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The Effect of Variations in HPMC and Carbopol Bases on The Physical Stability of Okra (Abelmoschus esculentus L.) Fruit Gel Formulations Irman Idrus; Rahayu Apriyanti; Syaiful Katadi; Nurfitriyana Rahmat; Sabda Wahab; Dzul Asfi
Biocity Journal of Pharmacy Bioscience and Clinical Community Vol 2 No 1 (2023): Biocity: Journal of Pharmacy Bioscience and Clinical Community
Publisher : Department of Pharmacy, Bumigora University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/biocity.v2i1.3399

Abstract

Okra fruit (Abelmoschus esculentus L.) is a vegetable that is often used as medicine. Okra fruit contains flavonoids which are antioxidants. Gel formulation with a concentration of 5%, and various combinations of HPMC and carbopol bases. This research aims to determine the physical stability of gel preparations and the effect of variations in the concentration of gelling ingredients in the preparations. The gel formulation consists of 4 formulas, namely F0, F1, F2, and F3. Physical stability tests include organoleptic tests (odor, color and texture), homogeneity, pH, spreadability, stickiness, viscosity and synergy. Tests were carried out for 14 days of storage, namely on days 1, 3, 5, 7, and 14 at room temperature (25℃). The observation results showed that in the organoleptic test there was no change in color, odor and texture in the gel preparation during 14 days of storage. The four gel formulas are homogeneous and there is no synergy. Variations in the combination of HPMC and carbopol bases affect the physical properties of the gel, including pH, viscosity, spreadability and adhesion. HPMC and Carbopol affect the pH of the preparation, the higher the Carbopol content and the lower the HPMC content, the more acidic it is. Carbopol and HPMC affect the values of spreadability, viscosity and adhesion because the higher the concentration of carbopol and HPMC produces a thick gel preparation so that the spreadability decreases, viscosity increases and adhesion also increases.
EDUKASI PEMANFAATAN POTENSI BAHAN ALAM LOKAL SEBAGAI UPAYA PENCEGAHAN STUNTING PADA MASYARAKAT Salam, Muhamad Ramadhan; Rahmat, Nurfitriyana; Katadi, Syaiful; Apriyanti, Rahayu; Idrus, Irman; Pemudi, Yusniati Dwi
GEMAKES: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2024): GEMAKES: Jurnal Pengabdian Kepada Masyarakat
Publisher : Politeknik Kesehatan Kemenkes RI Jakarta I

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36082/gemakes.v4i1.1467

Abstract

Stunting merupakan kelainan dimana tumbuh kembang balita terhambat akibat kekurangan gizi selama di dalam kandungan dan kondisi ini dapat diketahui dengan melihat kondisi tubuh anak yang lebih kecil dari anak lain seusianya. Pada tahun 2022 prevalensi stunting di Indonesia menurun 21,6% dibandingkan tahun 2021 sebesar 24,4%. Untuk Kabupaten Konawe sendiri tidak mengalami penurunan angka kejadian stunting dimana prevalensi tahun 2021 adalah sebesar 26,3% dan meningkat pada tahun 2022 sebesar 28,3%. Hal tersebut membuktikan bahwa masing kurangnya pengetahuan orang tua dalam memahami kebutuhan gizi anak semenjak anak masih didalam kandungan sampai dengan umur 2 tahun karena pengetahuan yang baik orang tua terhadap kebutuhan gizi dapat menjauhkan anak dari gangguan kesehatan kronis. Kegiatan dimulai dari analisis situasi wilayah kegiatan yaitu Desa Waworaha, Kecamatan Soropia, Kabupaten Konawe, Sulawesi Tenggara; pengurusan perijinan kegiatan kepada aparat desa setempat; pengembangan media edukasi; sosialisasi dan edukasi dalam bentuk pemaparan power point, pengisian kuesioner; analisis deskriptif dengan bantuan software IBM SPSS Statistics 26. Berdasarkan hasil kegiatan dan evaluasi yang telah dilakukan, pengetahuan masyarakat akan stunting dan pemanfaatan tanaman local sebagai Upaya pencegahan stunting masih kurang. Setelah dilakukan edukasi terhadap peserta kegiatan, pengetahuan masyarakat meningkat menjadi 88,54%. Perlu dilakukan sosialisasi kembali oleh pemerintah setempat dan tenaga Kesehatan terkait mengenai stunting dan intervensi spesifik untuk menurunkan angka kejadian stunting.
IDENTIFIKASI FOSFOR BELUT RAWA ASIA (MONOPTERUS ALBUS) DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM Idrus, Irman; Wahab, Sabda; Wibowo, Dwiprayogo
JOURNAL OF HEALTH SCIENCE Vol 1 No 1 (2021): Journal Of Health Science
Publisher : LPPM Universitas Kader Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (573.703 KB)

