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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Pharmascience Jurnal Farmasi Sains dan Komunitas JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Mandala Pharmacon Indonesia Jurnal Pengabdian Kepada Masyarakat (Mediteg) Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Abdi Masyarakat Kita JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Farmasi Sains dan Praktis Jurnal Bakti Untuk Negeri JURNAL JAMU KUSUMA Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Sinteza Jurnal Ilmiah Kesehatan Jurnal Pengabdian Masyarakat Panacea
Nur Mahdi
Universitas Lambung Mangkurat
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Journal : Sinteza

 1 
Bioactive Compound Profiling of Ethyl Acetate Fraction from Oil Palm (Elaeis guineensis Jacq.) Leaves using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS) Setiawan, Deni; Hadi, Samsul; Mahdi, Nur; Mardiati, Nurul; Normaidah; Hadiah Akbar, Nabila; Rasyid Ridha, Muhammad; Apriliany, Fitri
Sinteza Vol. 5 No. 2 (2025): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i2.30147

Abstract

Oil palm leaves could yield various health benefits, potentially leading to innovative applications in natural remedies, supplements, and dietary products. Targeted extraction and sophisticated analytical methods have become necessary for investigating bioactive compounds in plant materials. The combination of liquid chromatography and high-resolution mass spectrometry (LC–HRMS) makes for a potent technique for analyzing a wide range of metabolites, allowing for the precise and sensitive identification of various plant compounds. This investigation aimed to examine the active compounds in the ethyl acetate fraction of Elaeis guineensis leaves using LC–HRMS to identify potential new avenues for drug research. The simplicia was extracted by completely immersing 500 g of granules in acetone for three days. The crude extract was fractionated with n-hexane, ethyl acetate, and n-butanol solvents to separate components according to their polarity. The ethyl acetate part was analyzed using LC–HRMS with specific settings, including a temperature of 30°C and a gas flow rate of 11.01 L/min. The extract yield from dense oil palm leaves was 32.5 g, equivalent to 6.5%. Subsequently, the components were separated by fractionating the complete yield. The n-hexane fraction yield was 7.085 g or 21.83%, the ethyl acetate fraction yield was 3.38 g or 10.4%, the n-butanol fraction yield was 8.84 g or 27.2%, and the remaining fraction yield was 3.93 g or 12.1%. In conclusion, oil palm leaves are a prospective source of zingerol compounds, suggesting potential to be used as an alternative to rhizomes.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Bintaro (Cerbera odollam) dalam Menghambat Pertumbuhan Streptococcus mutans dan Escherichia coli Mahdi, Nur; Susanti, Susi; Agustina, Ani; Mukhlis, Andi Zsazsa Rafiatul
Sinteza Vol. 4 No. 1 (2024): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i1.21431

Abstract

Tanaman bintaro (Cerbera odollam) salah satu dari banyak tanaman antimikroba yang ditemukan di Indonesia. Tanaman bintaro efektif dalam mengendalikan serangan hama, namun dalam penelitian antibakteri belum banyak diteliti. Penelitian ini bertujuan untuk menguji aktivitas antibakteri ekstrak etanol daun bintaro menghambat pertumbuhan bakteri Streptococcus mutans dan Escherichia coli. Penelitian ini menggunakan metode eksperimental untuk menguji aktivitas antibakteri menggunakan metode difusi cakram. Pengujian dilakukan dengan menggunakan konsentrasi ekstrak daun bintaro terdiri dari 25%, 50%, 75%, dan 100%, kemudian dilanjutkan dengan analisis data menggunakan uji Kruskal Wallis dan uji Chi Square. Hasil penelitian menunjukkan bahwa ekstrak etanol daun bintaro memiliki sifat antibakteri. Pada konsentrasi ekstrak 75% terhadap Streptococcus mutans diperoleh rata-rata zona hambat sebesar 6,125 mm dengan kategori daya hambat sedang dan pada Escherichia coli diperoleh rata-rata zona hambat sebesar 6,5mm. Kemudian pada pada konsentrasi 100% diperoleh pada kedua bakteri tersebut dengan zona hambat 7,5 mm dengan kategori daya hambat sedang. Uji Kruskal Wallis diperoleh nilai signifikansi sebesar 0,003 atau (p < 0,05) menunjukkan perbedaan bermakna. Uji Chi Square menunjukkan nilai signifikansi untuk Streptococcus mutans sebesar 0,433 atau (p < 0,05) dan Escherichia coli sebesar 0,433 atau (p < 0,05). Pada konsentrasi 100% diameter zona hambat 7,5 mm, hasil ekstrak etanol daun bintaro menunjukkan aktivitas antibakteri dengan kategori sedang terhadap bakteri Streptococcus mutans dan Escherichia coli.
Formulasi Sediaan Sabun Cair Ekstrak Daun Ramania (Bouea macrophylla Griffith) sebagai Antiseptik Mahdi, Nur; Rezekiah, Rezekiah; Ani, Agustina
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.25475

