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All Journal Jurnal Kesehatan Andalas Majalah Obat Tradisional Media Ilmu Kesehatan Majalah Kedokteran Andalas Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) SENTRI: Jurnal Riset Ilmiah Innovative: Journal Of Social Science Research Jurnal Riset Ilmiah Jurnal Kedokteran Meditek Jurnal Akademika Baiturrahim Jambi
Zelly Dia Rofinda
Unknown Affiliation
Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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The Relationship between Albumin Levels with SGOT, SGPT, and de Ritis Ratio in Chronic Hepatitis B Patients: A Single-Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Nursasmi, Ami Tri; Zelly Dia Rofinda; Desywar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1074

Abstract

Background: Chronic hepatitis B (CHB) is a persistent hepatitis B virus (HBV) infection and can cause progressive liver damage. This damage can be measured through a decrease in albumin levels and an increase in liver enzymes such as aspartate aminotransferase (AST/SGOT), alanine aminotransferase (ALT/SGPT), and de Ritis ratio (AST/ALT). This study aims to analyze the relationship between albumin levels and SGOT, SGPT, and de Ritis ratio in CHB patients. Methods: This cross-sectional retrospective analytical study involved 50 CHB patients diagnosed at Dr. M. Djamil General Hospital Padang between June 2022 to June 2023. Data on albumin levels, SGOT, SGPT, and de Ritis ratio were obtained from medical records. The de Ritis ratio, SGOT, and SGPT were grouped into normal and increased. Statistical analysis used an independent t-test with a significance of p < 0.05. Results: The research subjects consisted of 26 men (52%) and 24 women (48%) with an average age of 42.46 ± 13.39 years. The mean albumin level in the increased SGOT group (3.69 ± 0.78 g/dL) was significantly lower than the normal SGOT group (4.39 ± 0.61 g/dL) (p = 0.003). The mean albumin level in the increased de Ritis ratio group (3.90 ± 0.80 g/dL) was also significantly lower than the normal de Ritis ratio group (4.46 ± 0.70 g/dL) (p = 0.006). There was no significant difference between albumin levels in the normal and increased SGPT groups (p = 0.548). Conclusion: There is a significant negative relationship between albumin levels and SGOT and de Ritis ratio in CHB patients. Decreased albumin levels may be an indicator of more severe liver damage in these patients.
Screening and Identification of Erythrocyte Antibodies: A Narrative Literature Review Yashinta Octavian Gita Setyanda; Rofinda, Zelly Dia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1091

Abstract

Red blood cell (RBC) alloimmunization, the development of antibodies against foreign red blood cell antigens, is a critical concern in transfusion medicine. Alloantibodies can lead to adverse transfusion reactions, including hemolytic disease of the fetus and newborn (HDFN) and delayed hemolytic transfusion reactions (DHTR). This comprehensive literature review explores the intricacies of RBC alloimmunization, focusing on the screening and identification of erythrocyte antibodies. We delve into the prevalence and clinical significance of various alloantibodies, the underlying immunological mechanisms, and the evolution of laboratory techniques for their detection. Additionally, we discuss the challenges and future directions in managing alloimmunization, emphasizing the importance of personalized medicine and innovative approaches to ensure safe and effective blood transfusions.
Pengaruh Pemberian Kukis Kombinasi Tepung Ikan Tongkol (Euthynnus affinis) dan Tepung Bayam (Amaranthus tricolor) Dengan Penambahan Probiotik Dadih Terhadap Kadar Feritin Serum Pada Tikus Wistar Anemia Azahra, Azizah Firda; Lipoeto, Nur Indrawaty; Rofinda, Zelly Dia; Rita, Rauza Sukma; Desmawati, Desmawati; Yulia, Dwi; Fasrini, Ulya Uti
SENTRI: Jurnal Riset Ilmiah Vol. 4 No. 11 (2025): SENTRI : Jurnal Riset Ilmiah, November 2025
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/sentri.v4i11.4950

Abstract

Anemia is a global health problem characterized by low hemoglobin and ferritin levels due to iron deficiency, which affects growth, cognition, and disease risk, particularly in children and women of reproductive age. Local food–based nutritional interventions such as skipjack tuna (heme iron), spinach (non-heme iron), and dadih (probiotics) have the potential to provide synergistic effects in improving iron status. This study aimed to determine the effect of cookies made from a combination of skipjack tuna flour and spinach with the addition of dadih probiotics on serum ferritin levels, as well as the effectiveness of Sodium Nitrite (NaNO₂) in decreasing ferritin and hemoglobin levels as indicators of anemia. The study used a Post-Test Only Control Group design with 36 female Wistar rats induced with anemia using NaNO₂ at a dose of 25 mg/200 g BW for 18 days, then divided into six treatment groups for 28 days. Ferritin levels were measured using the ELISA method. The results showed that administering cookies made from the combination of skipjack tuna flour and spinach with dadih probiotics significantly increased ferritin levels (P=0.000) compared to the control and single-ingredient groups. NaNO₂ was proven effective as an anemia-inducing agent. This combined cookie formulation has the potential to improve serum ferritin levels.
Effect of Kawa Gambir (Uncaria gambir Roxb.) Leaves on Serum LDL in Diabetic Model Rats Siregar, Muhammad Abi Ghoffari; Rita, Rauza Sukma; Reza, Mohamad; Ali, Hirowati; Rofinda, Zelly Dia; Welan, Rahmani
Jurnal Kedokteran Meditek Vol 32 No 2 (2026): MARET
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i2.4012

