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Immunomodulatory Effects of Probiotics on Th17-Mediated Immune Responses in Psoriasis: A Systematic Review and Meta-Analysis Rindi Rosalina Fadly; Usman Pato; Maya Savira
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1615

Background: Psoriasis is a chronic inflammatory skin disorder with increasing evidence supporting the role of the gut-skin axis in its pathogenesis. Recent studies suggest that probiotic supplementation may modulate Th17-mediated immune responses and improve clinical outcomes in psoriasis. Methods: A systematic review and random-effects meta-analysis was conducted using PubMed, Scopus, Web of Science, and Cochrane Library databases (through February 2025). Randomised controlled trials evaluating probiotic supplementation in adult patients with psoriasis were included. The primary outcome was change in Psoriasis Area and Severity Index (PASI) score. Secondary outcomes included inflammatory markers (IL-6, CRP, IL-17) and immunological markers (Foxp3+ regulatory T cells, IL-10, TGF-β). Risk of bias was assessed using the Cochrane Risk of Bias tool (RoB 2), and evidence quality was evaluated using GRADE methodology. Results: Five randomised controlled trials encompassing 268 participants (132 intervention, 136 control) were analysed. The pooled effect size for clinical outcomes (PASI) showed significant improvement favouring probiotic supplementation (Hedges' g = −0.8165; 95% confidence interval [CI], −1.6487 to −0.0483; p = 0.048; I² = 92.45%). Substantial heterogeneity was observed, with the Alshihmani 2025 pilot study demonstrating markedly larger effects on immunological markers (Hedges' g = −5.6963). Subgroup analysis revealed single-strain probiotics (pooled Hedges' g = −0.3487) had smaller effect sizes than multi-strain formulations (pooled Hedges' g = −3.6740). Publication bias assessment via funnel plot and Egger's regression showed no statistically significant asymmetry (p = 0.087). Conclusion: Probiotic supplementation demonstrated statistically significant improvements in clinical outcomes and immunological markers in psoriasis. However, substantial heterogeneity and reliance on small trials limit certainty. The mechanistic evidence supporting gut-skin axis modulation warrants further investigation in adequately powered, long-term randomised controlled trials with standardised outcome measures and strain-specific analysis.

Effect of Blue Pea Flower (Clitoria ternatea) Infusion on Blood Pressure and Sleep Quality in Individuals with Prehypertension Ardha, Nabilah Shofiyyah; Savira, Maya; Fitri, Aida; Lintang, Letta Sari
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol. 9 No. 1 (2026): Herb-Medicine Journal April 2026
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v9i1.29135

Prehypertension is a condition in which blood pressure is above the normal range but has not yet reached the threshold for hypertension. This condition increases the risk of developing hypertension and cardiovascular diseases and is also associated with decreased sleep quality. One nonpharmacological approach that may help reduce blood pressure while improving sleep quality is the regular consumption of butterfly pea flower (Clitoria ternatea) infusion. Objective: This study aimed to analyze the effect of Clitoria ternatea infusion on blood pressure and sleep quality in individuals with prehypertension. This study employed a one-group pretest–posttest experimental design. A total of 34 participants with prehypertension were recruited using purposive sampling. Data were analyzed using the Wilcoxon Signed Rank Test. After the intervention, the mean systolic blood pressure decreased to 113.71 ± 8.09 mmHg and diastolic blood pressure to 73.00 ± 4.52 mmHg. The mean heart rate decreased to 73.97 ± 7.14 beats per minute, and the mean Pittsburgh Sleep Quality Index (PSQI) score improved to 4.41 ± 0.96. Statistical analysis showed significant reductions in systolic and diastolic blood pressure, heart rate, and a significant improvement in sleep quality, as indicated by a decrease in PSQI scores (p < 0.001). This study concludes that the administration of Clitoria ternatea infusion is associated with a reduction in blood pressure and an improvement in sleep quality among individuals with prehypertension.