Abstract

Ramania leaves (Bouea macrophylla Griffith) are natural ingredients that have activity as an antiseptic. Ramania leaves contain flavonoids, alkaloids, steroids and tannins. This study aims to make antiseptic liquid soap from ramania leaf extract with a concentration of 5%, 10%, 15%. This study used experimental methods in the laboratory. three formulations were made (FI, FII, FIII with a concentration of 5%, 10%, 15%). Evaluation includes organoleptic, homogeneity, pH, specific gravity, foam height. Antiseptic test was carried out using the zigzag method. he antiseptic test was carried out using the replica method. The statistical test for evaluating preparations is One Way Anova, for antiseptic testing using Paired sample t-test. The results of several evaluations have met the requirements, except that the specific gravity does not meet the SNI criteria. The antiseptic test is indicated by the percentage of bacterial reduction. The percentage of bacterial reduction in FI, II, and III respectively was 40.5; 48.5; and 57.5%. It can be seen that increasing the extract concentration can reduce the number of bacterial colonies. The results of the One Way Anova statistical test (a = 0.05) showed that there was no difference in the results of the preparation evaluation, the results of the paired sample test (a = 0.05) showed a significant difference in the antiseptic test. Based on the results of research on the specific gravity test however all formulas do not meet the criteria. In the antiseptic test, all formulas were effective in inhibiting bacterial growth.
Co-Authors Agustina, Ani Agustina, Ni Kadek Ayu Akbar, Nabila Hadiah Alpia Damayanti Andi Sultang Andi Sultang AS Andi Zsazsa Rafiatul Mukhlis Anggreni, Nova Ani Agustina Ani Agustina Ani Agustina Ani, Agustina Aulia, Hilma Buih, Putri Helena Junjung Chatarina Umbul Wahyuni Deni Setiawan Deni Setiawan DENI SETIAWAN Diky Mudhakir DOLIH GOZALI Dolih Gozali Dyah Ariani Perwitasari Dyah Aryani Perwitasari Farhandika Putra Fatmawati Fitri Apriliany, Fitri Fitriyati, Fitriyati Hamiddani Syaiful, Raisha Hardianti, Sitti Iis Wahyuningsih Izma, Hayatun Liling Triyasmono Maghfirah, Rahmayani Mahdi, Lukman Malahayati, Siti Maryani, Henny Melindawati, Vina Moch. Saiful Bachri Muhammad Ikhwan Rizki Muhammad Rasyid Ridha Muhammad Riki Shindi Praristiya Mukhlis, Andi Zsazsa Rafiatul Muliasari, Dreiyani Abdi Mustika Muthaharah Mustika Muthaharah Nabila, Nabila Nashrul Wathan Noorma Yahni Normaidah, Normaidah Nur Meina Anjeli Nur Meina Anjeli Nuraini Manurung Nurul Mardiati Nyoman Kertia Pertiwi, Hana Retno Rahmayani Maghfirah Rahmayani Maghfirah Raisha Hamiddani S Raisha Hamiddani Syaiful Rakhil Zulfansyah Ratnapuri, Prima Happy Rezekiah, Rezekiah Rikha Arliandini Rinda, Ririn Purnama Samsul Hadi Samsul Hadi Sapto Yuliani Sari, Okta Mutia Savitri, Riswandayani Shindi, Muhammad Riki Siti Nur Farida Sofa, Maida Solly Aryza Sri Mulyaningsih Sri Sulistyorini, Sri Susi Susanti Syaiful, Raisha Hamiddani Tuty Alawiyah Ulfah Wilda Maulida Nur Fatimatuzzahra