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All Journal Indonesian Journal of Cancer Chemoprevention Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Majalah Obat Tradisional JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Farmasi Sains dan Komunitas Jurnal Pengabdian UntukMu NegeRI JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal BALIRESO JCES (Journal of Character Education Society) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JKPK (Jurnal Kimia dan Pendidikan Kimia) Asian Journal of Management Analytics Jurnal Pengabdian Kepada Masyarakat Itekes Bali Jurnal Kefarmasian Indonesia
Heru Sasongko
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Topical Application Type of Fish Oil Promotes Re-Epithelialization in Burn Wound Healing in Rats Sasongko, Heru; Pitaloka, Nirwana Asri Diah; Kurniawan, Muhammad Rizki; Pramono, Edi; Setyawan, Novan Adi; Rohman, Abdul
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95644

Abstract

Burns are a condition that is often found in the world in various cases such as accidents. The incidence of burns will probably increase as human activities become more complex. Wounds that are not treated immediately tend to become infected and cause death. Fish oil is one of the ingredients that has been studied for wound healing. Previous research shows that fish oil is rich in long-chain omega-3 fatty acids such as docosahexaenoic acid and eicosapentaenoic acid, which have anti-inflammatory effects. However, there has not been much research on the type of fish oil used and the wound healing process. The aim of this study was to determine the wound-healing activity of milkfish (Chanos chanos Forsskal.), patin (Pangasius djambal), and eel (Anguilla bicolor) fish oil. Tests were carried out on 25 mice as an experimental animal model for burn wounds. Data on percent wound reduction and the re-epithelialization process were statistically calculated using one-way analysis of variance (ANOVA) followed by a post-hoc LSD test. The research results showed that milkfish oil, patin fish oil, and eel fish oil in a concentration of 10% on an ointment basis were able to reduce wounds significantly. Eel fish oil shows the greatest burn wound healing process with re-epithelialization when compared to other oils. The type of fish oil affects the wound healing process.
Pelatihan Pembuatan Lulur Tradisional Berbahan Dasar TOGA di Kelompok Wanita Tani (KWT) Bagas Waras Boyolali: Training on Making Traditional Scrubs Based on TOGA at KWT Bagas Waras Boyolali Darojati, Ulfa Afrinurfadhilah; Rohmani, Sholichah; Sasongko, Heru; Susanto, Nindita Clourisa Amaris; Zulpadly, M. Fiqri; Utami, Diyah Tri; Meitasari, Annisa Diyan; Untari, Meta Kartika; Ermawati, Dian Eka; Artanti, Anif Nur
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 9 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i9.8562

Abstract

The Bagas Waras Women's Farmers Group (KWT) is one of the women's groups that cultivates a lot of TOGA in Banyuanyar Village, Boyolali. Their seriousness in cultivating TOGA is proven by the establishment of Omah TOGA, which has become an educational tourism destination. KWT members also have high enthusiasm for developing TOGA's potential and have produced many processed food products from TOGA. KWT Bagas Waras needs innovations in TOGA products, namely traditional cosmetic products. The service team provides scientific insight through training on developing traditional cosmetic products, namely body scrubs made from various types of TOGA. This activity involves 40 KWT members who will participate in a series of stages: preparation, training, practice, and evaluation. This training activity can increase the scientific insight of KWT members and help them develop traditional body scrubs made from TOGA and good packaging methods. This training has gone well, with all participants very enthusiastically listening to material related to traditional cosmetics and demonstrating how to make body scrubs. The results obtained are traditional body scrubs with various variants originating from TOGA.
Pendampingan Pembuatan Hand Sanitizer Aroma Minyak Atsiri Sebagai Penunjang Pembelajaran Luring Di SMP Muhammadiyah 1 Prambanan Kundarto, Wisnu; Ermawati, Dian Eka; Zulpadly, Muhammad Fiqri; Sasongko, Heru; Rohmani, Sholichah; Artanti, Anif Nur; Sahifah, Daswati Rofiatun
Jurnal Pengabdian UntukMu NegeRI Vol. 5 No. 2 (2021): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v5i2.3085

