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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Sains dan Komunitas JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Mandala Pharmacon Indonesia Jurnal Pengabdian Kepada Masyarakat (Mediteg) Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Abdi Masyarakat Kita JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Farmasi Sains dan Praktis Jurnal Bakti Untuk Negeri JURNAL JAMU KUSUMA Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Sinteza Jurnal Ilmiah Kesehatan Jurnal Pengabdian Masyarakat Panacea JPEPT Journal of Pharmascience
Nur Mahdi
Universitas Lambung Mangkurat
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Uji Efek Analgetik Ekstrak Etanol Kulit Buah Langsat (Lansium domesticum var. pubescens) Secara In Vivo Pertiwi, Hana Retno; Mahdi, Nur; Syaiful, Raisha Hamiddani
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.601

Abstract

Nyeri merupakan perasaan sensitif yang tidak menyenangkan dikarenakan cedera jaringan. Pengobatan nyeri menggunakan tanaman obat sudah banyak dikenal masyarakat salah satunya adalah tanaman langsat (Lansium domesticum var. pubescens). Tujuan penelitian ini adalah untuk mengetahui efek analgetik ekstrak etanol kulit buah langsat (EEKBL) secara in vivo. Metode yang digunakan yaitu eksperimental dan metode Writhing test. Sebanyak 25 ekor mencit digunakan sebagai hewan percobaan, yang dibagi ke dalam lima kelompok: kontrol negatif diberi Na-CMC 0,5%, kontrol positif diberi parasetamol, serta tiga kelompok dosis berbeda, yaitu dosis I (80 mg/kgBB), dosis II (160 mg/kgBB), dan dosis III (240 mg/kgBB). Diamati geliat dan total persen proteksi jumlah geliat dan uji hipotesis menggunakan ANOVA. Hasil persentase proteksi menunjukkan bahwa kontrol positif (parasetamol) sebanyak 39,91% dan untuk ketiga kelompok perlakuan menunjukkan persen proteksi yaitu dosis I sebanyak 34,45%, dosis II sebanyak 47,04%, dan dosis III sebanyak 68,59%. Hasil analisis ANOVA pada semua kelompok perlakuan terdapat perbedaan bermakna (p<0.05). Dapat disimpulkan bahwa EEKBL memiliki efek analgetik dan pada dosis II dan dosis III EEKBL memiliki persen efektivitas analgetik lebih tinggi dari parasetamol yaitu berturut-turut sebesar 117,87% dan 171,86%.
Peningkatan Produktivitas Hortikultura Melalui Pembuatan dan Aplikasi Bioaktivator Pada Kelompok Wanita Tani (KWT) Sri Rejeki Setiawan, Deni; Hadi, Samsul; Wathan, Nashrul; Mardiati, Nurul; Mahdi, Nur; Mahdi, Lukman; Aulia, Hilma; Sofa, Maida; Ulfah
Jurnal Pengabdian Kepada Masyarakat (MEDITEG) Vol. 10 No. 2 (2025): Jurnal Pengabdian Kepada Masyarakat (MEDITEG)
Publisher : Pusat Penelitian dan Pengabdian Kepada Masyarakat (P3M) Politeknik Negeri Tanah Laut (Politala)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34128/mediteg.v10i2.378

