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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik As-syifaa Jurnal Farmasi Adi Widya : Jurnal Pengabdian Masyarakat Journal of Dedicators Community JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Biomedika Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Intan Husada : Jurnal Ilmiah Keperawatan Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Fundamental and Applied Pharmaceutical Science Jurnal Pengabdian kepada Masyarakat Jurnal Buana Farma Indonesian Journal of Pharmaceutical Education Media Farmasi Indonesia Indonesian Journal of Pharmacy and Natural Product Parapemikir Jurnal Ilmiah Farmasi Prosiding Seminar Nasional Unimus
Reslely Harjanti
Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Setia Budi Jl. LetJend.Sutoyo Mojosongo, Solo 57127.
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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FORMULASI SERUM ANTIOKSIDAN EKSTRAK ETANOL DAUN MATOA (POMETIA PINNATA J.R FORST AND G. FORST) DENGAN VARIASI GELLING AGENT CARBOPOL 940 : ANTIOXIDANT SERUM FORMULATION OF MATOA LEAF ETHANOL EXTRACT (POMETIA PINNATA J.R FORST AND G. FORST) WITH VARIATIONS OF GELLING AGENT CARBOPOL 940 Anita Nilawati; Ayu Bainunniza; Reslely Harjanti
Intan Husada : Jurnal Ilmiah Keperawatan Vol. 12 No. 02 (2024): Vol. 12 No.2 , Juli 2024
Publisher : Politeknik Insan Husada Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52236/ih.v12i2.608

Abstract

Daun matoa (Pometia pinnata J.R Forst and G. Forst) mengandung flavonoid yang berpotensi sebagai antioksidan alami. Senyawa yang berasal dari bahan alam, terutama flavonoid banyak dimanfaatkan salah satunya sebagai komponen aktif dalam sediaan kosmetik. Serum adalah salah satu jenis sediaan kosmetik dengan konsentrasi kandungan zat aktif tinggi dan viskositas rendah, yang mampu menghantarkan film tipis dari bahan aktif pada permukaan kulit. Carbopol 940 digunakan sebagai gelling agent yang dapat mempengaruhi nilai viskositas dan daya sebar pada sediaan. Tujuan. Penelitian ini bertujuan untuk menentukan pengaruh variasi basis carbopol 940 terhadap sifat fisik dan stabilitas serum ekstrak daun matoa yang berpotensi antioksidan. Metode. Ekstrak etanol daun matoa diperoleh melalui proses maserasi menggunakan pelarut etanol 96%. Selanjutnya ekstrak tersebut diformulasi menjadi sediaan serum dengan variasi konsentrasi carbopol 940 pada FI (0,4%), FII (0,5%) dan FIII (0,6%). Ekstrak dan sediaan tersebut kemudian dievaluasi sifat fisik dan stabilitasnya serta diuji potensi antioksidannya terhadap radikal DPPH (1,1-difenil-2-pikrilhidrazil). Hasil. Hasil penelitian menunjukkan bahwa hanya FII yang memenuhi persyaratan mutu fisik dan stabilitas. Variasi konsentrasi carbopol berpengaruh terhadap parameter pH, viskositas serta daya sebar sediaan serum. Semakin rendah konsentrasi carbopol akan menyebabkan penurunan viskositas dan peningkatan daya sebar. Serum FI menghasilkan potensi antioksidan terbaik dengan nilai IC50 sebesar 69,74 ppm±0,80. Kesimpulan. Serum ekstrak etanol daun matoa mempunyai potensi antioksidan dan variasi konsentrasi Carbopol berpengaruh terhadap mutu fisik sediaan serum.
Formulasi Dan Uji Aktivitas Antioksidan Sediaan Essence Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) Dengan Variasi Konsentrasi Butilen Glikol Dzulhija, Aleyda Freshananda; Aisiyah, Siti; Harjanti, Reslely
Jurnal Farmasi (Journal of Pharmacy) Vol 13, No 2 (2024)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v13i2.313