Abstract

The schools have been allowed for doing face-to-face learning process with many requirements.Making own hand sanitizer will help schools to keep applying health protocol beside washing hands. Essential oils have been trusted for a long time give a calm effect and reduce stres. This activity have purpose to assistance hand sanitizer production with essential oils fragrance at SMP Muhammadiyah 1 Prambanan Yogyakarta. Knowledge have been transfered by team followed with demo and training to produce hand sanitizer with lemongrass fragrance at first activity. Knowledge score was determined from pre-test and post test answer score from multiple choice questions about hand sanitizer. Follow up became the next activity to ensure school can make their own hand sanitizer independently. The result showed knowledge score was increased from 52,11 to 92,11. School also have been made hand sanitizer independently with another essential oil varians. This products were limited used for school. Communication between team and school still continues.
Physicochemical Characterization, Cytotoxic Activity, and Caspase-9 Expression of Nanogold-Parijoto (Medinilla Speciosa Reinw .Ex, Bl ) in Hela Cell Lines Artanti, Anif Nur; Rohmani, Sholichah; Prihapsara, Fea; Utami, Diyah Tri; Amaris Susanto, Nindita Clourisa; Zulphadly, M.Fiqri; Meitasari, Annisa Diyan; Darojati, Ulfa Afrinurfadhilah; Untari, Meta Kartika; Sasongko, Heru; Ermawati, Dian Eka
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp175-185

Abstract

Parijoto (Medinilla speciosa, Reinw. ex. Bl.), a tropical plant native to Southeast Asia, contains flavonoids, tannins, and saponins, which have the potential as an anticancer. Gold nanoparticle-based drug formulations are applied to increase the anticancer effectiveness of herbal medicines. The compounds in the stalk of parijoto have the potential to be bioreductor in the biosynthesis of gold nanoparticles. This study aims to determine the physicochemical characterization, cytotoxic activity, and expression of protein caspase-9 after treatment with nanogold parijoto (AuNPs-PR) on HeLa cell. The nanogold biosynthesis process was done by reacting 1 mM HAuCl4 with parijoto aqueous extract (EP). Physicochemical characterization measure of particle size, Polydisperse Index (PdI), and zeta potential of AuNPs-PR was carried out using a particle size analyzer. The cytotoxic effect and viability cell of AuNPs- PR were carried out using the MTT assay. The expression of caspase-9 was observed by immunocytochemistry assay. Physicochemical characterization of AuNPs-PR shows that the particle size value is 160.8 nm with PdI and zeta potential values of 0.430 and -4.56 mV respectively. In the MTT assay, both AuNPs-PR and EP demonstrated a reduction in the viability of Hela cells after 24 h in a dose-dependent manner, yielding IC50 values of 3.28 μg/mL and 19.22 μg/mL, respectively. AuNPs-PR and EP showed low cytotoxic activity against Vero normal cells, with IC50 values of over 500 μM. Further, the immunocytochemistry assay indicated that there was upregulation of caspase-9 by their expression. These results indicate that AuNPs-PR could effectively induce apoptosis in HeLa cells by upregulating caspase-9.Keywords: caspase-9, HeLa cells, MTT, nanogold, parijoto.
Evaluation of Virgin Coconut Oil Concentration Variations in Emulgel Formulations of Garlic (Allium sativum L.) Extract as an Antibacterial Hand Sanitizer Rohmani, Sholichah; Fitria, Krismona Rizky Nur; Utami, Diyah Tri; Susanto, Nindita Clourisa Amaris; Ermawati, Dian Eka; Sasongko, Heru; Zulpadly, M. Fiqri; Darojati, Ulfa Afrinurfadhilah; Meitasari, Annisa Diyan; Aratanti, Anif Nur; Untari, Meta Kartika
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 2, JULY-DECEMBER 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

