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UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN TUMBUHAN AKAR KAIK-KAIK (Uncaria cordata (Lour) Merr) TERHADAP MENCIT PUTIH JANTAN (Mus musculus L) Meiriza Djohari; Noveri Rahmawati; Nur Indah Melati
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1402

Abstract

Research on the acute toxicity test of the ethanol extract of kaik-kaik (Uncaria cordata (Lour) Merr) leaves has been carried out on male white mice (Mus musculus L.). This study aims to determine the effects of acute and delayed toxicity of the ethanol extract of kaik- kaik root (Uncaria cordata (Lour) Merr) leaves by determining the LD50 value. The experimental animals were divided into 4 groups, namely the negative control group (NaCMC), and the ethanol extract group of kaik-kaik root leaves with doses of 200, 1000, and 5000 mg / KgBB. The results showed that the LD50 value was> 5000 mg / kg BW and was included in the practical non-toxic category. In the observation, there were no tremors, seizures, salivation, diarrhea, lethargy, weakness, sleep, and coma in each experimental animal.
Analisis Outcome Terapi Amikasin Terhadap Penurunan Sesak Pada Pneumonia Pediatrik di Instalasi Rawat Inap RSUD Arifin Achmad Provinsi Riau Septi Muharni; Sulastri; Nesa Agistia; Husnawati; Fina Aryani; Meiriza Djohari
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 1 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.625 KB) | DOI: 10.35617/jfionline.v12i1.29

Abstract

Amikasin merupakan salah satu antibiotik golongan aminoglikosida yang bersifat bakterisid dan termasuk dalam golongan obat indeks terapi sempit. Penggunaan antibiotik harus tepat agar outcome terapi tercapai maksimal. Penelitian ini bertujuan untuk melihat korelasi penggunaan antibiotik amikasin terhadap pencapian outcome terapi penurunan sesak pada pneumonia pediatrik di RSUD Arifin Achmad Provinsi Riau. Jenis penelitian ini adalah penelitian observasional dengan metode deskriptif dengan pendekatan secara retrospektif pada 20 rekam medis pasien pneumonia pediatrik yang mendapatkan amikasin dengan menggunakan teknik purposive sampling di RSUD Arifin Achmad Provinsi Riau. Berdasarkan analisis korelasi jenis kelamin dan rentang usia berkorelasi sedang dan tidak bermakna dengan outcome terapi amikasin (r=0,404 dan nilai p=0,143), (r=0,452 dan nilai p=0,274) dan tingkat keparahan pernapasan terhadap outcome terapi penggunaan amikasin didapatkan korelasi kuat dan bermakna (r= 0,675; P= 0,002). Hasil ini menunjukkan penggunaan amikasin memberikan perubahan pada outcome terapi dan outcome terapi dipengaruhi oleh tingkat keparahan pernafasan pasien.
PENGARUH PEMBERIAN INFUSA DAUN KATUK (Sauropus androgynus (L) Merr) TERHADAP KADAR GLUKOSA DARAH MENCIT PUTIH (Mus musculus L) JANTAN YANG DIINDUKSI ALOKSAN Meiriza Djohari; Husnawati; Fina Aryani; Belia Sonali Bendre
Jurnal Penelitian Farmasi Indonesia Vol 12 No 1 (2023): JPFI
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (P3M) Sekolah Tinggi Ilmu Farmasi Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v12i1.1754

