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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences METAMORFOSA Journal of Biological Sciences Jurnal Biologi Udayana El-Hayah : Jurnal Biologi Jurnal Sains Peternakan Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Pharmasipha JURNAL ILMIAH PETERNAKAN TERPADU Journal of Dedicators Community Biota Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) JSMARTech : Journal of Smart Bioprospecting and Technology J-PEN Borneo : Jurnal Ilmu Pertanian Jurnal Sains Alami (Known Nature) Berkala Penelitian Hayati Jurnal Riset Perikanan dan Kelautan Jurnal Sains Alami (Known Nature) KOPEMAS Exhibition and Seminar on Science and Creative Technology – Al Azhar Proceeding Genbinesia Journal of Biology
Nurul Jadid Mubarokati
Universitas Islam Malang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary Other

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INOVASI MASYARAKAT DESA PAGAK DALAM MENGOLAH KEJI LELE (KERIPIK BIJI LAMTORO) WUJUDKAN EKONOMI TANGGUH COVID19 Ismatud Diniyah; Siti Khoirun Ni’mah; Nur Laily Azizah; Della Aljanna Savita; Nurul Jadid Mubarakati
Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024 Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) 2020
Publisher : Konferensi Nasional Pengabdian Masyarakat (KOPEMAS) #5 2024

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pagak merupakan salah satu desa di Kecamatan Pagak, Kabupaten Malang. Hamparan perkebunan yang luas merupakan pesona desa Pagak. Namun, potensi sumber daya alam pesona Pagak belum terekplorasi secara maksimal.  Biji lamtoro merupakan salah satu sumber daya alam melimpah di desa pagak. Masyarakat pagak pada umumnya memanfaatkan lamtoro sebagai bahan pakan ternak, sumber kayu bakar, pohon peneduh, pencegah erosi dan sebagai pupuk hijau. Salah satu upaya meningkatkan kesejahraan ekonomi masyarakat, maka biji lamtoro akan berdayaguna jika dikemas sebagai produk pangan alternatif makanan kering yang disebut keripik. Adanya inovasi biji lamtoro sebagai keripik merupakan alternatif produk pangan yang siap konsumsi serta menjadikan lamtoro lebih bernilai ekonomis. Melalui kegiatan program Kreatif Mahasiswa Unisma dapat mengajak masyarakat terutama Desa Pagak untuk ikut aktif mengelola potensi sumber daya dengan cara memberikan penyuluhan dan pelatihan pengolahan keripik biji lamtoro. Kegiatan ini bertujuan untuk meningkatkan pengetahuan dan keterampilan masyarakat Desa Pagak, sehingga mampu menghasilkan masyarakat yang kreatif dan inovatif. Metode yang digunakan dalam pengumpulan data dan informasi adalah metode Rapid Rural Appraisal yaitu pengamatan lapang secara langsung, telaah data sekunder dan wawancara dengan informan. Hasil dari program pengabdian masyarakat ini antara lain penyuluhan dan pelatihan tentang pengolahan biji lamtoro menjadi keripik merupakan titik awal terciptanya sentra industri dan menjadi wadah dalam mengembangkan ekonomi kreatif di Desa Pagak.
Detection of Secondary Metabolites in Cucumber (Cucumis sativus) Leaves and Its Potential as Candidates for Acne Drug Using Histochemical Analysis and In Silico Study Devi Indrayani Fitri Asari; Ramizard Rafsanjani; Muchammad Faruq Vikriansyah; Abdullah Rozzen Muzayyan; Nurul Jadid Mubarakati; Gatra Ervi Jayanti
EXSACT-A Vol 1, No 1 (2023)
Publisher : Universitas Al Azhar Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36722/exc.v1i1.2232

