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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Tropical and Infectious Disease Majalah Kesehatan FKUB Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Medica Hospitalia Jurnal Pengabdian Masyarakat dalam Kesehatan Respiratory Science Malang Respiratory Journal Jurnal Klinik dan Riset Kesehatan Indonesian Journal of Cancer
Setyawan, Ungky Agus
Department Of Pulmonology And Respiratory Medicine Faculty Of Medicine Universitas Brawijaya Malang
Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Analysis of Urinary Midkine and Volatile Organic Compound (VOC) Levels Using a Breath Analyzer for Screening and Early Diagnosis of Lung Cancer Mafisah, Saidah; Setyawan, Ungky Agus; Tantular, Rezki; Permana, Deden; Djajalaksana, Susanthy; Wardoyo, Arinto Yudi Ponco; Listyoko, Aditya Sri
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.223-231

Abstract

Introduction: Lung cancer is the leading cause of cancer-related mortality worldwide. Midkine, a heparin-binding growth factor, promotes proliferation, angiogenesis, and metastasis. Volatile organic compounds (VOCs) reflect cellular and molecular changes, aiding in cancer diagnosis. This study explored urinary midkine and VOC profiles as biomarkers for lung cancer screening and early diagnosis. Methods: A case-control, cross-sectional study was conducted on 20 controls (family members of lung cancer patients) and 20 lung cancer patients who had not received therapy. Volatile organic compounds breath analysis and urinary midkine measurements were performed. Volatile organic compounds, including total volatile organic compounds (TVOCs), ethanol (C2H5OH), formaldehyde (CH2O), toluene (C7H8), acetone (C3H6O), hexane (C6H14), and methane (CH4), were collected from exhaled breath using Tedlar bags and measured with a µβreath analyzer. Meanwhile, urinary midkine levels were determined using the Enzyme-Linked ImmunoSorbent Assay (ELISA) method. Statistical analyses included an independent t-test, Mann-Whitney U test, Spearman correlation, and diagnostic testing with receiver operating characteristic (ROC) analysis. Results: Urinary midkine levels were higher in lung cancer patients than in controls (330.56±120.50 vs. 282.18±146.28 pg/mL), although not significant (p>0.05). The independent t-test revealed that ethanol levels were significantly elevated in lung cancer patients (p < 0.001), whereas methane levels were not (p > 0.50). Receiver operating characteristic analysis demonstrated sensitivity and specificity: urinary midkine (60%, 60%), ethanol (75%, 75%), and methane (45%, 45%). Conclusion: Ethanol VOC appears to be a promising non-invasive biomarker for the early detection of lung cancer, whereas elevated urinary midkine levels did not demonstrate significant diagnostic value.
Analisis Ketahanan Hidup Pasien Kanker Paru di RSUD Dr. Saiful Anwar Pratiwi, Suryanti Dwi; Setyawan, Ungky Agus; Falyani, Silvy Amalia; Permatasari, Adinda Pramitra; Santosa, Andrew; Febriawati, Juwita; Prasetyo, Kevin Wahyudy; Yokanan
Jurnal Klinik dan Riset Kesehatan Vol 3 No 3 (2024): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.3.2

