy Jurnal Kefarmasian Indonesia Journal of Pharmascience
Ari Satia Nugraha
Drug Utilisation And Discovery Research Group, Faculty Of Pharmacy, University Of Jember, Jember, Indonesia 68121
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Isolasi Fungi Tanah Muara Sungai Desa Kalinaun Sulawesi Utara serta Skrining Antibakteri terhadap Pseudomonas aeruginosa Muhammad Habiburrohman; Nafa Rosyida Zanuba; Muhammad Zainul Arifin; Saeful Akhmad Tauladani; Gani Asri Muharam; Asia Asia; Dwi Koko Pratoko; Bawon Triatmoko; Ari Satia Nugraha
Journal of Pharmascience Vol. 10 No. 1 (2023): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i1.13825

Abstract

Penyakit infeksi merupakan salah satu penyakit yang menyebabkan mortalitas dan morbiditas di dunia yang dapat diterapi menggunakan antibotik. Adanya resistensi dapat mengancam efektivitas antibiotik. Penelitian ini bertujuan untuk mencari kandidat antibiotik yang bersumber dari fungi tanah muara yang diuji aktivitasnya terhadap bakteri Pseudomonas aeruginosa. Ekosistem tanah muara  mangrove memiliki kondisi ekstrem sehingga menuntut mikroorganisme untuk bertahan hidup dengan memproduksi senyawa antibiotik untuk bersaing dengan mikroorganisme lain. Sampel tanah diambil dari Muara Sungai Desa Kalinaun, Kecamatan Likupang Timur, Kabupaten Minahasa Utara, Provinsi Sulawesi Utara. Sampel tanah yang didapat sebanyak empat isolat fungi berpotensi dalam menghambat bakteri uji, yaitu IS2-BTG11-1-1, IS2-BTG11-2-1, IS2-BTG11-2-2, IS2-BTG11-2-3. Keempat isolat tersebut dilakukan fermentasi selama 14 hari lalu diekstraksi dengan pelarut etil asetat. Setelah didapatkan ekstrak etil asetat, dilakukan skrining fitokimia dan didapatkan hasil bahwa keempat ekstrak mengandung senyawa golongan terpenoid. Setelah dilakukan skrining fitokimia, dilakukan uji aktivitas antibakteri menggunakan metode mikrodilusi. Uji mikrodilusi dilakukan dengan konsentrasi tunggal 50 µg/mL. Berdasarkan uji mikrodilusi, keempat ekstrak fungi tanah muara memberikan aktivitas penghambatan berturut-turut dari terbesar ke terkecil : IS2-BTG11-2-3 (50,9% ± 7,6); IS2-BTG11-2-1 (49,8% ± 13,5); IS2-BTG11-1-1 (34,4% ± 2,4); IS2-BTG11-2-2 (37,2% ± 7,7). Pada penelitian ini senyawa yang berperan sebagai antibakteri belum bisa dipastikan, sehingga membutuhkan penelitian lebih lanjut. Kata Kunci: Antibakteri, Pseudomonas aeruginosa, Fungi Tanah Muara, Mikrodilusi, Desa Kalinaun  Infectious diseases are one of the leading causes of mortality and morbidity in the world that  can be treated with antibiotics. The existence of resistance can threaten the effectiveness of antibiotics. This study aims to find new antibiotic candidates from fungi in estuary soils and tested the activity against Pseudomonas aeruginosa bacteria. Estuary soil ecosystems have extreme conditions that require microorganisms to be able to survive Soil samples were taken from the Estuary of the Kalinaun Village, East Likupang District, North Minahasa Regency, North Sulawesi Province. Soil samples obtained were 4 isolates of fungi that had the potential bacteria inhibition, namely IS2-BTG11-1-1, IS2-BTG11-2-1, IS2-BTG11-2-2, IS2-BTG11-2-3. Four isolates were fermented for 14 days and extracted with ethyl acetate solvent. Phytochemical screening of the extract was carried out and the results showed that the four extracts contained terpenoid compounds. Antibacterial activity was tested using the microdilution methods with a single concentration of 50 µg/mL. Based on the microdilution test, four estuary soil fungal extracts gave inhibitory activity from the largest to the smallest: IS2-BTG11-2-3 (50.9% ± 7.6); IS2-BTG11-2-1 (49.8% ± 13.5); IS2-BTG11-1-1 (34.4% ± 2.4); IS2-BTG11-2-2 (37.2% ± 7.7). In this study, the compound that acts as an antibacterial has not been determined, so it requires further research.
The Effect of Workload and Demographic Characteristics on Employee Performance: A Case Study of Secretariat Division Employees at the Subang District Court Dede Irma Rahmawati; Herlina; Hari Satia Nugraha
Journal of Multidisciplinary Science: MIKAILALSYS Vol 4 No 3 (2026): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v4i3.12016

