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All Journal Jurnal Kesehatan Andalas Majalah Obat Tradisional Media Ilmu Kesehatan Majalah Kedokteran Andalas Jurnal Sehat Mandiri Bioscientia Medicina : Journal of Biomedicine and Translational Research Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Akademika Baiturrahim Jambi
Zelly Dia Rofinda
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Gambaran Faktor Risiko Hiperbilirubinemia Pada Neonatus yang Dirawat di Ruang Perinatologi RSUP Dr. M. Djamil Padang Fadhillah, Ilham Arief; Afdal, Afdal; Pertiwi, Dian; Masnadi, Nice Rachmawati; Rofinda, Zelly Dia; Handayani, Tuti
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 2 (2024): Juni 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i2.1208

Abstract

Abstrak Latar Belakang: Hiperbilirubinemia ditandai dengan adanya ikterus. Hiperbilirubinemia dibedakan menjadi dua jenis, yaitu hiperbilirubinemia fisiologis dan patologis. Hiperbilirubinemia pada neonatus perlu mendapat perhatian karena dapat menyebabkan neonatus mengalami bilirubin ensefalopati akut atau pada fase lanjut akan menyebabkan kernikterus Objektif: Penelitian ini bertujuan untuk mengetahui gambaran faktor risiko hiperbilirubinemia pada neonatus yang dirawat di perinatologi RSUP Dr. M. Djamil Padang Metode: Penelitian ini merupakan penelitian deskriptif retrospektif yang menggunakan data rekam medis neonatus dengan hiperbilirubinemia pada bulan Januari 2021 hingga Desember 2022 Hasil: Hasil penelitian ini didapatkan 58,6% neonatus dengan hiperbilirubinemia berjenis kelamin laki-laki, dan 35,7% masuk dalam kategori high risk. Kejadian faktor risiko hiperbilrubinemia pada neonatus adalah 35,6% dengan berat lahir rendah, 32,8% dengan inkompatibilitas darah, 32,8% dengan preterm, 21,4% dengan infeksi, 7,1% dengan breastfeeding jaundice, dan 1,4% dengan ibu diabetes melitus. Tidak ditemukan faktor risiko polisitemia pada neonatus yang hiperbilirubinemia. Kesimpulan. Pada penelitian ini didapatkan faktor risiko hiperbilirubinemia pada neonatus terbanyak adalah BBLR, diikuti oleh faktor risiko lainnya seperti inkompatibilitas darah, usia gestasi, infeksi, breastfeeding jaundice, dan ibu diabetes melitus Abstract Background: Hyperbilirubinemia is an increased level of bilirubin in the blood which is clinically characterized by icterus. There are various risk factors for hyperbilirubinemia in neonates so attention needs to be paid because it can cause neonates to experience acute bilirubin encephalopathy or in the advanced phase it can cause kernicterus. Objective: This study aims to describe the risk factors for hyperbilirubinemia in neonates treated at the neonatology department of RSUP Dr. M. Djamil Padang. Method: This research is a retrospective descriptive study using medical records of neonates with hyperbilirubinemia. This research was conducted at RSUP Dr. M. Djamil Padang in January 2021 – December 2022. In this study, 70 samples were obtained from neonates with a diagnosis of hyperbilirubinemia who met the inclusion criteria. Result: The results of this study founded that 35,7% of neonates with hyperbilirubinemia were included in the high risk category. 41% of neonates with hyperbilirubinemia are male. The risk factors for hyperbilirubinemia in neonates were 35.6% with low birth weight neonates, 32.8% with blood incompatibility, 32.8% with preterm, 21.4% with infections, 7.1% with breastfeeding jaundice, and 1.4% with diabetes mellitus. No risk factors for polycythemia were found in neonates with hyperbilirubinemia. Conclusion: The conclusion of this study is the most common risk factor for hyperbilirubinemia in neonates is LBW, followed by other risk factors such as blood incompatibility, gestational age, infection, breastfeeding jaundice, cholestasis, and maternal diabetes mellitus. Keyword: Neonates, hyperbilirubinemia, risk factors.
Karakteristik Pasien Leukemia Granulositik Kronik Berdasarkan Hasil Direct Coomb’s Test di RSUP Dr. M. Djamil Zahira, Aisyah Dhia; Rofinda, Zelly Dia; Izzah, Amirah Zatil; Efrida, Efrida; Afriant, Rudy; Rahmatini, Rahmatini
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 3 (2024): September 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i3.1314

