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All Journal Jurnal Kesehatan Andalas Jurnal Kesehatan Jurnal Penelitian Kesehatan Suara Forikes Jurnal Kesehatan Medika Saintika Indonesian Journal of Obstetrics & Gynecology Science The Southeast Asian Journal of Midwifery Jurnal Ipteks Terapan Journal of Midwifery Majalah Kedokteran Andalas Maternal Child Health Care Journal Science Midwifery pendidikan, science, teknologi, dan ekonomi Jurnal Ilmu Kesehatan Indonesia (JIKSI) Andragogi Kesehatan

Amir, Arni

Bagian Biologi Fakultas Kedokteran Universitas Andalas Padang

Author-ID : 3443713

Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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PENGARUH PEMBERIAN TERAPI TABLET BESI DAN ASAM FOLAT TERHADAP PERUBAHAN RED CELL DISTRIBUTION WIDTH PADA IBU HAMIL YANG ANEMIA Silvi Zaimy; Arni Amir; Nur Indrawaty Lipoeto
Jurnal Kesehatan Medika Saintika Vol 9, No 2 (2018): Desember 2018
Publisher : Stikes Syedza Saintika Padang

Anemia merupakan masalah gizi yang sering terjadi pada ibu hamil. Anemia pada ibu hamil sangat terkait dengan mortalitas dan morbiditas pada ibu dan bayi. 40% kematian Ibu di negara berkembang berkaitan dengan anemia dalam kehamilan. Red Cell Distribution Width (RDW) merupakan salah satu parameter laboratorium yang digunakan untuk mendeteksi anemia defisiensi besi. Penelitian ini bertujuan untuk mengetahui Pengaruh pemberian terapi tablet besi dan asam folat terhadap perubahan Red Cell Distribution Width (RDW) pada ibu hamil yang anemia. Penelitian ini menggunakan desain eksperimental dengan pendekatan pre test and post test control design yang dilaksanakan di Puskesmas Anak Air dan Puskesmas Alai. pada bulan Juni 2017-Juli 2018. Populasi adalah ibu hamil dengan anemia yang terdata mulai dari januari-april 2018. Sampel penelitian berjumlah 35 ibu hamil anemia dengan pemberian terapi tablet besi dan 35 ibu hamil anemia dengan pemberian terapi tablet besi dan asam folat Pengamnilan sampel menggunakan teknik puposive sampling. Pemeriksaan kadar hemoglobin dan RDW menggunakan Hematology Analizer. Uji normalitas data menggunakan uji Kolmogorov-Smirnov (n>50). Analisis data komparatif menggunakan uji Paired sample t-Test dan Independence Sample t-Test. Hasil penelitian menunjukkan rerata RDW setelah pemberian terapi pada kelompok terapi tablet besi (15,58%) lebih rendah dibandingkan sebelum pemberian terapi (16,31 %) dengan nilai p= 0,00 (p<0,05). RerataRDW setelah pemberian terapi tablet besi dan asam folat (15,19%) lebih rendah dibandingkan sebelum pemberian terapi (16,20 %) dengan nilai p= 0,00 (p<0,05). Delta RDW pada kelompok pemberian terapi tablet besi dan asam folat lebih tinggi (1,03%) dibandingkan pada kelompok pemberian terapi tablet besi (0,77%). Terdapat perbedaan yang bermakna RDW sebelum dan setelah pemberian terapi tablet besi . Terdapat perbedaan bermakna RDW sebelum dan setelah pemberian terapi tablet besi dan asam folat. Tidak terdapat perbedaan yang bermakna perubahan RDW setelah pemberian terapi antara kelompok terapi tablet besi dengan terapi tablet besi dan asam folat.Kata kunci: Anemia, Red Cell Distribution Width, tablet besi, asam folat

