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All Journal Jurnal Veteriner Media Kedokteran Hewan Jurnal Medik Veteriner JURNAL KAJIAN VETERINER Ovozoa: Journal of Animal Reproduction Journal of Applied Veterinary Science and Technology journal of Basic Medical Veterinary Journal of Fisheries & Marine
Widiyatno, Thomas Valentinus
Departemen Patologi Veteriner, Fakultas Kedokteran Hewan, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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AKTIVITAS ANTIHIPERGLIKEMIA FRAKSI ETIL ASETAT DAUN SALAM (Syzygium polyanthum) TERHADAP TIKUS PUTIH YANG DIINDUKSI ALOKSAN MONOHIDRAT Prambudi, Dhimas Toni Angger; Meles, Dewa Ketut; Widiyatno, Thomas Valentinus
JURNAL KAJIAN VETERINER Vol 10 No 1 (2022): Jurnal Kajian Veteriner
Publisher : FAKULTAS KEDOKTERAN HEWAN UNIVERSITAS NUSA CENDANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jkv.v10i1.6469

Abstract

Bay leaf (Syzygium polyanthum) is traditionally used for diabetes treatment in Indonesia. It’s contains antioxidant that prevent the free radicals due to hyperglycemic condition. The purpose of this study is to demonstrate the ability of the ethyl acetate fraction of bay leaf in male white rats had hyperglycemia due to alloxan administration. This study used laboratory tests in which up to 24 white rats were randomly separated into six groups. Intraperitoneal administration of alloxan at a dose of 170 mg/Kgbw is used to induce hyperglycemia. A group of healthy rats (K-) were administered 0,5% CMC Na suspension 1mL/day. A group of hyperglycemic rats (K+) received metformin at a dose of 45 mg/Kgbw/1mL/day, while a group of hyperglycemic rats (P0) received 0.5% CMC Na suspension at a dose of 1mL/day. Three hyperglycemia treatment groups received different amounts of ethyl acetate fraction of bay leaf for 14 days. The P1 group received 125 mg/Kgbw/1mL/day of bay leaf ethyl acetate fraction extract, the P2 group received 250 mg/Kgbw/1mL/day, and the P3 group received 500 mg/Kgbw/1mL/day. Blood glucose levels were measured before and after alloxan administration, and then again on day 14. After 14 days of treatment, all rats were euthanized, and blood from the heart was collected to examine the insulin levels. To determine the differences between treatments, statistical analysis utilizing ANOVA was used, followed by Duncan's test. The findings revealed administered an ethyl acetate fraction of bay leaf can lower blood glucose and increased insulin levels in rats had hyperglycemia.
Curative Properties of Kencur (Kaempferia galanga L.) Extract on Mice (Mus musculus) Kidney Histopathology Exposed to Cigarette Smoke Arianto, Intan Diah Safitri; Lastoaji, Firman; Sudjarwo, Sri Agus; Valentinus, Thomas Widiyatno; Hestiana, Eka Pramyrtha; Hamid, Iwan Sahrial; Herupradoto, Eduardus Bimo Aksono; Lovela, Aprinda Ratna
Media Kedokteran Hewan Vol. 36 No. 1 (2025): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v36i1.2025.30-39

Abstract

The aim of this research was to investigate the therapeutic effects of Kencur (Kaempferia galanga L.) extract on kidney histopathological damage in male mice exposed to cigarette smoke. Twenty 8-week-old male mice were randomly divided into five treatment groups (n=5). The negative control group (C-) consisted of mice not given kencur extract or exposed to cigarette smoke, while the positive control group (C+) comprised mice exposed to cigarette smoke without kencur extract. Treatment groups included Treatment 1 (T1) administered 150 mg/kg BW of kencur extract, Treatment 2 (T2) administered 300 mg/kg BW, and Treatment 3 (T3) administered 600 mg/kg BW. Mice were exposed to cigarette smoke for 14 days. The data were analyzed using the Kruskal-Wallis test to evaluate overall differences among the treatment groups. Where significant differences were found (p<0.05), further pairwise comparisons were conducted using the Mann-Whitney test, confirming statistically significant differences between specific treatment groups.  Treatment 3 (T3) was found to be the most effective in reducing histopathological damage in the kidneys of male mice. This study demonstrates that kencur extract effectively reduces histopathological damage in the kidneys of mice exposed to cigarette smoke, highlighting its potential as a protective agent against smoke-induced tissue injury.
Polip endometrium pada sapi bunting tua Yusuf, Anang; Widiyatno, Thomas Valentinus; Samik, Abdul
Ovozoa: Journal of Animal Reproduction Vol. 10 No. 1 (2021): Ovozoa: Journal of Animal Reproduction
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ovz.v10i1.2021.25-31