Abstract

Abstrak Latar Belakang: Leukemia Granulositik Kronik (LGK) merupakan penyakit mieloproliferatif yang ditandai dengan adanya proliferasi seri granulosit tanpa ada gangguan diferensiasi. Direct Coomb’s Test (DCT) digunakan untuk mendekteksi adanya antibodi imun, baik IgG maupun komponen komplemen (umumnya C3d) yang menutupi atau mensensitisasi sel eritrosit. Pemeriksaan coomb’s test pada pasien LGK dilakukan apabila adanya kecurigaan anemia dan terjadinya retikulositosis tanpa ditemukan adanya sumber perdarahan yang jelas. Objektif: Tujuan penelitian ini untuk mengetahui karakteristik pasien LGK berdasarkan hasil direct coomb’s test di RSUP Dr. M.Djamil Padang. Metode: Penelitian deskriptif dilakukan terhadap semua pasien yang didiagnosis LGK yang memiliki hasil direct coomb’s test. Pengambilan sampel dilakukan secara consecutive sampling dengan 30 sampel yang memiliki data berupa usia, jenis kelamin, hasil direct coomb’s test, derajat anemia, hitung retikulosit, dan jenis terapi. Hasil: Penelitian berdasarkan jenis kelamin pada pasien leukemia granulositik kronik didapatkan lebih banyak perempuan yaitu 18 pasien (60%) dan laki-laki 12 pasien (40%) dengan rerata usia 44 tahun. Direct coomb’s test menunjukkan hasil positif pada 21 pasien (70%) dan negatif pada 9 pasien (30%). Anemia berat paling banyak ditemukan pada direct coomb’s test negatif dengan 55,6%. Retikulositosis lebih banyak ditemukan pada hasil direct coomb’s test positif. Kesimpulan: Pasien LGK dengan hasil direct coomb’s test positif lebih banyak ditemukan anemia berat, anemia sedang, dan retikulositosis. Kata kunci: direct coomb’s test, leukemia granulositik kronik, luka sedang
Monocyte-to-HDL Cholesterol Ratio Predicts 30-Day Mortality in ST-Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention Kurniawan; Yaswir, Rismawati; Deswita Sari; Zelly Dia Rofinda; Dwi Yulia; Syofiati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1279

Abstract

Background: ST-elevation myocardial infarction (STEMI) is a leading cause of mortality worldwide. Despite advancements in treatment, especially with primary percutaneous coronary intervention (pPCI), 30-day mortality rates remain significant. The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) has emerged as a potential predictor of mortality in STEMI patients, reflecting the balance between inflammation and anti-atherosclerotic processes in atherosclerotic plaques. This study aimed to evaluate the association between MHR and 30-day mortality in STEMI patients undergoing pPCI. Methods: This prospective observational study included 55 STEMI patients treated with pPCI at Dr. M. Djamil General Hospital in Padang, Indonesia, between January and July 2024. Patients were included if they were ≥18 years old, undergoing their first pPCI, and had blood tests done within 24 hours of admission. Patients with prior revascularization, acute/chronic infections, malignancies, autoimmune diseases, or on lipid-lowering therapy were excluded. Blood samples were collected within 24 hours of admission. Monocyte counts were measured using flow cytometry, and HDL cholesterol levels were determined using a homogeneous enzymatic colorimetric method. The MHR was calculated by dividing the monocyte count by the HDL cholesterol level. The primary outcome was 30-day mortality, assessed through hospital records and telephone follow-up. Statistical analysis included chi square, t-tests, and Mann-Whitney U tests. Results: The mean age of the study participants was 59.5 (±11.4) years, with 81.8% being male. The mean monocyte count and MHR were 968 (±212)/mm3 and 28.3 (±6.06), respectively. The median HDL cholesterol level was 33.4 (27-49) mg/dL. Both monocyte count and MHR were significantly higher in patients who died within 30 days compared to those who survived (p<0.001). Conclusion: The MHR is an independent predictor of 30-day mortality in STEMI patients undergoing pPCI. This readily available and cost-effective biomarker may aid in risk stratification and guide treatment strategies for this high-risk population.
Mean Platelet Volume and Immature Platelet Fraction as Biomarkers in Differentiating Early-Onset and Late-Onset Neonatal Sepsis Rahmi Dina Indra; Rikarni; Desiekawati; Zelly Dia Rofinda; Dwi Yulia; Elfira Yusri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1280