Abstract

Acne is a facial skin problem that is generally experienced by 75-80% of adolescents as a result of excessive production of oil glands and sweat, inflammatory mediators. The acnecausing bacteria, Propionibacterium acnes, involves KAS III and JNK 1 proteins, so it is expected to be an effective anti-inflammatory and antibacterial strategy. Cucumber leaves are known to have biological activity as a candidate for acne medication. This study aims to detect secondary metabolites in cucumber leaves through histochemical and in silico analysis. Histochemical analysis was carried out by preparing fresh leaves through lower leaf incisions by dropping secondary metabolite detection reagents and then observing the color changes microscopically. The in silico test aims to determine the physicochemical properties, pharmacokinetic properties and interactions of the active compounds with KAS III and JNK1 as acne drug targets through molecular docking. Histochemical analysis showed that cucumber leaves positively contained secondary metabolites, namely terpenoids, flavonoids, alkaloids, tannins, and phenols. Meanwhile, it was known that isovitexin, cucurbitacin B & C had fairly good physicochemical properties, but only isovitexin and cucurbitacin C had the best pharmacokinetic properties. Based on the results of molecular docking, there are the same amino acid bonds between isovitexin and the control at the JNK1 receptor, namely the amino acids Ile:32, Val:40 and Leu:168 and the binding affinity value is low so it is predicted to be the most effective in inhibiting JNK1. Therefore, cucumber leaves open up a new potential as a candidate for natural acne preparations.Keywords: acne, cucumber, secondary metabolites, histochemical, in silico
Studi Kenyamanan Termal Terhadap Produksi Susu Sapi Perah FH (Friesian Holstein) Di KUD Sembada Puspo Kabupaten Pasuruan : Study of Thermal Comfort on Milk Production of FH (Friesian Holstein) Dairy Cows at KUD Sembada Puspo Pasuruan Regency Islamya, Nur Afni Auli; Tito, Sama' Iradat; Mubarakati, Nurul Jadid
Jurnal SAINS ALAMI (Known Nature) Vol. 7 No. 2 (2025)
Publisher : FMIPA UNISMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/j.sa.v7i2.18826

Abstract

Friesian Holstein (FH) dairy cows are the breed of cows that have the highest level of milk production. The decrease in milk production for dairy cows includes environmental factors, such as the intensity of sunlight, air humidity, wind speed, rainfall, and temperature, which significantly affect the level of heat stress in dairy cows. This study aims to see the appropriate thermal comfort for FH dairy cows. The parameters observed in this study were the temperature and humidity inside and outside the pen, the enclosure area, the roof height, the number of cows in the enclosure, and milk production. Mixed methods research is used in this study, and data collection techniques are done through observation, literature study, research, and interviews. Multiple linear regression is the data analysis used in this study. In addition, the average daily temperature and humidity, heat of the cage roof, and THI are also calculated. The results obtained are Fs of 4.133 and F-table of 3.01 with a confidence level of 0.05 or 5%, which means Fs is 4.133˃F-table 3.01. The results of the analysis that has been carried out show that simultaneously, the inside temperature, outside temperature, inside humidity, outside humidity, the area of ​​the cage, the height of the roof of the stable, the number of cows in the stable have an influence on the milk production of FH cows in KUD Sembada Puspo, Pasuruan Regency. Keywords: dairy cows, milk production, thermal comfort Sapi perah FH ialah bangsa sapi yang memiliki tingkat produksi susu tertinggi. Penurunan produksi susu sapi perah diantaranya yakni, faktor lingkungan yang mencakup atas intensitas cahaya matahari, kelembaban udara, kecepatan angin, curah hujan dan suhu yang berpengaruh besar terhadap tingkat stress panas pada sapi perah. Penelitian ini memiliki tujuan guna melihat kenyamanan termal yang sesuai untuk sapi perah FH. Parameter yang diamati didalam penelitian ini ialah suhu serta kelembaban di dalam dan luar kandang, luas kandang, tinggi atap kandang, jumlah sapi di dalam kandang, dan produksi susu. Metode penelitian campuran (mixed methods) ialah metode penelitian yang dipakai didalam penelitian ini. Teknik pengumpulan datanya dengan cara observasi, studi pustaka, penelitian, dan wawancara. Regresi linier berganda ialah analisis data yang digunakan didalam penelitian ini, selain itu dihitung juga rata-rata harian suhu dan kelembaban, kalor atap kandang, dan THI. Didapatkan hasil F-hitung senilai 4,133 dan F-tabel senilai 3,01 dengan taraf kepercayaan 0,05 atau 5% yang berarti F-hitung 4,133˃F-tabel 3,01. Hasil analisis yang telah dilakukan menunjukkan secara simultan suhu dalam, suhu luar, kelembaban dalam, kelembaban luar, luas kandang, tinggi atap kandang, jumlah sapi di kandang memberikan pengaruh terhadap produksi susu sapi FH di KUD Sembada Puspo Kabupaten Pasuruan.    Kata Kunci : kenyamanan termal, produksi susu, sapi perah
Dampak Stres Pra dan Pasca Pemotongan Terhadap Profil Darah Sapi Simental Islami, Darajatun; Mubarakati, Nurul Jadid; Humaidah, Nurul
Jurnal Sains Peternakan Vol 12 No 2 (2024): Jurnal Sains Peternakan Vol. 12 No. 2
Publisher : Fakultas Peternakan, Universitas PGRI Kanjuruhan Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21067/jsp.v12i2.10495