Abstract

Background: Comprising 14% of all cancer, lung cancer is the main cause of cancer-related mortality worldwide. Previous studies showed various findings regarding the survival rate of lung cancer, and factors significantly correlated with survival rate in lung cancer patients. Aim: This research aims to identify the profile and survival rate of lung cancer patients receiving chemotherapy in Saiful Anwar General Hospital from 2018 to 2020. Methods: This cohort retrospective study used medical records of patients diagnosed with lung cancer who underwent chemotherapy from 2018 to 2020. Data analysis was done using the Mantel Cox log rank test. Survival data shown as progression free survival (PFS) and overall survival (OS) were shown using Kaplan-Meier curves. Results: Subjects were largely male (73,2%). Adenocarcinoma is the most often type of lung cancer found (59,8%) with wild type EGFR mutation being the most prevalent (20,6%). Carboplatin – Paclitaxel is the most widely used chemotherapy regimen (54,6%). Survival analysis showed a significant correlation between age, OS, and PFS (p < 0,05) Conclusion: Various factors such as gender, cancer cell type, EGFR mutation, and chemotherapy regimen were not found to be related to survival rate in lung cancer patients. A significant correlation between age and survival rate showed potential in utilizing age as a predictor of survival rate in lung cancer patients.
Analisa Trombositosis, Leukositosis dan Kombinasi Trombositosis- Leukositosis terhadap Hasil RECIST 1.1, Progression Free Survival dan Stadium pada Pasien Karsinoma Paru Bukan Sel Kecil yang mendapatkan Kemoterapi Analisa Trombositosis, Leukositosis dan Kombinasi Trombositosis-Leukositosis terhadap Hasil RECIST 1.1, Progression Free Survival dan Stadium pada Pasien Karsinoma Paru Bukan Sel Kecil yang mendapatkan Kemoterapi Wiyono, Hendri; Setyawan, Ungky Agus; Pratiwi, Suryanti Dwi
Jurnal Klinik dan Riset Kesehatan Vol 5 No 1 (2025): Edisi Oktober 2025
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.05.1.2

Abstract

Background: Lung cancer is the most common malignancies that lead to highest mortality and morbidity. Advanced lung cancer is treated with chemotherapy and the evaluation is using RECIST. Thrombocytosis and or leukocytosis in lung cancer, theoritically stand with bad condition.The aim of this study is to analyse whether thrombocytosis and or leukocytosis can be a prognostic factor compare to the result of RECIST,Progression Free Survival and the stadium of lung cancer. Method: This study uses retrospective analytic cross-sectional design.Data were taken from medical record at Saiful Anwar Hospital,2018-2021,processed with Chi square,Mann-Whitney, and Fisher Exact test. Result:The result of Chi square Thrombocytosis and Leukocytosis to the first result of RECIST are ᵡ²(1) =59,659; p=0,000 and ᵡ²(1) = 5,707:p=0,017.To the median PFS 5,66 months the test are ᵡ²(1)=51,776:p=0,000; ᵡ²(1)=4,259:p=0,039.To the state of progression, the test are ᵡ² (1)=15,171:p=0,000; ᵡ²(1)=2,226:p=0,329.To stadium, Mann-Whitney test are:1145,00;Z= -1,026:p=0,305 and 1040,500;Z= -1,393:p=0,164. Conclusion: There is statistically significance between thrombocytosis or leukocytosis to the first result of RECIST,median PFS 5,66 months.No significance to the stadium of lung cancer.Thrombocytosis and or leukocytosis can be a prognostic factor for result of chemoteraphy.
The Role of Serum IL-23 and Volatile Organic Compound Levels to RECIST 1.1 in The Evaluation of Therapeutic Response in Lung Cancer Tjahyadi, Rizal Muldani; Setyawan, Ungky Agus; Astuti, Tri Wahju; Djajalaksana, Susanthy; Wardoyo, Arinto Yudi Ponco
Indonesian Journal of Cancer Chemoprevention Vol 14, No 3 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss3pp171-180

Abstract

The Response Evaluation Criteria in Solid Tumors (RECIST 1.1) is the gold standard for the assessment of lung cancer progression. However, the assessment and diagnosis of early treatment failure is challenging due to the limitations of current tools, as well as the long intervals and unavoidable side effects.This study aims to correlate volatile organic compound (VOC) patterns, serum level of interleukin-23 (IL-23), and RECIST 1.1 to assess chemotherapy response in lung cancer patients at Saiful Anwar Hospital. A prospective observational study was performed to 47 lung cancer patients who received three cycles of platinum-based chemotherapy. Using the Breath Analyzer to measure certain volatile organic compounds (VOCs), the study observed that three of the seven VOCs examined, formaldehyde (CH2O), toluene (C7H8), and hexane (C6H14), showed lower levels after three cycles of chemotherapy. Furthermore, there was a negative correlation between RECIST1.1 and acetone (C3H6O) (p=0.023), while RECIST1.1 and methane (CH4) had a positive correlation (p=0.011). Moreover, a significant positive correlation was observed between IL-23 after-chemotherapy and RECIST 1.1 (p=0.000). According to this study, a correlation exists between methane, IL-23, and RECIST 1.1 after three cycles of chemotherapy. The increase in methane and IL-23 aligns with the disease progression determined by RECIST 1.1. Furthermore, The decrease in acetone after chemotherapy showed a negative correlation with RECIST1.1, consistent with disease progression.Keywords: Volatile Organic Compound, Interleukin-23, RECIST 1.1.
D-Dimer and Brixia Score to Mortality in COVID-19 Patients Falyani, Silvy Amalia; Pratiwi, Suryanti Dwi; Setyawan, Ungky Agus; Erawati, Dini Rachma; Djajalaksana, Susanthy; Listyoko, Aditya Sri
Jurnal Respirasi Vol. 10 No. 2 (2024): May 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.2.2024.99-106

