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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia VALENSI Biospecies Jurnal MIPA AL KAUNIYAH Buletin Plasma Nutfah Transformasi: Jurnal Pengabdian Masyarakat Unnes Science Education Journal Wikrama Parahita : Jurnal Pengabdian Masyarakat Jurnal Penelitian Pendidikan IPA (JPPIPA) Biosfer: Jurnal Pendidikan Biologi Jurnal Mikologi Indonesia Bioma : Jurnal Biologi Indonesia Biosaintifika: Journal of Biology & Biology Education Acta Biochimica Indonesiana Health Information : Jurnal Penelitian Jurnal Riset Sains dan Kimia Terapan Journal of Microbial Systematics and Biotechnology JSMARTech : Journal of Smart Bioprospecting and Technology Jurnal Pengabdian kepada Masyarakat Nusantara Aptekmas : Jurnal Pengabdian Kepada Masyarakat Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Buitenzorg: Journal of Tropical Science Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Dalia Sukmawati
Universitas Negeri Jakarta
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Journal : Jurnal MIPA

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Nilai Indeks Aterogenik Plasma (IAP) Dan Indeks Castelli (IC) Mencit Model yang Diinduksi Minyak Trans Supiyani, Atin; Sukmawati, Dalia; Kusumorini, Nastiti; Santoso, Koekoeh; Satyaningtijas, Aryani Sismin
Jurnal MIPA Vol 10, No 2 (2021)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jmuo.10.2.2021.34094

Abstract

dikembangkan melalui pendekatan hewan model untuk mempelajari tentang PJK. Minyak goreng yang digunakan secara berulang dapat meningkatkan kadar asam lemak bebas yang berdampak negatif bagi kesehatan terutama jantung dan pembuluh. Tujuan dari penelitian ini mengukur indeks aterogenik plasma (IAP) dan indeks Castelli (IC) dari mencit model yang diinduksi minyak trans (MT). Sebanyak 16 ekor mencit galur DDY dibagi menjadi 4 kelompok yaitu mencit yang diinduksi 20% minyak trans (MT20), 40% minyak trans (MT40) dan 60% minyak trans (MT60) dan kontrol (K). Persentase minyak trans diberikan berdasarkan dari total energi konsumsi pakan harian. Minyak trans diberikan per oral sehari sekali selama 70 hari. Darah diambil pada hari ke-70 dari vena lateral ekor tikus untuk mengukur profil lipid plasma yaitu kolesterol total, trigliserida (TG), High Density Lippoprotein (HDL) dan Low Density Lipoprotein (LDL) plasma  menggunakan alat uji cepat Lipid Pro®. Nilai Indeks Aterogenik Plasma (IAP) yaitu log (TG/HDL) dan Indeks Castelli (IC) yaitu LDL/HDL. Hasil pengkuran profil lipid plasma menunjukkan kolesterol total, trigliserida, HDL dan LDL plasma pada kelompok MT meningkat secara nyata dibandingkan kontrol (sig<0,05). Nilai IA pada mencit yang diberi minyak trans berbeda nyata dari kontrol (sig<0,05) dan memiliki risiko tinggi. Nilai IC pada mencit yang diberi minyak trans berbeda nyata dari kontrol (sig<0,05) dan memiliki risiko sedang-tinggi. Minyak trans meningkatkan nilai indeks aterosklerosis dan indeks resiko koroner mencit.Coronary Heart Disease (CHD) is a "silent killer" disease. Various studies were developed through an animal model approach to studying CHD. Cooking oil that is used repeatedly can increase levels of free fatty acids which have a negative impact on health, especially the heart and vessels. The aim of this study was to measure the plasma atherogenic index (IAP) and Castelli index (IC) of trans oil-induced model mice (MT). A total of 16 DDY mice were divided into 4 groups, namely mice induced with 20% trans oil (MT20), 40% trans oil (MT40) and 60% trans oil (MT60) and control (K). The percentage of trans oil is given based on the total energy consumption of the daily feed. Trans oil is given orally once a day for 70 days. Blood was taken on the 70th day from the lateral vein of the rat tail to measure the plasma lipid profile, namely total cholesterol, triglycerides (TG), High Density Lippoprotein (HDL) and plasma Low Density Lipoprotein (LDL) using the Lipid Pro® rapid test kit. The Plasma Atherogenic Index (IAP) values are log (TG / HDL) and the Castelli Index (IC) is LDL / HDL. The results of measuring the plasma lipid profile showed that plasma total cholesterol, triglycerides, HDL and LDL in the MT group increased significantly compared to the control (sig<0,05). The IA value in mice treated with trans oil was significantly different from the control (sig<0.05) and had a high risk. The IC value in mice treated with trans oil was significantly different from the control (sig<0.05) and had a medium-high risk. Trans oil increased the atherosclerosis index and coronary risk index of mice.
Histomorfometri Duodenum Mencit (Mus musculus) yang Diinfeksi Telur Infektif Hymenolepis nana dan diberi Ekstrak Daun Kelor (Moringa oleifera Lam.) Atin Supiyani; Sekar Liyundzira; Daniel Ramadhan; Dalia Sukmawati
Jurnal MIPA Vol. 12 No. 2 (2023): Artikel
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jm.v12i2.45964