Abstract

Telah dilakukan penelitian tentang  pengaruh  infusa daun katuk  (Sauropus  androginus (L.) Merr) terhadap  kadar glukosa darah mencit putih (Mus musculus L.) jantan yang diinduksi aloksan. Penelitian ini bertujuan untuk melihat pengaruh  infusa  daun  katuk  terhadap  kadar  glukosa  darah  mencit  putih  jantan yang diinduksi aloksan 200mg/kgBB sebanyak 1% dari BB. Hewan percobaan dibagi menjadi 6 kelompok. Kelompok kontrol negatif diinduksi aloksan dan hanya diberi aquades, kelompok kontrol positif diberi glibenklamid dengan dosis 0,65mg/kggBB, kelompok normal diberi akuades dan pakan standar, kelompok perlakuan diberi sediaan infusa daun katuk dengan konsentrasi 10%, 20% dan 30%. 3 hari sebelum perlakuan mencit diinduksi aloksan terlebih dahulu dengan dosis 200mg/kgBB. Perlakuan dilakukan selama 15 hari  berturut-turut.  Kemudian diukur  kadar  glukosa darah  mencit  pada  hari ke-5,  10,  dan 15.  Berdasarkan  hasil pengujian infusa daun katuk pada konsentrasi 10%, 20% dan 30% dapat menurunkan kadar glukosa darah mencit putih jantan yang diinduksi aloksan, dan perlakuan yang paling efektif menurunkan glukosa darah mencit adalah pada konsentasi 30%. Hasil yang diperoleh dari hasil uji ANOVA satu arah dilanjutkan dengan uji Post Hoc Tukey juga menunjukkan bahwa lama pemberian infusa daun katuk dapat mempengaruhi penurunan kadar glukosa darah mencit (p<0,05). Research of the effect of katuk (Sauropus androginus (L.) Merr) leaves infusion on the blood glucose levels of alloxan-induced male white mice (Mus musculus L.) was performed. This study aims to investigate the effect of the infusion of katuk leaves on the blood glucose values of male white mice induced by 200 mg/kgBB alloxan to 1% of BW. Experimental animals were divided into 6 groups. The negative control group was induced by alloxan and received aquades only, the positive control group received glibenclamide in a dose o f 0.65 mg/kgBB, the normal group received distilled water and standard food, the treatment group received the preparation of katuk leaves infusion with a concentration of 10%, 20% and 30%. 3 days before the treatment of mice, alloxan first induced with a dose of 200 mg/kgBB. The treatment was carried out for 15 consecutive days. Then measured the blood glucose levels of mice on days 5, 10 and 15. Based on the test result, the katuk leaves infusion at concentrations of 10%, 20% and 30%, can decrease the blood glucose levels in alloxan-induced male white mice, and the most effective treatment to reduce blood glucose in mice is at a concentration of 30%. The results obtained from the one-way ANOVA test followed by the Post Hoc Tukey test also showed that the duration of administration could influence the decrease in blood glucose levels in mice (p <0.05).
Isolation of Endophytic Fungus from Leaves of Uncaria cordata (Lour.) Merr and Antibacterial Activity Against Propionibacterium acnes and Escherichia coli Melzi Octaviani; Winda Yusma Ameliah; Neni Frimayanti; Meiriza Djohari; Haiyul Fadhli
Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i3.3692

Abstract

Uncaria cordata (Lour). Merr (akar kaik-kaik) is one of the medicinal plants used as antibacterial because it contains bioactive compounds that can inhibit the growth of microorganisms. The plant is one of the sources of endophyte fungal isolates that can be developed as an alternative to producing antibacterial compounds. This research aimed to isolate the endophytic fungus from the leaves of U. cordata and know the antibacterial activity against Propionibacterium acnes and Escherichia coli by disc diffusion. The Fungi that were isolated from the leaves of U. cordata were 17 isolates. The isolates were continued for antibacterial activity testing: IFED 1 (Nigrospora sp.), IFED 2 (Aspergillus sp.), IFED 3 (Fusarium sp.), and IFED 4, whose genus was unknown. The results obtained were fungal isolates IFED 1 to IFED 4 had activity in inhibiting the growth of P. acnes with moderate category (18.16 mm) and weak categories (6.21, 6.16, and 6.68 mm) and in E. coli with moderate category (14.56 mm) and weak categories (6.53, 6.71, and 7.23 mm). The results of One-Way ANOVA and Tukey's test showed a significant difference (p <0.05) between the diameter of the inhibition zone with the type of endophytic fungus supernatant isolated from the leaves of U. cordata. The best isolate of endophytic fungi inhibiting P. acnes and E. coli bacteria was IFED 1 (Nigrospora sp).
Review Artikel: Tumbuhan Obat Mondokaki (Tabernaemontana divaricata (L). R.Br) Fadhli, Haiyul; Fadhila, Qonita Nur; Djohari, Meiriza; Ulfa, Rodhia
Farmaka Vol 21, No 3 (2023): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v21i3.49056