Abstract

Penanganan ternak sebelum dibawa ke Rumah Potong Hewan (RPH) dan perlakuan sebelum dipotong di RPH menentukan tingkat kesetresan ternak. Salah satu cara untuk mengetahui kondisi kesehatan hewan dapat dilakukan dengan melakukan pengamatan terhadap status hematologi. Tujuan penelitian adalah menganalisa dampak stres pra dan pasca pemotongan terhadap profil darah Sapi Simental. Metode penelitian yang digunakan adalah observasi dengan analisis statistic deskriptif. Hasil yang didapatkan dihitung dengan uji t menggunakan software SPSS versi 27.0.1. Observasi meliputi proses penurunan ternak dari transportasi dan proses pemotongan ternak. Variabel yang diukur adalah kadar hemoglobin, nilai hematokrit dan jumlah eritrosit. Hasil analisis rerata uji t pada profil darah Sapi Simental yaitu, kadar Hb pra pemotongan tidak berbeda nyata (P>0,005) dengan pasca pemotongan. Kadar Hb pra pemotongan adalah 10.26 ± 1.71 g/dL dan pasca pemotongan 11.84 ± 3.19 g/dL. Hasil analisis rerata nilai hematokrit Sapi Simental pra pemotongan yaitu berbeda nyata (P<0.005) dengan pasca pemotongan. Nilai hematokrit pra pemotongan adalah 30.58 ± 5.27 % dan pasca pemotongan 42.13 ± 5.27 %. Hasil perhitungan rerata jumlah eritrosit Sapi Simental pra pemotongan yaitu berbeda nyata (P<0.005) dengan pasca pemotongan. Jumlah eritrosit pra pemotongan adalah 7.64 ± 0.91 /µl) dan pasca pemotongan 10.44 ± 1.42 /µl). Kesimpulan adalah profil darah Sapi Simental pra pemotongan berbeda dengan pasca pemotongan. Kadar Hemoglobin, Hematokrit, Eritrosit cenderung meningkat tetapi masih dalam kisaran normal. Ada tendensi Sapi Simental mengalami stress sebelum dilakukan pemotongan.
Pengaruh pemberian benalu teh dan benalu mangga terhadap kadar malondialdehid serum pada tikus wistar jantan Ma'ruf, Muhammad; Sjakoer, Nour Athiroh Abdoes; Mubarakati, Nurul Jadid; Kumalasari, Eka
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 9 No. 1 (2025): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v9i1.12534

Abstract

Tea mistletoe and mango mistletoe are plants known to possess strong antioxidant activity. The antioxidants in these plants play a role in combating free radicals, inhibiting cell oxidation, and reducing the risk of cellular damage. The active compounds present in tea and mango mistletoe have the potential to reduce malondialdehyde (MDA) levels caused by free radical exposure. This study aimed to evaluate the effect of tea and mango mistletoe (BTBM) administration on MDA levels in male Wistar rats induced with deoxycorticosterone acetate (DOCA)-salt. This study used 25 male Wistar rats, divided into five groups: normal, control (DOCA-salt), and three treatment groups receiving BTBM at doses of 50, 100, and 200 mg/kgBW. The study lasted 28 days, beginning with BTBM administration for 14 days, followed by DOCA-salt induction alongside BTBM administration from day 15 to day 28. MDA levels were measured using the Thiobarbituric Acid Reactive Substances (TBARS) method with a UV-Vis spectrophotometer at a wavelength of 531 nm. Data were statistically analyzed using one-way ANOVA, followed by a Post Hoc Tukey test to determine differences between groups. The results showed that BTBM administration at a dose of 50 mg/kgBW significantly (p<0.05) reduced MDA levels compared to the control group. Thus, it can be concluded that the combination of tea and mango mistletoe has potential as an antioxidant agent in reducing MDA levels, with 50 mg/kgBW as the optimal dose in the DOCA-salt-induced rat model.      
In Silico Analysis of Kaempferol from Foeniculum vulgare and Coumarin from Alyxia reinwardtii Targeting Anti-Apoptotic Proteins: Potential Anticancer Agents Pinanti, Honesty Nurizza; Mubarakati, Nurul jadid
El-Hayah:Jurnal Biologi Vol 10, No 3 (2025): EL-HAYAH (VOL 10, NO 3 September 2025)
Publisher : Program Study of Biology, Science and Technology Faculty, UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v10i3.35082