Genetic diversity in the E6 and E7 gene of human papillomavirus type 16 among cervical cancer patients in Riau Province, Indonesia Savira, Maya; Rachmadina, Rachmadina; Mahargyarani, Azza Enggar; Admiral, Muhammad Zhafran; S, Donel; Sofian, Amru; Razali, Renady Reza; Ilmiah, Zidny; Farniga, Analdi
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.6652

Cervical cancer mostly occurs due to persistent high-risk human papillomavirus (HPV), with type 16 being the most frequent. In Indonesia, cervical cancer ranks second in mortality, with a fatality rate of 57%. The E6 and E7 genes of HPV-16 play crucial roles in the virus’s oncogenic transformation, leading to cervical cancer. This study was conducted to determine the prevalence and genetic diversity of the E6 and E7 genes of HPV-16 in Riau Province, Indonesia. There were 37 HPV-positive samples analyzed using the MY09/11 primers. This was followed by the amplification of the E6 and E7 genes. Nineteen samples were detected as HPV-16, thirteen of which were coinfected with HPV-18. Seven E6 and E7 sequences were aligned compared with the reference sequence NC_001526.4. The most common nucleotide changes in the E6 gene, 7318A>G, was detected in 30.7% of samples, leading to an amino acid change from 65N>S. Three nucleotide changes were identified in the E7 gene of sample 89: two synonymous (7831T>C, 7837T>G) and one non-synonymous (7989A>G), resulting in an amino acid change of 29N>S. The most frequent E7 nucleotide change, 7708G>A, was found in 80% of samples. Phylogenetic analysis revealed that HPV-16 isolates from Riau have close kinship with the European lineage, with 57.1% (E6) and 85.7% (E7). In conclusion, the incidence of cervical cancer in Riau Province caused by HPV-16 is 52.8% and 7318A>G and 7708G>A are the most common genetic diversity. Furthermore, the majority of HPV-16 isolates in Riau Province show close kinship with the European lineage.

Immunomodulatory Effects of Probiotics on Th17-Mediated Immune Responses in Psoriasis: A Systematic Review and Meta-Analysis Rindi Rosalina Fadly; Usman Pato; Maya Savira
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1615

Background: Psoriasis is a chronic inflammatory skin disorder with increasing evidence supporting the role of the gut-skin axis in its pathogenesis. Recent studies suggest that probiotic supplementation may modulate Th17-mediated immune responses and improve clinical outcomes in psoriasis. Methods: A systematic review and random-effects meta-analysis was conducted using PubMed, Scopus, Web of Science, and Cochrane Library databases (through February 2025). Randomised controlled trials evaluating probiotic supplementation in adult patients with psoriasis were included. The primary outcome was change in Psoriasis Area and Severity Index (PASI) score. Secondary outcomes included inflammatory markers (IL-6, CRP, IL-17) and immunological markers (Foxp3+ regulatory T cells, IL-10, TGF-β). Risk of bias was assessed using the Cochrane Risk of Bias tool (RoB 2), and evidence quality was evaluated using GRADE methodology. Results: Five randomised controlled trials encompassing 268 participants (132 intervention, 136 control) were analysed. The pooled effect size for clinical outcomes (PASI) showed significant improvement favouring probiotic supplementation (Hedges' g = −0.8165; 95% confidence interval [CI], −1.6487 to −0.0483; p = 0.048; I² = 92.45%). Substantial heterogeneity was observed, with the Alshihmani 2025 pilot study demonstrating markedly larger effects on immunological markers (Hedges' g = −5.6963). Subgroup analysis revealed single-strain probiotics (pooled Hedges' g = −0.3487) had smaller effect sizes than multi-strain formulations (pooled Hedges' g = −3.6740). Publication bias assessment via funnel plot and Egger's regression showed no statistically significant asymmetry (p = 0.087). Conclusion: Probiotic supplementation demonstrated statistically significant improvements in clinical outcomes and immunological markers in psoriasis. However, substantial heterogeneity and reliance on small trials limit certainty. The mechanistic evidence supporting gut-skin axis modulation warrants further investigation in adequately powered, long-term randomised controlled trials with standardised outcome measures and strain-specific analysis.

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