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All Journal Indonesian Journal of Applied Sciences Majalah Kedokteran Bandung Althea Medical Journal Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication UNEJ e-Proceeding The Indonesian Biomedical Journal Sari Pediatri Jurnal Sistem Kesehatan Journal of Health (JoH) Bunda Edu-Midwifery Journal (BEMJ) Jurnal Riset Kesehatan Poltekkes Depkes Bandung Jurnal Medikes (Media Informasi Kesehatan) Majalah Kedokteran Neurosains Journal of Applied Health Management and Technology Jurnal Integrasi Kesehatan dan Sains Indonesian Journal of Global Health research Jurnal Riset Kedokteran Bandung Conference Series : Medical Science
Herri S. Sastramihardja
Bagian Farmakologi, Fakultas Kedokteran, Universitas Islam Bandung, Bandung
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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DEFISIT SOSIAL SEBAGAI PREDIKTOR GANGGUAN SPEKTRUM AUTISME Veranita Pandia, Setiawan, Tuti Wahmurti Ari Sapiie, Herri Suhari Sastramihardja
NEURONA Vol 30 No. 4 September 2013
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION AUTISM SPECTRUM DISORDERS ASDS IS DEFINED BY DEFICITS IN THREE AREAS OF FUNCTIONING SOCIAL COMMUNICATIVE AND BEHAVIOR HOWEVER IMPAIRMENTS IN SOCIAL INTEREST SOCIAL DEFICIT IS CENTRAL TO THE DISORDER CURRENTLY ASDS PREVALENCE SEEMS TO HAVE INCREASED GREATLY THESE ESTIMATES ARE CLOSE TO 6 PER 1000HOWEVER ASDS IS DIAGNOSED INFREQUENTLY IN CHILDREN YOUNGER THAN 3 YEARS OF AGE THE DIAGNOSTIC PROCESS IS PROMPTED MOST OFTEN BY PARENTAL CONCERN ABOUT ABSENT OR DELAYED SPECCH ALTHOUGH THE SOCIAL DEFICIT ARE PRESENT IN MOST CHILDREN BY 18 MONTHS OF AGE INDEED SOCIAL DEFICIT SYMPTOMS CAN BE DETECTED EARLY THEREFORE THAT TREATMENT FOR CHILDREN AS DIAGNOSED ASD CAN BE DONE AS EARLY AS POSSIBLE IMPLICATIONS FOR STUDY INTO SOCIAL DEFICIT AS PREDICTOR IN ASDS ARE DISCUSSED
ANTIOKSIDAN EKSTRAK AIR BIJI KOPI ROBUSTA LAMPUNG DALAM MENGHAMBAT DEGENERASI SEL HATI TIKUS MODEL HEPATITIS YANG DIINDUKSI CCL4 Sukohar, Asep; Sastramihardja, Herri S.
Majalah Kedokteran Bandung Vol 44, No 3 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Hati berperan penting dalam mempertahankan homeostasis dan sangat dibutuhkan untuk fungsi fisiologis organ lain. Perubahan morfologi hati akan berdampak pada perubahan fungsi dan dapat muncul sebagai manifestasi klinisnya. Hepatitis merupakan gangguan serius yang menyebabkan inflamasi sel hati disebabkan oleh virus, kimia, dan toksin. Reaksi yang terjadi berupa stres oksidatif serta meningkatnya radikal bebas yang dapat dinetralisir dengan senyawa antioksidan. Secara tradisional kopi digunakan sebagai minuman sehari-hari dan dikenal sebagai antioksidan karena mengandung flavonoid (asam klorogenat). Tujuan penelitian untuk menentukan efek hepatoprotektif/antioksidan kopi yang tumbuh di kabupaten Pesawaran Lampung, terhadap gambaran kerusakan sel hepatosit pada tikus Wistar model hepatitis yang diinduksi karbon tetraklorida (CCL4). Telah dilakukan penelitian eksperimental laboratorik di Departemen Farmakologi Fakultas Kedokteran Universitas Padjadjaran Bandung dan pemeriksaan patologi anatomi dilakukan di Rumah Sakit Abdoel Moeloek Lampung pada Desember 2008?Juli 2009 dengan menggunakan 15 ekor tikus Wistar jantan yang terbagi dalam 3 kelompok, yaitu kelompok kontrol negatif, kontrol positif sebagai model hepatitis, dan perlakuan yaitu model hepatitis yang mendapat ekstrak air biji kopi robusta 25 mg/kgBB selama 7 hari dan mendapat induksi CCl4. Hasilnya dianalisis dengan uji analysis of variance dan uji independen t. Pemberian ekstrak air biji kopi robusta dapat mencegah kerusakan gambaran degenerasi sel hati dari 58,4±7,09 menjadi 34,4±5,85. Hasil ini berbeda bermakna (p?0,05) bila dibandingkan dengan kontrol positif dan negatif. Simpulan, ekstrak air biji kopi robusta berpotensi mencegah gangguan fungsi hati dengan efek sebagai antioksidan pada tikus model hepatitis yang diinduksi CCL4. [MKB. 2012;44(3):127?32].Kata kunci: Antioksidan, gambaran degenerasi