Abstract

Bunga telang (Clitoria ternatea L.) mengandung senyawa polifenol dengan komponen utamanya yaitu antosianin yang memiliki sifat antioksidan tinggi. Pengaplikasian antioksidan sebagai agen proteksi kulit dibuat dalam bentuk sediaan essence. Tujuan dari penelituan ini adalah membuat sediaan essence ekstrak etanol bunga telang (Clitoria ternatea L.) dengan variasi konsentrasi butilen glikol untuk memperoleh formula dengan mutu fisik dan strabilitas terbaik serta memiliki aktivitas sebagai antioksidan. Ektrak etanol bunga telang diperoleh dari proses maserasi menggunakan pelarut etanol 70%, selanjutnya dilakukan pembuatan formula essence dengan variasi konsentrasi butilen glikol sebagai humektan yaitu 5%; 7,5%; 10%. Uji mutu fisik sediaan essence meliputi pengamatan organoleptis, homogenitas, viskositas, pH, dan uji stabilitas menggunakan metode Freeze-Thaw. Pengujian aktivitas antioksidan sediaan essence menggunakan metode DPPH. Data yang diperoleh dianalisis menggunakan SPSS. Hasil penelitian menunjukkan bahwa ekstrak etanol bunga telang dapat dibuat menjadi sediaan essence dengan mutu fisik yang baik, dimana variasi konsentrasi butilen glikol mempengaruhi viskositas sediaan yaitu semakin tinggi konsentrasi butilen glikol, maka sediaan essence yang dihasilkan semakin kental. Formula dengan konsentrasi 5% butilen glikol, memiliki mutu fisik baik, stabil pada organoleptis dan homogenitas serta memiliki aktivitas antioksidan terhadap peredaman radikal bebas DPPH (2,2-diphenyl-1-picrylhydrazyl).
Pengaruh Suhu Penyimpanan terhadap Kadar Parasetamol Sirup Selama Beyond Use Date Secara Spektrofotometri UV-Vis: Effect of Storage Temperature on Paracetamol Syrup Concentration During Beyond Use Date by UV-Vis Spectrophotometry Indra Meilina Yusefa; Nuraini Harmastuti; Reslely Harjanti
Indonesian Journal of Pharmacy and Natural Product Vol. 7 No. 02 (2024): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v7i02.3344

Abstract

Paracetamol or acetaminophen is a widely used analgesic-antipyretic drug worldwide. Paracetamol in liquid form is preferred because of its easy administration and rapid absorption in the body and large doses are easily adjusted for children. Storage of paracetamol syrup in accordance with the etiquette is at controlled room temperature. Beyond use date (BUD) is the time limit for the use of a drug after it has been formulated, prepared or after its primary packaging has been opened or tampered with. The purpose of this study was to determine the effect of storage temperature on paracetamol syrup levels during BUD. Paracetamol syrup was stored in a room with air conditioning (20-25oC) and without air conditioning (30-40oC) for 14 days. Observation of levels was carried out on days 0, 3, 7, 10 and 14 using UV-Vis spectrophotometry with a wavelength of 247 nm and operating time for 22 minutes. The results of the determination of paracetamol syrup levels after storage for 14 days in a room with air conditioning in generic and trademark samples were 90.05 ± 1.34% and 92.73 ± 1.01%, respectively. Paracetamol syrup levels in a room without air conditioning in generic and trademark samples are 79.07 ± 0.99% and 81.10 ± 2.02%. Storage temperature affects paracetamol syrup levels during storage with a difference in levels of 10.98% for generic samples and 11.63% for trademark samples during BUD.   ABSTRAK Parasetamol merupakan obat analgesik-antipiretik yang banyak digunakan di seluruh dunia. Parasetamol dalam bentuk cairan lebih disukai karena pemberiannya yang mudah dan cepat terabsorpsi dalam tubuh serta dalam pemberian dosis besar mudah disesuaikan untuk anak. Penyimpanan parasetamol sirup yang sesuai dengan etiket adalah pada suhu ruang terkendali. Beyond use date (BUD) adalah batas waktu penggunaan obat setelah diracik, disiapkan atau setelah kemasan primernya dibuka atau dirusak. Tujuan penelitian ini adalah untuk mengetahui pengaruh suhu penyimpanan terhadap kadar parasetamol sirup selama BUD. Parasetamol sirup disimpan pada ruang dengan penyejuk udara (20 – 25oC) dan tanpa penyejuk udara (30 – 40oC) selama 14 hari. Pengamatan kadar dilakukan pada hari ke-0, 3, 7, 10 dan 14 menggunakan spektrofotometri UV-Vis dengan panjang gelombang 247 nm dan waktu operasi selama 22 menit. Hasil penetapan kadar parasetamol sirup setelah penyimpanan selama 14 hari di ruang dengan penyejuk udara pada merek generik dan merek dagang berturut-turut yaitu 90,05 ± 1,34% dan 92,73 ± 1,01%. Kadar parasetamol sirup diruang tanpa penyejuk udara pada merek generik dan merek dagang yaitu 79,07 ± 0,99% dan 81,10 ± 2,02%. Suhu penyimpanan mempengaruhi kadar parasetamol sirup selama penyimpanan dengan selisih kadar 10,98% untuk merek generik dan 11,63% untuk merek dagang selama BUD.
ANALISIS BAHAN KIMIA OBAT ASAM MEFENAMAT DALAM JAMU PEREDA NYERI YANG BEREDAR DI NGAWI DAN ONLINE SHOP SECARA KLT DAN SPEKTROFOTOMETRI UV-VIS Harjanti, Reslely; Pratiwi, Intan; Sarimanah, Jamilah
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p7-16