Abstract

Foeniculum vulgare and Alyxia reinwardtii are two herbal plants frequently co-utilized by Javanese people in Indonesia to treat various diseases, as evidenced by ancient manuscripts about traditional medicine (Jamu). However, the potential of the combination of kaempferol and coumarin, the major bioactive compounds derived from each plant, to inhibit BCL-2 and BCL-XL anti-apoptotic proteins in cancer has not yet been investigated. Therefore, this study aimed to identify the inhibitory activity of kaempferol, coumarin, and their combinations on BCL-2 and BCL-XL through in silico studies. The physicochemical properties of both compounds were predicted using the SwissADME web server. Meanwhile, the docking activity prediction of these compounds on BCL-2 and BCL-XL was performed using the molecular docking method with HEX 8.0.0 CUDA. Docking visualization was performed using BIOVIA Discovery Studio 2020 Client. The results of this study indicated that kaempferol could bind the binding groove of both BCL-2 (-246.40 kcal/mol) and BCL-XL (-245.76 kcal/mol), whereas coumarin only interacted with the binding groove of BCL-XL (-160.61 kcal/mol). The combination of the two compounds exhibited a stronger interaction with BCL-2 (-248.50 kcal/mol) and BCL-XL (-260.43 kcal/mol) compared to each compound individually. Therefore, the combination of these compounds is predicted to exhibit greater anticancer potential than either kaempferol or coumarin alone. Nevertheless, further extensive studies are required to validate the findings of this study.
Peningkatan Budaya Literasi dan Numerasi melalui Program Kampus Mengajar di Sekolah Dasar Mubarakati, Nurul Jadid; Dewi, Atikah Nur Shabrina Razan; Kamilah, Nahdhiyatun; Fradina, IntanTrixi; Kurniasari, Yulia; Ula, Erfa Navadiatul; Arifiati, Shinta
Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Vol. 3 No. 4 (2022)
Publisher : Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jp2m.v3i4.19384

Abstract

Merdeka Belajar Kampus Merdeka (MBKM) yang dinaungi oleh Kementrian Pendidikan, Kebudayaan, Riset dan Teknologi meluncurkan sebuah program yaitu Kampus Mengajar. Program ini memberikan kesempatan kepada mahasiswa di seluruh Indonesia untuk belajar menjadi mitra guru yang berfokus pada peningkatan budaya literasi dan numerasi siswa di sekolah sasaran. Mahasiswa berkontribusi secara langsung dengan menyalurkan seluruh kreativitas dan inovasinya. Tujuan dari penelitian ini yaitu menjabarkan kegiatan dalam rangka peningkatan budaya literasi dan numerasi pada peserta didik sekolah dasar melalui program Kampus Mengajar. Penelitian ini merupakan jenis penelitian pengabdian kepada masyarakat yang melibatkan siswa sekolah dasar dan guru. Terdapat tiga tahap dalam pelaksanaan kegiatan pengabdian ini. Pertama, persiapan yaitu penulis melakukan pembekalan dan observasi di sekolah penempatan. Kedua, pelaksanaan peningkatan literasi dan numerasi pada peserta didik. Terakhir yaitu analisis hasil dari pelaksanaan kegiatan pengabdian. Hasil dari pengabdian ini yaitu mampu memberikan dampak positif khusus nya dalam literasi dan numerasi peserta didik melalui berbagai kegiatan seperti pembiasaan membaca pagi, pengadaan dan penataan pojok literasi, serta belajar penjumlahan, pengulangan, perkalian dan pembagian dengan cara yang menyenangkan Seluruh elemen masyarakat sekolah memberikan respon yang sangat positif dalam kegiatan Kampus Mengajar.
Exploring active compounds of kelor (Moringa oleifera Lam.) leaves as an alternative medicine to improve immunity in facing COVID-19 via in silico study Hikam, Agus Mohammad; Mubarakati, Nurul Jadid; Probojati, Rasyadan Taufiq; Widyananda, Muhammad Hermawan; Kharisma, Viol Dhea; Ansori, Arif Nur Muhammad
Genbinesia Journal of Biology Vol. 1 No. 1 (2021): November 2021
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v1i1.7

