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All Journal Jurnal Ilmu Dasar Jurnal NERS UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Panrita Abdi - Jurnal Pengabdian pada Masyarakat JFM (Jurnal Farmasi Malahayati) Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Indian Journal of Forensic Medicine & Toxicology Humanism : Jurnal Pengabdian Masyarakat Berkala Penelitian Hayati Pharmaceutical Sciences and Research (PSR) Journal of Pharmaceutical and Sciences. Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Inovasi Kesehatan Global Jurnal Sains dan Kesehatan Folia Medica Indonesiana
Widji Soeratri
Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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Journal : Science and Technology Indonesia

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Stability and Antiaging Effectiveness Studies of Astaxanthin-Loaded Nanostructured Lipid Carriers Using a Combination of Cetyl Palmitate and Soybean Oil Zhihrotulwida, Dzakiya; Soeratri, Widji; Erawati, Tristiana; Rosita, Noorma
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.473-481

Abstract

Astaxanthin is a potent antioxidant belonging to carotenoid compounds that is mainly produced from green microalgae Haematococcus pluvialis. Astaxanthin is beneficial for skin health as antiaging agent, but has limitations in its delivery through the skin. Astaxanthin could be formulated in nanostructured lipid carriers to improve its efficacy. The purpose of this study was to evaluate the stability and antiaging effectiveness of astaxanthin-loaded nanostructured lipid carriers (ASX-NLCs) with cetyl palmitate and soybean oil as lipid combinations at several ratios of 100:0, 90:10, 80:20, and 70:30. ASX-NLCs were synthesized using a high-shear homogenization technique. ASX-NLCs were characterized and stability evaluated after storage for 90 days. The antiaging effectiveness of ASX-NLCs was evaluated by in vitro release test using dialysis bag for 8 hours, as well as collagen density and fibroblast count evaluation on UV-induced skin aging mice for 28 days. After storage, all ASX-NLCs did not change significantly in organoleptic, pH, and particle size. However, other parameters including polydispersity index, viscosity, and entrapment efficiency experienced significant changes in some formulas. The release test showed that F4 (70:30) gave the highest cumulative release and was significantly different from F1 (100:0). The collagen density of the groups treated with ASX-NLC F3 (80:20) and F4 (70:30) increased significantly compared to the UVB control group, while the fibroblast count did not differ significantly in all groups. Overall, ASX-NLCs containing cetyl palmitate and soybean oil at ratios of 80:20 and 70:30 could improve the antiaging effect of astaxanthin which might be influenced by its better stability and release.
Co-Authors A'liyatur Rosyidah, M.Si., Ph.D Abdurahman Abdurrahman Abhimata Paramanandana Afra, Fairuz Yaumil Allyssia Salma Anita Natalia Suryawijaya Athiyyah, Wafa'ul Bambang Widjaja Bella Fevi Aristia Cindi Dia Annisa Cita Rosita Sigit Prakoeswa Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu Damaranie Dipahayu, Damaranie Dewi Febiyanti Dewi Isadiartuti Dewi Melani Hariyadi DEWI RAHMAWATI Diana Fitrianingrum Djoko Agus Purwanto Dwi Setyawan Dyah Rahmasari Eko Pujiono, Feri Elkania Putri, Safira Epipit Eryka A. Novarinandha Fairuz Yaumil Afra Fedik Abdul Rantam Fransisca Dita Mayangsari Hadi Poerwono Herra Studiawan Hidayah, Rohmawati I Gusti Ayu Adhi Aryapatni I NYOMAN WIJAYA Isnaeni Juni Ekowati Kadeq Novita Prajawanti Khoirun Nisyak Luky Hayuning Les Mangestuti Agil Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Maulina Apriani Miatmoko, Andang Nabilla Navyani P.A Ninis Yuliati, Ninis Nisa Qurrota Ayun Noor Ifansyah Noor Ifansyah Noorma Rosita Nugroho, Nadia Paramitha Nuruddin, Mahrus Naufal Nurul Islami Ningtiyas Paramita, Diajeng Putri Pawahid Pawahid Poernomo, A.Toto Purwanto , Djoko Agus Ressa Marisa Retno Sari Ria Hanistya Rina Mutya Suzliana Rohmawati Hidayah Rufaidah Azzahrah Safiul Fitria, Nur Indah Setyo Wiyono, Anang Siswandono Siti Hartini Hamdan Soemiyati Srinalesti Mahanani, Srinalesti Suko Hardjono Suwarno Putra, Adryansyah Tri Widiandani Tristiana Erawati Tristiana Erawati Tristiana Erawati Munandar Tutiek Purwanti Virnanda Syafira Hartatiningrum Yulis Setiya Dewi Yusuf, Helmy Zahwa Natasya Novita P. Zhihrotulwida, Dzakiya