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All Journal Farmaka Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional The Indonesian Biomedical Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Penelitian Farmasi Indonesia SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JOPS (Journal Of Pharmacy and Science) JISIP: Jurnal Ilmu Sosial dan Pendidikan Jurnal Ilmu Kefarmasian Indonesia Jurnal Riset Kefarmasian Indonesia JPK: Jurnal Proteksi Kesehatan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Masyarakat Medika Sinteza Jurnal Farmasi Indonesia Jurnal Pengabdian Masyarakat Borneo Journal of Pharmacy Jurnal Medika: Medika Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan

Meiriza Djohari, Meiriza

Sekolah Tinggi Ilmu Farmasi Riau

Author-ID : 3415695

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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IDENTIFIKASI DAN UJI AKTIVITAS DAYA HAMBAT EKSTRAK ETANOL BIJI PINANG (Areca catechu L.) TERHADAP ISOLAT BAKTERI GUSI: IDENTIFIKASI DAN UJI AKTIVITAS DAYA HAMBAT EKSTRAK ETANOL BIJI PINANG (Areca catechu L.) TERHADAP ISOLAT BAKTERI GUSI rina Lestari; meiriza djohari; Syilfia Hasti
Jurnal Penelitian Farmasi Indonesia Vol. 7 No. 2: JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (290.975 KB)

Periodontal prevalence in all age groups in Indonesia is 96.58%. The main cause ofperiodontal is microorganisms in dental plaque. Control of plaque reduction can be done using natural ingredients which contain antibacterial, one of which is areca nut seed (Areca catechu L.). This research aims to determine the type of bacteria on the gums, and to determine the antibacterial activity of ethanol extract of areca nut (Areca catechu L.) on gums' bacteria isolate. Antibacterial activity test used Agar diffusion method with concentration series 10%, 20%, 30%. The results of phytochemical screening of areca nut seed ethanol extract showed the presence of alkaloids, terpenoids and flavonoids. The results from the identification test based on macroscopic, microscopic, and biochemical observations obtained two Gram-positive bacteria (Staphylococcus epidermidis and Streptococcus sp) and one Gram-negative bacteria (Enterobacter aerogenes). Antibacterial activity test of ethanol extract of areca nut seed (Areca catechu L.) on gums' bacterial isolates was analyzed statistically with One Way Anovaand alternative test withKruskal-Wallis . Antibacterial activity of ethanol extract of areca nut seed (Areca catechu L.) on Staphylococcus epidermidis and Streptococcus spbacteria at concentrations of 10%, 20%, and 30% showed significant difference diameter of inhibitory power compared to positive and negative controls on Enterobacter aerogenes bacteria at concentration of 10 %, 20%, and 30% showed that the diameter of inhibitory power was significantly different compared to positive controls and not significantly different compared to negative controls.

UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN TUMBUHAN AKAR KAIK-KAIK (Uncaria cordata (Lour) Merr) TERHADAP MENCIT PUTIH JANTAN (Mus musculus L) Meiriza Djohari; Noveri Rahmawati; Nur Indah Melati
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1402

Research on the acute toxicity test of the ethanol extract of kaik-kaik (Uncaria cordata (Lour) Merr) leaves has been carried out on male white mice (Mus musculus L.). This study aims to determine the effects of acute and delayed toxicity of the ethanol extract of kaik- kaik root (Uncaria cordata (Lour) Merr) leaves by determining the LD50 value. The experimental animals were divided into 4 groups, namely the negative control group (NaCMC), and the ethanol extract group of kaik-kaik root leaves with doses of 200, 1000, and 5000 mg / KgBB. The results showed that the LD50 value was> 5000 mg / kg BW and was included in the practical non-toxic category. In the observation, there were no tremors, seizures, salivation, diarrhea, lethargy, weakness, sleep, and coma in each experimental animal.