Abstract

Sektor hortikultura berperan penting dalam perekonomian Indonesia, namun produktivitasnya masih terhambat oleh penurunan kualitas tanah, biaya pupuk yang tinggi, serta rendahnya pemanfaatan teknologi ramah lingkungan. Kelompok (KWT) Sri Rejeki yang berada di Kota Banjarbaru menghadapi kendala serupa karena masih bergantung pada pupuk anorganik sehingga pendapatan bersih dapat berkurang hingga 20% karena peningkatan harga pupuk. Novelty program ini terletak pada pengembangan bioaktivator berbahan lokal yang mudah diperoleh di lingkungan KWT Sri Rejeki serta integrasi pelatihan teori dan praktik, mulai dari pembuatan dan fermentasi hingga penerapan langsung bioaktivator pada lahan hortikultura anggota KWT. Untuk menjawab permasalahan tersebut, kegiatan pengabdian masyarakat dilaksanakan melalui penyuluhan dan pelatihan pembuatan serta aplikasi bioaktivator berbahan dasar limbah sayuran dan empon-empon. Kegiatan berlangsung pada 11 Juni–13 Agustus 2025 dengan peserta sebanyak 20 orang anggota KWT. Tahapan kegiatan meliputi identifikasi permasalahan, koordinasi, persiapan, pelaksanaan praktik, serta pelaksanaan pre-test, post-test, dan observasi lapangan. Hasil kegiatan meningkatkan pengetahuan peserta dari nilai awal 45% menjadi 82%, serta keterampilan 85% peserta dalam memproduksi bioaktivator cair secara mandiri. Aplikasi bioaktivator terbukti memperbaiki tekstur lahan, mendorong pertumbuhan tanaman, dan meminimalisir ketergantungan pada pupuk kimia. Program ini efektif dalam meningkatkan kapasitas petani terhadap teknologi bioaktivator, sekaligus mendukung keberlanjutan lingkungan melalui pemanfaatan limbah organik.
Biomedicine Potential of Oil Palm (Elaeis guineensis) Leaves: In Vitro Evaluation of Antibacterial, Antibiofilm, and Antioxidant Activities Setiawan, Deni; Hadi, Samsul; Mahdi, Nur; Mardiati, Nurul; Dwi Sandi, Dita Ayulia; Ridha, Muhammad Rasyid; Bachri, Moch. Saiful
BORNEO JOURNAL OF PHARMASCIENTECH Vol 10 No 1 (2026): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v10i1.794

Abstract

Oil palm (Elaeis guineensis) leaves possess diverse pharmacological properties with promising development potential, particularly as antibiofilm and antioxidant agents. This study aimed to evaluate the antibacterial, antibiofilm, and antioxidant activities of E. guineensis leaf extract. The leaves were macerated in acetone for five days. Antibacterial activity was determined using the disc diffusion method against four bacterial species: Staphylococcus aureus, Propionibacterium acnes, Escherichia coli, and Pseudomonas aeruginosa. The extract exhibited moderate antibacterial activity, with the highest inhibition observed against P. acnes (6.79 mm at 25%). Antibiofilm activity was evaluated using a microdilution method, showing concentration-dependent inhibition, with the highest activity at 1% concentration, reaching 83.90% (mid-phase, S. aureus) and 71.28% (E. coli). Antioxidant activity was assessed using DPPH, FRAP, and ABTS assays, yielding IC50 values of 99.19 ppm, 119.12 ppm, and 123.37 ppm, respectively, indicating moderate antioxidant capacity (IC50 > 50-150 ppm). Overall, E. guineensis leaf extract demonstrates moderate antibacterial, antibiofilm, and antioxidant activities, suggesting its potential as a preliminary candidate for further pharmacological investigation.
Formulation of Form Gel Peel Off Mask from Ethanol Extract of Hibiscus Rosa-Sinensis L. Leaves Intana Merdeka Sari; Nur Mahdi; Raisha Hamiddani Syaiful
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 1 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i1.4

Abstract

Cosmetics made from synthetic materials can cause side effects and damage the natural shape of the skin. One of the cosmetics that can repair, care for facial skin, cleanse and moisturize the skin is a peel-off gel face mask. Hibiscus leaves have the potential to be antibacterial containing flavonoids, saponins and polyphenols. This study aims to determine the optimal formulation of a peel-off gel mask preparation of ethanol extract of Hibiscus leaves (Hibiscus rosa-sinensis L) with concentrations of 40%, 60% and 80%. The method used is the Experimental method. The results of the evaluation test of the physical properties of the peel-off gel mask preparation showed that all formulas met the requirements for a good peel-off gel mask. Analysis of research data with one way ANOVA produced a pH test sig. 0.168> 0.05, a spread power test sig. 0.392> 0.05 showed no significant difference in each formula group while in the adhesion test sig. 0.000 < 0.05, drying time test 0.008 < 0.05, viscosity test 0.010 < 0.05 showed significant differences in each formula group. The peel-off gel mask formula of hibiscus leaf ethanol extract (Hibiscus rosa-sinensis L) which has the most optimal physical properties of the preparation is a formula with a concentration of 80%.
FORMULATION AND EFFECTIVENESS TEST OF ANTISEPTIC LIQUID HAND WASHING SOAP PREPARATION FROM TARO LEAF ETHANOL EXTRACT (Colocasia esculenta) Elvita Nurwahdini; Nur Mahdi; Ani Agustina
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 1 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i1.5

