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All Journal Majalah Kedokteran Bandung JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal Journal of Dentomaxillofacial Science MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Majalah Patologi Indonesia Jurnal Respirasi (JR) Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat Jurnal Pengabdian Masyarakat Formosa (JPMF) Indonesian Journal of Cancer Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Ika Kustiyah Oktaviyanti
Departemen Patologi Anatomi Fakultas Kedokteran, Universitas Lambung Mangkurat, Banjarmasin, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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HUBUNGAN FAKTOR PREDISPOSISI DENGAN KETERLAMBATAN BEROBAT PASIEN KANKER PAYUDARA LANJUT LOKAL Juliana, Adies; Budiwinata, Winardi; Oktaviyanti, Ika Kustiyah
Homeostasis Vol 7, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i2.13175

Abstract

Abstract: Breast cancer patients often come to the doctor diagnosed at a locally advanced stage. The cause of delay in treatment is influenced by predisposing factors, namely knowledge, family history, education level, attitude, action to seek health facilities, fear, and family income. The study aimed to analyze the relationship between predisposing factors and the delay in treatment of locally advanced breast cancer patients. The study used an analytic observational method with a cross sectional approach. The study respondents were 51 patients with locally advanced breast cancer who sought treatment at the Oncology Surgery Polyclinic and were recorded in the medical records of RSUD Ulin Banjarmasin for the period January 2020-November 2023. Data were collected based on a questionnaire of predisposing factors for delay in treatment. Data analysis used Fisher's test on SPSS and was said to have a significant relationship if p < 0.05. As a result, the majority of respondents were in the inoperable category 96.1% with poor knowledge (84.3%; p=0.022), low education level (51%; p=1), no family history (56.9%; p=0.5), poor attitude (92.2%; p=0.152), poor action to seek health facilities (90.2%; p=0.188), fear of symptoms (82.4%; p=0.152), and low family income (60.8%; p=1). In conclusion, there was a significant association between knowledge and delay in seeking treatment for locally advanced breast cancer patients. Meanwhile, the level of education, family history, attitude, action to seek health facilities, fear and family income did not have a significant relationship with the delay in treatment of locally advanced breast cancer patients. Keywords: breast cancer, locally advanced, predisposing factor, treatment delay Abstrak: Pasien kanker payudara seringkali datang ke dokter terdiagnosis pada stadium lanjut lokal. Penyebab keterlambatan berobat tersebut dipengaruhi oleh faktor predisposisi, yaitu pengetahuan, riwayat keluarga, tingkat pendidikan, sikap, tindakan mencari fasilitas kesehatan, rasa takut, dan penghasilan keluarga. Penelitian bertujuan menganalisis hubungan faktor predisposisi dengan keterlambatan berobat pasien kanker payudara lanjut lokal. Penelitian menggunakan metode observasional analitik dengan pendekatan cross sectional. Responden penelitian adalah 51 pasien kanker payudara lanjut lokal yang berobat ke Poliklinik Bedah Onkologi dan terdata di rekam medis RSUD Ulin Banjarmasin periode Januari 2020-November 2023. Data dikumpulkan berdasarkan kuesioner dan analisis data menggunakan uji Fisher pada SPSS, dikatakan memiliki hubungan signifikan apabila p < 0,05. Hasilnya, mayoritas responden dalam kategori inoperable 96,1% dengan pengetahuan kurang (84,3%; p=0,022) tingkat pendidikan rendah (51%; p=1), tidak memiliki riwayat keluarga (56,9%; p=0,5), sikap kurang (92,2%; p=0,152), tindakan mencari fasilitas kesehatan kurang (90,2%; p=0,188), takut gejala (82,4%; p=0,152), dan penghasilan keluarga rendah (60,8%; p=1). Kesimpulannya, terdapat hubungan signifikan antara pengetahuan dengan keterlambatan berobat pasien kanker payudara lanjut lokal. Aspek tingkat pendidikan, riwayat keluarga, sikap, tindakan mencari fasilitas kesehatan, rasa takut dan penghasilan keluarga tidak terdapat hubungan signifikan dengan keterlambatan berobat pasien kanker payudara lanjut lokal. Kata-kata kunci: kanker payudara, stadium lanjut lokal, faktor predisposisi, keterlambatan berobat
HUBUNGAN DERAJAT DIFERENSIASI DENGAN JUMLAH SEL RADANG LIMFOSIT PADA HISTOPATOLOGI KANKER KOLOREKTAL Wahyuni, Dina; Wibowo, Agung Ary; Oktaviyanti, Ika Kustiyah; Budiwinata, Winardi; Rosida, Lena
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11450