Abstract

Background: Neonatal sepsis is a significant contributor to infant mortality, with millions of cases occurring globally each year. It is classified into early-onset neonatal sepsis (EONS), occurring within the first 72 hours of life, and late-onset neonatal sepsis (LONS), occurring after 72 hours. Thrombocytopenia is a common finding in neonatal sepsis, and the degree of thrombocytopenia has been associated with the severity of the disease. Mean platelet volume (MPV) and immature platelet fraction (IPF) are markers of platelet size and immaturity, respectively, and may provide insights into the pathophysiology of sepsis and aid in its diagnosis. Methods: This cross-sectional analytical study was conducted at Dr. M. Djamil General Hospital in Padang, Indonesia, from June to September 2024. The study included 41 neonates diagnosed with sepsis. Complete blood counts were performed using an automated hematology analyzer to determine MPV, IPF, and platelet count. Neonatal sepsis was classified as EONS (within the first 7 days of life) or LONS (from day 8 to 28). Data were analyzed using descriptive statistics and the unpaired t-test. Results: The mean age of the neonates was 11.6 days. There were 19 neonates with EONS and 22 with LONS. The mean MPV was significantly higher in the LONS group (11.7 fL) compared to the EONS group (10.2 fL) (p=0.001). Similarly, the mean IPF was significantly higher in the LONS group (10.9%) compared to the EONS group (7.7%) (p=0.001). There was no significant difference in platelet count between the two groups. Conclusion: MPV and IPF were significantly higher in neonates with LONS compared to those with EONS, suggesting that these parameters may be useful biomarkers for differentiating between the two conditions. Further research with a larger sample size and longitudinal follow-up is needed to confirm these findings and to assess the potential clinical utility of MPV and IPF in the management of neonatal sepsis.
Impact of Donation Frequency on Iron Stores and Hemoglobin Levels in Regular Blood Donors Lili Novri Yanti; Rofinda, Zelly Dia; Syofiati; Rikarni; Husni; Elfira Yusri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1282

Abstract

Background: Regular blood donation, while crucial for healthcare systems, can lead to iron deficiency and anemia in donors. This study investigated the impact of donation frequency on iron stores and hemoglobin levels in regular blood donors. Methods: A cross-sectional study was conducted on 82 regular blood donors at the blood transfusion unit of Dr. M. Djamil General Hospital from February to April 2024. Participants underwent pre-transfusion screening, including a questionnaire on donation frequency and iron supplement use. Blood samples were collected during donation, and serum ferritin, hemoglobin, and erythrocyte indices (MCV, MCH, MCHC) were measured if the C-reactive protein (CRP) test was negative. Data were analyzed using the Kruskal-Wallis test. Results: The mean age of the donors was 31 years, with the majority being female (56.1%). The most common donation frequency was 6-10 times (34.15%). None of the donors reported using iron supplements. Serum ferritin levels showed significant differences among female donors based on donation frequency (p=0.004) but not among male donors (p=0.114). Hemoglobin levels also differed significantly among female donors (p=0.002), but not among male donors (p=0.213). Significant differences were observed in MCV and MCH values in both male and female donors (p<0.001 and p=0.001, respectively), but not in MCHC values (p=0.135). Conclusion: Donation frequency significantly impacts iron stores and hemoglobin levels in female blood donors but not in male donors. Regular monitoring of iron stores, particularly in female donors, is crucial to prevent iron deficiency and anemia.
The Clinical Significance of DAT Positivity: A Comparative Analysis of IgG, C3d, and IgG/C3d-Positive Patients Khaulah Karimah; Zelly Dia Rofinda; Husni; Rikarni; Deswita Sari; Yoshie Anto Chicamy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1288