One of the effective ways to stay healthy is maintaining cleanliness, including hand hygiene. Various diseases can be easily transmitted through the hands. However, modern developments have changed the habit of handwashing with water to using hand antiseptics. Hand sanitizer is an alternative to overcome this problem. Unfortunately, some hand sanitizer gels on the market still contain alcohol as an antibacterial ingredient. It is necessary to innovate in making hand sanitizers using non-alcoholic ingredients as antibacterials, for example, natural ingredients like garlic. Garlic contains allicin that functions as an antibacterial. Meanwhile, VCO contains high lauric acid with antibiotic properties that function as antiviral, antibacterial, and antiprotozoal. It also contains capric acid, with antiviral and antibacterial functions. This study aims to examine the effect of concentration variation of VCO on the physical stability of garlic extract emulgel preparation and antibacterial effectiveness against the growth of Staphylococcus aureus. The concentration variation of VCO in this study was 3%, 5%, and 7% for 3 types of formulas. The results showed that the concentration variation of VCO in emulgel preparations gave differences in the physical properties of the gel, including pH, viscosity, adhesive strength, and spreadability. It can be concluded that the higher the VCO concentration, the higher the pH, viscosity, and adhesive power, and the lower the spreadability and antibacterial inhibition power against Staphylococcus aureus. The best result from the evaluation of physicochemical properties and antibacterial tests was Formula 1, although it was still in the weak inhibitory power category.
HPLC Analysis with Evaluation of Antioxidant and Antisenescence Activities of Parijoto (Medinilla speciosa Reinw. ex Bl.) Methanolic Extract in Vero Cells Artanti, Anif Nur; Rohmani, Sholichah; Utami, Diyah Tri; Susanto, Nindita Clourisa Amaris; Zulpadly, M. Fiqri; Meitasari, Annisa Diyan; Darojati, Ulfa Afrinurfadhilah; Untari, Meta Kartika; Sasongko, Heru; Ermawati, Dian Eka; Setyawan, Feri
Indonesian Journal of Cancer Chemoprevention Vol 16, No 1 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss1pp44-56

Abstract

Parijoto (Medinilla speciosa Reinw. ex Bl.) is a traditional medicinal plant rich in polyphenolic compounds that are associated with antioxidant and cytoprotective activities. The present study aims to investigate the phytochemical profile, antioxidant capacity, cytotoxicity, and anti-senescence effects of parijoto methanolic extract. The methanolic extract of parijoto (MEP) was subjected to qualitative thin-layer chromatography (TLC) for the detection of flavonoids, quantitative high-performance liquid chromatography (HPLC) for the determination of quercetin and naringin, and antioxidant activity assessment using the DPPH method. The mobile phase for quercetin analysis was water: acetonitrile (45:55), while for naringin, it was acetonitrile:water: formic acid (21:78.8:0.2). Cytotoxicity was evaluated in Vero cells using the MTT assay, while senescence in normal kidney cells was assessed by senescence-associated β-galactosidase (SA-β-gal) staining. Results showed that the extract contained quercetin (5.76±0.11 ppm). The extract exhibited strong antioxidant activity with an IC₅₀ value of 40.46 ppm. Cytotoxicity testing of MEP on Vero cells revealed low toxicity (529±0.77 μM) at physiologically relevant concentrations, supporting its safety for normal kidney cells. Moreover, in normal kidney cells, the extract conferred cytoprotective effects by reducing oxidative stress–induced damage and attenuating senescence-associated β-galactosidase. Collectively, these findings suggest that MEP exhibits potent antioxidant, cytoprotective, and anti-senescence activity in vitro, warranting further in vivo studies to validate its potential effects on kidney health and age-related cellular damage.
Co-Authors . Sugiyarto Abdul Rohman Achmad Fudholi Achmad Fudholi Agung Budihardjo Amaris Susanto, Nindita Clourisa Anif Nur Artanti, Anif Nur Aratanti, Anif Nur Darojati, Ulfa Afrinurfadhilah Daswati Daswati Edi Pramono ERMAWATI, DIAN EKA Farida, Yeni Fea Prihapsara, Fea Fitria, Krismona Rizky Nur Gea Ros Alifa Hanuriansyah, Yavi Khoiry, Qisty Aulia Kundarto, Wisnu Meitasari, Annisa Diyah Meitasari, Annisa Diyan Muhammad Rizki Kurniawan, Muhammad Rizki Novan Adi Setyawan Noveri, Priscilla Nur Indiana K Pitaloka, Nirwana Asri Diah Rahmat S, Anang Kuncoro Rochmani, Sholichah Satibi Satibi Satibi Satibi Setyawan, Feri Sholichah Rohmani, Sholichah Siska Noviaristanti Sugiyarto Sugiyarto Susanto, Nindita Clourisa Amaris Sutarno Sutarno Syafira, Muthia Ulfa, Fathya untari, meta kartika Utami, Diyah Tri Wulandari, Wening Yeni Farid Yeni Farida Zulpadly, M. Fiqri Zulpadly, M.Fiqri Zulpadly, Muhammad Fiqri Zulphadly, M.Fiqri