Abstract

Colorectal cancer is the third most common cause of death in the world. Colorectal cancer was ranked third in Indonesia. Colorectal cancer patients had a statistically significant difference in lymphocyte inflammatory cell values compared to healthy controls. Colorectal cancer patients had much higher lymphocyte inflammatory cell values than healthy controls. Lymphocyte infiltration can provide additional prognostic information for treatment options in some situations. Histopathology is an essential factor in determining the diagnosis, treatment management, and prognosis. Histopathological examination of the degree of differentiation can determine whether a neoplasm is malignant. The prognosis of colorectal cancer depends on the presence or absence of metastases and the degree of differentiation; with a histopathological examination, we can see the spread of inflammatory cell infiltration at the degree of differentiation which can be used to determine the prognosis of colorectal cancer. The normality test results of the p-value of inflammatory lymphocyte cells were <0.001. Correlation data analysis using the rank-spearman test showed p>0.05 in colorectal cancer patients at Ulin Hospital Banjarmasin. 
GAMBARAN SEL RADANG AKUT DAN SEL RADANG KRONIK PADA HEMOROID INTERNA Berdasarkan Gambaran Histopatologi Pasien Hemoroid di Laboratorium Patologi Anatomi RSUD Ulin Banjarmasin Tahun 2017-2021 Al Hasani, Siti Atthahirah; Oktaviyanti, Ika Kustiyah; Rosida, Lena; Wibowo, Agung Ary; Ulfah, Maria
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11470

Abstract

Hemorrhoids are dilation and inflammation of the veins in the anus from the hemorrhoidal plexus. Based on histopathological characteristics, hemorrhoids are divided into internal, external and mixed hemorrhoids. Hemorrhoids become inflamed when they experience supporting tissue degeneration, which is divided into acute and chronic inflammation. The study aims to describe acute inflammatory cells and chronic inflammatory cells in internal hemorrhoids at the Anatomical Pathology Laboratory of Ulin Hospital, Banjarmasin, 2017-2021. This study used a descriptive observational method with a cross sectional approach through secondary data collection, using a total sampling technique. Of the 24 preparations, 20 samples (83.33%) showed acute inflammatory cells. In addition, chronic inflammatory cells were found in all samples. In the categorization of chronic inflammatory cells, the highest degree of chronic inflammatory cells was shown, namely moderate degrees of 14 samples (58.33%), 7 samples (29.17%) of severe chronic inflammatory cells, and 3 samples (12.5%) of chronic inflammatory cells. light degree. So it can be concluded that chronic inflammatory cells are found more frequently than acute inflammatory cells.
HUBUNGAN RIWAYAT KELUARGA DENGAN KEJADIAN KANKER PAYUDARA USIA MUDA DI RSUD ULIN BANJARMASIN Zakia, Sukma Dina; Oktaviyanti, Ika Kustiyah; Budiwinata, Winardi; Rahman, Eka Yudha; Rosida, Lena
Homeostasis Vol 7, No 3 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i3.14601

