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Journal : Journal of Global Pharma Technology

A Brief Review Self Nanoemulsifying Mouth Dissolving Film: Formulation and Applications in Herbal Medicine Lusi Nurdianti
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

The use of herbal medicines is increasing, because of the belief that natural medicines have fewer side effects than synthetic drugs. But many herbal products show low therapeutic action due to problems with solubility and improper molecular size which have an impact on low bioavailability despite having good potential. The development of self nanoemulsion (spontaneous nanoemulsion) in fast-dissolving intraoral film preparations is one alternative formulation that can be used, to improve the limitations of bioavailability and increase patient acceptance and compliance because the application of developments is effortless, given through the oral cavity, so that direct absorption occurs in the cavity mouth and enter the systemic circulation without experiencing the effects of the first cross metabolism. This study aims to explain the concepts and techniques of self nanoemulsion formulation in intraoral (mouth dissolving film) preparations to increase the bioavailability of natural active compounds in extracts with low solubility in water and their characterization and evaluation.Keyworlds: Self nanoemulsifying, Mouth dissolving fim, Herbal medicine, Bioavailability.
Comparison Of Ethanol Emulgel Extract Activity Of Duku Fruit Peels (Lansium domesticum Corr) With Tranexamic Acid As A Skin Lightener Lusi Nurdianti
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

ABSTRACT Objective : Emulgel which has the potential for skin lightener is a medical cosmetic preparation used to inhibit the formation of melanin pigments so that it can brighten the skin. The purpose of this study was to determine the effect of concentration variations of duku (Lansium domesticum Corr.) peel waste extracts on the evaluation results of preparations, the level of irritation to rabbits, and an increase in brightness on human skin compared with emulgel containing tranexamic acid. A dermatoscopic test is used to look at the imaging of the skin surface after the use of an emulgel. Material and Method : In this study, concentration variations of ethanol extract from duku peel waste of 10%, 15% and 20% were used. Result : The test results obtained that all formulas meet the requirements of organoleptic test, pH, homogeneity, dispersibility, and centrifugation test. Irritation test with the Draize method obtained all formulas do not irritate. The results of testing the increase in skin brightness on emulgel preparations showed that F1 (16.67%), F2 (33.33%), F3 (60%), F4 (60%). Conclusion : Increasing the brightness of emulgel preparations containing 20% ethanol extract of duku peel is comparable to 4% tranexamic acid.Keywords: Tyrosinase, Lightening cream, Duku fruit Peel, Tranexamic acid.
Co-Authors Ade Putri Suci Lestari Ade Yeni Ade Yeni Aprilia Ade Yeni Aprilia Ade Yeni Aprilia Ade Yeni Aprillia Adhani, Ai Gita Aisah Agustiani, Dika Tri Agustini, Tina Albie, Fadhlan Adtya Alhikam Nazabullah Aliifah, Maitsa Wafaa Alma Meidina Anindita Tri Kusuma Pratita Anjuni, Dhea Putri Anna Yuliana, Anna Annisa Pebiansyah Annissya, Widia Primi Aprillia, Ade Yeni Ardianes Firmansya Ardianes Firmansya Ardiansyah, Dandi Arif Maulana Yusuf, Fitra Aris Priyanto Arya Purba Wasana Ayu Geamul Maskur Bagas Pra Ramdani Billah, Tazkia Hasna Cahyati, Keni Ida Damas Anjar Nugraha, Damas Anjar Devita Septiani Diana Sri Zustika Diana Sri Zustika, Diana Sri Dika Tri Agustiani Dwi Lestari, Oktaviana Dwi Lista Ligarsari Eka Khaelani Eka Yuniarti Elia Novianti, Elia Elis Lisnawati Elva Kurniasari, Elva Erin Yustira Fabillah Kurniadi Fajar Setiawan Fajar Setiawan Fajar Setiawan Fajar Setiawan Fajar Setiawan FAJAR SETIAWAN Farid, Rifa Agnia Fathurohman, Mochamad Fauziyah, Fitriya Febby Pratama Firman Gustaman Firman Gustaman Firman Gustaman Firman Gustaman Firman Gustaman Firmansya, Ardianes Fujianti Putri Nuraisah Gatut Ari Wardani Gatut Ari Wardhani Gustaman, Firman Hanna Nurul Husna Hanna Nurul Husna Hanna Nurul Husna Idacahyati, Keni indra indra Indra Indra Indra Indra Indra, Indra Intan Gita Cahyani Ira Rahmiyani Ira Rahmiyani Ira Rahmiyani Iyan Sofyan, Iyan Jayanty, Rizka Sri Julyanti, Ai Rian Keni Ida Cahyani Keni Idacahyati Keni Idacahyati Khaelani, Eka Khusnul, Khusnul Kurniady, Fabillah Kusumah, Firdan Gusmara Laksana, Tiara Putri Laras Rizkia Widyastuti Latifah, Nanda Nurul Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah Lilis tuslinah Lilis Tuslinah, Lilis Meri Meri Meri, Meri Mina Audina, Mina Mulya Tri Sugiharti Mustafidah, Syifa Nur Fadilah, Yayang Nur Rahayuningsih, Nur Nurbaitin, Azkia Ma’rifah Nurfaiza Safitri Nurhalimah, Riyan Siti Nurmalasari, Anisa Octavia, Tasya Oktaviana Dwi Lestari Parha, Syipa Zalia Pebiansyah, Anisa Pratita, Anindita Pratita, Anindita Tri Kusuma Prolina, Riska Puspita, Puput Resti Putri, Seulistia Rachman, Dineu Septy Ulfiatur Ramadan, Fajar Rani Rubiyanti, Rani Raras, Euis Ratih Aryani Reiza Alvita Rafanida Reza Ariza Wildan Rika Yulianti, Rika Rizka Sri Jayanty Rosmawati, Eli Rosydah, Meli Ruswanto, Ruswanto Saka Bekti Subagja Seina Lathifa Subagja Setiawan, Fajar Sri Mulyani Subagja, Seina Lathifa Sutiawan, Agus Taofik Hidayat Taofik Rusdiana Taufik Hidayat Taufik Hidayat Taufik Hidayat Tina Agustini Tita Nofianti, Tita Tresna Lestari, Tresna Vera Nurviana W F Annissya, W F Wawan Rismawan Wawan rismawan Widiyanti Widiyanti Wildan Muhtar, Mohammad Winda Trisna Wulandari, Winda Trisna Y M Pamela, Y M Yeni Aprilia, Ade Yuliansyah, Ivan Zahrotun Naqiah Zain, Dichy Nuryadin Zakia Nurul Izzah