PERBANDINGAN KADAR INTERLEUKIN 6 PADA PERSALINAN PRETERM DAN KEHAMILAN NORMAL Visti Delvina; Arni Amir; Ermawati Ermawati
Maternal Child Health Care Vol 1, No 3 (2019): Maternal Child Health Care
Publisher : Universitas Fort de Kock Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/mchc.v1i3.961

Preterm labor occurs between 20 weeks and before 37 weeks of pregnancy. It is indicated by regular contractions of the uterus and it may cause the thinning and flattening of the cervix. Preterm labor also causes the high rates of perinatal morbidity and mortality. Increasing levels of interleukin 6 during pregnancy can stimulate the preterm labor. The design of this reseacrh was a comparative cross sectional study. It was conducted in Rasidin District Hospital, Siti Rahmah Hospital and Biomedical Laboratory, Faculty of Medicine, Andalas University, Padang on March to June 2018. There were 50 samples in this reseach. It was selected by consecutive sampling. The samples were divided into two groups: preterm labor and normal pregnancy. The interleukin 6 levels were examined by the ELISA method. Then, the data were analyzed by using the t test. The results of this reseach showed that the mean level of IL-6 in the preterm labor group was 90.22 ± 21.41ng / L. Then, 75.57 ± 14.01 ng / L for the mean level of IL-6 in the normal pregnancy group with p= 0.006. Moreover, statistical test inffered that there were significant differences between IL-6 levels in preterm labor and normal pregnancy. In short, it can be concluded that IL-6 levels in the preterm labor group were higher than normal pregnancy group.Keywords: IL-6 levels, preterm labor

Uji Efektivitas Putih Telur Ayam Kampung (Gallus domesticus) Terhadap Penyembuhan Luka Bakar Derajat II pada Mencit (Mus musculus) Sri Juleli Sakerebau; Arni Amir; Joserizal Serudji
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 2 (2020): Juli 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Luka bakar merupakan masalah kesehatan yang terjadi secara global. Luka bakar menyebabkan morbiditas dan mortalitas yang cukup signifikan. Pengembangan terapi untuk mengobati luka bakar telah dilakukan bertahun-tahun, salah satunya dengan putih telur. Putih telur mengandung protein yang dapat melepaskan fakor pertumbuhan. Penelitian ini bertujuan untuk mengetahui efektivitas putih telur terhadap penyembuhan luka bakar derajat II pada mencit. Penelitian ini merupakan penelitian eksperimental dengan menggunakan desain studi Posttest Only Control Group. Subjek penelitian ini berupa mencit jantan (Mus Musculus) sebanyak 36 ekor dibagi menjadi 2 kelompok yaitu kelompok perlakuan dengan pemberian putih telur dan kelompok kontrol dengan pemberian NaCl 0,9%. Pengambilan jaringan dilakukan setelah terminasi hewan coba pada hari ke-3, hari ke-7 dan hari ke-14 kemudian dilakuan pembuatan preparat histologis untuk menilai pembuluh darah dan fibroblast. Data dianalisis dengan menggunakan Uji Mann Whitney. Penelitian ini menunjukan jumlah rerata pembuluh darah pada pengamatan hari ke-3 dan hari ke-7 antara kelompok kontrol dan kelompok perlakuan secara statistik tidak terdapat perbedaan yang bermakna. Sedangkan jumlah rerata pembuluh darah pada pengamatan hari ke-14 antara kelompok kontrol dan kelompok perlakuan secara statistik terdapat perbedaan yang bermakna. Jumlah retara fibroblast pada kelompok kontrol dan kelompok perlakuan tidak mempunyai perbedaan yang bermakna pada semua periode pengamatan.

