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Journal : Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

Potential Plants With Antidiabetic Activity In Glut-4 Translocation: A Narrative Review Rabiatul Adawiyah; Ayu Shabrina; Sapto Yuliani; Nurkhasanah Nurkhasanah
Jurnal Ilmu Farmasi dan Farmasi Klinik 2023: [Special Edition] Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v0i1.9344

Abstract

Diabetes Mellitus (DM) is a chronic disease caused by decreased activity of the pancreas in producing insulin. Insulin resistance is characterized by decreased synthesis and translocation of GLUT-4 to cell membranes, GLUT-4 can be found in several tissues, but mainly in muscle and adipose tissue. The purpose of this study was to identify plants that have antidiabetic activity in Glut-4 translocation and further can be used as reference material in research. This research method is Article Review, by searching for articles published in 2013-2023 in the Pubmed, Google Scholar, Proquest, Springer Link, and Science Direct databases. The sample in this study was in the form of research articles that met the inclusion criteria and obtained a total of 15 articles. The results of this study showed that there was significant antidiabetic activity from the administration of Ethanol Extract on 125 mg/kg BW of Salam Leaf, 200 mg/kg BW of Areca Nut, 200 mg/kg of Papaya Seed, 96 mg/kg of Black Cumin, Combination of Sambiloto Leaf and Gotu kola leaves 300 mg/kg BW, 400 mg/kg BW of Adem Ati Bark, 100 mg/kg BW of Artemisia Leaf, 250 mg/kg BW of Coffee Beans, 200 mg/kg BW of Tapak Dara Leaves, 300 mg/kg BW of Puguntano Leaves, 50 mg/kg BW of Ginger, and 200 mg/kg BW of Cinnamon. These plant extracts have antidiabetic activity as GLUT4 translocates to the plasma membrane of muscle cells. The bioactive compounds contained in them which act as antidiabetic activity are flavonoids, saponins and tannins.
Phytochemical Screening of Secondary Metabolites, Antioxidant and Antibacterial Activities of Kalangkala Plant (Litsea Angulata): A Review Article Daipadli, Daipadli; Shabrina, Ayu; Yuliani, Sapto; Nurkhasanah, Nurkhasanah
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 20, No 2 (2023)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v20i2.9529

Abstract

Litsea angulata, more commonly known as Kalangkala, is a type of plant that belongs to the Lauraceae family. Empirically, the plant has been used traditionally by local people for the treatment of boils, diarrhea, stomachache, dyspepsia, gastroenteritis, diabetes, insect bites, and anti-irritation. This review article aims to find out the results of phytochemical screening of metabolites from parts of Kalangkala plant with various solvents as well as the results of the tests of antioxidant and antibacterial activities that several researchers have carried out. The method used was a literature search on Google Scholar and Pubmed with the keywords kalangkala, Litsea angulata, phytochemical screening, antioxidant, and antibacterial. The results of this review showed that various solvents, such as water, ethanol, methanol, N-hexane, and ethyl acetate in seed, fruit flesh, bark, stem, and leave parts of Kalangakala plant produces different amounts of secondary metabolites. Secondary metabolites such as alkaloids, flavonoids, saponins, and tannins extracted well using etanol as a solvent due to their polarity. The results of the antioxidant activity showed that the part of kalangakala plant such as the bark of the tree, has a very good antioxidant activity of 2.41 ppm when tested using ethyl acetate solvent. Furthermore, the results of the antibacterial activity test show an inhibition of 50 mm on S. mutans bacteria when tested using ethanol solvent. In conclusion, kalangkala plant has secondary metabolites which act as antioxidants and antimicrobials that also potential to developed as traditional medicine.
Co-Authors A'Yun, Qurotul AA Sudharmawan, AA Abdul Rahman Wahid Ade Irawan Adelita, Audrey Adiba, Thoriq Agus Nasihin Ahmad, Aunillah Akrom, Akrom Albab, Farah Qistih Alif Muarifah Amalya Nurul Khairi Amini, Nurul Fajar Anisah, Retnani Anjani, Arlian Sherly Aprilia, Kartini Aryastuti, Nurul Athifah Candra Dewi Ayu Shabrina Baroroh, Erli Carmel Meiden Chasanah, Hikmah Rochimatul Christin Angelina Febriani Daipadli Daipadli Deni Firmansyah Dianingsig, Dianingsih Easter Yanti, Dhiny Elya Zulfa, Elya Farah Qistih Albab Fitri Usfa, Hafiratul Fitrilya Mustikahati Yusuf, Fitrilya Mustikahati Flora Pasaru Gabrilla Yusuf, Ghina Harni, Harni Humaya, Humaya Ika Dyah Kumalasari Ika Kumalasari Imas Juidah Irawati, Riana Jailani, Muhammad Taufiq Bin Mohd Jayadinata, Asep Kurnia Jihad Lukis Panjawa Kariza, Alifia Ninda karmila karmila Kautsar, Akhmad Khairi, Amalya Nurul Laela Hayu Nurani Lola Angelita Lolita Sary Lovrina Rahmi Zulkarmen Mahdi, Lukman Maknun, Lu'lu'ul Meta Safitri Moch. Saiful Bachri Muhammad Syakbani Murinto Murinto Nada, Rafa Nanik Sulistyani Neni Fidya Santi Nihayati, Nihayati Ningsih, Nur Cahyati Nofa Risma Azis Nora Afriza, Zelda Nugroho, Bondan Nur Ahmad, Nur Nurul, Amalya Ofa Suzanti Betha Pramudianti, Ulfa Rahma Puri, Putri Ratna Rabiatul Adawiyah Rahman, Ika Ristia Ramadani, Cahya Ricke Desyratnaputri Rizka Indri Arfianti Rizky H. Mawardi Rostika, Rostika Sabrina Dahlizar Sapto Yuliani Saputri, Ginanjar Zukhruf Sari Manulang, Chanita Sepitriani, Sepitriani Siti Pandanwangi TW Siti Pandawangi TW Siti Sarifah Soedjono Soedjono Tri Yanuarto Tri Yanuarto Utami, Zhazha Zetira W, Ratna Kurnia Winata, Nana Triana Wiwin Lismidiati Wulandari, Dita yesi budiarti, yesi Yuni Anggraeni Yunni Arnidha, Yunni Zuniarto, Ahmad Azrul