sel hati, kopi Antioxidant of Lampung Robusta Coffee Beans Water Extract in Inhibiting Liver Cell Degeneration in CCl4 Induced Hepatitis Rats ModelLiver plays an important role in maintaining homeostasis and is critical for physiological functions of other organs. Morphological changes of the liver will have an impact on changes in liver function and may appear as clinical manifestations. Hepatitis is a serious disorder that causes inflammation of the liver cells and is caused by viruses, chemicals and toxins. Reactions that occur in the form of oxidative stress, free radicals dominant condition of antioxidants. Traditionally coffee is used as an everyday beverage and known as antioxidants because it contains flavonoids (chlorogenic acid). This study aim was to determine the hepatoprotective/antioxidant effect of coffee growing in Pesawaran Lampung, on the description of hepatocyte cell damage in Wistar rats hepatitis model induced with carbon tetrachloride (CCl4). Laboratory experimental research has been conducted in Pharmacology >Department, Faculty Medicine Padjadjaran University Bandung and pathology examinations was performed at the Hospital Abdoel Moeloek Lampung in December 2008?July 2009, using 15 male Wistar rats divided in three groups, the negative control group, positive control as a model of hepatitis, and hepatitis model that received the water extract of robusta coffee beans 25 mg/kgBW/days for 7 days and then received CCl4 induction. The results were analyzed by analysis of variance and independent t test. Administration of water extract of robusta coffee beans can prevented damage to the liver cell degeneration picture from 58.4±7.09 to 34.4±5.85, these results differed significantly (p?0.05) compared with positive and negative control. In conclusion, water extract of robusta coffee beans has the potential to prevent interference with the effects of liver function as antioxidants in the ra model of hepatitis which has been inducted with CCL4. [MKB. 2012;44(3):127?32].Key words: Antioxidants, coffee, degeneration of liver cells preview DOI: http://dx.doi.org/10.15395/mkb.v44n3.84
Efek Antioksidan Jamur Tiram Putih pada Kadar Malondialdehid dan Kepadatan Permukaan Sel Paru Tikus yang Terpapar Asap Rokok Rahimah, Santun Bhekti; Sastramihardja, Herri S.; Sitorus, Trully Detty
Majalah Kedokteran Bandung Vol 42, No 4
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Radikal bebas asap rokok dapat menyebabkan peroksidasi lipid dan perubahan patologis pada sel paru. Hal ini dapat dicegah oleh senyawa yang terkandung dalam jamur tiram putih (Pleurotus ostreatus), antara lain fenol, vitamin C, selenium, dan ergotien. Penelitian bertujuan untuk melihat efek ekstrak jamur tiram putih pada kadar malondialdehid (MDA) dan nilai surface density (S/V) setelah terpapar asap rokok. Metode penelitian menggunakan rancangan acak lengkap dan sebagai pembanding digunakan vitamin E. Dosis ekstrak etanol jamur tiram putih adalah 250 mg/kgBB dan paparan asap rokok diberikan 30 menit/tikus/hari menggunakan smoking pump. Pada hari ke-11 perlakuan, dilakukan pemeriksaan kadar MDA darah dengan metode thiobarbituric acid assay (TBARS) dan perhitungan nilai S/V paru secara mikroskopis. Penelitian dilakukan pada bulan Juli 2009 di Departemen Farmakologi Klinik Rumah Sakit Hasan Sadikin Bandung. Hasil menunjukkan ekstrak etanol jamur tiram putih mencegah kenaikan kadar MDA darah (0,4667+0,22295 nm/mL) dan efeknya sama baik dengan vitamin E (0,7467+0,24089 nm/mL). Ekstrak etanol jamur juga mencegah penurunan nilai S/V (0,62283+0,47939) dan mempunyai efek yang lebih baik dari vitamin E (0,54683+0,39832), p<0,05. Disimpulkan bahwa ekstrak etanol jamur tiram putih merupakan antioksidan kuat yang lebih baik dibandingkan dengan vitamin E dalam mencegah kerusakan oksidatif akibat paparan asap rokok. [MKB. 2010;42(4):195–202].Kata kunci: Asap rokok, jamur tiram putih, malondiadehid, nilai S/V, radikal bebasAntioxidant Effect of Pleurotus ostreatus on Malondialdehyde Level and Surface