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All Journal Majalah Kedokteran Bandung Medical Journal of Indonesia The Indonesian Biomedical Journal Indonesian Journal of Rheumatology eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Cleopas Martin Rumende
Division Of Pulmonology, Department Of Internal Medicine, Faculty Of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Multidrug-Resistant Organisms Infection on Mortality of Burn Patients at Public Hospital X in Jakarta: A Retrospective Study Veronica, Raja Merlinda; Kumalawati, July; Rumende, Cleopas Martin; Nainggolan, Leonard; Simadibrata, Marcellus; Shatri, Hamzah; Yunir, Em; Wardhana, Aditya; Nelwan, Erni Juwita; Rustam, Musfardi
Kesmas Vol. 19, No. 5
Publisher : UI Scholars Hub

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Abstract

Susceptibility to infection and increasing antibiotic resistance put burn patients at risk of developing infections caused by multidrug-resistant organisms (MDRO). This condition can progress to sepsis, increasing morbidity and mortality. This retrospective cohort study employed the medical record data of patients treated at Public Hospital X in Jakarta, Indonesia, from January 2020 to June 2022. Of 160 subjects, most were aged <60 years (82.5%) and had comorbidities (16.88%). The most common cause of burns was fire (86.25%). The use of medical devices was 90.63%, with a 14-day median length of stay. The most common gram-negative MDRO pathogens were K. pneumoniae (29.91%), Enterobacter sp (22.32%), and Acinetobacter (20.54%); 45% of patients infected with MDRO died. The bivariate analysis found an increased risk of death due to MDRO infection in burn patients (RR 1.103; 95%CI 1.004-1.211, p-value = 0.046). After adjusting for role variables (age, comorbidities, total body surface area, use of medical devices, length of stay) and from multivariate analysis, the confounding variables for MDRO infection and mortality were length of stay and age. MDRO infection increases the mortality rate in burn patients. Mortality in burn patients due to MDRO infection is greater than non-MDRO.
Validity and reliability of the Indonesian version of the 9-item Inflammatory Bowel Disease Questionnaire (IBDQ-9) Esa, Dekta Filantropi; Shatri, Hamzah; Rumende, Cleopas Martin; Susilo, Adityo; Maulahela, Hasan; Fauzi, Achmad; Simadibrata, Marcellus
Medical Journal of Indonesia Vol. 32 No. 3 (2023): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.236848

Abstract

BACKGROUND Decreasing the quality of life (QoL) of patients with inflammatory bowel disease (IBD) will increase morbidity and mortality. A valid and reliable instrument is needed to assess the QoL of patients with IBD. This study aimed to analyze the validity and reliability of the Indonesian version of the 9-item Inflammatory Bowel Disease Questionnaire (IBDQ-9). METHODS This cross-sectional study was conducted using the Indonesian version of the IBDQ-9 in adult patients with IBD at the Gastroenterology Outpatient Clinic, Cipto Mangunkusumo Hospital, Jakarta, in November 2022. Patients aged 18 to 59 years who had experienced IBD for at least 2 weeks and provided informed consents were included. The total score of the IBDQ-9 Indonesian version was compared with the 36-item Short-Form Health Survey (SF-36) using the Spearman's correlation test. Reliability tests were examined using Cronbach’s alpha and the intraclass correlation coefficient (ICC). RESULTS A total of 124 participants were included in this study. The Spearman's test showed a high and significant result for the IBDQ-9 Indonesian version and the SF-36 (r = 0.769 and p<0.001). Cronbach’s alpha and ICC coefficient were equal to 0.883. CONCLUSIONS This study provided evidence of the good validity and reliability of the IBDQ-9 Indonesian version for assessing the QoL of patients with IBD in Indonesia.
Vitamin D levels and depression in type 2 diabetes mellitus patients: a cross-sectional study Putranto, Rudi; Adhiatma, Kresna; Tarigan, Tri Juli Edi; Rumende, Cleopas Martin; Shatri, Hamzah; Rengganis, Iris; Nugroho, Pringgodigdo; Rinaldi, Ikhwan
Medical Journal of Indonesia Vol. 32 No. 3 (2023): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.237005

Abstract

BACKGROUND The prevalence of type 2 diabetes mellitus (T2DM) is increasing and commonly accompanied by comorbidities, such as depression. Vitamin D levels have been associated with T2DM and depression although the mechanism is uncertain. This study aimed to compare vitamin D levels between patients with T2DM with and without depression in the Indonesian community, where such research is rare. METHODS This cross-sectional study was conducted at Cipto Mangunkusumo Hospital. The participants who met the inclusion criteria on an outpatient basis were screened for depression using the Beck Depression Inventory-II (BDI-II) questionnaire and then divided into 2 groups: patients with T2DM with (BDI-II ≥14) and without (BDI-II <14) depression. Both groups were examined for vitamin D levels using the ELISA method, and an analysis of the mean difference between both groups was performed. RESULTS Of 60 patients, 23 (38%) experienced depression. The median vitamin D levels were 21.8 ng/ml (IQR 14.9–26.6) in the depression group and 26.5 ng/ml (IQR 23.96–34.08) in the non-depression group (p = 0.001). After performing multivariate analysis with confounding variables, the adjusted OR of variables (sex, sun exposure score, and body mass index) was 1.123 (95% CI: 1.003–1.259; p = 0.045). CONCLUSIONS Vitamin D levels were significantly lower in patients with T2DM with depression. Future studies should be carried out to determine the benefits of vitamin D supplementation in patients with T2DM with depression and their pathophysiology.
Effects of Physalis angulata extracts on bleomycin-induced rat: analysis on lung inflammation and fibrosis Wibowo, Suryo Anggoro Kusumo; Rumende, Cleopas Martin; Isbagio, Harry; Setiyono, Agus; Setiabudy, Rianto; Rachmadi, Lisnawati; Kertia, Nyoman
Medical Journal of Indonesia Online First
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257875