Karakteristik Penderita Laryngopharyngeal Reflux di Bagian THT-KL RSUP Dr. M. Djamil Padang Tahun 2019 Fitrahul Afifah; Fachzi Fitri; Arni Amir
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 1 (2021): Maret 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Background: LPR is often not diagnosed by ENT doctors because of its atypical symptoms, so patients often go to a doctor for help with the same symptoms, but although the doctor gives treatment, the symptops keep recurring.Objective: This study aims to determine the characteristics of patients with laryngopharyngeal reflux in the ENT department of RSUP Dr. M. Djamil Padang in 2019.Methods: This study was a retrospective descriptive study by taking secondary data in medical records of LPR patients at RSUP Dr. M. Djamil Padang period 1 January – 31 December 2019 and used a total sampling technique. The data were analyzed univariately to find the frequency distribution.Results: The total number of LPR patients was 106 patients with 50 people fulfilling the inclusion criteria; the majority of LPR suffers are women (70%); the largest age group is 51-60 years (34%); the most BMI group were 18.5–25.0 (46%); the most symptom is globus pharyngeus (88%); the most common finding of flexible laryngoscopy is erythema (60%); the most prescribed was lansoprazole (82%), whereas the most combination therapy was lansoprazole, N.Acetylcysteine, and sucralfate (14%).Conclusion: The majority of LPR suffers have a normal body mass index, the most combination theraphy are lansoprazole, N. Acetylcysteine, and sucralfate.

Relationship between Blood Lead Levels and Nitric Oxide (NO) Levels in Preeclampsia Rina Oktaviana; Yusrawati Yusrawati; Arni Amir
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 2 September 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n2.423

Objective: This study aims to determine the relationship between blood lead levels and NO levels in preeclampsia.Methods: This research applied analytical survey research with a cross-sectional design. Moreover, the samples were 99 pregnant women, 33 with normal pregnancies, 33 with preeclampsia living >10km from Semen Padang factory, and 33 with preeclampsia who lived ≤10km from Semen Padang factory. Spearman correlation test and logistic regression analysis is used for data analysis.Result: The result of this study shows that the blood lead level median in preeclampsia ≤10km is 26.23 g/dL, and the lead level median in preeclampsia >10km is 23.52 g/dL. Meanwhile, the NO level median in preeclampsia ≤10km is 22.50µmol/L and NO level median in preeclampsia >10km is 28.00µmol/L. There is a relationship between blood lead levels and NO levels in preeclampsia ≤10km, with r-value = -0.601 and p-value <0.001, in preeclampsia >10km, there is no relationship with p-value >0.500 and the strength of the correlation is fragile. In addition, the results of multivariate analysis of reduced levels of NO in preeclampsia with high blood lead levels are two times compared to preeclampsia with normal blood lead levels with 95% CI (0.652-6.362) after being controlled by distance of residence, smoking status and living environment variables.Conclusion: there is a relationship between blood lead levels and NO levels in preeclampsia.Hubungan Kadar Timbal dengan Kadar Nitric Oxide (NO) pada Ibu Hamil PreeklampsiaAbstrakTujuan: Penelitian ini bertujuan untuk mengetahui hubungan kadar timbal dengan kadar Nitric Oxide (NO) pada ibu hamil preeklampsia. Metode: Penelitian ini merupakan penelitian survei analitik, dengan rancangan cross sectional. Sampel diteliti sebanyak 99 orang ibu hamil, 33 orang ibu hamil normal dan 33 orang preeklampsia yang tinggal yang tinggal radius >10km, dan 33 orang preeklampsia yang tinggal radius ≤10km. Kadar timbal diperiksa menggunakan metode AAS dan Kadar Nitric Oxide (NO) diperiksa menggunakan metode ELISA. Analisis data menggunakan uji korelasi Spearman dan analisis regresi logistik.Hasil: Hasil penelitian ini median kadar timbal pada preeklampsia ≤10km adalah 26,23 µg/dL, dan median kadar timbal preeklampsia >10km adalah 23,52 µg/dL. Median kadar Nitric Oxide (NO) preeklampsia ≤10km adalah 22,50µmol/L, median kadar Nitric Oxide (NO) preeklampsia >10km adalah 28,00µmol/L. Terdapat hubungan kadar timbal dengan kadar Nitric Oxide (NO) pada preeklampsia ≤10km, diperoleh nilai r = -0,601 dan nilai p < 0,001, pada preeklampsia >10km tidak terdapat hubungan dengan nilai p > 0.500 dan kekuatan korelasi sangat lemah. Hasil analisis multivariat penurunan kadar Nitric Oxide (NO) preeclampsia yang memiliki kadar timbal tinggi adalah 2 kali dibandingkan ibu hamil preeclampsia dengan kadar timbal normal dengan 95% CI (0.652-6.362) setelah dikontrol variabel jarak tempat tinggal, status merokok dan lingkungan tempat tinggal.Kesimpulan: Terdapat hubungan kadar timbal dengan kadar Nitric Oxide (NO) pada ibu hamil preeklampsia.Kata kunci: Timbal, Nitric Oxide, Preeklampsia