Density of Rat Lung Cells Exposed to Cigarette SmokeCigarette smoke-free radicals can cause lipid peroxidation and pathological changes in lung cells. This effect could be prevented by highly active metabolite in Pleurotus ostreatus such us fenol, ascorbid acid, selenium, and ergothiene. This study aimed to analyze the effect of the Pleurotus ostreatus extract on the levels of malondialdehyde (MDA) and surface density (S/V) after exposure to cigarette smoke. The research used completed randomized design and á-tocopherol was used as control group. The dose of Pleurotus ostreatus ethanol extract was 250 mg/kg body weight and cigarette smoke exposure was given in 30 minutes/day for 10 days by smoking pump. Malondialdehyde (MDA) level and lung surface density (S/V) were observed on day 11th. This research was done at Clinical Pharmacology Department, Hasan Sadikin Hospital on July 2009.The result showed that ethanol extract of Pleurotus ostreatus can prevent increasing level of MDA (0.4667+ 0.22295 nm/mL), as good as that of á-tocopherol(0,7467+ 0,24089 nm/mL). Ethanol extract also prevented the reduction of lung S/V (0.62283+0.4793) and it's effect was better from á-tocopherol (0.54683±0.39832), p=<0.05. In conclusion, our data shows that etanolic extract of Pleurotus ostreatus is a strong antioxidant that have better effect than á-tocopherol in preventing oxidative damage of cigarette smoke. [MKB. 2010;42(4):195–202].Key words: Cigarette smoke, free radical, Pleurotus ostreatus, malondyaldehyde, S/V DOI: http://dx.doi.org/10.15395/mkb.v42n4.36
Penurunan Nyeri Persalinan Primigravida Kala I Fase Aktif Pascapenghirupan Aromaterapi Lavender Tarsikah, -; Susanto, Herman; Sastramihardja, Herri S.
Majalah Kedokteran Bandung Vol 44, No 1 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Nyeri persalinan merupakan bagian pada proses normal yang tidak jarang menyebabkan stres fisiologis dan psikologis terhadap ibu yang berdampak pada ibu maupun janin. Sebagian besar persalinan (90%) disertai nyeri, bahkan sampai nyeri berat. Penanganan nonfarmakologi merupakan salah satu alternatif untuk mengurangi nyeri persalinan. Penelitian ini bertujuan untuk menganalisis efek analgesik penghirupan aromaterapi lavender pada nyeri persalinan primigravida kala I fase aktif. Rancangan yang digunakan adalah studi praeksperimental, satu kelompok diobservasi sebelum dan sesudah perlakuan terhadap 30 ibu bersalin di Rumah Bersalin (RB) Kasih Ibu Jatirogo kabupaten Tuban provinsi Jawa Timur sebagai sampel yang dipilih secara konsekutif. Pengukuran variabel menggunakan skala nyeri numerik. Dilakukan analisis univariabel kuantitatif untuk mengetahui nyeri sebelum dan sesudah perlakuan. Analisis kuantitatif bivariabel Wilcoxon signed ranks test digunakan untuk mengetahui pengurangan nyeri dengan tingkat kemaknaan p<0,05. Penelitian ini dilakukan periode 14 September–31 Oktober 2009. Hasil analisis univariabel menyatakan bahwa skor nyeri rata-rata sebelum perlakuan 7,3 (SD 1,1) dansesudah perlakuan 5,9 (SD 1,4). Hasil uji Wilcoxon signed ranks test menunjukkan pengurangan nyeri yang bermakna pascapenghirupan aromaterapi lavender (Z=-4,338; p=0,000). Simpulan, terdapat pengurangan nyeri persalinan pascapenghirupan aromaterapi lavender. [MKB. 2012;44(1):19–25].Kata kunci: Nyeri persalinan, penghirupan aromaterapi lavender Labor Pain Reduction in Primigravida Active Phase after Inhalation of Lavender AromatherapyLabor pain is part of a normal process, which often causes physiological and psychological stress to mother. These stress have impact to both mother and fetus. Largely (90%) labor comes with pain and in some cases severe pain. Non-pharmacological approach is one of alternatives to reduce labor pain. This research aims to analyse the analgesic effect of lavender aromatherapy inhalation on labor pain in primigravida in the active phase. The study was pra-experimental by observing one group before and after treatment. The group involved 30 parturients in RB Kasih Ibu Jatirogo district of