Abstract

The use of natural ingredients as active ingredients with antibacterial activity for making hand soap is still very little. The researcher is interested in conducting research on the formulation and effectiveness test of antiseptic liquid hand soap preparations from ethanol extract of taro leaves (Colocasia esculenta). The extraction process using 70% ethanol solvent at a ratio of 1:10 for 3x24 hours. Phytochemical screening tests were carried out by testing flavonoid compounds, alkaloids, saponins, tannins, and terpenoids. We prepared a Liquid Hand Washing Soap from Taro Leaf Extract (Colocasia esculenta) using a standard formula with three concentrations. Antiseptic Effectiveness Test of Liquid Hand Washing Soap. The method used is the zigzag method. The extraction results obtained were 21.10 grams or 14.06%. The results of the phytochemical screening test were only steroids that showed negative results. Preparation of liquid handwashing soap with concentrations of ethanol extract from taro leaves at 4%, 6%, and 78% can reduce the number of colonies by 30.9%, 51.9%, and 52.5%, respectively.
EFFECTIVENESS TEST OF LARVACIDE FROM COCOR BEBEK LEAF EXTRACT (Kalanchoe pinnata L.) ON Aedes albopictus MOSQUITO LARVAE Sindi Ahmayanti; Nur Mahdi; Andi Zsazsa RM
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 1 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i1.7

Abstract

Dengue Hemorrhagic Fever (DHF) is a disease transmitted by female mosquitoes of the species Aedes aegypti, but sometimes also by Aedes albopictus, which has spread worldwide recently. The goal of this study was to find out how well Kalanchoe pinnata L. (life plant) leaf extract killed Aedes albopictus mosquito larvae. This study used 600 Aedes albopictus larvae in an experimental laboratory setting with a control group that only took the post-test. There were 6 treatment groups: Manila tamarind leaf extract concentrations of 0.2 mg/ml, 0.4 mg/ml, 0.6 mg/ml, and 0.8 mg/ml; a positive control group with temephos; and a negative control group with distilled water. Observations were conducted 24 hours after treatment, with larval mortality counted every hour. The probit analysis indicated that the LC90 for Kalanchoe pinnata L. leaf extract was 12.779 mg/ml, and the LT50 at 0.8 mg/ml, which was the concentration that killed the most quickly, was 48,058 hours. The results show that an extract from Kalanchoe pinnata L. leaves can kill Aedes albopictus mosquito larvae.
ANALGESIC POWER TEST OF MAHOGANY LEAF EXTRACT (Swietenia mahagoni) ON MALE MICE (Mus musculus. L) Linda Sari; Nur Mahdi; Ani Agustina
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 1 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept(journalofpharmacologyexperimentandpharmaceuticaltechnology).v1i1.8