Abstract

Beberapa penelitian melaporkan bahwa Belut Rawa Asia (Asian swamp eel / ASE) merupakan salah satu spesies yang banyak dibudidayakan karena memiliki rasa daging yang enak, tingkat gizi yang tinggi, dan nilai ekonomis yang tinggi. Dalam penelitian ini, kami mengeksplorasi nutrisi tingkat tinggi seperti kandungan fosfor (P) yang berpotensi membentuk massa tulang. Penentuan kandungan P dilakukan dengan dua teknik yaitu kualitatif dan kuantitatif. Pengumpulan data kualitatif menggunakan visualisasi perubahan warna dengan menambahkan reagen, sedangkan data kuantitatif dikumpulkan dengan menggunakan metode bantuan spektrofotometri dengan λmax 650 nm. Berdasarkan hasil analisis menunjukkan bahwa analisis data kualitatif ASE terdapat kandungan P dengan identitas berubah warna menjadi biru. Selanjutnya data kualitatif diperoleh bahwa konsentrasi P pada daging ASE mengandung 11,54 mg.L-1 yang diubah secara stoikiometri menjadi 0,01154 mg.g-1. Dalam penelitian ini memberikan kesan bahwa daging ASE mengandung unsur P yang dapat digunakan sebagai pangan bergizi tinggi bagi pertumbuhan manusia. Kata kunci: Fosfor (P); Fosfat; Belut rawa Asia; Spektrofotometri Serapan Atom
Gambaran Tingkat Pengetahuan Masyarakat RT 22 Di Kelurahan Tangga Takat Palembang Tentang Penggunaan Obat Tradisional Pada Masa Pandemi Covid-19 Wahab, Sabda; Hatria, Nur; Idrus, Irman; Muliana, Hilda; Azzahra, Nia
JOURNAL OF HEALTH SCIENCE Vol 2 No 1 (2024): Journal of Health Science
Publisher : LPPM Universitas Kader Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.599 KB) | DOI: 10.54816/jhs.v2i1.514

Abstract

Penggunaan obat herbal sebagai pengobatan komplementer ataupun alternativ semakin meningkat di seluruh dunia. Pengetahuan mempengaruhi pemilihan pengobatan. Penelitian ini bertujuan untuk mengetahui gambaran penggunaan obat tradisional pada masa pandemi Covid-19oleh masyarakat RT 22 Kelurahan Tangga Takat Palembang. Jenis penelitian ini adalah penelitian deskriptif. Digunakan obat tradisonal kaerena mudah diperoleh (52,6%) dengan pengetahuan responden tentang obat tradisonal (73,7%) yang bersumber dari keluarga (43%) serta memperolehnya dari penjual jamu gendong (36,8%) digunakan untuk menyembuhkan penyakit yang mendadak/ringan (45,6%), obat tradisional yang sering digunakan adalah sediaan cair (50,9%) untuk waktu penggunaan sampai sembuh (38,6) dan (84%) responden merasa sembuh dengan menggunakan jamu (54%) dan tidak merasakan efek samping (93%), namun tidak mengetahui kandungan obat tradisional yang diminum (77,2%). Gambaran tingkat pengetahuan masyarakat RT 22 di Kelurahan Tangga Takat Palembang tentang penggunaan obat-obatan tradisional di masa pandemi Covid-19 secara keseluruhan tercatat sangat baik. Kata kunci : Pengetahuan, Obat Tradisonal
A CREAM FORMULATION HERBA ETHANOL EXTRACT Peperomia pellucida AND ANTIBACTERIAL ACTIVITY OF Propionibacterium acnes Hasan, Dzulasfi; Faradika Abdullah, A. Yayan; Agustina, Satri; Idrus, Irman
Jurnal Kesehatan Vol 16 No 2 (2023): : JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v16i2.33315