Tuban, East Java. The sampling method was based on consecutive admission. The variables were measured by using numerical rating scales (NRS). Univariable quantitative analysis was applied to describe the pain before and after treatment. Wilcoxon signed ranks test bivariable quantitative analysis was used to investigate pain relief with significance level of p<0.05. The univariable analysis result revealed that mean pain score before treatment was 7.3 (SD 1.1) and after treatment 5.9 (SD 1.4). Wilcoxon signed ranks test result showed significant pain relief after lavender aromatherapy inhalation (Z=-4.338, p=0.000). The research shows that there is a reduction of labor pain after lavender aromatherapy inhalation. [MKB. 2012;44(1):19–25].Key words: Inhalation lavender aromatherapy, labor pain DOI:  http://dx.doi.org/10.15395/mkb.v44n1.210
Efek Hepatoprotektif Rosella (Hibiscus sabdariffa L.) pada Tikus Model Hepatitis Husen, Ike Rostikawati; Sastramihardja, Herri S.
Majalah Kedokteran Bandung Vol 44, No 2 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Hepatitis disebabkan oleh polutan yang menimbulkan stres oksidatif. Secara tradisional rosella (Hibiscus sabdariffa L.) mengandung flavonoid, suatu antioksidan yang digunakan untuk mengobati penyakit hati. Penelitian bertujuan menentukan efek hepatoprotektif ekstrak etanol bunga rosella segar (EEBRS) terhadap kadar malondialdehid (MDA) hati, serum glutamic piruvic transaminase (SGPT), dan kerusakan morfologi hepatosit tikus model hepatitis dibandingkan dengan efek vitamin E. Telah dilakukan penelitian ekperimental laboratorik di Departemen Farmakologi dan Terapi Fakultas Kedokteran Universitas Padjadjaran-Rumah Sakit Dr. Hasan Sadikin Bandung pada bulan Agustus 2009 dengan menggunakan 25 ekor tikus Wistar jantan dibagi dalam 5 kelompok. Kelompok 1/kontrol negatif, kelompok 2/kontrol positif (model hepatitis-karbon tetraklorida/CCl4), kelompok 3 dan 4 merupakan model hepatitis yang selama 8 hari sebelumnya mendapat EEBRS 125 mg/kgBB/hr (kelompok 3) dan vitamin E 2,7 IU/hari per oral (kelompok 4), sedangkan kelompok 5 mendapat EEBRS. Pengamatan dilakukan 48 jam setelah induksi dengan CCl4. Analisis statistik menggunakan uji analysis of varian (ANOVA) dan uji Tukey. Hasil penelitian menunjukkan bahwa EEBRS mencegah kenaikan kadar MDA hati dan SGPT, berbeda secara bermakna dibandingkan dengan kontrol positif (MDA p=0,00; SGPT p=0,041) dan tidak berbeda bermakna dibandingkan dengan kelompok 4 (MDA p=1,00; SGPT p=0,192). Gambaran histopatologi hati kelompok 3 berupa vakuolisasi makrovesikular, pada tikus model hepatitis berupa vakuolisasi mikrovesikular, sedangkan vitamin E menghambat kerusakan morfologi. Simpulan, EEBRS memiliki efek hepatoprotektif sebagai antioksidan pada tikus model hepatitis namun efeknya tidak lebih baik dibandingkan dengan vitamin E. [MKB. 2012;44(2):83–9].Kata kunci: Hepatosit, MDA, rosella, SGPT The Hepatoprotective Effect of Rosella (Hibiscus sabdariffa L.) on Hepatitis Model Rats Hepatitis is initiated by pollutant which caused oxidative stress. Rosella (Hibiscus sabdariffa L.) contain flavonoid, an antioxidant which has been used traditionally in treating liver disease. The study aims to define the hepatoprotective effects of fresh rosella calyx ethanol extract (FRCEE) on hepatitis model rats with liver malondialdehyde (MDA) and serum glutamic piruvic transaminase (SGPT) level and hepatocyte morphology damage compared to vitamin E’s effects. The laboratory experimental study has been conducted on August 2009 at Department Pharmacology and Therapy Faculty of Medicine Padjadjaran University/Dr. Hasan Sadikin Hospital in 25 male Wistar rats, divided into 5 groups. Group 1 was negative control, group 2 was positive control (carbon tetrachloride/CCl4-hepatitis model rats), group 3 and 4 were hepatitis model rats that subsequently given 125 mg/kgBW of FRCEE (group 3) and 2.7 IU of vitamin E (group 4) for 8 days; group 5 was given FRCEE. Observations were done 48 hours after CCL4 induction. The results