Abstract

Employee performance is essential to the effectiveness of public organizations, particularly judicial institutions confronted with complex administrative demands and public service responsibilities. This study examines the effects of workload and demographic characteristics on employee performance at the Subang District Court. A quantitative associative design using a survey method was employed. The study involved all 70 employees, selected through saturated sampling. Data were collected using a Likert-scale questionnaire, observations, and documentation and analyzed through multiple linear regression, classical assumption testing, t-tests, an F-test, and the coefficient of determination. The findings indicate that workload does not have a statistically significant individual effect on employee performance, whereas demographic characteristics have a positive and significant effect. Collectively, workload and demographic characteristics significantly influence employee performance and explain 24% of its variance. These findings demonstrate that demographic characteristics play a more prominent role than workload in explaining employee performance within the examined organizational context. The study contributes empirical evidence concerning the determinants of employee performance in a judicial institution and highlights the importance of considering individual characteristics in public-sector human resource management. Practically, the findings support more effective workload allocation and competency-based employee placement to strengthen organizational performance.
Co-Authors Adinda Kusuma Pertiwi Afrian Rosyadi Aissa Dinar Yanuariski Alfarisyi, Muhammad Iqbal Amrina Rosyada Fajriyanti Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arum, Asyifa Yasmin Asia Asia Asia Asia Asia Asia Asia, Asia Ayik Rosita Puspaningtyas1 Azhari, Nuri Putri Azis, Deri Abdul Bambang Kuswandi Bambang Kuswandi Banun Kusumawardani Bawon Triatmoko Billy Harnaldo Putra, Dini Fatmi, Dede Irma Rahmawati Dewi, Itut Septiana Dian Agung Pangaribowo Dinar Mutia Rani Dinarwati, Sri Dwi Koko Pratoko Dwi Setyati Dwinianti, Edia Fitria Endah Puspitasari Fathunnisa, Fathunnisa Fawwas Batio Putra Pamungkas Febi, Qonita Nafilah Fuad Bahrul Ulum Gani Asri Muharam Gani Asri Muharam Gusriyani, Sri Harry Ade Saputra Herlina Ifan Arif Maulana Indah Purnama Sary, Indah Purnama Indah Purnamasary Ita Husnul Chotimah Iyan Setiawan Kartika Senjarini Kintoko Kintoko Larissa Tania Lestyo Wulandari Lestyo Wulandari Luh Putu Ratna Sundari Mardani Eka Ningrum Mariatul Kibthiyyah Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Zainul Arifin Muhammad Zainul Arifin Muhammad Zainul Arifin Muhammad Zainul Arifin Muharam, Gani Asri Nafa Rosyida Zanuba Naura Bathari Winarto Nimas Ayu Amanda Putri Ninisita Sri Hadi Nuri Nuri Nuri Putri Azhari Prakoso, Arthur Hariyanto Putri Dwi Apriliani Putri Handayani, Maulina Surindri Rajamani, Ranjithkumar Ramadhan Bagus Cahyono Rike Oktarianti Rofiko Nuning Rahayu Rohmatillah, Wilda Nur Rosidah, Malihatul S. Sudarko Saeful Akhmad Tauladani Savitri, Ganevi Resta Sa’adah, Kurnia Silvya Fitri Nur Azizah Sri Untari Siwi Su’udi, Mukhamad Tauladani, Saeful Akhmad Wathon, Syubbanul Wilda Nur Rohmatilah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Yandy Noviandri Yashinta Nirmala Siswanti Yoshinta Debby Yulia Yesti, Yulia Ziyan Nihlatul Millah