Abstract

Tanaman mondocaki (Tabernaemontana divaricata (L.R.Br.)) merupakan tanaman dalam famili Apocynaceae. Review artikel ini dibuat untuk memberikan informasi tentang kegunaan tanaman mondokaki dalam pengobatan herbal. Literatur online dan offline digunakan untuk ulasan artikel ini. Literatur online bersumber dari publikasi jurnal lokal dan internasional yang bersumber dari penyedia jurnal di internet. Literatur offline menggunakan buku atau e-book. Berdasarkan literatur yang diperoleh, tanaman ini telah digunakan secara tradisional untuk mengobati berbagai penyakit seperti patah tulang, demam, sakit kepala, dan sebagainya. Metabolit sekunder tanaman ini telah diisolasi dari daun, bunga dan batang. Bagian daunnya mengandung alkaloid indole staffinin, dimer alkaloid indole seperti conofylline dan conofylidine. Bunga tanaman ini mengandung amyrin acetate, lupeol, sitosterol, stigmasterol, flavon dan apigenin. Batangnya mengandung coronidine, heyneanin dan voacristin. Tumbuhan ini memiliki efek farmakologi seperti anti-inflamasi, anti-kanker, anti-diabetes, analgesik, antioksidan, antimikroba dan efek lainnya.
Formulation of Microemulsion of Cayenne Pepper (Capsicum Frutescens L.) Ethanol Extract and Hair Growth Activity Test Anggraini, Deni; Sandi, Nofri Hendri; Djohari, Meiriza
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87206

Abstract

Cayenne pepper contains capsaicin, which exhibits properties that promote hair growth. Microemulsion is an oil and water dispersion system with a particle size of 10-200 nm which can be used topically as a drug delivery system through the scalp to stimulate hair growth. The microemulsion was made with olive oil and tween 80 as surfactants and stirred using a magnetic stirrer at 1000 rpm for 3 minutes. The ethanol extract of cayenne pepper was prepared in microemulsions at three different concentrations: 0.1%, 0.2%, and 0.3%. Microemulsion tests included organoleptic tests, specific gravity, pH, viscosity, freezing and thawing stability tests, and hair growth activity tests on rabbits. The results showed that the microemulsion of cayenne pepper ethanol extract at concentrations of 0.1%, 0.2%, and 0.3% was quite stable with a clear appearance and a particle size ranging from 27.7 nm to 167.8 nm. The microemulsion of cayenne pepper ethanol extract at a concentration of 0.2% was the most effective in enhancing hair growth, achieving a hair growth length of 1.27 over a 30-day period. A two-way ANOVA statistical test showed that the hair length of rabbits using microemulsion was significantly different from the hair length of negative control animals at p<0.05.
Self Medication Drugs During The Covid-19 Pandemic At Pharmacy Aryani, Fina; Amalia, Annisa Yuri; Djohari, Meiriza; Humairah, Anugrah
JURNAL PROTEKSI KESEHATAN Vol 13 No 2 (2024): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v13i2.846

Abstract

Corona Virus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-Cov2) with a high mortality rate. Self-medication is the behavior of taking self-medication based on a diagnosis of the symptoms of illness that occurs. This study aims to determine the profile of the use of self-medication drugs that are often used to treat symptoms similar to COVID-19 during the COVID-19 pandemic at the Pekanbaru City Pharmacy, Riau Province in the period of July 2021. The type of research is observational with a descriptive design and concurrent data collection. The population is the respondent who self-medicates in a pharmacy in Pekanbaru. The sample is 100 respondents who have met the inclusion criteria with a purposive sampling technique. The results showed that the most used drugs were for fever symptoms (27.8%), the most pharmacological class of drugs purchased by patients were antipyretics-analgesics (32.5%), the most used dosage forms were tablets (58, 7%). During the self-medication process, patients most often received information from health workers (35.4%). Based on gender, the most patients who self-medicated were women (56%), the age of the most patients was around 17-25 years (46%), while from the last education level the most patients were high school/equivalent (44%) with the type of work as private employees (48%). Drugs that are often purchased during the Covid-19 pandemic are analgesics-antipyretic.
PENANGANAN DAN PENCEGAHAN GAMBARAN DIABETES MELITUS DENGAN MENINGKATKAN TINGKAT PENGETAHUAN MASYARAKAT KOTA PEKANBARU Ulfa, Rodhia; Djohari, Meiriza; Susanty, Adriani; Mora, Enda; Afridho, Arif; Cahyani, Astri; Fitriani, Dewi; Melisa, Eva; Fadhila, Metha; Hasanah, Mitha; Rustam, Muhanifa; Fadhila, Qonita Nur; Sisca, Sari Kurnia
Jurnal Pengabdian Masyarakat Medika Vol 5. No. 1, Maret 2025
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v5i1.3684