were analyzed by analysis of varian (ANOVA) and Tukey. The result showed that FRCEE inhibited increasing of liver MDA and SGPT level significantly different compared to positive control (MDA p=0.00, SGPT p=0.041) but not significantly different to group 4 (MDA p=1.00, SGPT p=0.192). Histological features showed macrovesicular on group 3, microvesicular vacuole on group 2; whereas vitamin E inhibited morphological damage. In conclusion, FRCEE has hepatoprotective effect on hepatitis model rats as antioxidant, but not superior compared to vitamin E. [MKB. 2012;44(2):83–9].Key words: Hepatocyte, MDA, rosella, SGPT DOI: http://dx.doi.org/10.15395/mkb.v44n2.128
Efek Pemberian Niasin terhadap Glukosa Darah pada Tikus Wistar dengan Obesitas Hermawan, Robby; Sitorus, Trully D.; Sastramihardja, Herri S.
Majalah Kedokteran Bandung Vol 43, No 1
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Niasin memiliki kontroversi mengenai efeknya terhadap pengaturan glukosa darah. Penelitian bertujuan untuk mengetahui efek niasin terhadap kadar glukosa darah pada tikus Wistar dengan obesitas yang diinduksi diet. Penelitian ini merupakan penelitian eksperimental laboratorik dengan desain paralel yang menggunakan randomisasi di laboratorium Farmakologi Fakultas Kedokteran Unpad periode Juli 2008–Maret 2009. Penelitian dilakukan pada tikus jantan galur Wistar. Pertama, semua subjek penelitian diinduksi menjadi obesitas dengan diet tinggi lemak selama 10 minggu. Tikus yang memenuhi kriteria dibagi dalam dua kelompok secara acak. Kelompok pertama diberikan plasebo. Kelompok kedua diberikan niasin. Niasin dan plasebo diberikan selama 20 hari. Dosis niasin yang diberikan sebesar 0,135 mg/gBB/hari. Glukosa darah puasa (GDP) dan tes toleransi glukosa oral (TTGO) diukur pada hari ke-21. Hasil penelitian menunjukkan bahwa tidak terdapat perbedaan yang bermakna antara kelompok kontrol dan perlakuan baik pada GDP maupun TTGO. GDP kelompok niasin lebih rendah 4,0 mg/dL (IK95% -0,342–8,4) dibandingkan dengan kelompok kontrol, dengan p=0,068, sedangkan hasil TTGO kelompok niasin lebih tinggi 0,8 mg/dL (IK95% -5,6–7,1) dibandingkan dengan kelompok kontrol, dengan p=0,800. Disimpulkan pemberian niasin tidak menyebabkan perbedaan kadar GDP dan TTGO pada tikus jantan galur Wistar dengan obesitas yang diinduksi diet. [MKB. 2011;43(1):16–20].Kata kunci: Glukosa darah puasa, niasin, obesitas, tes toleransi glukosa oralThe Effect of Niacin to the Blood Glucose in Obese Wistar RatsNiacin has many controversies about its effect to the management of the blood glucose. The objective of the research was to know the effect of niacin to the blood glucose in obese wistar rats. This research was an experimental laboratory study with a parallel design using randomization. Male Wistar rats were used in this research. All rats were induced to be obesed with high-fat feeding for 10 weeks. Rats that fulfill the criteria were randomly divided into two groups. The first group was given the placebo. The second group was given the niacin. The niacin and the placebo were given for the next 20 days. The niacin dose was 0.135 mg/g body weight/day. Fasting blood glucose (FBG) and oral glucose tolerance test (OGTT) were taken on the 21st day. The results showed that there were not any significant differences in FBG and OGTT between control and treated group. The FBG of the niacin group was 4.0 mg/dL (95% CI -0.342–8.4) lower than the control group, with p=0.068. The OGTT result of the niacin group was 0.8 mg/dL (95% CI -5.6 –7.1) higher than the control group, with p=0.800. This study concludes that taking niacin does not cause differences in FBG and OGTT results in the male Wistar rats with diet induced obesity. [MKB. 2011;43(1):16–20].Key words: Fasting blood glucose, niacin, obesity, oral glucose tolerance test DOI: http://dx.doi.org/10.15395/mkb.v43n1.39
Efek Ekstrak Air Buah Pepaya (Carica papaya L.) Muda terhadap Gambaran Histologi Kelenjar Mamma Mencit Laktasi Kharisma, Yuktiana; Ariyoga, Armaya; Sastramihardja, Herri S.