Abstract

BACKGROUND Scleroderma is an immune-mediated connective tissue disease, with interstitial lung disease as one of its manifestations. Physalis angulata (P. angulata) or ciplukan has shown potential in treating fibrosis, but its role in preventing lung inflammation and fibrosis remains unknown. This study aimed to evaluate the effect of P. angulata extract in a bleomycin (BLM)-induced scleroderma rat. METHODS Sprague-Dawley rats were divided into 6 groups. For lung inflammation prevention, 3 groups received: (1) BLM only, (2) BLM+50 mg/kgBW P. angulata, and (3) BLM+100 mg/kgBW P. angulata. After 14 days, rats were sacrificed and bronchoalveolar lavage (BAL) leukocyte count, interleukin-6 (IL-6) levels, and lung injury score were assessed. For fibrosis prevention, another 3 groups received the same interventions and were sacrificed after 51 days. Fibrosis score, fibrosis area, hydroxyproline, transforming growth factor-beta (TGF-β), and matrix metalloproteinase-13 (MMP-13) levels were analyzed. BLM was administered subcutaneously, while P. angulata was given orally for 14 days. IL-6, TGF-β, and MMP-13 were measured by ELISA and hydroxyproline by colorimetric method. Mean differences and p-values were calculated using appropriate statistical tests. RESULTS P. angulata extract did not prevent lung inflammation, as there were no differences in BAL leukocyte count (p = 0.126), IL-6 levels (p = 0.173), or lung injury scores (p = 0.397) between the BLM-only group and those receiving P. angulata. The extract also did not prevent lung fibrosis, with no differences in fibrosis scores (p = 0.173), fibrosis area (p = 0.359), hydroxyproline (p = 0.295), TGF-β (p = 0.374), or MMP-13 (p = 0.088) levels among groups. CONCLUSIONS P. angulata extract did not prevent the development of lung inflammation or fibrosis.
Co-Authors A Harahap A Harahap, A A.A. Ketut Agung Cahyawan W Achmad Fauzi Adang Sabarudin Ade Dharmawan Adhiatma, Kresna Adi Surya Komala, Adi Surya Aditya Wardhana Adityo Susilo, Adityo Afifah Is Agasjtya Wisjnu Wardhana Agus Setiyono Aida Lydia Alexander Michael Joseph Saudale Alexander, Reinaldo Andhika Rachman Andri Sanityoso Andri Sanityoso Andri Sanityoso Sulaiman Anis Karuniawati Anna Ujainah, Anna Ari Fahrial Syam Arif Mansjoer Asrul Harsal, Asrul Aulia Rizka, Aulia Bambang Setiyohadi Bambang Setiyohadi Birry Karim C Rinaldi A Lesmana Ceva W. Pitoyo Daniel Martin Simadibrata Delly Chipta Lestari Dharmeizar Dharmeizar Dono Antono E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Em Yunir, Em Endang Susalit Erni Juwita Nelwan, Erni Juwita Esa, Dekta Filantropi Estie Puspitasari, Estie Evy Yunihastuti Fahmi Razi Darkuthni Falasiva, Rezyta Fitri Imelda, Fitri Griskalia Christine Gunawan Gunawan Gunawan Gunawan Hadi, Edward J Harry Isbagio Harry Isbagio Hasan Maulahela, Hasan Hutauruk, Syahrial M. Idrus Alwi Ignatius Bima Prasetya, Ignatius Bima Ika Prasetya Wijaya Ikhwan Rinaldi Iris Rengganis Irsan Hasan Islamadina, Balqis Joyce Bratanata, Joyce Juferdy Kurniawan Kemal Fariz Kalista, Kemal Fariz Khie Chen Kumalawati, July Kuntjoro Harimurti Leonard Nainggolan Lisnawati Rachmadi Lugyanti Sukrisman Lusiani Lusiani Lusiani Rusdi, Lusiani M Yamin M. Yamin Mansur, M. Tasrif Marcellus Simadibrata Marcellus Simadibrata Marcellus Simadibrata Marihot Tambunan, Marihot Maruhum B.H. Marbun Mochamad Pasha Muhammad Yamin Munadi Munadi Murdani Abdullah Murdani Abdullah Murdani Abdullah Nababan, Toman Noorwati Sutandyo Nury Nusdwinuringtyas Nyoman Kertia Parlindungan Siregar Pasha, Mochamad Pratiwi Pujilestari Sudarmono Pringgodigdo Nugroho, Pringgodigdo Rahmad Mulyadi Rasmijon, Rasmijon Ratih Tri Kusuma Dewi, Ratih Tri Kusuma Retno Wahyuningsih Rianto Setiabudy Rino Alvani Gani Rino Alvani Gani Rino Alvani Gani RR. Ella Evrita Hestiandari Rudi Putranto Rustam, Musfardi Sabarudin, Adang Salim Harris, Salim Sally A. Nasution Sally Aman Nasution Sally Aman Nasution, Sally Aman Salman Paris Harahap, Salman Paris Santoso, Fidiaji Hiltono Saputri, Imelda N Sasongko, Raditya Siahaan, Billy Stinggo Sitorus, Truly Panca Soroy Lardo Suhendro Suwarto, Suhendro Susanto, Erwin Christian Tanjung, Gloria Telly Kamelia Tri Juli Edi Tarigan Veronica, Raja Merlinda Wardhana, Agasjtya Wisjnu Wibowo, Suryo Anggoro Kusumo Widayat Djoko Santoso, Widayat Djoko Willy Brodus Uwan, Willy Brodus Wismandari Wisnu Zuljasri Albar Zuljasri Albar