Abstract

Cacing cestoda Hymenolepis nana merupakan cacing parasit intestinal yang bersifat zoonosis. Infeksi dari cacing H.nana berdampak buruk pada saluran pencernaan, terutama pada duodenum host. Tujuan dari penelitian ini adalah untuk menguji pengaruh dari pemberian ekstrak daun kelor terhadap struktur duodenum mencit yang diinfeksi H.nana. Sebanyak 27 ekor mencit dibagi dalam 3 kelompok yaitu aquades (kontrol negatif), albendazole (kontrol positif), dan ekstrak daun kelor 500 ppm. Dosis letal 100 diperoleh dari uji in vitro ekstrak daun kelor pada telur dan larva cacing H.nana pada masa inkubasi 24, 48 dan 72 jam. Setiap mencit diinfeksi 40 butir telur H.nana secara oral. Ekstrak daun kelor diberikan selama 21 hari setelah infeksi. Histomorfometri struktur duodenum dengan mengukur tinggi vili, tebal mukosa, sub-mukosa, tunika muskularis, dan serosa pada 10 vili. Hasil penelitian diperoleh dosis letal 100-24 jam ekstrak daun kelor terhadap telur H.nana sebesar 397 ppm. Tinggi vili, tebal lapis mukosa, sub-mukosa, muskularis dan serosa mencit yang diberi ekstrak daun kelor berbeda signifikan (Sig<0.05). Pemberian ekstrak daun kelor dapat mempengaruhi struktur duodenum mencit yang terinfeksi cacing Hymenolepis nana.   The cestode worm Hymenolepis nana is a zoonotic intestinal parasitic worm. Infection from H. nana worms adversely affects the gastrointestinal tract, especially on the host duodenum. The purpose of this study was to determine the effect of Moringa leaf extract on the structure of the duodenum of mice infected with H. nana. A total of 27 mice were divided into 3 groups, namely aquades (negative control), albendazole (positive control), and Moringa leaf extract of 500 ppm. A lethal dose of 100 was obtained from in vitro tests of Moringa leaf extract on eggs and larvae of H. nana worms during the incubation period of 24, 48 and 72 hours. Each mice is infected with 40 H. nana eggs orally. Moringa leaf extract is administered for 21 days after infection. Histomorphometry of duodenal structures by measuring villi height, mucosal thickness, sub-mucosa, muscular tunica, and serous on 10 villi. The results of the study obtained a lethal dose of 100-24 hours of Moringa leaf extract against H. nana eggs of 397 ppm. Tall villi, thick layer mucosa, sub-mucosa, muscular and serous mice given Moringa leaf extract differed significantly (Sig<0.05). Administration of Moringa leaf extract can affect the structure of the duodenum of mice infected with Hymenolepis nana
Co-Authors . HERNAYANTI A.S. Satyaningtijas Abomoelak, Bassam Abumoelak, Bassam Adinda Myra Amalia Putri Agung Gumelar Agussetiandari, Indah Akbar, Dandy Andarwanti, Suci Anggraeni, Rosita Gio Atikah Nur Rahmawati Atin Supiyani Atin Supiyani Axel Mareta Ayu Berkahingrum Azzahra, Maharanianska Balqis, Mutia Balqis Bassam Abomoelak Berkahingrum, Ayu Dandy Akbar Juliansyah Daniel Ramadhan Diat Nurhidayat Dwi Ningsih Susilowati El Enshasy, Hesham El Enshasy, Hesham Ali El-Enshasy, Hesham Ali Elenshasy, Hesham Ali Endang Sri Purwanti Endang Sri Purwanti Fahriza, Tiara Fera Kurniadewi Fikriyyah, Nabilah Nov Fitriyanti, Anisa Gladys Indira Putri Guspri Devi Artanti Hanifia Rizky HD Marham Hernayanti Hernayanti Hesham Ali El-Enshasy I Made Wiranatha Iman Hidayat Iman Hidayat Irma Ratna Kartika Irvan Maulana Ismaya Krisdawati Jefferson Lynford Declan Juliansyah, Dandy Akbar Kartika, Irma Ratna koekoeh santoso Krisdawati, Ismaya Kurniadewi, Fera Lita Citra Dewi Maharanianska Azzahra Marham, Hilma Dianti Maulana, Irvan Medita, Havana Zahra Moersilah, Moersilah Muktiningsih Nurjayadi Musie, Royna Rahma Nabila, Dasilva Azka NASTITI KUSUMORINI Nuniek Ina Ratnaningtyas Nur Afifah, Zakiah Nuraeni Ekowati Nuraeni Ekowati, Nuraeni Pinkan Amanda Putri Priyo Wahyudi Puspitasari, Sherly Indah Putri Novitasari Putri, Adinda Myra Amalia Putri, Gladys Indira R Rusdi R. Haryo Bimo Setiarto, R. Haryo Bimo RADEN HARYO BIMO SETIARTO Raden Haryo Bimo Setiarto Rahmawati, Atikah Nur Retno Widowati Rheva Amadea Rini Fahmi, Melta Rista Putri Nur Ifa Roshanida A. Rahman Rosita Gio Anggraeni Rusdi Rusdi Rusilanti Rusilanti Rustam, K. Yoswita RUSTAM, YOSWITA Saamia, Vira Saamia4, Vira Saputro, Dwi Anna Oktaviani Sari, Dessy Putriana Sekar Liyundzira Shabrina, Andisa Shangkara, Muhammad Arkent SRI RAHAYU Sri Rahayu Sri Rahayu Suci Andarwanti Sulistiyani Supiyani, Atin Supiyani, Atin Supiyani Supriyatin Supriyatin Tiara Fahriza Tri Handayani Tri Handayani Kurniati Umiatin Vira Saamia Wiranatha, I Made Wulandari, Tria Putri Yadi Suryadi Yohana Caroline Sihombing Yohannes Eka Cordias Buulolo Yunita Sari Zahra, Lamya Nauratu