Majalah Kedokteran Bandung Vol 43, No 4
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Air susu ibu (ASI) merupakan makanan terbaik bagi bayi. Menurut Survei Kesehatan Rumah Tangga tahun 2005,ASI eksklusif di perkotaan 4−12% dan pedesaan 4–5%. Penelitian ini bertujuan untuk mengetahui efek ekstrak air buah pepaya muda (Carica papaya L.) terhadap gambaran histologi kelenjar mamma laktasi. Penelitian dilakukan di laboratorium Farmakologi Klinik Unpad dan laboratorium Unit Penelitian Kesehatan RS Dr. Hasan Sadikin pada bulan Juli−September 2009. Penelitian merupakan penelitian eksperimental laboratorium terhadap 21 ekor induk mencit laktasi galur Swiss Webster, diacak menjadi 3 kelompok (n=7) dengan jumlah anak 10 ekor/induk. Kelompok I merupakan kontrol negatif. Kelompok II diberikan luteotropin 6 mg/30 g BB/hari per oral (p.o.) dan kelompok III diberikan sediaan uji 20 mg/30 g BB/hari (p.o.). Peningkatan produksi air susu diketahui melalui peningkatan jumlah dan diameter rata-rata alveoli kelenjar mamma laktasi. Perlakuan diberikan pada hari ke-4 hingga ke-16 masa menyusui. Hasil dianalisis dengan uji analysis of variance (ANOVA), dilanjutkan dengan uji Tukey. Hasil penelitian terhadap jumlah alveoli kelompok I: 310,57±30,16; kelompok II: 464,42±25,83 dan kelompok III: 465,14±72,41. Diameter alveoli kelenjar mamma laktasi kelompok I, II, dan III berturut-turut sebesar 296,50±21,27 μ; 394,57±53,97 μ; dan 384,29±40,40 μ. Simpulan bahwa ekstrak air buah pepaya muda memberikan efek lebih baik dibandingkan dengan kontrol negatif dan sebanding dengan luteotropin dalam meningkatkan jumlah dan diameter alveoli rata-rata kelenjar mamma laktasi. [MKB.2011;43(4):160–5].Kata kunci: Carica papaya L., histologi kelenjar mamma, produksi air susuEffect of Unripe Papaya (Carica papaya L.) Aqueous Extract on Histological Feature of Mice Lactating Mammary GlandsBreast milk is the best food for infants. Household Health Survey in 2005 showed exclusive breastfeeding were 4–12% in urban and 4–5% in rural areas. Objective of the study was to examine the effect of unripe papaya aqueous extract (Carica papaya L.) on lactating mammary glands histological appearance. The experiment was held on July–September 2009 at Padjadjaran University Clinical Pharmacology Laboratory and Health Research Unit of Dr. Hasan Sadikin Hospital in July–September 2009. A laboratorium experimental study conducted to 21 lactating Swiss Webster mice with 10 babies each. They were divided randomly into 3 groups (n=7). Group I was negative control. Group II: luteotropin 6 mg/30 g BW/day (per oral) and group III: unripe papaya aqueous extract 20 mg/30 g BW/day (per oral). Increased milk production was measured by average lactating mammary glands alveolar amounts and diameter count. Experiment started at 4th–16th lactation day. The result was analyzed using analysis of variance (ANOVA) followed by Tukey test. The average of alveolar amounts of group I, II and III, were 310.57±30.16, 464.42±25.83, and 465.14±72.41, respectively. The average lactating mamary glands alveolar diameter of group I: 296.50±21.27 μ, group II: 394.57±53.97 μ and group III: 384.29±40.40 μ. Research showed that unripe papaya aqueous extract has better than negative control and equivalent effect with luteotropin on lactating mammary glands histological appearance. [MKB. 2011;43(4):160–5].Key words: Carica papaya L., histological mammary glands, milk production DOI: http://dx.doi.org/10.15395/mkb.v43n4.63
Hepatoprotective Effect of Solanum melongena/Eggplant against Acute Hepatitis Nabhan Komara; Herri S. Sastramihardja; Afiati Afiati