Abstract

SARS-CoV-2 is a new strain of coronavirus (CoV) that was identified in Wuhan in 2019. This virus is known to have the ability to reduce human immunity. Kelor (Moringa oleifera) is a potential natural resource in Indonesia, which is very abundant and contains several metabolic compounds such as phenolics, flavonoids, saponins, cytokines, and caffeoylquinic acid, which was reported to show antioxidants, antibacterial and antiviral. This study aims to predict the biological activity, physicochemical properties, toxicity, and affinity-interactions of the active compounds of M. oleifera leave. The active compounds of M. oleifera were obtained from the KNApSAcK and PubChem. Analysis of the bioactivity of the compounds using the Way2Drug Pass Online. Analysis of drug-likeness and toxicity using the Lipinski web server and pkCSM. Docking is done using Autodock vina software to analyze the interaction of the compounds with Mpro. The results indicate that the compound astragalin is the compound with the highest affinity value, namely -8.7 (kcal/mol), compared to lopinavir as a control compound with an affinity value -6.6 (kcal/mol). The types of bonds in astragalin compounds are hydrogen bonds with amino acids Glutamine 127 and Arginine 298. From these results, it is predicted that astragalin compounds have the highest potential as alternative drugs to increase body immunity against the COVID-19.
Co-Authors Abdul Hamid A. Toha Abdullah Rozzen Muzayyan Adi Sofyan Ansori, Muhammad Agus Mohammad Hikam Ahmad Taufiq Alik Maulidiyah Annisatul Anis Hakimah Ari Hayati Arifiati, Shinta Arina Roikhana Aulanni'am Aulanni'am Aulanni'am, Aulanni'am Azis Mawardi Azis Mawardi Chintya Ayu Pertiwi Della Aljanna Savita Devi Indrayani Fitri Asari Dewi Qurrot &#039;Aini Dewi, Atikah Nur Shabrina Razan Dyan Aprillia Susanti Eka Kumalasari Fradina, IntanTrixi Gatot Ciptadi Gatra Ervi Jayanti Gatra Ervi Jayanti Hakimah, Annisatul Anis Hasan Zayadi Hatif Khusnin Nida' Hikam, Agus Mohammad Husain Latuconsina Islami, Darajatun Islamya, Nur Afni Auli Ismatud Diniyah Istirochah Pujiwati Januarista, Terra Kamilah, Nahdhiyatun Kharisma, Viol Dhea Kurniasari, Yulia Lestari, Tengku Anggun M. Abdul Qodir Jailani Ma'ruf, Muhammad Maghfiroh, Faldha Laili Malia Anjani Moch Mustakim Moch Mustakim Muchammad Faruq Vikriansyah Muhammad Dailami, Muhammad Musaffak, Taufik Ridwan Nabilah Miftachul Khoiriyah Nafisa Nafisa Nia Novita Nurrohmah Nour Athiroh Abdoes Sjakoer Nur Cahya Kartika Slamet Nur Laily Azizah Nur Mufida Nur Mufida Nurrohmah, Nia Novita Nurul Humaidah Oktavia Rahayu Puspitarini Oktaviana, Nimas Ajeng Pinanti, Honesty Nurizza Pratiwi, Radita Intan Aisyah Radita Intan Aisyah Pratiwi Rahayu Dwi Lestari Ramadhan, Majida Ramizard Rafsanjani Rasyadan Taufiq Probojati Rossa Martha Wulandari Rossa Martha Wulandari Saimul Laili Sama’ Iradat Tito Saputri, Syntia Diyah Hayu Ria Silvia, Putri Azizatul Siti Khoirun Ni’mah Siti Qurrotul Aini Sulis Setiawati Suroyya, Mariyam Sutiman B. Sumitro Sutiman Bambang Sumitro Syaiful Arifin Tengku Anggun Lestari Thiya Fathiyatul Fauziyah Tintrim Rahayu, Tintrim Ula, Erfa Navadiatul Umu Intan Kinasih Vina Fitria Wulandari Waliyyul Ahdi Alhikami Widyananda, Muhammad Hermawan Yunani, Silvi