Article Per Year (5 Year)
p-Index From 2020 - 2025
2.926
P-Index
This Author published in this journals
All Journal INDONESIAN JOURNAL OF PHARMACY Jurnal Dinamika Pengabdian (JDP) Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal Farmasi Sains dan Komunitas Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JCRS (Journal of Community Research and Service) Jurnal Layanan Masyarakat (Journal of Public Service) Berkala Ilmiah Kimia Farmasi Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Farmasis: Jurnal Sains Farmasi JAMAS: Jurnal Abdi Masyarakat Jurnal Kefarmasian Indonesia
Dewi Isadiartuti
Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Airlangga, Campus C Mulyorejo, Surabaya 60115, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

Published : 21 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search
Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
The formation of inclusion complex of phenobarbital with hydroxypropyl-β-cyclodextrine Isadiartuti, Dewi; ., Suwaldi
INDONESIAN JOURNAL OF PHARMACY Vol 16 No 1, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.436 KB) | DOI: 10.14499/indonesianjpharm0iss0pp28-37

Abstract

Phenobarbital, a hypnotic and sedative agent, was found to form inclusion complex with hydroxypropyl-β-cyclodextrine at 1:1 molar ratio. The formation of inclusion complex in the solution was detected due to the increased solubility of phenobarbital and in the solid was confirmed by differential scanning calorimetry, X-Ray diffractometry, and infrared spectroscopy.In the solid, inclusion complex was prepared by freezed drying method. The inclusion complex formed was characterized, compared with phenobarbital, hydroxypropyl-β-cyclodextrine, and the physical mixture of phenobarbital and hydroxypropyl-β-cyclodextrine.Analyses using DSC and X-ray diffractometry showed that phenobarbital formed inclusion complex with hydroxypropyl-β-cyclodextrine.Key words : phenobarbital, hydroxypropyl-β-cyclodextrine, inclusion complex
The thermodynamics of inclusion complex of phenobarbital with hydroxypropyl-β-cyclodextrin Martodihardjo, Suwaldi; Isadiartuti, Dewi
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.749 KB) | DOI: 10.14499/indonesianjpharm0iss0pp57-62

Abstract

Cyclodextrins are cyclic oligosaccharides which have been used extensively to improve the solubility in the formation of inclusion complex. The ability of cyclodextrin to form an inclusion complex has been attributed to factors including size of cyclodextrin cavity to the guest molecule and thermodynamics of their interactions.In this study, complex formation of phenobarbital and hidroxypropyl-β-cyclodextrin in the acetate buffer 0.01 M pH 4.4 and phosphate buffer 0.01 M pH 7.4 all with μ =0.10 and at temperatures of 32.o, 37.o, and 42o±0.5oC were determined.The results showed that phenobarbital formed inclusion complex with hidroxypropyl-β-cyclodextrin. The interaction shown a negative enthalphy (ΔH < 0 ), a spontaneous processes (ΔG < 0) and an increase in the entropy of the system (ΔS > 0).Key words : phenobarbital and hidroxypropyl-β-cyclodextrin, inclusion complex, thermodynamics
PHYSICAL CHARACTERIZATION OF IBUPROFEN-STEARIC ACID BINARY MIXTURE DUE TO COMPRESSION FORCE Setyawan, Dwi; Isadiartuti, Dewi; Betari, Sita Desti; Paramita, Diajeng Putri
Indonesian Journal of Pharmacy Vol 27 No 1, 2016
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (865.652 KB) | DOI: 10.14499/indonesianjpharm27iss1pp28

Abstract

Aim of this research is to determine physical characteristic of ibuprofen-stearic acid due to compression force. Binary mixture of ibuprofen-stearic acid with weight ratio of 4:6, 5:5, and 6:4 was compressed under various compression force using hydraulic press with 13mm diameter flat punch.Identification of solid state interaction between these two components was performed by Hot Stage Microscopy (HSM). Physical characterization has been studied byDifferential Thermal Analysis (DTA), X-ray Powder Diffraction (XRPD), Scanning Electron Microscopy (SEM), and (Fourier Transform Infrared (FT-IR) spectroscopy. According to hardness measurement, 4:6 weight ratio has the highest tensile strength on 170.6N/cm2 under 19.93kN compression force. Interaction identification by HSM showed single blank line that indicates eutectic formation. Thermal analysis of DTA also revealed eutectic formation upon compression whichthe endotermic peak of ratio of 4:6has the lowest melting temperature of 53.2°C. X-ray diffraction of three peaksgenerally showed that peak intensity decreases as compression force increases, but at particular point it begins to increase again. Sintering phenomenon at the surface of compressed tablet was observed from SEM analysis. FT-IR study confirms the formation of simple eutectic. Key words: ibuprofen, stearic acid, binary mixture, compression force, physical characterization
Antiseptic activity evaluation of piper leave from Piper betle Linn extract in hand gel antiseptic preparation Sari, Retno; Isadiartuti, Dewi
Indonesian Journal of Pharmacy Vol 17 No 4, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.263 KB) | DOI: 10.14499/indonesianjpharm0iss0pp163-169