Abstract

Peperomia pellucida (L). Kunth) contains chemical compounds that are useful in the world of health in the pharmaceutical field. This study aims to make and test the physical quality of Peperomia pellucida herbal extract cream and to test the inhibitory power of Peperomia pellucida herbal extract cream against Propionibacterium acnes. The research method used was a laboratory experiment by making Peperomia pellucida extract using a physicochemical method to obtain 70% ethanol extract, then cream preparations were made and varied in several concentrations, namely 1% w/v; 2% w/v; and 3% w/v, then physical stability was carried out including organoleptic tests, homogeneity, pH, spreadability and the final stage was the Propionibacterium acnes antibacterial test by observing and measuring the inhibition zones. The results of the physical quality test showed that Peperomia pellucida herbal cream was made before and after storage at 4°C and 40°C for 24 hours with a concentration of 1% w/v; 2% w/v; and 3% w/v, on organoleptic, homogeneity, pH, spreadability and irritation tests, which meet the requirements for physical quality according to SNI standards. The antibacterial test was carried out using the well method and the inhibition zone formed was measured using a shear rod. Nutrient Agar (NA) as a medium with an incubation period of 1 x 24 hours with a temperature of 37OC. The average inhibition zone measurement results for a 1% concentration is 10.9 mm, 2% concentration is 12.1 mm, a 3% concentration is 12.8 mm and negative control no no inhibition zone.
Concentration Effect of Leaf Extract from Kekara Laut (Canavalia Maritima Thou.) in inhibiting of Staphylococcus Epidermidis Bacteria with a Statistical Science Approach Idrus, Irman; Kurniawan, Fajar; Mustapa, Faizal; Wibowo, Dwiprayogo
Indonesian Journal of Chemical Research Vol 8 No 3 (2021): Edition for January 2021
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2021.8-irm

Abstract

Importantly to study the coastal vegetation from Kekara Laut (Canavalia maritima Thou.) to observe the antibacterial agents towards Staphylococcus epidermidis. The purpose of this study to examine the variation concentration effect of an ethanol leaf extract from Canavalia maritima Thou. in inhibiting the growth of S. epiderimidis bacteria. The leaf of Canavalia maritima Thou. was prepared using a physicochemical method to obtain ethanol extract, then varied in several concentrations, namely 5% w/v; 10% w/v; 15% w/v; and 20% w/v. Based on these results, we obtain the ethanol leaf extract can inhibit the growth of S. epidermidis with a concentration of 15% w/v for 24 hours having an inhibition zone of 17.17 mm. The statistical analysis test was very significantly different from all antibacterial tests, the value of F count was 682.1 with F table (3.48), at the level of α = 0.05 (3.48) and α = 0.01 (5.99), which indicates that H0 is rejected, but using the Variance method in the Newman-Keuls range approach shows that each concentration has a good inhibitory ability. The use of Canavalia maritima Thou. leaf extract in low concentrations can significantly inhibit bacterial growth (bacteriostatic).
Regulations for Organizing Immunizations in Indonesia Wahab, Sabda; Idrus, Irman; Muliana, Hilda; Azzahra, Nia
Soepra Jurnal Hukum Kesehatan Vol 9, No 1: Juni 2023
Publisher : Universitas Katolik Soegijapranata Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24167/sjhk.v9i1.5938