Abstract

One of the medicinal chemicals (BKO) that is abused in herbs preparations for pain reliever is mefenamic acid. Mefenamic acid is a class of non-steroidal anti-inflammatory drug (NSAID). The addition of mefenamic acid in herbs medicine aims to increase the effect of pain relief, but can caused harmful effects, including digestive tract disorders, hemolytic anemia, and seizures. The purpose of this study is to determine the presence of mefenamic acid in pain reliever herbs circulating in Ngawi and online shop.The samples in this study were several brands of pain reliever herbs from 4 herbal medicine shops (A,B,C, and D). This research is using purposive sampling method based on inclusion criteria. Samples was analyzed qualitatively by thin layer chromatography (TLC) method using cyclohexane:chloroform: methanol:glacial acetic acid (60:30:5:5) as mobile phase and silica GF254 as stationary phase. Quantitive analysis using spectrophotometry UV-Vis method. The results showed that 10 of 16 samples of herbal pain reliever were positive for mefenamic acid with levels ranging from 1.28% -7.30%. The UV-Vis spectrophotometric analysis method suitable for the analysis of mefenamic acid in herbal medicine for pain reliever based on validation results that meet the requirements includes linearity with r value 0.99956, accuracy 8 ppm was 100.32%, 10 ppm was 100.84%, 12 ppm was 100.61%, precision 1.33%, LOD 0.8914299023 ppm, and LOQ 2.701302734 ppm.
Pengaruh Croscarmellose Sodium Terhadap Mutu Fisik Orally Disintegrating Tablet Glibenklamid Hasil Dispersi Padat Hariyani, Bunga Fitri; Harjanti, Reslely; Priyanto, Widodo
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p154-161

Abstract

Glibenclamide is the second generation of the sulfonylurea group, which is used orally in patients with type 2 diabetes mellitus. Oral tablet preparations are still the main choice because they have the exact size of the usual desired dose, whereas for liquid preparations, patients must measure the medicine themselves. Pediatric and geriatric patients generally often experience difficulties when swallowing tablet or oral medications. So, to overcome this, an ODT preparation was made, the way to consume it is just to put it on the tongue, then the ODT tablet will disintegrate and dissolve in saliva. The aim of this research was to determine the variation of croscarmellose sodium that produces the best physical quality of Glibenclamide ODT tablets. The manufacture of Glibenclamide ODT has been carried out using the mixture method (dissolution-mixing). The solid dispersion that has been used is PEG 4000 and uses various concentrations of Croscarmellose Sodium, namely 0 mg, 2 mg, 4 mg, 6 mg, and 8 mg. The resulting ODT tablets were evaluated using several parameters, namely hardness test, friability test, wetting test, in vitro disintegration time test, and taste response test. The data obtained will be analyzed using one-way ANOVA with a confidence level of 95%. Research results have shown that the use of 4% Croscarmellose Sodium has resulted in the fastest in vitro disintegration (disintegration) time of 4.44 seconds, and the fastest wetting time of 21.67 seconds. The higher the concentration of croscarmellose sodium can produce the best physical quality.
OPTIMASI HPMC DAN XANTHAN GUM SEBAGAI MATRIKS TABLET LEPAS LAMBAT KAPTOPRIL MENGGUNAKAN METODE Simplex Lattice Design (SLD) Sari, Sandra Eka Purna; Aisyah, Siti; Harjanti, Reslely
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p162-171