Abstract

Abstract: Breast cancer is a malignant tumor that grows in breast tissue. Family history is the main risk factor for breast cancer because it plays a role in 5-10% of breast cancer cases. This is related to the inheritance of BRCA1 and BRCA2 gene mutations which are more often found at young ages compared to older ages. The research aims to analyze the relationship between family history and the incidence of breast cancer in young people at Ulin Hospital, Banjarmasin. Analytical observational research method, cross sectional design. The sample was taken as a total sampling of breast cancer patients who sought treatment at the Surgical Oncology Polyclinic, Ulin Banjarmasin Regional Hospital for the period January 2020-November 2023 according to the inclusion and exclusion criteria. Data was taken using a questionnaire and analyzed using Fisher's test. The results obtained were respondents who had a family history at a very young age (27.3%), young age (72.7%), who had no family history at a very young age (3.6%), young age (96.4%). ), p-value=0.034. The conclusion is that there is a significant relationship between family history and the incidence of breast cancer at a young age. Keywords: breast cancer, young age, family history. Abstrak: Kanker payudara adalah tumor ganas yang tumbuh dalam jaringan payudara. Riwayat keluarga merupakan faktor risiko utama kanker payudara dikarenakan berperan pada 5-10% kasus kanker payudara. Hal ini berkaitan dengan pewarisan mutasi gen BRCA1 dan BRCA2 yang lebih sering ditemukan pada usia muda dibandingkan usia yang lebih tua. Penelitian bertujuan untuk menganalisis hubungan riwayat keluarga dengan kejadian kanker payudara usia muda di RSUD Ulin Banjarmasin. Metode penelitian observasional analitik, desain cross sectional. Sampel diambil secara total sampling pasien kanker payudara yang berobat ke Poliklinik Bedah Onkologi RSUD Ulin Banjarmasin periode Januari 2020-November 2023 sesuai kriteria inklusi dan eksklusi. Data diambil menggunakan kuesioner dan dianalisis dengan uji Fisher. Hasil didapatkan responden yang memiliki riwayat keluarga pada usia sangat muda (27,3%), usia muda (72,7%), yang tidak memiliki riwayat keluarga pada usia sangat muda (3,6%), usia muda (96,4%), p-value=0,034. Kesimpulan terdapat hubungan yang bermakna antara riwayat keluarga dengan kejadian kanker payudara usia muda. Kata-kata kunci: kanker payudara, usia muda, riwayat keluarga.
HUBUNGAN PAPARAN ASAP ROKOK DENGAN KEJADIAN KANKER PAYUDARA PADA USIA MUDA Ambarita, Winona Vida Vita Nathania; Budiwinata, Winardi; Oktaviyanti, Ika Kustiyah; Priyono, Sasongko Hadi; Rosida, Lena
Homeostasis Vol 7, No 3 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i3.14611

Abstract

Abstract: Breast cancer is often discovered and diagnosed at a young age which is associated with family history, gene mutations, and poor lifestyle. One of the risk factors is exposure to cigarette smoke. The aim of the research is to determine whether there is a relationship between exposure to cigarette smoke and the incidence of breast cancer at a young age at Ulin Regional Hospital, Banjarmasin. Analytic observational research method, cross sectional research design. Total sampling of breast cancer patients who seek treatment at the Oncology Surgery Polyclinic of Ulin Banjarmasin Hospital for the period January 2020-November 2023 according to the inclusion and exclusion criteria. Data collection using questionnaires related to cigarette smoke exposure. Analysis using the Fisher test. The results were young breast cancer respondents exposed to cigarette smoke (91.1%), very young age exposed to cigarette smoke (8.9%), young age not exposed to cigarette smoke (40.0%) and very young age not exposed to cigarette smoke (60.0%) with a p-value = 0.016. In conclusion, there is a significant relationship between exposure to cigarette smoke and the incidence of breast cancer at a young age. Keywords: breast cancer, young age, cigarette smoke exposure Abstrak: Kanker payudara sering ditemukan dan didiagnosa pada usia muda yang dikaitkan dengan riwayat keluarga, mutasi gen, serta gaya hidup yang buruk. Salah satu faktor risiko yaitu terpapar asap rokok. Tujuan penelitian mengetahui apakah terdapat hubungan paparan asap rokok dengan kejadian kanker payudara pada usia muda di RSUD Ulin Banjarmasin. Metode penelitian observasional analitik, desain penelitian cross sectional. Pengambilan sampel total sampling pasien kanker payudara yang berobat ke Poliklinik Bedah Onkologi RSUD Ulin Banjarmasin periode Januari 2020-November 2023 sesuai kriteria inklusi dan ekslusi. Pengambilan data menggunakan kuesioner terkait paparan asap rokok. Analisis menggunakan uji Fisher. Hasilnya responden kanker payudara usia muda yang terpapar asap rokok (91,1%), usia sangat muda yang terpapar asap rokok (8,9%), usia muda yang tidak terpapar asap rokok (40,0%) dan usia sangat muda yang tidak terpapar asap rokok (60,0%) dengan p-value = 0,016. Kesimpulannya terdapat hubungan bermakna antara paparan asap rokok dengan kejadian kanker payudara pada usia muda. Kata-kata kunci: kanker payudara, usia muda, paparan asap rokok.
Effect of Mercury Administration as an Oxidative Stress Trigger in Hepato-Renal Injuries Yuliana, Ida; Triawanti; Prenggono, Muhammad Darwin; Oktaviyanti, Ika Kustiyah; Irfan Maulana; Fahrina Ulfah
JURNAL KESEHATAN LINGKUNGAN Vol. 17 No. 2 (2025): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v17i2.2025.159-167