Abstract

Immunization is an effort to increase a person's immunity through the administration of antigens to prevent certain diseases which are packaged in the form of programs organized by the Government in the implementation of preventive health efforts. In 2021, during the time when the Covid-19 pandemic hit Indonesia, only 79.6% of children in Indonesia received complete basic immunization. The government implements the immunization program through the Ministry of Health. Based on the implementation, there are several types of immunization, namely routine immunization and follow-up immunization. This study uses an analytic descriptive research method with a normative juridical research approach. The results of the study are: 1) Immunization in Indonesia is carried out based on the provisions of the 1945 Constitution of the Republic of Indonesia, the Law of the Republic of Indonesia Number 36 of 2009 concerning Health and the Law of the Republic of Indonesia Number 35 of 2014 concerning Amendments to Law Number 23 of 2002 Concerning Child Protection. 2) Implementation of immunization in Indonesia is regulated by Regulation of the Minister of Health Number 12 of 2017 concerning Implementation of Immunization which includes types of immunization, implementation of immunization programs, implementation of selected immunizations, monitoring and prevention of kipi (adverse events after immunization), research and development, community participation, recording and reporting and guidance and supervision aimed at maintaining the health of children so that they can be physically, mentally and spiritually healthy, as well as efforts to fulfill children's social rights to live free from infectious diseases and create a prosperous future for children, with the aim of fulfilling the provision of happiness that is as large as - as much as possible to as many people
Profil Fitokimia dan Aktivitas Antibakteri Bunga Kekara Laut (Canavalia rosea) Menggunakan Metode Difusi Cakram Idrus, Irman; Nasrun, Efa Kelya; Ramandha, Muhammad Eka Putra
Biocity Journal of Pharmacy Bioscience and Clinical Community Vol 2 No 2 (2024): Biocity: Journal of Pharmacy Bioscience and Clinical Community
Publisher : Department of Pharmacy, Bumigora University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/biocity.v2i2.3988

Abstract

Bacterial infection is one of the leading causes of chronic diseases and ongoing risks of mortality that continuously threaten public health globally. Improper use of antibiotics can lead to pathogenic bacteria developing resistance to antibiotics and cause dangerous side effects. Therefore, searching for alternative antibiotic sources derived from natural materials is essential. One type of plant that has the potential as an antibacterial agent is Canavalia rosea. This research aims to qualitatively assess the phytochemical content using tube methods and evaluate the antibacterial activity of the ethyl acetate fraction of Canavalia rosea extract using the disc diffusion method. Canavalia rosea leaves were extracted using a maceration method using 96% ethanol, and fractionation was done using ethyl acetate. Phytochemical analysis showed alkaloid, saponin, flavonoid, polyphenol, and tannin compounds in the Canavalia rosea flower extract. The antibacterial activity of the ethyl acetate fraction of the extract showed a significant inhibition zone against the growth of Staphylococcus aureus bacteria. At a concentration of 9 mg/mL, the inhibition zone reached 20.31 ± 0.27 mm, falling into the moderate to strong category. While at a concentration of 1.5 mg/mL, the inhibition zone reached 5.13 ± 0.32 mm, indicating lower inhibitory effects. Statistical analysis showed that the ethyl acetate fraction of Canavalia rosea extract has significant antibacterial activity, with each concentration having different effects in inhibiting the growth of S. aureus.
Kajian Praklinis Ekstrak Etanol Herba Tridax procumbens (Linn.) sebagai Antidiabetik pada Tikus Putih Diabetes (Rattus norvegicus) yang Diinduksi Streptozotosin: Preclinical Study of Ethanol Extract of Herba Tridax procumbens (Linn.) as Antidiabetic in Streptozotocin-Induced Diabetic White Rats (Rattus norvegicus) Syaiful Katadi; Irman Idrus; Arman Rusman; Sitti Sarfila
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1597