Abstract

Background: Kawa gambir leaves, dried in a furnace and brewed as tea, are rich in flavonoids, phenolics, steroids, and tannins and have antioxidant, antihyperglycemic, and antidyslipidemic properties. In diabetes, elevated low-density lipoprotein (LDL) is a dyslipidemic abnormality that increases atherogenic risk. However, the effect of Kawa gambir on LDL in diabetic conditions remains unclear. Objective: To evaluate the effect of Kawa gambir leaf administration on LDL in alloxan-induced diabetic rats. Methods: This experimental study used a post-test-only control group design in 36 Wistar rats randomized into six groups: K−, K+, MET, P1, P2, and P3. Diabetes was induced with alloxan in K+, MET, and P1–P3. MET received metformin, whereas P1, P2, and P3 received Kawa gambir infusions at 1, 2, and 4 g/100 mL once daily for 4 weeks. Serum LDL was estimated using the Friedewald formula. Data were analyzed by one-way ANOVA followed by Least Significant Difference post hoc testing. Results: Mean±SD LDL levels (mg/dL) were 37.16±3.03, 59.90±8.91, 41.30±6.74, 40.60±5.75, 38.95±10.15, and 40.33±7.01 in K−, K+, MET, P1, P2, and P3, respectively. Group differences were significant (p=0.001). The largest numerical reduction versus K+ was found in P2, with a difference of 20.95 mg/dL (95% CI 8.64–33.26). Conclusion: Kawa gambir infusion significantly reduced LDL compared with the untreated diabetic control. Although the 2 g/100 mL group showed the lowest LDL numerically, no significant differences were observed among active treatment groups. These findings support Kawa gambir as an antidyslipidemic agent in diabetic dyslipidemia.
Co-Authors Adrial Adrial, Adrial Afdal Afdal, Afdal Afriwardi Afriwardi Aisah Aisah Aisyah Elliyanti Alfitri, Maura Salsabila Alinia, Hessa Sena Almurdi Almurdi Alvarino Alvarino Ami Tri Nursasmi Amirah Zatil Izzah Aprilia, Dinda Arina Widya Murni Ashal, Taufik Aswiyanti Asri Atmi, Serly Rahma Azahra, Azizah Firda Azura, Rahla Beni Indra, Beni Bobby Indra Utama Desiekawati Desmawati Desmawati Dessy Arisanti Deswita Sari Desywar Dian Pertiwi Dian Pertiwi Dwi Yulia Dwitya Elvira, Dwitya Efrida Efrida Elfira Yusri Elizabeth Bahar Elmatris Sy Endrinaldi Eti Yerizel Etriyel Myh Eva Decroli Fadhillah, Ilham Arief Fathiyyatul Khaira, Fathiyyatul Fereshti Lailani Finny Fitry Yani Gestina Aliska Hasmiwati Herinda, Dwi Putri Hessa Sena Alinia Hirowati Ali, Hirowati Husni Husni Husni Ihsan, Indra Julizar Nazar Khaulah Karimah Kurniawan Lili Novri Yanti Mahata, Liganda Endo Masnadi, Nice Rachmawati Masrul Djalal Mohamad Reza Muhammad Abi Ghoffari Siregar Mulya, Fiona Septi Nur Indrawaty Lipoeto Nurhajjah, Sitti Purwati, Desta Rahmatini . Rahmi Dina Indra Rahmi, Yannisa Mutiara Rauza Sukma Rita Reza, Mohamad Rikarni Rikarni Rikarni Rismawati Yaswir Rosfita Rasyid Rudy Afriant Santril, Nitri Ramadhani Sari, Deswita Selfi Renita Rusjdi Suchitra, Avit Syofiati Ulya Uti Fasrini Wahyuni, Febby Genta Yashinta Octavian Gita Setyanda Yoshie Anto Chicamy Yufani, Hevrina Yulia, Dwi Yulistini, Yulistini Yusri, Elfira Zahira, Aisyah Dhia zahra salsabila Zulmitra, Elsa Zurayya Fadila