Analisis Outcome Terapi Amikasin Terhadap Penurunan Sesak Pada Pneumonia Pediatrik di Instalasi Rawat Inap RSUD Arifin Achmad Provinsi Riau Septi Muharni; Sulastri; Nesa Agistia; Husnawati; Fina Aryani; Meiriza Djohari
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 1 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Amikasin merupakan salah satu antibiotik golongan aminoglikosida yang bersifat bakterisid dan termasuk dalam golongan obat indeks terapi sempit. Penggunaan antibiotik harus tepat agar outcome terapi tercapai maksimal. Penelitian ini bertujuan untuk melihat korelasi penggunaan antibiotik amikasin terhadap pencapian outcome terapi penurunan sesak pada pneumonia pediatrik di RSUD Arifin Achmad Provinsi Riau. Jenis penelitian ini adalah penelitian observasional dengan metode deskriptif dengan pendekatan secara retrospektif pada 20 rekam medis pasien pneumonia pediatrik yang mendapatkan amikasin dengan menggunakan teknik purposive sampling di RSUD Arifin Achmad Provinsi Riau. Berdasarkan analisis korelasi jenis kelamin dan rentang usia berkorelasi sedang dan tidak bermakna dengan outcome terapi amikasin (r=0,404 dan nilai p=0,143), (r=0,452 dan nilai p=0,274) dan tingkat keparahan pernapasan terhadap outcome terapi penggunaan amikasin didapatkan korelasi kuat dan bermakna (r= 0,675; P= 0,002). Hasil ini menunjukkan penggunaan amikasin memberikan perubahan pada outcome terapi dan outcome terapi dipengaruhi oleh tingkat keparahan pernafasan pasien.

PENGARUH PEMBERIAN INFUSA DAUN KATUK (Sauropus androgynus (L) Merr) TERHADAP KADAR GLUKOSA DARAH MENCIT PUTIH (Mus musculus L) JANTAN YANG DIINDUKSI ALOKSAN Meiriza Djohari; Husnawati; Fina Aryani; Belia Sonali Bendre
Jurnal Penelitian Farmasi Indonesia Vol 12 No 1 (2023): JPFI
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (P3M) Sekolah Tinggi Ilmu Farmasi Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v12i1.1754

Telah dilakukan penelitian tentang pengaruh infusa daun katuk (Sauropus androginus (L.) Merr) terhadap kadar glukosa darah mencit putih (Mus musculus L.) jantan yang diinduksi aloksan. Penelitian ini bertujuan untuk melihat pengaruh infusa daun katuk terhadap kadar glukosa darah mencit putih jantan yang diinduksi aloksan 200mg/kgBB sebanyak 1% dari BB. Hewan percobaan dibagi menjadi 6 kelompok. Kelompok kontrol negatif diinduksi aloksan dan hanya diberi aquades, kelompok kontrol positif diberi glibenklamid dengan dosis 0,65mg/kggBB, kelompok normal diberi akuades dan pakan standar, kelompok perlakuan diberi sediaan infusa daun katuk dengan konsentrasi 10%, 20% dan 30%. 3 hari sebelum perlakuan mencit diinduksi aloksan terlebih dahulu dengan dosis 200mg/kgBB. Perlakuan dilakukan selama 15 hari berturut-turut. Kemudian diukur kadar glukosa darah mencit pada hari ke-5, 10, dan 15. Berdasarkan hasil pengujian infusa daun katuk pada konsentrasi 10%, 20% dan 30% dapat menurunkan kadar glukosa darah mencit putih jantan yang diinduksi aloksan, dan perlakuan yang paling efektif menurunkan glukosa darah mencit adalah pada konsentasi 30%. Hasil yang diperoleh dari hasil uji ANOVA satu arah dilanjutkan dengan uji Post Hoc Tukey juga menunjukkan bahwa lama pemberian infusa daun katuk dapat mempengaruhi penurunan kadar glukosa darah mencit (p<0,05). Research of the effect of katuk (Sauropus androginus (L.) Merr) leaves infusion on the blood glucose levels of alloxan-induced male white mice (Mus musculus L.) was performed. This study aims to investigate the effect of the infusion of katuk leaves on the blood glucose values of male white mice induced by 200 mg/kgBB alloxan to 1% of BW. Experimental animals were divided into 6 groups. The negative control group was induced by alloxan and received aquades only, the positive control group received glibenclamide in a dose o f 0.65 mg/kgBB, the normal group received distilled water and standard food, the treatment group received the preparation of katuk leaves infusion with a concentration of 10%, 20% and 30%. 3 days before the treatment of mice, alloxan first induced with a dose of 200 mg/kgBB. The treatment was carried out for 15 consecutive days. Then measured the blood glucose levels of mice on days 5, 10 and 15. Based on the test result, the katuk leaves infusion at concentrations of 10%, 20% and 30%, can decrease the blood glucose levels in alloxan-induced male white mice, and the most effective treatment to reduce blood glucose in mice is at a concentration of 30%. The results obtained from the one-way ANOVA test followed by the Post Hoc Tukey test also showed that the duration of administration could influence the decrease in blood glucose levels in mice (p <0.05).