Abstract

This study aims to conduct a preclinical study of the antidiabetic effect of the ethanol extract of the herb Tridax procumbens (Asteraceae) in streptozotocin-induced diabetic rats. The research procedure began by collecting test samples of the Tridax procumbens Linn (TP) herb. All parts of the TP plant which were air-dried were extracted with ethanol (95%) by maceration for 72 hours, then phytochemical screening was carried out to determine the content of secondary metabolites in general. The antidiabetic test was initiated by inducing male Wistar rats with streptozotocin (50 mg/jk, i.p.) and nicotinamide (120 mg/kg, i.p.) by injection. Diabetic rats were treated with glibenclamide (0.25 mg/kg, po) and TP extract (250 and 500 mg/kg, p.o.) for 21 consecutive days. Blood samples were collected periodically to measure the hypoglycemic effect of the TP extract. Then, variations in body weight at the fair were monitored for all experimental animals. The results showed that TP extract had a significant antidiabetic effect on diabetic white rats (Rattus norvegicus), with the best results given TP extract at a dose of 500 mg/kg. Keywords: Tridax procumbens, diabetes mellitus, antidiabetic Abstrak Penelitian ini bertujuan untuk melakukan kajian praklinis efek antidiabetes dari ekstrak etanol herba Tridax procumbens (Asteraceae) pada tikus diabetes yang diinduksi streptozotocin. Prosedur penelitian dimulai dengan mengumpulkan sampel uji herba Tridax procumbens Linn (TP). Seluruh bagian tanaman TP yang telah dikeringkan diekstraksi dengan etanol (95%) dengan cara dimaserasi selama 72 jam, selanjutnya dilakukan skrining fitokimia untuk mengetahui kandungan metabolit sekundernya secara umum. Untuk Uji antidiabetes dimulai dengan menginduksi tikus Wistar jantan dengan streptozotocin (50 mg/kg, ip) dan nicotinamide (120 mg/kg, ip). Tikus diabetes diobati dengan glibenklamid (0,25 mg/kg, po) dan ekstrak TP (250 dan 500 mg/kg, p.o.) selama 21 hari berturut-turut. Sampel darah dikumpulkan secara berkala untuk mengukur efek hipoglikemik ektrak TP. Kemudian, variasi berat badan mingguan dipantau untuk semua hewan percobaan. Hasil penelitian menunjukkan ekstrak TP memiliki efek antidiabetik yang signifikan terhadap tikus putih diabetes (Rattus norvegicus), dengan hasil terbaik pada pemberian ekstrak TP dosis 500 mg/KgBB. Kata Kunci: Tridax procumbens, diabetes mellitus, antidiabetik
Edukasi Budaya Jamu: Memperkuat Kesehatan Masyarakat Dengan Pendekatan Alternatif Muhamad Ramadhan Salam; Nurfitriyana Rahmat; Syaiful Katadi; Rahayu Aprianti; Irman Idrus; Ira Nurmala
ABDI: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol 6 No 3 (2024): Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat
Publisher : Labor Jurusan Sosiologi, Fakultas Ilmu Sosial, Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/abdi.v6i3.869

Abstract

Pengobatan tradisional adalah bagian dari sistem budaya masyarakat yang dapat sangat membantu pembangunan kesehatan masyarakat. Akan tetapi, akan ada masalah dengan penggunaan jamu karena semakin banyak orang yang menggunakannya tanpa mengetahui cara menggunakannya dengan benar untuk memastikan manfaat dan keamanannya. Kegiatan ini bertujuan untuk meningkatkan pengetahuan masyarakat desa Waworaha, Soropia, Konawe, Sulawesi Tenggara tentang penggunaan jamu yang baik dan benar untuk meningkatkan derajat Kesehatan masyarakat. Proses dimulai dengan menilai situasi wilayah, pengurusan izin kegiatan, perancangan media edukasi, sosialisasi dan edukasi, evaluasi kegiatan dengan pengisian kuesioner pengetahuan pre test dan post test, dan selanjutnya analisis karakteristik dan data pengetahuan dengan bantuan Microsoft Excel. Tingkat pengetahuan peserta kegiatan tentang penggunaan tanaman tradisional sebagai bahan utama jamu cukup baik, dengan rata-rata 83,01%. Ada beberapa indikator yang masih kurang dipahami oleh masyarakat, terutama cara penggunaan, cara pengolahan, dan proses seleksi tanaman. Namun, pengetahuan rata-rata meningkat sebesar 91,60% setelah edukasi dan sosialisasi.