Kontaminasi Parasit pada Uang Kertas yang Beredar di Pasar Raya Kota Padang Tahun 2021 Rendi Aulia; Arni Amir; Nurhayati Nurhayati
Jurnal Ilmu Kesehatan Indonesia Vol 3 No 1 (2022): Maret 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v3i1.733

Latar Belakang: Uang kertas merupakan alat yang digunakan untuk melakukan transaksi jual-beli terutama di pasar. Kebiasaan masyarakat yang kurang memperhatikan bagaimana cara memperlakukan uang mengakibatkan uang tersebut rusak dan kotor sehingga meningkatkan risiko menempelnya parasit. Objektif: Tujuan penelitian ini untuk melihat kontaminasi parasit pada uang kertas yang beredar di Pasar Raya Kota Padang Tahun 2021 Metode: Penelitian ini merupakan penelitian deskriptif dengan desain cross sectional yang berlangsung pada bulan Juli 2020-Desember 2021 yang menggunakan teknik pengambilan sampel random sampling dengan total 100 sampel uang kertas uang kertas yang ada pada pedagang bahan pangan sayur dan daging, dengan nominal Rp.2000, Rp.5000, Rp.10000 dan Rp.20.000. Setiap uang dicuci menggunakan normal saline,cairan kemudian di sentrifugasi dan sedimen diamati dengan pembesaran x100 dan x400 Hasil: Hasil penelitian menunjukkan bahwa 5% uang kertas terkontaminasi parasit. Parasit yang mengontaminasi adalah G.lamblia (40%) dan parasit E histolytica (60%). Uang Rp.5.000,- menjadi uang dengan tingkat kontaminasi tertinggi Kesimpulan: Uang yang beredar di Pasar Raya Kota Padang terkontaminasi oleh G. Lamblia dan E. Histolytica. Direkomendasikan kepada pengelola pasar untuk melakukan promosi dan konseling kesehatan kepada pedagang dan mengimplementasikan transaksi menggunakan QRIS.

Correlation between Zinc and Folic Acid Intake with Hemoglobin Levels in Pregnancy Eka Darmayanti Putri Siregar; Arni Amir; Nuzulia Irawati
Science Midwifery Vol 10 No 5 (2022): December: Science Midwifery
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v10i5.896

The deficiency of micronutrients and anemia are nutritional problems in pregnancy. WHO in 2019 and Riskesdas in 2018 reported that anemic pregnant women in Indonesia were 44.2% and 48.9%. Public Health Service also reported there was an increased prevalence of this problem in West Sumatra and Padang City in 2019 which was 18.1% and 11.2%. Micronutrient deficiency affected the hemoglobin (Hb) level, which is one of the indicators marking anemia in pregnancy. The objective was to determine the correlation between zinc and folic acid with hemoglobin levels in the third trimester of pregnancy. This analytical cross-sectional research was held in the Health Center and laboratory of Lubuk Kilangan on May-July 2022. The population and samples were 64 third-trimester pregnant women with total sampling. Intake data were collected through interviews using the Food Frequency Questionnaire (FFQ). Hemoglobin levels were examined by a hematology analyzer. Pearson correlation was used to identify the correlation of the variables (P< 0.05) . The mean levels of zinc and folic acid intake and hemoglobin levels were 7.35 mg, 215.56 mcg, and 11.08 g/dL. There was a positive correlation between zinc (p=0,015) and folic acid (p=0.004) with hemoglobin levels in the third trimester of pregnancy.