Abstract

Introduction: Coronavirus disease 2019 (COVID-19) is a highly contagious severe and acute respiratory syndrome caused by the SARS-CoV-2 virus. A variety of factors can increase a patient's risk of death, including coagulopathy characterized by increased D-dimer levels. Brixia scores could be one of the determinants of COVID-19 severity, as assessed by chest radiographs. This study aimed to analyze chest radiographic severity based on the Brixia score at the degree of coagulation based on D-dimer in mortality of COVID-19 patients who were hospitalized. Methods: This cohort retrospective study was conducted at Dr. Saiful Anwar General Hospital, Malang, using an observational cross-sectional design. The study included 300 medical records of COVID-19 patients who passed away while hospitalized. The data were analyzed using the Wilcoxon test, and the results were also tested for Spearman correlation to determine the relationship between variables. Results: Significance results of median D-dimer were found by age and severity of COVID-19 (p-values 0.015 and 0.002), and median Brixia scores by age, gender, severity of COVID-19, and length of treatment (p-values 0.001, 0.001, 0.001, and 0.005). The results were also compared with normal values, which were significant (p = 0.000). Spearman correlation test results between the final D-dimer and the initial Brixia score (p = 0.005). Conclusion: The research results display a retrospective study of the correlation between D-dimer and Brixia score values "‹"‹and outcomes in COVID-19 patients. Higher D-dimer values"‹ "‹and Brixia scores on admission were shown to be associated with mortality.
Case Report: 43-years old-Male with Pulmonary Sequestration which Mimics Lung Tumor and Aspergillosis Rumaratu, Simon Petrus Hardiyanto; Setyawan, Ungky Agus; Wardhana, Koernia Kusuma; Erawati, Dini Rachma; Yudhanto, Hendy Setyo
Malang Respiratory Journal Vol. 4 No. 1 (2022): Vol. 4 No. 1
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2022.004.01.4

Abstract

Background: Pulmonary sequestration is a very rare congenital abnormality of the lung, which was responsible for 0.15-6.4% of all cases of congenital lung formation disorders. Pulmonary sequestration is often seen as recurrent pneumonia, accompanied by complaints of chest pain, shortness of breath and hemoptysis. Conventional angiography is the gold standard for diagnosing pulmonary sequestration and for demonstrating arterial supply and venous drainage. The optimal therapy for pulmonary sequestration is operative resection to avoid infection and damage to the lung parenchyma. Case Report: We reported a case of 43-years old-male with pulmonary sequestration, previously diagnosed with a lung tumor with massive left pleural effusion and pneumonia. A series of diagnostic tests found no malignant cells. During FNAB with CT scan guiding, we found an image of a fungus ball, thus, he was diagnosed with Aspergillosis. The patient was planned to undergo VATS. There were complications during the operation, thus, a lobectomy with an open thoracotomy was performed, and an arterial anomaly was found from the abdominal aorta. The operation was successful and the patient was able to carry on with his normal activities.Conclusion: Establishing a definite diagnosis of pulmonary sequestration is very difficult, and in this case, it was done through lobectomy with thoracotomy and through a multidisciplinary approach.
Indonesian Society of Respirology Position Paper on Lung Cancer Control in Indonesia Andarini, Sita; Santoso, Andintia Aisyah; Arfiansyah, Mochammad Aris; Syahruddin, Elisna; Zaini, Jamal; Putra, Andika Chandra; Kurniawan, Ferry Dwi; Ermayanti, Sabrina; Soeroso, Noni Novisari; Munir, Sri Melati; Infianto, Andreas; Setijadi, Ana Rima; Setyawan, Ungky Agus; Wulandari, Laksmi; Haryati, Haryati; Jasminarti, Ida Ayu; Hidayat, Moulid; Santoso, Arif
Jurnal Respirologi Indonesia Vol 44 No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.884