Abstract

Mahogany leaves (Swietenia mahagoni) have flavonoids in them that might help with pain by stopping the cyclooxygenase enzyme from working. The purpose of this study is to see if compounds from mahogany leaves (Swietenia mahagoni) can help relieve pain in mice that have been given acetic acid. This study used the chemical stimulation method (writhing). Twenty-five mice were divided into 5 treatment groups, namely group 1 was given Na-CMC as a negative control, group 2 was given paracetamol at a dose of 1.3 mg/20 gBW as a positive control, and groups 3, 4, and 5 were given mahogany leaf extract (Swietenia mahagoni) at a dose of 2.8 mg/20 gBW, 5.6 mg/20 gBW, and 11.2 mg/20 gBW. Each group was given treatment orally; 30 minutes later, the mice were injected with 1% acetic acid intraperitoneally. Additionally, researchers observed and counted the number of wriggles every 15 minutes for a duration of 90 minutes. This study shows that the ethanol extract of mahogany leaves (Swietenia mahagoni) at a dose of 11.2 mg/20 g BB with a 100% success rate can relieve pain.
Test of the tonic effects of dragon fruit extract (cortice hylocereus polyrhizus) on white miice Nurul Wahdah; Muhammad Riki Shindi Praristiya; Nur Mahdi
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 1 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i1.9

Abstract

Stamina is the body's resistance to fight fatigue within a certain time limit of a person's physical ability to survive at work. Dragon fruit skin contains flavonoid compounds, which have a tonic effect on male mice. This study aims to examine the tonic effect and the dosage used in male mice. We use the Natatory Exhaustion method to determine how drugs affect the coordinates of motion, especially when they reduce central nervous control. This research is an experimental research study. This study falls under the experimental research category. They were divided into 5 treatment groups: group I received Caffeine 100 mg/KgBB as a positive control, group II received Na-CMC as a negative control, and groups III, IV, and V received extract from dragon fruit peel (Cortice Hylocereus Polyhirzus) at doses of 750 mg/KgBB, 1000 mg/KgBB, and 1250 mg/KgBB. We administered oral treatments to each group. Next, observe the length of the mice's swimming duration. The test results data were analysed by the ANOVA analysis method. The results indicated that the extract from dragon fruit peel had a tonic effect on male mice, compared to positive and negative control doses. The three groups of dragon fruit peel extract had different swimming durations of 5.32 minutes, 5.45 minutes, and 5.92 minutes, respectively.
Formulation and Evaluation of the Physical Stability of Liquid Soap Preparations with Sonneratia caseolaris Leaf Extract Muhammad Syarif Hidayatullah; Andi Zsazsa Rafiatul Muklis; Raisha Hamiddani Syaiful; Nur Mahdi
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.11

Abstract

Red pidada leaf (Sonneratia caseolaris L.) is a plant that has benefits as an antioxidant with active compounds such as alkaloids, flavonoids, tannins, terpenoids, and saponins. Usually the local community uses this plant as a wet pupur. The purpose of this study was to determine whether red pidada leaves can be formulated into a liquid soap preparation that meets the requirements of physical properties and stability evaluation. This type of research is true experimental laboratory. Extraction of red pidada leaves is carried out by maceration using ethanol as a solvent. The formulation used three extract concentrations, namely F1 (2%), F2 (4%), and F3 (8%). Parameters carried out in the form of physical properties testing, including organoleptic test, pH, specific gravity, viscosity, foam resistance and stability testing with the cycling test method. The results of organoleptic physical properties testing on the three formulations showed that the F1 preparation was light brown, F2 brown, and F3 dark brown, had a distinctive aroma and had a liquid consistency in F1 and slightly thick in F2 and F3. Testing of pH, specific gravity, viscosity and foam resistance in the three formulations has met the requirements, except for the specific gravity test in the F3 preparation. Testing with the cycling test method has affected the evaluation of physical properties in the three formulations which causes a very thick consistency in the preparation. So that the tests that meet the requirements are only the pH and foam resistance tests, while the specific gravity is only in the F1 preparation.
EXPLORING THE ANTIDIABETIC POTENTIAL OF LANGSAT (Lansium Domesticum L.): A COMBINED EXTRACT APPROACH IN VIVO Juliana Handyka Rosanty Hutasoit; Andi Zsazsa Rafiatul Muklis; Nur Mahdi
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.12