FAKTOR FAKTOR YANG MEMPENGARUHI UNMET NEED KB PADA WANITA USIA SUBUR DI WILAYAH BUNGUS PADANG, SUMATERA BARAT Yolanda Dwi Santi Violentina; Husna Yetti; Arni Amir
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Publisher : Andragogi Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRACTUnmet needs for family planning is a problem in family planning (KB) that needs special attention. The highest unmet need for family planning in Padang City is in Bungus District, with a percentage of 29.6%, while the national target is 6.5%. The purpose of this study was to analyze the factors that influence the unmet need for family planning in the Bungus Padang area. This study uses a qualitative descriptive research method which was carried out in March-May 2019 at the Bungus Health Center, Bungus BKKBN Representative Office, and the Bungus Health Center working area with samples taken using the principles of appropriateness and adequacy, namely the Head of the MCH/KB Responsible Division, PLKB, two midwifes, and five women of childbearing age. The results of the analysis show that there are obstacles that cause the high unmet need for family planning, namely the lack of human resources, lack of socialization, lack of the role of midwives, religious factors, and the husband's support. The conclusion is that the unmet need for family planning in the Bungus area is still high due to various factors. The process of socialization and implementation needs improvement in order to increase community activity. Keywords: Husband’s support, Role of Midwife, Unmet need for family planningABSTRAKUnmet need KB merupakan permasalahan yang terdapat pada keluarga berencana (KB) yang perlu mendapatkan perhatian yang khusus. Angka unmeet need KB tertinggi di Kota Padang terdapat di Kecamatan Bungus dengan persentase 29,6%, sedangkan target nasional 6,5%. Tujuan penelitian ini untuk menganalisis faktor yang mempengaruhi unmet need KB di wilayah Bungus Padang. Penelitian ini menggunakan metode penelitian deskriptif kualitatif yang dilaksanakan pada bulan Maret-Mei 2019 di Puskesmas Bungus, Kantor Perwakilan BKKBN Bungus dan wilayah kerja Puskesmas Bungus dengan subjek penelitian diambil menggunakan prinsip appropriateness and adequacy yaitu pada Kepala Bidang Penanggung jawab KIA/KB, PLKB, dua orang bidan pustu, 5 orang wanita usia subur. Hasil analisis menunjukkan bahwa terdapat kendala yang menyebabkan tingginya unmet need KB adalah kurangnya Sumber Daya Manusia (SDM), kurangnya sosialisasi, kurangnya peran bidan, faktor agama dan dukungan suami. Masih tingginya unmet need KB di Daerah Bungus yang disebabkan oleh berbagai faktor. Proses sosialisasi dan pelaksanaan membutuhkan perbaikan agar dapat meningkatkan keaktifan masyarakat.Kata Kunci : Dukungan Suami, Peran bidan, Unmet need KB

Time and Concentration-dependent Cytotoxicity of Piperine on Hela Cells Sri Oktavia; Arni Amir; Fatma Sri Wahyuni; Hasmiwati Hasmiwati
Majalah Kedokteran Andalas Vol 46, No 7 (2023): Supplementary December 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i7.p1174-1179.2023

Piperine, the primary alkaloid of Piper nigrum and Piper longum, is believed to have anticancer properties. Although research on cervical cancer is still in its early stages, piperine's anticancer capabilities have been established in numerous types of cancer and have been shown to target pathways involved in the cell cycle and apoptosis. This study aims to determine how piperine administration time and concentration affect the viability of Hela cells. The MTT method was used to conduct this study. The concentration of piperine utilized was 1,000; 500; 250; 125, and 62.5 µg/mL, and it was administered for 24 and 48 hours. The IC50 values, obtained after incubation for 24 and 48 hours, were 711.21 µg/mL and 419.75 µg/mL, respectively. We may conclude that the viability of HeLa cells is influenced by piperine in a time- and concentration-dependent manner (p<0.05).