Isolation of Endophytic Fungus from Leaves of Uncaria cordata (Lour.) Merr and Antibacterial Activity Against Propionibacterium acnes and Escherichia coli Melzi Octaviani; Winda Yusma Ameliah; Neni Frimayanti; Meiriza Djohari; Haiyul Fadhli
Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i3.3692

Uncaria cordata (Lour). Merr (akar kaik-kaik) is one of the medicinal plants used as antibacterial because it contains bioactive compounds that can inhibit the growth of microorganisms. The plant is one of the sources of endophyte fungal isolates that can be developed as an alternative to producing antibacterial compounds. This research aimed to isolate the endophytic fungus from the leaves of U. cordata and know the antibacterial activity against Propionibacterium acnes and Escherichia coli by disc diffusion. The Fungi that were isolated from the leaves of U. cordata were 17 isolates. The isolates were continued for antibacterial activity testing: IFED 1 (Nigrospora sp.), IFED 2 (Aspergillus sp.), IFED 3 (Fusarium sp.), and IFED 4, whose genus was unknown. The results obtained were fungal isolates IFED 1 to IFED 4 had activity in inhibiting the growth of P. acnes with moderate category (18.16 mm) and weak categories (6.21, 6.16, and 6.68 mm) and in E. coli with moderate category (14.56 mm) and weak categories (6.53, 6.71, and 7.23 mm). The results of One-Way ANOVA and Tukey's test showed a significant difference (p <0.05) between the diameter of the inhibition zone with the type of endophytic fungus supernatant isolated from the leaves of U. cordata. The best isolate of endophytic fungi inhibiting P. acnes and E. coli bacteria was IFED 1 (Nigrospora sp).

Review Artikel: Tumbuhan Obat Mondokaki (Tabernaemontana divaricata (L). R.Br) Fadhli, Haiyul; Fadhila, Qonita Nur; Djohari, Meiriza; Ulfa, Rodhia
Farmaka Vol 21, No 3 (2023): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v21i3.49056

Tanaman mondocaki (Tabernaemontana divaricata (L.R.Br.)) merupakan tanaman dalam famili Apocynaceae. Review artikel ini dibuat untuk memberikan informasi tentang kegunaan tanaman mondokaki dalam pengobatan herbal. Literatur online dan offline digunakan untuk ulasan artikel ini. Literatur online bersumber dari publikasi jurnal lokal dan internasional yang bersumber dari penyedia jurnal di internet. Literatur offline menggunakan buku atau e-book. Berdasarkan literatur yang diperoleh, tanaman ini telah digunakan secara tradisional untuk mengobati berbagai penyakit seperti patah tulang, demam, sakit kepala, dan sebagainya. Metabolit sekunder tanaman ini telah diisolasi dari daun, bunga dan batang. Bagian daunnya mengandung alkaloid indole staffinin, dimer alkaloid indole seperti conofylline dan conofylidine. Bunga tanaman ini mengandung amyrin acetate, lupeol, sitosterol, stigmasterol, flavon dan apigenin. Batangnya mengandung coronidine, heyneanin dan voacristin. Tumbuhan ini memiliki efek farmakologi seperti anti-inflamasi, anti-kanker, anti-diabetes, analgesik, antioksidan, antimikroba dan efek lainnya.