Abstract

Diabetes Mellitus is a chronic condition caused by increased blood glucose levels due to the body no longer being able to produce enough insulin hormone or use insulin effectively. Traditional medicine has long used Langsat, a native plant of Indonesia. Langsat is widely used by the community in treating various diseases, including as a worm medicine, fever medicine, diarrhoea medicine, and cancer medicine. This study aims to find out how well a mix of antidiabetics works with EKDL (Lansium domesticum L) in lowering blood sugar levels in male white mice (Mus musculus) and to figure out the best dose of EKDL for reducing blood sugar in the mice. Experimental research method using 35 white male mice divided into 7 groups, each group containing 5 mice, namely negative control, positive control, EK, ED, EKKDL 1:1, EKKDL 2:1, and EKKDL 1:2. The results of the ANOVA test of the EKKDL dose 1:2 (200 mg / 240 mg / kgBW) were effective in reducing blood sugar levels in mice. Analysis of blood sugar level data of mice using paired T-tests and post hoc. The results of the paired t-test showed a significant difference in blood sugar levels after treatment (p <0.005) and the results of the post hoc test showed that there was a significant difference (p < 0.005) and there was no significant difference (p > 0.005) between all EKKDL in reducing blood sugar levels in mice. The combination of langsat skin and leaf extract (Lansium domesticum L.) has effectiveness in reducing blood sugar levels in experimental animals.
Co-Authors Agustina Ani Agustina, Ani Agustina, Ni Kadek Ayu Alpia Damayanti Andi Sultang Andi Sultang AS Andi Zsaza Rafiatul Muklis Andi Zsazsa Rafiatul Mukhlis Andi Zsazsa Rafiatul Mukhlis Andi Zsazsa Rafiatul Muklis Andi Zsazsa RM Anggreni, Nova Ani Agustina Ani Agustina Ani Agustina Ani Agustina Ani Agustina Aulia, Hilma Ayulia Dwi Sandi, Dita Buih, Putri Helena Junjung Chatarina Umbul Wahyuni Deni Setiawan Deni Setiawan Diky Mudhakir Dinna Fitria Kumala Dolih Gozali Dyah Ariani Perwitasari Dyah Aryani Perwitasari Elvita Nurwahdini Farhandika Putra Fatmawati Fitriyati, Fitriyati Hardianti, Sitti Hema Novita Rendati Iis Wahyuningsih Intana Merdeka Sari Izma, Hayatun Juliana Handyka Rosanty Hutasoit Liling Triyasmono Linda Sari Lukman Mahdi Maghfirah, Rahmayani Mahdi, Lukman Malahayati, Siti Maryani, Henny Melindawati, Vina Moch. Saiful Bachri Mochammad Saiful Bachri Muhammad Ikhwan Rizki Muhammad Rasyid Ridha Muhammad Riki Shindi Praristiya Muhammad Riki Shindi Praristiya Muhammad Syarif Hidayatullah Mustika Muthaharah Mustika Muthaharah Nashrul Wathan Nidha Luthfiana Fawziah Noorma Yahni Normaidah, Normaidah Novia Fahrina Purnama Sari Nur Meina Anjeli Nur Meina Anjeli Nuraini Manurung Nurul Mardiati Nurul Wahdah Nyoman Kertia Pertiwi, Hana Retno Rahmatullah, Satrio Wibowo Rahmayani Maghfirah Rahmayani Maghfirah Rahmayani Maghfirah Raisha Hamiddani Syaiful Raisha hamiddani Syaiful Rakhil Zulfansyah Ratnapuri, Prima Happy Rezekiah Rezekiah Rikha Arliandini Rina Astiyani Jennah Rinda, Ririn Purnama Risa Susanti Rita Muliyani Samsul Hadi Samsul Hadi Sapto Yuliani Sari, Okta Mutia Savitri, Riswandayani Shindi, Muhammad Riki Sindi Ahmayanti Siti Nur Farida Sofa, Maida Sri Mulyaningsih Sri Mulyaningsih Sri Sulistyorini, Sri Susi Susanti Syaiful, Raisha Hamiddani Titin Maulida Tuty Alawiyah Ulfah Wilda Maulida Nur Fatimatuzzahra Yuniarti Suryatinah