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Journal : INDONESIAN JOURNAL OF PHARMACY

Niosomes entrapment capacity of ketoprofen and prediction transdermal administration rahman, Latifah; Ismail, Isriany; Wahyudin, Elly
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.378 KB) | DOI: 10.14499/indonesianjpharm0iss0pp85-91

Abstract

Niosomes  are  vesicles  system  that  have  applications in  the  delivery  of lipophilic,hydrophilic  and  amphiphilic  drugs.  Ketoprofen,  is  very  insoluble  in water  and  cause  gastric  irritation  when  taken  orally.  It  is  very  important  to develop a transdermal delivery system for ketoprofen. This research was aimed to  design  niosomes  which  can  deliver  ketoprofen  via transdermal  route. Experiments  were  designed  to  incorporate  ketoprofen into  niosomes   with  lipid film  hydration  method.  Lipid  mixture  consist  of  cholesterol  and  sorbitan  ester (span  20,  60,  80).  Niosomes  which  can  deliver  ketoprofen  trough  the  skin barrier  determined  by  calculating  amount  of   ketoprofen  in  the  blood  of  rabbit. The  type  of  sorbitan  ester  was  chosen  based  on  the  highest  drugs  entrapment and  ketoprofen  as  drugs  model.  Preparation  of  niosomes  was  optimized  for  the highest  percent  drug  entrapment  by  increasing   molar  concentration  of  lipidmixture  with  the  stable  comparison  of  1:1.  This  research  result  are  niosomes with  lipid  mixture  span  60  and  cholesterol  have  the highest  drug  entrapment efficiency  of  niosomes  66.16%  with  range  size  1–6  µm.  Niosomes  can  deliver ketoprofen  to  the  systemic  circulation  via  transdermal  route  with  plasma  level concentration achieved in 1.5 hour.Key words: niosomes, ketoprofen, transdermal 
Co-Authors . Lukman . Mufidah . Subehan A. Prasetiyo, Nugraha Ahmad Fuady Aisyah Fatmawaty Aliyah Aliyah Alkaff, Sylmina D. Amin, Irnawati H. Andi Anggriani Ardiansyah, Akhmad Arif Santoso Asniar Pascayantri Bahar, Muhammad A. Bapulo, Nurdewi N. Bustanul Arifin Cangara, Husni Chaeratunnisa, Rizkya Dewita Fatiah Djaharuddin, Irawaty Dwi Leboe Ermina Pakki Fatmawati Fatmawati Firzan Nainu Gatot S Lawrence Gatot S. Lawrence Gemini Alam Habibie Habibie Hakim, Azima Hardiana, Iyan Hardiyanti, Widya Hasteti Husni - Herlina Rante Herlina Rante Iman Setiawan Inda Pratiwi Indriani Indriani Irawan Yusuf Ismail Ismail Isriany Ismail Jumriani Tammas Kasim, Hasyim Khairuddin - Latada, Nadila P. Latifah Rahman Latifah Rahman M Natsir Djide M Rusdi M. Natsir Djide Madolangan, Jamaluddin Mae Sri Hartati Wahyuningsih Marianti A Manggau Massi, Muhammad N. Mirianti A. Manggau, Mirianti A. Mudjahid, Mukarram Mufidah Mufidah Muh. Akbar Bahar Muhammad Aswad Munawarah Munawarah Munawwaroh, Makiyatul Nasruddin AM Niamuzisilawati, Eva Nurhikma A Pieter, Nova Audrey Luetta Pratama, Muhammad R. Pratiwi, Nadya Purba, Fredrick D. Putri, Tenri ZAD. Rina Agustina Risfah Yulianty Risfah Yulianty Risfah Yulianty Rosany tayeb Sanusi, Mayamariska Sarifah, Latifah M. Sartini Sartini Sarwadan, Muhamad G. Sri Yolandari Sumarheni Sumarheni Sunarti Syamsu Nur, Syamsu Tadjuddin Naid Tuti Handayani Zainal Umar, Abdul H. Utami, Ikrimah N. Veni Hadju Yayuk S. Rahayu Yulia Yusrini Djabir Yusnita Rifai Yuyun Sulitiani Zhulhajsyirah Zhulhajsyirah