Abstract

ABSTRAK Diabetes melitus (DM) adalah penyakit yang disebabkan gagalnya pankreas memproduksi hormon insulin. Penyakit DM menjadi permasalahan kesehatan yang banyak terjadi di masyarakat Riau. Kegiatan pengabdian ini bertujuan untuk memberikan pemahaman terkait penanganan DM. Metode pelaksanaan kegiatan ini berupa penyuluhan yang didukung dengan adanya pre dan post-test. Kegiatan ini dilaksanakan di kawasan CFD (Car Free Day) Kota Pekanbaru. Alat ukur yang digunakan adalah lembar checklist pre dan post-test serta hasilnya dihitung dengan menggunakan skala Guttmann. Hasil dari kegiatan pengabdian ini adalah sebanyak 30 responden baik laki-laki maupun perempuan mempunyai pemahaman yang sama tentang DM yaitu 82%. Jika dilihat dari segi usia, mayoritas orang dewasa di usia prima memiliki pengetahuan yang lebih tinggi dibandingkan orang yang lebih tua. Mengenai tingkat pendidikan akhir, responden yang berpendidikan tinggi mempunyai pemahaman yang lebih baik (92%). Terkait status pekerjaan, responden yang berstatus bekerja memiliki pengetahuan paling tinggi (84%). Berdasarkan hasil kegiatan terdapat perbedaan yang signifikan antara sebelum dan sesudah kegiatan penyuluhan. Hal ini terlihat dari nilai signifikansi <0,05 (0,000), artinya terdapat perbedaan yang signifikan secara deskriptif antara pre-test dan post-test. Tingkat pengetahuan yang didapatkan adalah rata-rata pengetahuan pre-test (baik) dan post-test (sangat baik). Kesimpulan yang didapat adalah terjadinya peningkatan pengetahuan dari baik menjasi sangat baik.   ABSTRACT Diabetes mellitus (DM) is a disease caused by the failure of the pancreas to produce the hormone insulin. DM is a health problem that occurs in many communities in Riau. This service activity aims to provide an understanding of DM management. The method of implementing this activity is in the form of counseling supported by the pre and post-test. This activity was carried out in the CFD (Car Free Day) area of Pekanbaru City. The measuring instrument used is a pre and post-test checklist sheet and the results are calculated using the Guttmann scale. The results of this service activity are as many as 30 respondents, both men and women, have the same understanding of DM, namely 82%. When viewed in terms of age, the majority of adults in prime age have higher knowledge than older people. Regarding the final level of education, respondents with higher education had a better understanding (92%). Regarding employment status, respondents who were employed had the highest knowledge (84%). Based on the results of the activity, there was a significant difference between before and after the counseling activity. This can be seen from the significance value <0.05 (0.000), meaning that there is a descriptively significant difference between the pre-test and post-test. The level of knowledge obtained is the average knowledge of pre-test (good) and post-test (very good). The conclusion is that there is an increase in knowledge from good to very good.
Description of the Level of Community Knowledge About DAGUSIBU at the Melur Pekanbaru Community Health Center Meiriza Djohari; Ayu Indah Lestari Afandi; Dea Adilla; Dinda Zulfi Rosadi; Diova Yuswidia Putra
JISIP: Jurnal Ilmu Sosial dan Pendidikan Vol 8, No 4 (2024): JISIP (Jurnal Ilmu Sosial dan Pendidikan) (November)
Publisher : Lembaga Penelitian dan Pendidikan (LPP) Mandala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58258/jisip.v8i4.7526

Abstract

The rational use of medicine is one of the important aspects in maintaining public health. However, there are still many people who do not understand how to obtain, use, store, and dispose of drugs properly. To overcome this, the government through the Food and Drug Monitoring Agency (BPOM) has launched an educational program known as the DAGUSIBU concept (Get, Use, Store, and Dispose of Medicines Correctly). The purpose of this study was to determine the level of public knowledge about DAGUSIBU at Melur Health Center Pekanbaru, Riau. The research design carried out in this study was observational which was descriptive analytic, with a cross sectional research design, data collection techniques were carried out concurrently. The subjects of this study were people who came for treatment and bought medicine at Puskesmas Melur Pekanbaru. Data collection in this study used a questionnaire on the level of knowledge of the community. Based on the research that has been done about the description of the level of public knowledge about DAGUSIBU, the results obtained that the four dimensions namely Daptkan, Use, Save and Dispose are in the category strongly agree with a percentage of 76% and the category agree with a percentage of 24%. It can be concluded that the community of Puskesmas Melur Pekanbaru generally has a good knowledge of how to get, use, store and dispose of drugs.
SOSMED (SOSIALISASI MENCEGAH DIABETES PADA USIA MUDA) Djohari, Meiriza; Susanty, Adriani; Mora, Enda; Ulfa, Rodhia; Putri, Bayzola Ditya; Tania, Berla; Yuti, Denisyah Fitri; Adelina, Helmi Rahmah; Dewi, Irana; Karismawati, Karismawati; Kuang, Liau Che; Achdar, Ridza Fitria; Linda, Rosa; Putri, Widia Rahma
BESIRU : Jurnal Pengabdian Masyarakat Vol. 2 No. 5 (2025): BESIRU : Jurnal Pengabdian Masyarakat, Mei 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v2i5.1152