Formulation of Microemulsion of Cayenne Pepper (Capsicum Frutescens L.) Ethanol Extract and Hair Growth Activity Test Anggraini, Deni; Sandi, Nofri Hendri; Djohari, Meiriza
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87206

Cayenne pepper contains capsaicin, which exhibits properties that promote hair growth. Microemulsion is an oil and water dispersion system with a particle size of 10-200 nm which can be used topically as a drug delivery system through the scalp to stimulate hair growth. The microemulsion was made with olive oil and tween 80 as surfactants and stirred using a magnetic stirrer at 1000 rpm for 3 minutes. The ethanol extract of cayenne pepper was prepared in microemulsions at three different concentrations: 0.1%, 0.2%, and 0.3%. Microemulsion tests included organoleptic tests, specific gravity, pH, viscosity, freezing and thawing stability tests, and hair growth activity tests on rabbits. The results showed that the microemulsion of cayenne pepper ethanol extract at concentrations of 0.1%, 0.2%, and 0.3% was quite stable with a clear appearance and a particle size ranging from 27.7 nm to 167.8 nm. The microemulsion of cayenne pepper ethanol extract at a concentration of 0.2% was the most effective in enhancing hair growth, achieving a hair growth length of 1.27 over a 30-day period. A two-way ANOVA statistical test showed that the hair length of rabbits using microemulsion was significantly different from the hair length of negative control animals at p<0.05.

Gambaran Penggunaan Obat Infeksi Saluran Pernapasan Akut (Ispa) Pada Pasien Pediatri Di Puskesmas Sidomulyo Rawat Jalan Kota Pekanbaru Djohari, Meiriza; Suhery, Wira Noviana; Utami, Ewika Pritiya
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.3696

Infeksi Saluran Pernapasan Akut (ISPA) adalah penyakit infeksi yang menyerang salah satu bagian atau lebih dari saluran napas, mulai dari hidung (saluran atas) hingga alveoli (saluran bawah). Infeksi saluran pernapasan akut adalah infeksi yang disebabkan oleh virus dan bakteri. Penelitian ini bertujuan untuk mengetahui gambaran penggunaan obat infeksi saluran pernapasan akut (ISPA) pada pasien pediatri di puskesmas sidomulyo rawat jalan kota pekanbaru. sampel yang digunakan yaitu data pasien pediatri ISPA puskesmas pada tahun 2021 di Puskesmas Sidomulyo Rawat Jalan Kota Pekanbaru. Metode yang digunakan retrospektif dengan teknik purposive sampling. Berdasarkan hasil penelitian yang di lakukan, di dapatkan hasil penggunaan antihistamin 165 obat (31,79%), ekspektoran 156 obat (30,05%), analgetik 103 obat (19,84%), antibiotik 87 obat (16,76%), mukolitik 5 obat (0,96%), bronkodilator 2 obat (0,38%), dan kortikosteroid 1 obat (0,19%). Berdasarkan zat aktif obat didapatkan, CTM 165 obat (31,79%), guafenesin 156 obat (30,05%), paracetamol 103 obat (19,84%), amoxicillin 83 obat (15,99%), ambroxol 5 obat (0,96%), cefadroksil 3 obat (0,57%), salbutamol 2 obat (0,38%) dan eritromisin 1 obat (0,19%).

Pengaruh Jenis Minyak Terhadap Karakterisasi Sifat Fisik dan Disolusi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Asam Fenofibrat Suhery, Wira Noviana; Djohari, Meiriza; Nur, Novia Risky
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4161

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh komponen minyak pada sistem penghantaran obat self nanoemulsifying asam fenofibrat. Minyak yang diteliti adalah trigliserida rantai panjang (LCT) dan trigliserida rantai menengah (MCT). Minyak yang digunakan adalah minyak kacang tanah (F1), minyak jarak (F2), minyak kelapa murni (F3), dan minyak sawit (F4). Hasil penelitian menunjukkan bahwa kelarutan asam fenofibrat pada masing-masing minyak F1 (0,57 ± 0,009 mg/ml), F2 (5,45 ± 0,17 mg/ml), F3 (0,85±0,007 mg/ml), F4 (1,04±0,03 mg/ml) Kelarutan asam fenofibrat dalam SNEDDS; F1 (27,72±0,54 mg/ml), F2 (35,50±0,96mg/ml), F3 (29,58±0,47 mg/ml), dan F4 (32,14±0,44 mg/ml). Waktu emulsifikasi spontan yang berbeda yaitu F1 (146,51 ± 2,85 detik), F2 (37,11 ± 1,83 detik), F3 (99,98 ± 0,63 detik), dan F4 (56,40 ± 1,71 detik), dan hasil disolusi pada waktu 60 menit adalah F1 ( 73,66 ± 0,56%), F2 (96,52 ± 0,34%), F3 (77,87±0,81%), F4 (85,23 ± 0,98%). Jenis minyak dapat mempengaruhi karakterisasi sifat fisik dan disolusi asam fenofibrat SNEDDS. Formula terbaik adalah F2 yang mengandung minyak jarak sebagai komponen minyak.