Abstract

Lung cancer is a major health concern in Indonesia due to its increasing prevalence, late-stage diagnosis, younger population, and high mortality. Addressing this issue requires nationwide implementation of comprehensive lung cancer control, which includes risk reduction and prevention strategies, focusing on tobacco control and air pollution mitigation. Screening with low-dose computed tomography (LDCT) and early detection in symptomatic patients, along with TB screening programs and all non-communicable diseases, is strongly recommended to enhance early case findings, treatment effectiveness, and overall patient outcomes. A multidisciplinary team (MDT) approach is important to ensure accurate diagnosis and comprehensive care. Moreover, the integration of palliative care at the early stages of advanced lung cancer is vital, focusing on symptom management and enhancing the quality of life for patients. While national guidelines are available for the diagnosis and treatment of lung cancer, significant disparities in healthcare access remain across Indonesia. Thus, it is essential to improve universal health coverage and referral systems to guarantee equal access to lung cancer care for patients at all levels through advocacy and ease of access.
Co-Authors Aditya Sri Listyoko Aditya Sri Listyoko Agil Dananjaya Ana Rima Ana Rima Setijadi Andarini, Sita Andreas Infianto Arfiansyah, Mochammad Aris Arif Santoso Arif Santoso Arina Aftritia Izzati Arinto Yudi Ponco Arinto Yudi Ponco Wardoyo Arinto Yudi Ponco Wardoyo Aura Madarina Binharyanto, Adlan Pratama Binharyanto Caesar Ensang Timuda Chaerani Bahar Dewi, Dinda Ary Miranda Dini Rachma Erawati Djajalaksana, Susanthy Dwi Rosa Eka Agustina Elisna Syahruddin Erawati, Dini Rachma Ermayanti, Sabrina Ermayanti, Sabrina Fadhila, Audri Shabrina Fahmi, Kristia Falyani, Silvy Amalia Febriawati, Juwita Ferry Dwi Kurniawan Harun Al Rasyid Haryati Haryati Haryati Haryati Hendri Wiyono, Hendri Hendy Setyo Yudhanto Hendy Setyo Yudhanto Hidayat, Moulid Ida Ayu Jasminarti Iin Noor Chozin Infianto, Andreas Jasminarti, Ida Ayu Jimmy Akbar Karliasari, Liana Kevin Wahyudy Prasetyo Kristianto, Fransiskus Kurniawan, Ferry Dwi Laksmi Wulandari Listyoko, Aditya Sri Mafisah, Saidah Maria Kristiani Muhamad Yusuf Musthafa Nathaniel Aditya Ngakan Putu Parsama Putra Ngakan Putu Parsama Putra Noni Novisari Soeroso Noorhamdani AS Parsama Putra , Ngakan Putu Permana, Deden Permatasari, Adinda Pramitra Pratiwi, Suryanti Dwi Putra, Andika Chandra Putra, Ngakan Putu Parsama Raden Dicky Wirawan Listiandoko Rakhma, Sastia Ramadhan, Fitratul Rezki Tantular Rezki Tantular Rozi, Achmad Syamsufandi Rumaratu, Simon Petrus Hardiyanto Santosa, Andrew Santoso, Andintia Aisyah Simon Petrus Sita Andarini Sri Melati Munir Sri Melati Munir Susanthy Djajalaksana Susanthy Djajalaksana Tantular, Rezki Taufiq Abdullah, Taufiq Teguh Rahayu Sartono Teguh Wahyu Sardjono Timuda, Caesar Ensang Tjahyadi, Rizal Muldani Tri Wahju Astuti Tri Wahju Astuti, Tri Wahju Ulfah Kartikasari Wardhana, Koernia Kusuma Yenny Widowati Yokanan Yudhanto, Hendy Setyo Zaini, Jamal