Analysis of Allele Frequency Distribution Apoliprotein E Gene in Patients With Down Syndrome Trisomy 21 Malinda Meinapuri; Arni Amir; Eva Chundrayetti; efrida efrida; Susmiati Susmiati
Jurnal Kesehatan - STIKes Prima Nusantara Vol 15 No 1 (2024): Jurnal Kesehatan
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v15i1.1171

Background: Down syndrome is a global health problem of particular concern because people with Down syndrome have a wide variety of clinical disorders and are one of the causes of mental retardation and serious physical growth disorders.Down syndrome can occur at all socioeconomic, ethnic and demographic levels. The incidence of Down Syndrome will increase as the mother's age increases at the time of pregnancy and the incidence varies in different populations: 1 in 319 to 1 in 1000 live births. Each year, an estimated 3,000 to 5,000 children are born with Down syndrome. The APOE gene is located in the long arm (q) of chromosome 19 at position 13.2 (19q13.2). The APOE gene consists of four exons and three introns, a total of 3597 base pairs. In melanocyte cells APOE gene expression can be regulated by MITF. APOE is a form of polymorphic, which translates into three gene alleles: normal: allele ?3 and dysfunctional: allele ?2 and allele ?4. The polymorphism of the APOE gene had a strong effect on the level of allele production, a high concentration of APOE indicated that the production of ?4 allele was increased and a low concentration of APOE was associated with the production of ?2 allelePurpose:To Analyze of Allele Frequency Distribution Apoliprotein E Gene in Patients With Down Syndrome Trisomy 21Methods: This research is an analitic observasional study with a comparative study design. The sample used was the result of DNA extraction patients with Down's Syndrome Trisomy 21 as many as 33 samples and 33 controls stored in the Biomedical Laboratory, Faculty of Medicine, Andalas University, Padang, Indonesia. The next step is to examine the APOE gene polymorphisms using PCR and sequencing techniques.Results: Samples of Down syndrome patients had variations in the distribution of alleles, where alleles ?4 and ?2 were found even though the allele frequency ?3 was still the highest allele frequency. Meanwhile, in the samples representing the normal control population, ?3 and ?2 alleles were found and no ?4 allele was found. Although the allele is not associated with Down Syndrome, Down Syndrome sufferers have a 2.26 times greater risk for e2 and e4 alleles than e3.Conclusion: There was a difference in the frequency distribution pattern of the APOE gene allele in patients with Down Trisomy Syndrome 21 compared to the control.

Co-Authors Adang Bachtiar Citra Dewi Anitasari Darmayanti Siregar Defrin Defrin Defrin Defrin Delvina, Visti efrida efrida Ermawati Ermawati Ermawati Ermawati Ermawati, Ermawati Eryati Darwin Eva Chundrayetti Fachzi Fitri Fatma Sri Wahyuni Firdawati Firdawati Fitrahul Afifah Hasanalita, Hasanalita Hasmiwati Helmi Helmi Husna Yetti Malinda Meinapuri Nur Indrawaty Lipoeto Nurhayati, Nurhayati Nuzulia Irawati Putri Azzahroh Rahmatul Ulya Rahmi Junaida Rendi Aulia Rina Oktaviana Satria, Epi Silvi Zaimy Sri Juleli Sakerebau Sri Oktavia Susmiati Susmiati TITIN DEWI SARTIKA SILABAN Tiyan Febriyani Lestari Vaulinne Vaulinne VISTI DELVINA Visti Delvina Yaslinda Yaunin Yolanda Dwi Santi Violentina Yollanda Dwi Santi Violentina Yusrawati Yusrawati

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