Self Medication Drugs During The Covid-19 Pandemic At Pharmacy Aryani, Fina; Amalia, Annisa Yuri; Djohari, Meiriza; Humairah, Anugrah
JURNAL PROTEKSI KESEHATAN Vol 13 No 2 (2024): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v13i2.846

Corona Virus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-Cov2) with a high mortality rate. Self-medication is the behavior of taking self-medication based on a diagnosis of the symptoms of illness that occurs. This study aims to determine the profile of the use of self-medication drugs that are often used to treat symptoms similar to COVID-19 during the COVID-19 pandemic at the Pekanbaru City Pharmacy, Riau Province in the period of July 2021. The type of research is observational with a descriptive design and concurrent data collection. The population is the respondent who self-medicates in a pharmacy in Pekanbaru. The sample is 100 respondents who have met the inclusion criteria with a purposive sampling technique. The results showed that the most used drugs were for fever symptoms (27.8%), the most pharmacological class of drugs purchased by patients were antipyretics-analgesics (32.5%), the most used dosage forms were tablets (58, 7%). During the self-medication process, patients most often received information from health workers (35.4%). Based on gender, the most patients who self-medicated were women (56%), the age of the most patients was around 17-25 years (46%), while from the last education level the most patients were high school/equivalent (44%) with the type of work as private employees (48%). Drugs that are often purchased during the Covid-19 pandemic are analgesics-antipyretic.

Co-Authors Achdar, Ridza Fitria Adelina, Helmi Rahmah Adilla, Dea Adriani Susanty Afridho, Arif agistia, nesa Alifah Nurul Khusnah Amalia, Annisa Yuri Amrianis, Delfi Andi Wijaya Annisa Safitri Armon Fernando Ayu Indah Lestari Afandi Azizah, Wahyu Belia Sonali Bendre Burhanuddin Bahar Cahyani, Astri Dea Adilla Deni Anggraini Devi Safitri DEWI FITRIANI Dewi, Irana Dinda Zulfi Rosadi Diova Yuswidia Putra Dwi Pratiwi Enda Mora Fadhila, Metha Fadhila, Qonita Nur Fadila, Azhariah Farahdilla, Dinda Fina Aryani, Fina Haiyul Fadhli Harpirabi, T. Hasanah, Mitha Humairah, Anugrah Husnawati Husnawati Husnawati Husnawati Ihsan Ikhtiarudin Ikhwani, Ulfha Jasma, Jasma Karismawati, Karismawati Kuang, Liau Che Linda, Rosa M Almurdani Mansyur Arif Mansyur Arif Maqfiroh, Wirdarani Mardianti, Tengku Shella Melisa, Eva Melzi Octaviani Mira Febrina Muti’ah, Try Hadirah Nabilah, Clara Nasution, Musyirna Rahmah Neni Frimayanti Ningsih, Windi Sayuti Nofri Hendri Sandi Noveri Rahmawati Nur Indah Melati Nur, Novia Risky Nurhapipah, Nurhapipah Parina, Ana Bella Pratiwi, Erniza Pratiwi, Wirahma Indah Putri, Atika Putri, Bayzola Ditya Putri, Sella Hilmalia Nur Al Putri, Widia Rahma Putri, Wulandari Yulia Rahmatunnur, Siti Rahmi, Yuni Rasyid, Wildan Rifani, Mhd Rina Lestari Rizki, Rahmi Asrina Rovi Paramitha, Rovi Rustam, Muhanifa Septi Muharni Setyowati, Bonita Dwi Sinata, Novia Sinulingga, Yori Yunita Sisca, Sari Kurnia Sukma, Sukma Sulastri Sumbarita, Silvia Suryani As'ad Susanti, Adriani Syilfia Hasti Tami, Tami Tania Tiara Efendi Tania, Berla Tri Wahyuni Ulfa, Rodhia Utami, Ewika Pritiya Winda Yusma Ameliah Winekas, Bintang Bayu Wira Noviana Suhery Yuni Rahmi Yuti, Denisyah Fitri Zamri, Wiedya Alfitrya

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