Abstract

Introduction: Mercury as the source of free radicals can trigger the activation of oxidative stress pathways. With its high toxicity, it can cause hepato-renal injuries. There have been many studies on mercury toxicity in various organs, but there are still few scientific studies that examine the hepato-renal injuries caused by mercury through the oxidative stress pathway. This study was conducted to investigate the triggering of the oxidative stress pathway due to mercury exposure in hepato-renal injuries. Methods: Research using randomized true laboratory experiment method with post-test control group design. The number of samples used was 28 Wistar rats. The research group consisted of 2 groups, control group was given aquadest ad libitum, and intervention group was given water contaminated with mercury per oral once a day (15 kg/WB). The treatment period was 14 consecutive days and on the 15th day, blood samples were taken. Oxidative stress marker was assessed by examining MDA and GPx levels and hepato-renal injuries were assessed by examining liver function (ALT and AST) and kidney function (ureum and creatinine). The collected data were analyzed by independent t-test with 95% confidence level; significant if p>0.05. Results and Discussion: The study found that mercury can trigger the activation of oxidative stress pathways and have an impact on hepato-renal function. Conclusion: Research still needs to be continued to prove that impaired hepato-renal injuries also occur at the cellular histomorphologic and discover other biomolecular mechanisms such as activation of inflammatory pathways that can also cause organ damage.
Differentiation of Malignant Pleural Effusions from Lung Squamous Cell Carcinoma and Adenocarcinoma through FTIR Spectroscopy: A Prognostic Approach Madargerong, Vincentius Adrian; Suhartono, Eko; Oktaviyanti, Ika Kustiyah; Haryati, Haryati; Isa, Mohamad; Assagaf, Ali; Kusumawardhani, Erna; Nurrasyidah, Ira; Syafa’ah, Irmi
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.114-122

Abstract

Introduction: Malignant pleural effusion (MPE) is common in cancer patients and is often caused by neoplastic involvement of the pleural surface. This study aimed to determine the utility of Fourier transform infrared spectroscopy (FTIR) spectral analysis and anatomical pathological differentiation in MPE, squamous cell carcinoma (SCC), and lung adenocarcinoma as prognostic predictors. Methods: This study used a cross-sectional design at Ulin General Hospital, Banjarmasin, involving advanced lung cancer patients with MPE. A non-probability sampling technique was used to recruit 30 patients. Fourier transform infrared spectroscopy was analyzed to evaluate anatomical pathology differentiation. Results: Differences were observed in the FTIR spectral ratios A1080/A1243 and A1080/A1170 between SCC and adenocarcinoma, with p-values of 0.026 and 0.022, respectively. Significant differences were also found in the A2959/A1545 ratio between well-differentiated and poorly differentiated adenocarcinomas, with a p-value of 0.023. The receiver-operating characteristic curve (ROC) indicated good predictive value for poorly differentiated adenocarcinoma at a cut-off value of 0.944, with a sensitivity of 50% and specificity of 100%. However, no significant correlation was found between FTIR absorbance and anatomical pathology differentiation in MPE due to SCC and lung adenocarcinoma. Conclusion: The FTIR spectral ratios A1080/A1243 and A1080/A1170 differentiate SCC from adenocarcinoma. Fourier transform infrared spectroscopy may be an adjunct to cytology, offering a more rapid and cost-effective method for differentiating MPE.
The Effects of Heavy Metal Contamination on Liver Function in a Rat Model Yuliana, Ida; Triawanti, Triawanti; Prenggono, Muhammad Darwin; Oktaviyanti, Ika Kustiyah; Asnawati, Asnawati; Ulfah, Fahrina; Maulana, Irfan
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.145-153