Abstract

The current report describes acute death in 8.5 months pregnant cow, which no signs of illness before. Postmortem examination showed the presence of gastric bloat. Necropsy revealed no change in the viscera, but yellow and cloudy nodules were found on the endometrial wall, amniotic fluid mixed with blood, blood clots in the inner cervical canal, pneumonia in the lungs. Meanwhile, the anatomical condition of the fetus was normal. It could be concluded that the cow's sudden death was due to late pregnancy, causing high tension that triggers rupturing of the polyp blood vessels. The deep vein thrombosis due to late pregnancy causes pulmonary emboli and subsequent pneumonia.
A Comparative Study Between E-Cigarette Vapor and Cigarette Smoke Exposure on the Lungs of Mice (Mus musculus) Putri, Mirtanti Kiswandi; Hestianah, Eka Pramyrtha; Kuncorojakti, Suryo; Widiyatno, Thomas Valentinus; Sukmanadi, Mohammad; Santoso, Kuncoro Puguh; Plumeriastuti, Hani; Hidayatik, Nanik; Khairullah, Aswin Rafif
Journal of Applied Veterinary Science And Technology Vol. 6 No. 2 (2025): October 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/javest.V6.I2.2025.102-108

Abstract

Background: Cigarettes are tobacco products processed with or without additives and are known to contain addictive substances that pose serious health risks to individuals and the public. Inhaled cigarette smoke directly stimulates the activation of macrophage cells in the respiratory tract. Among the affected cells, type II alveolar cells which produce pulmonary surfactant to reduce alveolar surface tension are particularly vulnerable to smoke-induced damage. Purpose:  This study aimed to compare the effects of conventional cigarette smoke and e-cigarette vapor exposure on the number of alveolar macrophages and type II alveolar cells in male mice (Mus musculus). Method: A total of 28 male mice were randomly divided into seven groups. The control group (C) was exposed to ambient air only. Groups A1, A2, and A3 were exposed to 1, 2, and 3 conventional cigarettes per day, respectively, while groups B1, B2, and B3 were exposed to 0.7 mL, 1.3 mL, and 2 mL of e-liquid vapor per day, respectively. All exposures were conducted for 36 consecutive days. Results: A significant difference (p<0.05) was observed in the number of alveolar macrophages among groups C, A1, A2 , A3 , B2 , and B3 , whereas no significant difference was found between A1 and B1. The number of type II alveolar cells significantly differed (p < 0.05) across all groups: C, A1, A2, A3, B1, B2, and B3. Conclusion: Both conventional cigarette smoke and e-cigarette vapor increase alveolar macrophage counts and reduce type II alveolar cell numbers compared to controls. Although both exposures pose health risks, e-cigarette vapor appears to cause milder pulmonary effects than conventional cigarette smoke.
Co-Authors Abdul Samik, Abdul Aksono HP., Eduardus Bimo Amirotul Azhimah Anindya, Afifatus Arianto, Intan Diah Safitri Arief Budiman Arimbi Bambang Poernomo Bambang Sektiari Lukiswanto Boedi Setiawan Cahyono, Shahani Azpriyanne Dellavia, Yolanda Eka Pramyrtha Hestianah, Eka Pramyrtha Eko Agus Suyono Fedik Abdul Rantam Hana Eliyani Hani Plumeriastuti Hestiana, Eka Pramyrtha Hidajati, Nove Hidayatik, Nanik Hisyam, Mirza Atikah Madarina Ira Sari Yudaniayanti Iwan Sahrial Hamid Kadek Rachmawati Khairullah, Aswin Rafif Kuncorojakti, Suryo Lastoaji, Firman Lianny Nangoi Lilik Maslachah Lovela, Aprinda Ratna Lucia Tri Suwanti, Lucia Tri Ma'ruf, Anwar Mahendra Pujiyanto Meles, Dewa Ketut Mochamad Donny Koerniawan Nidom, Chairul Anwar Nugrahani, Anggi Dwi Nunuk Dyah Retno Lastuti Panggabean, Rosenna Tiara Poedji Hastutiek Prambudi, Dhimas Toni Angger Pratama, Ricki Putri, Mirtanti Kiswandi Renaldi, Nogi Rochmah Kurnijasanti Santoso, Kuncoro Puguh Sri Pantja Madyawati, Sri Pantja Sukmanadi, Mohammad Theresia, Sis Wisnuarti Ulfah Juniarti Siregar Wiwik Misaco Yuniarti Yeni Dhamayanti Yusuf, Anang Zhaza Afililla