Abstract

It is known that piper leaves (sirih) from Piper betle Linn has been used traditionally as medicine, for example for mouthwash and wound curing. The usage of hand gels antiseptic preparation was getting increased in the current time as the incidence of desease caused by virus and bacteria like SARS appears.This research was aimed to develop preparation of hand gels from piper leaves extract obtained from extraction with hot water. The formulation of gels were made using 5%, 10%, 15%, 20% and 25% of piper leaves extract in Carbopol gel base. The evaluation of antiseptics activity was carried out using the Replica method. A series of test was done by pouring the gels at hand palm and slightly tap the thumb fingerprint to nutrient agar media. The media was incubated at 37°C for 24 hours,and the number of colonies of microorganism was counted. The antiseptic activity of the gels also compared with two hand gels antiseptic preparation containing ethanol and triclosan as antiseptic agentThe result showed that the piper leaves extract gels had a transparent pale yellow performance. The gel preparation with concentration of 15% extract had activity to reduce the microorganism of skin normal flora up to 50%. Yet the 25% concentration of piper leave extract could eliminate all the microorganism. It was also known that the 15% piper leaves extract gel had no significance different with the ethanol preparation, since the 20% and 25% piper leaves extract gels had similar antiseptic activity to the triclosan preparation.Key words: piper leaves extract, gel, antiseptic activity, replica methods
Co-Authors Abhimata Paramanandana Alvina Violita Mulyanto Putri Alya Fakhirah Annisa Maulidia Rahayyu Ardhani Dwi Lestari, Maria Lucia Asri Darmawati Aulya Farah Fahreza Azzalia Firdanthi Bambang Widjaja Betari, Sita Desti Dewanthy, Kyrana Sekar Dinda Monika Nusantara Ratri Dinda Monika Nusantara Ratri Dini Retnowati Dini Retnowati Diyah, Nuzul Wahyuning Djoko Agus Purwanto Dwi Setyawan Esti Hendradi Fauzia, Alfi Nur Febri Annuryanti Firdausiah Fania Dwi Putri Putri Frida Magdalena Heinrich Dengi Hendra Wijaya Herra Studiawan I Gede Rekyadji Arimbawa I Gusti Ayu Adhi Aryapatni Idha Kusumawati Imamatin Nufus Melania Isnaeni Isnaeni Juni Ekowati Latifah, Luluk Mangestuti Agil Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowati Melanny Ika Sulistyowaty Miatmoko, Andang Mufariha, Mufariha Muh Agus S Rijal Muhammad Agus Syamsur Rijal Muhammad Agus Syamsur Rijal Muhammad Ilham Royyan Nafi Muhammad Pramudya Pangestu Nadya Ambarwati Nafa Nazilatul Fatihah Noor Erma Nasution Sugijanto Noorma Rosita Nuzul Wahyuning Diyah Oudrey Addriana Paramita, Diajeng Putri Prof. Dr. Retno Sari, M.Sc., Apt. Purwitasari, Neny Putri Hamidah Khairunnisa Putri, Syakirah Yasmin Rahayyu, Annisa Maulidia Retno Sari Rijal, M. Agus Syamsur Rohana, Melissa SETIAWAN, Catur Dian Siammita, Dhea Anansya Sugijanto Kartosentono Sugiyartono Sugiyartono Sugiyartono, Sugiyartono Suko Hardjono Suwaldi . Talitha Nabilla Wijayanata Tristiana Erawati Tutiek Purwanti Tutik Sri Wahyuni Umi Aida Rohma Virnanda Syafira Hartatiningrum Widji Soeratri Wisnu Prasetyo Yusniasari, Putri Antika Zulfa Diana