Abstract

Background:  Mining activities in South Kalimantan have been widely associated with the emergence of various health issues through heavy metal contamination in the water. Previous studies have demonstrated that the presence of heavy metals has an impact on physiological alterations inside many organs, notably the liver.Objective: The study aimed to determined the impact of liver damaged from heavy metal of lead (Pb), cadmium (Cd), and mercury (Hg), and the combination of the three in rat model.Methods: Our research used the true experiment laboratory method with a post-test group design. Male white rats (Rattus norvegicus), aged 2–6 months and weighing 250–300 grams, were assigned to the control group and the treatment group. Treatment groups were administered orally with water contaminated with heavy metals of Pb, Cd, and Hg orally for 28 days. The serum markers of liver damaged were then measured.Results: The levels of transaminase enzymes (AST and ALT) in the heavy metal-exposed group were increased compared to the control group. However, the increase was not statistically significant (p = 0.247; p = 0.349, respectively). The group exposed to Hg exhibited the highest levels of AST and ALT in comparison to the other groups.Conclusion: Heavy metal exposure tend to raise transaminase enzyme levels, indicating liver damage. Hg exhibited the greatest transaminase value increase of all heavy metals, indicating its highest potential for liver toxicity.
Co-Authors AA Sudharmawan, AA Achmad Rudijanto Agung Ary Wibowo Agung Ary Wibowo Agung Ary Wibowo Agung Ary Wibowo, Agung Ary Ahmad Marzuki Rifki Hanafi Ahmad Marzuki Rifki Hanafi, Ahmad Marzuki Rifki Al Hasani, Siti Atthahirah Alfi Yasmina Ali Assagaf Alifah Nadia Ambarita, Winona Vida Vita Nathania Anak Agung Istri Sri Wiadnyani Arganita, Fidya Rahmadhany Ariska Endariantari Asnawati Asnawati Asnawati Asnawati Brian Hansen Efraim Sitompul Budiwinata, Winardi Desi Rahmawaty Dewi Nurdiana Dini Desviana Rahmayanti Dini Desviana Rahmayanti, Dini Desviana Djanggan Sargowo Djanggan Sargowo Eka Yudha Rahman Eka Yudha Rahman Eka Yudha Rahman Eko Suhartono Eko Suhartono Erna Yulida Fadhil Hafidza Fahrina Ulfah Fatmathalia Ranti Firman Aprilianto Widodo Gading Aurora Puspita Kencana Haryati Haryati Hasfira, Fairuz Izdihar Hendra Sutapa Hendra Sutapa Heni Pujiastuti Hery Poerwosusanta Hery Poerwosusanta Hidayat Sujuti Hilda Ayu Setyawati Hilda Ayu Setyawati, Hilda Ayu Holly Diani Ida Yuliana Ida Yuliana Ira Nurrasyidah Irfan Maulana Irfan Maulana, Irfan Isa, Mohamad Isnaini Isnaini Istiana Istiana Istiana Istiana Juliana, Adies Kanessha Winola Sunata Karyono Mintaroem Karyono Mintarum Khairini Putri Khatimah, Husnul Kusumawardhani, Erna Lena Rosida Lena Rosida Lena Rosida Madargerong, Vincentius Adrian Maharani Laillyza Apriasari Maria Ulfah Mohammad Aris Widodo Muhammad Abianovan Ramadhan Muhammad Ajib Nuzula Muhammad Ali Faisal Muhammad Rizki Syabana Muhammad Sahal Imaduddin Muhammad Sahal Imaduddin, Muhammad Sahal Muthmainah, Noor Nazwa Salsabila Hadni Nurdiana Dewi Nurrafi Aliya Khasanah Oscar Tri Joko Putra Prenggono, Muhamad Darwin Priyono, Sasongko Hadi Rahmiati Rahmiati Rosmitha Monikayani Salma Nurul Ahyati Sasongko Hadi Priyono Sukses Hadi Syafa’ah, Irmi Tenri Ashari Wanahari Triawanti Triawanti Triawanti Ulfah, Fahrina Wahyuni, Dina Widya Noor Haliza Widya Shoffa Rosyida Widya Wulan Fitri Winardi Budiwinata Winardi Budiwinata Zakia, Sukma Dina