Abstract

Captopril extended-release preparations are preparations that are modified to maintain the drug at therapeutic blood or tissue levels thereby reducing fluctuations in plasma concentrations. The aim of this research was to determine the effect of a combination of HPMC and xanthan gum matrices on the physical properties of captopril extended-release tablets, as well as to determine the best concentration of HPMC and xanthan gum to obtain captopril sustained-release preparations with optimum physical properties. The preparation of the preparation used the wet granulation method and used 8 runs of the Design Expert Simplex Lattice Design with a concentration ratio of HPMC and xanthan gum. Research results have shown that the higher concentration of xanthan gum can increase tablet hardness, reduce tablet friability, and can inhibit the initial release of active substances so that the drug release rate becomes slower. The optimum formula for extended-release captopril tablets resulting from optimization was HPMC 8060-N 25.496 mg, xanthan gum 49.504 mg with a hardness of 15.668 kg, a friability of 0.026 g/second, and a dissolution rate of 45.512%. The release profiles of captopril extended release tablets in this study all followed the Higuchi model release kinetics except for formulas 4, 6, formula 8 which followed zero order release kinetics.
AKTIVITAS ANTIJAMUR FRAKSI KAYU SECANG TERHADAP Candida albicans DAN BIOAUTOGRAFI: Indonesia Senja, Salsadella Juwita; Indrayati, Ana; Harjanti, Reslely
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1415

Abstract

Sappan (Caesalpinia sappan L.) is a plant of the Caesalpiniaceae family that is used for traditional medicine. Utilized Secang (Caesalpinia sappan L.) is a plant from the Caesalpiniaceae family whose wood has long been used in traditional medicine and contains compounds such as brazilin, flavonoids, saponins, propane, tannins, and terpenoids with potential antifungal activity. Fungal infections, particularly Candida albicans, remain common health problems, and although antifungal drugs such as fluconazole are widely used, resistance cases continue to increase. This study aimed to evaluate the antifungal activity of secang wood extract and its fractions against C. albicans and to identify the most active compound group using thin-layer chromatography (TLC) bioautography. Secang wood was extracted by maceration with 96% ethanol and fractionated with n-hexane, ethyl acetate, and water, followed by antifungal testing using the paper disc diffusion method at concentrations of 6%, 9%, and 12%, with fluconazole as a positive control and 3% DMSO as a negative control. Data were analyzed using two-way ANOVA and showed normal distribution (Sig > 0.05). The results demonstrated that the extract, n-hexane fraction, ethyl acetate fraction, and water fraction inhibited the growth of C. albicans, with the water fraction at 12% producing the largest inhibition zone of 16.19 mm, categorized as strong activity. TLC bioautography of the water fraction revealed the presence of tannins as active compounds responsible for antifungal activity.
Penentuan Nilai SPF pada Serum Fraksi Etil Asetat Ekstrak Etanol Kelopak Bunga Rosela (Hibiscus sabdarifa L.) Nopiyanti, Vivin; Harjanti, Reslely; Aisiyah, Siti
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 1 (2022): Jurnal Farmasi (Journal of Pharmacy), April 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/0c0qrh09