Abstract

Background: The direct antiglobulin test (DAT) is a crucial diagnostic tool in immunohematology, used to detect the presence of antibodies and/or complement components on the surface of red blood cells. DAT positivity is frequently associated with autoimmune hemolytic anemia (AIHA) and other immune-mediated hemolytic conditions. This study aimed to investigate the clinical significance of DAT positivity by comparing the characteristics of patients with IgG, C3d, and IgG/C3d-positive results. Methods: A retrospective study was conducted on 55 patients with DAT-positive results, identified from the Blood Transfusion Unit of Dr. M. Djamil General Hospital Padang between June 2023 and August 2023. DAT-positive samples were further analyzed using monospecific anti-human globulin (AHG) reagents to determine the presence of IgG, C3d, or both on the red blood cells. Patient demographics, clinical diagnoses, blood groups, transfusion history, and hematological parameters were collected and analyzed. Results: Out of the 55 DAT-positive patients, 51 (92.7%) were positive for IgG alone, 3 (5.5%) were positive for both IgG and C3d, and only 1 (1.8%) was positive for C3d alone. The majority of patients were adults (>18 years old) and female. A history of blood transfusion (>3 times) was common, particularly in the IgG-positive group. Hematological parameters indicative of hemolysis (hemoglobin ≤9 g/dL, reticulocyte count >2%, and total bilirubin >2 mg/dL) were observed in a significant proportion of patients, especially those with IgG and/or C3d positivity. Conclusion: IgG positivity was the most common finding in DAT-positive patients, highlighting the prevalence of warm AIHA. The presence of C3d, alone or with IgG, suggests the involvement of complement activation and may indicate a different underlying pathology. This study emphasizes the importance of using monospecific AHG reagents to characterize DAT-positive results, as this information can aid in the diagnosis, management, and prediction of clinical outcomes.
The Effect of Basil Leaves Extract (Ocimum basilicum) on The Triglyceride Level in Atherosclerosis Rats Atmi, Serly Rahma; Mahata, Liganda Endo; Rahmatini, Rahmatini; Rofinda, Zelly Dia; Ali, Hirowati; Aliska, Gestina; Khaira, Fathiyyatul
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.94222

Abstract

Atherosclerosis is the main cause of cardiovascular disease (CVD) characterized by fat accumulation and transformation, inflammation, smooth muscle cell proliferation, and necrotic cell remnants in the tunica intima of blood vessels. Basil leaves are known to contain active biochemical compounds that have the potential to reduce lipids. This is an experimental study that investigated the effect of basil leaves on rat triglyceride levels in atherosclerotic models. This research consisted of five groups of rats that were induced atherosclerosis by partial carotid ligation and a high-fat diet for 7 days. The treatment group was given basil leaves extract ethanol with 100 mg/kgBW, 200 mg/kgBW dose, and simvastatin 1,5mg/rat/day. Examination of triglyceride levels by enzymatic calorimetry GPO-PAP method using Micro Lab 300. The data were analyzed using One-way ANOVA and Post Hoc Bonferroni. The results showed that there was an average decrease in triglyceride levels in rats given basil leaves extract with 100 mg/kg BW dose and indicated that the Ocimum basilicum leaves extract affected triglyceride levels in rats induced by atherosclerosis.
Gambaran Faktor Koagulasi dan Jumlah Trombosit pada Pasien Diabetes Melitus Tipe 2: Sebuah Studi Potong Lintang Alfitri, Maura Salsabila; Decroli, Eva; Rofinda, Zelly Dia; Aprilia, Dinda; Yulia, Dwi; Lailani, Mutia
MEDIA ILMU KESEHATAN Vol 14 No 2 (2025): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v14i2.1314

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a growing global health threat, where chronic hyperglycemia and insulin resistance can affect coagulation profiles.Objective: This study aims to examine coagulation factor profiles and platelet counts in T2DM patients. Methods: A descriptive cross-sectional observational study using data from prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio (INR), and platelet counts of T2DM patients admitted to the Internal Medicine Ward of Dr. M. Djamil General Hospital, Padang, in October 2023. Data analysis was performed descriptively using SPSS v26 software. Results: Of the 39 patients analyzed, the distribution of characteristics showed a male predominance of 64.1%, with the largest age group being 45–59 years (48.7%). The most common complication associated with T2DM was chronic kidney disease, identified in 82.1% of the study population. Evaluation of hemostasis parameters showed that APTT was prolonged in 56.4% of patients. Conversely, PT (87.2%), INR (87.2%), and platelet count (66.7%) were within reference ranges. Conclusion: This study found most coagulation parameters normal, but a relatively high proportion had prolonged APTT, underscoring the need for individualized coagulation monitoring in T2DM, especially with renal complications
Hubungan Asupan Kalsium dan Kadar Kalsium dalam Darah dengan Indeks Massa Tubuh pada Mahasiswa Poltekkes Kemenkes Padang Evynatra, Evynatra; Masrul, Masrul; Rofinda, Zelly Dia
Jurnal Sehat Mandiri Vol 20 No 2 (2025): Jurnal Sehat Mandiri, Volume 20, No.2 Desember 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i1.1798