Abstract

Diabetes melitus (DM) merupakan suatu kelompok penyakit metabolik yang terjadi karena kelainan sekresi insulin, kerja insulin atau kedua-duanya. Kegiatan pengabdian ini bertujuan untuk melihat pengaruh pemberian informasi media leaflet tentang diabetes pada usia muda serta memberikan informasi melalui edukasi terkait penyakit diabetes melitus. Kegiatan pengabdian ini dilakukan dengan metode face to face kepada masyarakat yang ada di Car Free Day (CFD). Responden pada kegiatan penegabdian ini adalah masyarakat yang ada di CFD dengan total responden yaitu 50 orang. Hasil pretest dan post-test menunjukkan peningkatan pengetahuan yang signifikan, dengan p-value 0,000 dari uji Wilcoxon, yang menunjukkan adanya pengaruh positif dari edukasi yang diberikan. 
Co-Authors Achdar, Ridza Fitria Adelina, Helmi Rahmah Adilla, Dea Adriani Susanty Afridho, Arif agistia, nesa Alifah Nurul Khusnah Amalia, Annisa Yuri Amrianis, Delfi Andi Wijaya Annisa Safitri Annisa, Refina Anugrah Humairah Apriella, Weri Armon Fernando Ayu Indah Lestari Afandi Azizah, Wahyu Belia Sonali Bendre Burhanuddin Bahar Cahyani, Astri Dea Adilla Deni Anggraini Devi Safitri DEWI FITRIANI Dewi, Irana Dinda Zulfi Rosadi Diova Yuswidia Putra Dwi Pratiwi Enda Mora Ewika Pritiya Utami Fadhila, Metha Fadhila, Qonita Nur Fadila, Azhariah Farahdilla, Dinda Fina Aryani Fina Aryani, Fina Haiyul Fadhli Haniyah Nabilah Hasanah, Mitha Humairah, Anugrah Husnawati Husnawati Husnawati Husnawati Ikhwani, Ulfha Karismawati, Karismawati Kuang, Liau Che Linda, Rosa Mansyur Arif Mansyur Arif Maqfiroh, Wirdarani Mardianti, Tengku Shella Melisa, Eva Melzi Octaviani Mira Febrina Musyirna Rahmah Nst Muti’ah, Try Hadirah Nabilah, Clara Neni Frimayanti Nofri Hendri Sandi Noveri Rahmawati Nur Indah Melati Nurhapipah, Nurhapipah Nurhasanah Nurhasanah Nursyah, Salsabila Putri Parina, Ana Bella Pratiwi, Erniza Putri, Atika Putri, Bayzola Ditya Putri, Sella Hilmalia Nur Al Putri, Widia Rahma Putri, Wulandari Yulia Rahmatunnur, Siti Rahmi, Yuni Rifani, Mhd Rina Lestari Rizki, Rahmi Asrina Rodhia Ulfa Rovi Paramitha, Rovi Rustam, Muhanifa Safitri, Salsa Widya Septi Muharni Setyowati, Bonita Dwi Sinata, Novia Sinulingga, Yori Yunita Sisca, Sari Kurnia Sufi, Tengku Yuni Atika Sulastri Sumbarita, Silvia Suryani As&#039;ad Susanti, Adriani Syilfia Hasti Tania Tiara Efendi Tania, Berla Tri Wahyuni Winda Yusma Ameliah Windi Sayuti Ningsih Winekas, Bintang Bayu Wira Noviana Suhery Yuni Rahmi Yuti, Denisyah Fitri Zamri, Wiedya Alfitrya