Abstract

The ethyl acetate fraction of the ethanol extract of roselle flower petals (Hibiscus sabdariffa L.) was reported to have an SPF value of 13.83 ± 1.50 which was higher than the ethanol extract. So with the SPF value, the ethyl acetate fraction of roselle flower ethanol extract can be used as a sunscreen. One of the cosmetic preparations that is currently growing rapidly is serum. The purpose of this study was to formulate the ethyl acetate fraction of roselle petals into a serum that had good physical quality with variations in the concentration of xanthan gum and then the SPF value was determined. This research begins with the manufacture of ethanol extract of roselle petals. Then fractionation (liquid-liquid partition) was carried out using solvents with different polarities, namely n-hexane and ethyl acetate. Furthermore, the ethyl acetate fraction was formulated into serum with variations in the concentration of xanthan gum 0.3%, respectively; 0.6% and 1.2% were then tested for physical quality and stability. The next step is to determine the SPF value of the serum by using the UV spectrophotometric method and its calculation using the Mansur equation. The results showed that the serum ethyl acetate fraction of the ethanolic extract of roselle petals could be made into gel preparations with good physical qualities including organoleptic, viscosity, pH and homogeneity. Serum ethyl acetate fraction ethanol extract of roselle flower formulas 1, 2 and 3 had SPF values ​​F1 respectively, namely 6.8595 ± 0.08 which included moderate protection potential; F2 is 7.0089 ± 0.17; and F3 which is 8.2251 ± 0.32 with extra protection potential. Variations in the concentration of xanthan gum in the serum formula affect the physical quality of the viscosity and potency of sunscreen preparations.
Formulasi dan Uji Aktivitas Antioksidan Sediaan Essence Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) dengan Variasi Konsentrasi Butilen Glikol Freshananda Dzulhija, Aleyda; Aisiyah, Siti; Harjanti, Reslely
Jurnal Farmasi (Journal of Pharmacy) Vol. 13 No. 2 (2024): Jurnal Farmasi (Journal of Pharmacy), October 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/227qcj79

Abstract

Telang flowers (Clitoria ternatea L.) contain polyphenolic compounds with the main component, anthocyanins, which have high antioxidant properties. The application of antioxidants as skin protection agents is made in the form of essence preparations. The purpose of this research is to make a preparation of ethanol extract of telang flower with varying concentrations of butylene glycol to obtain a formula with the best physical quality and stability and has antioxidant activity. The ethanol extract of telang flower was obtained from the maceration process using 70% ethanol solvent, then the essence formula was made with variations in the concentration of butylene glycol as a humectant, namely 5%; 7,5%; 10%. Physical quality test of essence preparation includes organoleptical observation, homogeneity, viscosity, pH, and stability test using Freeze-Thaw method. Testing the antioxidant activity of essence preparations using the DPPH method. The data obtained were analyzed using SPSS. The results of the research show that the ethanol extract of telang flower can be made into an essence preparation with good physical quality, where variations in the concentration of butylene glycol affect the viscosity of the preparation, namely the higher the concentration of butylene glycol, the thicker the resulting essence preparation. The formula with a concentration of 5% butylene glycol, has good physical quality, is stable in organoleptic and homogeneity and has antioxidant activity against DPPH (2,2-diphenyl-1-picrylhydrazyl) free radicals.
Co-Authors - Supriyadi Amanda Duta Wijaya Ana Indrayati Angeline Tamara Anita Nilawati Astiti Noer Cahyati Ayu Bainunniza Ayu Wikandita, Kharisma Benedikta Coo Mogi Bunga Fitri Hariyani Dewi Ekowati Dewi Purnamasari, Nur Aini Dyonisius Andang Arif Wibawa Dzulhija, Aleyda Freshananda Endang Sri Rejeki Fitri Jati Rukmana Freshananda Dzulhija, Aleyda Gregorius Prima Indra Budianto, Gregorius Prima Indra Gunawan Pamudji Hariyani, Bunga Fitri Ilham Kuncahyo Ilham Kuncahyo, Ilham Indra Meilina Yusefa Intan Pratiwi Jason Merari Peranginangin Mamik Ponco Rahayu Ni Wayan Devy Indah Lestari Nilawati, Anita Noela Riski Riani Sumbung NURAINI HARMASTUTI Nurrohim, Suci Padusitrada Padusitrada Pratiwi, Intan Priyanto, Widodo Pudiastuti R.S.P R.F.X Premihadi Putra Rahmatudina, Farikha Ratno Agung Samsumaharto Sandra Eka Purna Sari Sari, Sandra Eka Purna Sarimanah, Jamilah Sarimanah, Jamilah Sawal, Rizky Ardian Hartanto Senja, Salsadella Juwita SEPTINA DYAH NUGRAENI Sesilia Putri Nandita Siti Aisiyah Siti Aisiyah Siti Aisiyah Siti Aisyah Siti Aisyah Suhartinah Suhartinah Suhartinah Suhartinah, Suhartinah Sulastri   Titik Sunarni Titik Sunarni Vivin Nopiyanti Vivin Nopiyanti Vivin Nopiyanti Vivin Nopiyanti Vivin Nopiyanti Vivin Nopiyanti Vivin Nopiyanti Widodo Priyanto Widyasti, Jena Hayu Yari Mukti Wibowo