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

   Background: Hepatitis is a liver inflammation that can be acute or chronic and may cause damage to hepatocytes such as necrosis.. Hepatocyte necrosis can be inhibited by antioxidants such as flavonoids found in Solanum melongena fruit. This study aimed to determine the hepatoprotective effect of Solanum melongena fruit infusion to inhibit hepatocytes damage in CCl4-induced rats.Methods: Twenty five male Wistar rats were randomly divided into five groups, and adapted for 7 days before the experimental study. Negative and positive groups were given aquadest, Group III−V were given Solanum melongena fruit infusion containing 1.125 grams, 2.25 grams and 4.5 grams orally for 9 days. At the 9th day, all rats were induced by 8 mL/kgBW of 10% CCl4 in paraffin, except for the negative group. Rats were sacrificed on the 11th day, and liver biopsy preparations were made. Hepatocyte necrosis was counted and was analyzed by Kruskal-Wallis test and Mann-Whitney test. Results: The study showed that the percentage of necrotic hepatocytes in group III, IV a nd V were lower than in the positive group. Using Mann-Whitney test, there were significant differences in negative group, group III, and group V (p<0.05). Meanwhile, unsignificant difference was seen between the positive group and group IV (p>0.05). Kruskal-Wallis test showed that there weresignificantly differences among groups (p<0.05). Conclusions: Solanum melongena fruit infusion has hepatoprotective effects against acute hepatitis in rat model histopathologically.Keywords: CCl4, flavonoids, hepatocyte, necrosis, Solanum melongena DOI: 10.15850/amj.v2n1.434  
The Effect of Breadfruit Leaves Infusion on Acute Renal Failure Rat model Abstract Muhamad Risdan Hardani; Herri S. Sastramihardja; Afiatin Afiatin
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background : Empirically, breadfruit (Artocarpus altilis) leaf has been used as traditional medicine for several diseases, such as acute renal failure. This research is aimed at finding the effects of breadfruit leaf infusion on blood creatinine levels in rats to model acute renal failure.Methods : This research is an experimental study, using 30 male wistar rats, weighing 150–250 g, divided into 5 groups. The first group is a negative control and the second group is a positive control. Groups 2–5 were induced with Gentamicine and peroxicam for 7 days, and then groups 3–5 given infusion of breadfruit leaf in different doses for 7 days, and then blood creatinine levels were tested at the 15th day. This data was analyzed using a multiple comparison Dunnett T3 test because this data is not homogenous. This research was done in pharmacology laboratorium universitas padjadjaran from Oktober–November 2012.Result : Bases on average creatinine levels of 0.62, 0.87, 0.98, and 0.87 mg/dL observed for the diffetent groups, it was statistically show that significantly different creatinine levels, differing by 0.038 (p < 0.05) were observed for the control group and the group which was given an infusion of breadfruit leaf.Conclusion : It can be concluded that infusions of breadfruit leaf do have an effects on blood creatinine levels in acute renal failure.Key words : acute renal failure, breadfruit leaf, creatinine  DOI: 10.15850/amj.v2n4.527
Hand hygiene, health care workers, methicillin-resistant Staphylococcus aureus, nosocomial infection, Staphylococcus aureus Julius Gunadi; Herri S. Sastramihardja; Nina Susana Dewi