Abstract

Obesity or being overweight is a global problem that occurs due to improper diet and nutritional intake. The 2023 Indonesian Health Survey (SKI) report showed that the proportion of obesity in the population aged 15-24 years was 16.2%. This study aims to analyze the relationship between calcium intake and blood calcium levels with body mass index in students of the Padang Ministry of Health Polytechnic. The study design used a cross-sectional study with a sample size of 73 students selected randomly. Data were obtained through interviews using the SQ-FFQ sheet, anthropometric measurements, and analysis of blood calcium levels. The results showed that the respondents' BMI was 24.58, the average daily calcium intake was 259.07 mg, far below the daily recommendation of 1000-1200 mg. The average blood calcium levels of respondents were within the normal range (mean 9.71 mg/dL and standard deviation 0.35 mg/dL). Statistical analysis showed a significant negative relationship between calcium intake and Body Mass Index (BMI) (p=0.020), a significant relationship was found between blood calcium levels and BMI (p=0.027). In conclusion, low calcium intake is correlated with an increased risk of obesity. It is recommended to Poltekkes to always have continuity of BMI screening and pay attention to calcium intake education through healthy eating patterns among students and for students who experience calcium deficiency, it is expected to be consulted to the clinic.
Hubungan hidronefrosis pra operasi dengan penurunan hemoglobin pasca operasi percutaneous nephrolithotomy di RSUP Dr. M. Djamil Padang Wahyuni, Febby Genta; Alvarino, Alvarino; Rofinda, Zelly Dia; MYH, Etriyel; Ashal, Taufik; Reza, Mohamad
Majalah Kedokteran Andalas Vol. 47 No. 3 (2024): MKA July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1825-1838.2024

Abstract

Tujuan : Penelitian ini bertujuan untuk melihat hubungan hidronefrosis pra operasi dengan penurunan hemoglobin pasca PCNL pada penderita batu ginjal; Metode: Penelitian ini merupakan penelitian analitik dengan pendekatan prospektif. Jumlah dari sampel dalam penelitian ini sebanyak 21 sampel di RSUP Dr. M. Djamil Padang. Analisis data menggunakan uji Chi square dimana hubungan antar variabel dikatakan signifikan jika p value < 0,05;  Hasil:  Penelitian menunjukkan bahwa  21 pasien yang dioperasi PCNL, jumlah jenis kelamin terbanyak yakni pada perempuan dan berada pada rentang usia 46-64 tahun. Penurunan hemoglobin terbanyak  berada pada kelompok <2g/dl. Kebanyakan pasien batu ginjal disertai dengan adanya hidronefrosis. Analisis statistik menunjukkan bahwa tidak ada hubungan antara hidronefrosis pra operasi dan penurunan hemoglobin setelah PCNL (p value = 0,553); Simpulan: Tidak terdapat hubungan yang bermakna antara hidronefrosis pra operasi dengan penurunan hemoglobin pasca PCNL pada penderita batu ginjal di RSUP Dr.M.Djamil Padang.
Co-Authors Afdal Afdal, Afdal Afriwardi Afriwardi Aisah Aisah Aisyah Elliyanti Alfitri, Maura Salsabila Alinia, Hessa Sena Almurdi Almurdi Alvarino Alvarino Amirah Zatil Izzah Aprilia, Dinda Arina Widya Murni Ashal, Taufik Aswiyanti Asri Atmi, Serly Rahma Bobby Indra Utama Desiekawati Dessy Arisanti Deswita Sari Dian Pertiwi Dian Pertiwi Dwi Yulia Efrida Efrida, Efrida Elfira Yusri Elizabeth Bahar Elmatris Sy Endrinaldi Eti Yerizel Etriyel Myh Eva Decroli Evynatra, Evynatra Fadhillah, Ilham Arief Fathiyyatul Khaira, Fathiyyatul Gestina Aliska Hasmiwati Hessa Sena Alinia Hirowati Ali, Hirowati Husni Husni Husni Julizar Nazar Khaulah Karimah Kurniawan Lili Novri Yanti Mahata, Liganda Endo Masnadi, Nice Rachmawati Masrul Mohamad Reza Mulya, Fiona Septi Mutia Lailani Nurhajjah, Sitti Prima Astuti Handayani Purwati, Desta Rahmatini . Rahmi Dina Indra Rauza Sukma Rita Reza, Mohamad Rikarni Rikarni Rikarni Rismawati Yaswir Rosfita Rasyid Rudy Afriant Sari, Deswita Syofiati Wahyuni, Febby Genta Yoshie Anto Chicamy Yufani, Hevrina Yulia, Dwi Yulistini, Yulistini Zahira, Aisyah Dhia