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Hypercholesterolemia is a major risk factor for coronary heart disease. Ear fungus (Auricularia auricula) contains soluble fiber (beta glucan) which is believed to have an effect of reducing cholesterol level. The aim of this study was to determine the effect of fungus infusion in reducing blood cholesterol.Methods: This study used the laboratory experimental method conducted in the pharmacology laboratory of Dr. Hasan Sadikin General Hospital Bandung. The subjects were 25 male Wistar rats which were randomly divided into 5 groups. The first group was given only distilled water as a negative control, the remaining groups were induced to be dyslipidemic and received fungus infusion with different doses of 18%, 36%, 72% and one group received no treatment.Results: The comparison of different doses showed all had the effect of reducing cholesterol levels compared to the positive control group (p<0.05). Each dose showed slight differences in their effectiveness, 18% (p=0.007; p<0.05), 36% (p=0.002; p<0.05), and 72% (p=0.014; p<0.05).Conclusions: ear fungus infusion had the effect of reducing cholesterol with the most effective concentration was 36%. [AMJ.2015;2(1):153–61]
Co-Authors A/P Nayagam, Vasanthi Achmad Fudholi Achmad Fudholi Achmad Fudholi Achmad Fudholi Adjat Sedjati Rasyad Adjat Sedjati Rasyad Afiati Afiati Afiati Afiati Afiatin Afiatin Agly Adithya Agly Adithya, Agly Alamsyah Aziz Anas Subarnas Andriane, Yuke Anggia Skynta Ani M Maskoen Anita Deborah Anwar Anita Fitriaturohmah Annisa Rahmah Furqaani Ardini Saptaningsih Raksanagara Arief Budi Yulianti Armaya Ariyoga Arsita Pratiwi Asep Sukohar Della Erriani Akaputri Dicky Santosa Dida Akhmad Gurnida Djanuarsih Iwan Djanuarsih Iwan, Djanuarsih Djatnika Setiabudi Dwi Prasetyo Eman Sutrisna Enggar Hestu Enggar Hestu, Enggar Fajar Awalia Yulianto Fatmawati Karim Fenda Khafidhotenty Gembong Soeyono Putro Haifa Nur Bilqis Sahnella Hartanto Bayuaji Hartiningsih, Siti Sugih Heda Melinda Nazaruddin Nataprawira Herawati, Yanti Herman Susanto Herry Garna Hidayat Wijayanegara Ida Parwati Ika Wijayanti, Ika Ike Rostikawati Husen Ismayanty, Devie Ismet Muchtar Nur Julius Gunadi Julius Gunadi, Julius Karimah, Karimah Karmelia, Mela Kartika Malahayati Komalaningsih, Sri Lazuardhi Dwipa Lelly Yuniarti Leri Septiani Lestari, Meti Widya Lestari, Mia Dwi Lina Herlina M. Nurhalim Shahib M. Rizki Budiman Ma&#039;mun Sutisna Ma&#039;mun Sutisna Ma&#039;mun Sutisna Malahayati, Kartika Mamun Sutisna Maya Tejasari Ma’mun Sutisna Meike Rachmawati Meta Maulida Damayanti Metaliasari, Metaliasari Meti Widiya Lestari Miranti Kania Dewi Muayah Muayah MUCHTAN SUJATNO Muhamad Al Hadi A A Muhamad Faishal Ramadhan Muhamad Risdan Hardani Muhamad Risdan Hardani, Muhamad Risdan Muhammad Alief Abdul ‘Aziiz Muhammad Ilham Halim Muthiana Rizky Muthiana Rizky, Muthiana Nabhan Komara Nabhan Komara, Nabhan Nadira Fajriani Nike Arta Puspitasari Nina Susana Dewi Novita Arya Cahyani NUR AINI Nurhalim Shahib Nurlatifah, Teni Putro, Gembong Soeyono Ratu Intan Permatasari Robby Hermawan Rowawi, Roni Rudi Supriyadi Ruswana Anwar Ryandini, Gessyla Salma Raudhatusabrina Basuki Santun Bhekti Rahimah Selvi Puspan Sari Siska Nia Irasanti Sitanggang, Novtarina Siti Aminah Abdurachman Siti Sugih Sri Komalaningsih Sugih, Siti Suryani Soepadan Suryani Soepardan Suryani Suryani Sutisna, Ma’mun Suwendar Suwendar Tania Novy Tarsikah, Tarsikah Titik Respati Toni Praditya Irwansyah Tri M. Andayani Tri Murti Andayani Trully D. Sitorus Trully Detty Sitorus Udin Sabarudin Udin Sabarudin Vasanthi A/P Nayagam WaOde Nur Syuhada Wida Purbaningsih Winni Maharani Wiwiek Setiowulan Yeni Mahwati Yuktiana Kharisma Zahra Noerjanah Usmany