Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : JFIOnline

Uji Aktivitas Antidiabetes Ekstrak Etanol dari Akar dan Batang Tumbuhan Sekunyit (Fibraurea Tinctoria Lour) Utami, Rahayu; Sandi, Nofri Hendri; Hasti, Syilfia; Delvia, Sutri
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 4 (2015)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sekunyit (Fibraurea tinctoria Lour) is a species plant that has been used as traditional medicine for treating several diseases including jaundice, dysentery, headache, eye infection as well as anti diabetic drug. This research aims to evaluate antidiabetic activity of ethanol extract of roots and stem of sekunyit on white male mice (Mus musculus L) using glibenclamide as positive control. The experimental animals were induced with alloxan 175 mg/Kg BW i.p and devided into six groups, each group consisted of five mice. Group one served as negative control which was given NaCMC 1%, group second was positive control, given  glibenclamide 0,65 mg/KgBW, while group third, fourth, fifth were administered orally with etanol extract with doses of 100, 200 and 300 mg/KgBW, respectively. The observed parameter were measurement of blood glucose levels, urine volume and volume of drinking water as well as ratio of relative organ weight. The treatment was conducted for 15 days. The result showed that administration of ethanol extract of roots and stem of sekunyit can lowered significantly blood glucose levels (p<0,05) of alloxan induced-diabetic mice, decreased urine volume (p<0,05), decreased volume of drinking water (p<0,05), and did not affect relative organ weight of heart, liver and kidney (p>0,05).
Uji Aktivitas Antidiabetes Ekstrak Etanol dari Akar dan Batang Tumbuhan Sekunyit (Fibraurea Tinctoria Lour) Utami, Rahayu; Sandi, Nofri Hendri; Hasti, Syilfia; Delvia, Sutri
Jurnal Farmasi Indonesia Vol 7, No 4 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.003 KB) | DOI: 10.35617/jfi.v7i4.198

Abstract

Sekunyit (Fibraurea tinctoria Lour) is a species plant that has been used as traditional medicine for treating several diseases including jaundice, dysentery, headache, eye infection as well as anti diabetic drug. This research aims to evaluate antidiabetic activity of ethanol extract of roots and stem of sekunyit on white male mice (Mus musculus L) using glibenclamide as positive control. The experimental animals were induced with alloxan 175 mg/Kg BW i.p and devided into six groups, each group consisted of five mice. Group one served as negative control which was given NaCMC 1%, group second was positive control, given  glibenclamide 0,65 mg/KgBW, while group third, fourth, fifth were administered orally with etanol extract with doses of 100, 200 and 300 mg/KgBW, respectively. The observed parameter were measurement of blood glucose levels, urine volume and volume of drinking water as well as ratio of relative organ weight. The treatment was conducted for 15 days. The result showed that administration of ethanol extract of roots and stem of sekunyit can lowered significantly blood glucose levels (p<0,05) of alloxan induced-diabetic mice, decreased urine volume (p<0,05), decreased volume of drinking water (p<0,05), and did not affect relative organ weight of heart, liver and kidney (p>0,05).
Co-Authors Afandi, Rifath Ainun Alfatma Alhabil, Laras Allaya, Regina Alpasiri, Ikhsan Mauludi Andrea, Kamilah Dzikra Andriani, Sindy Anggraini, Hadistri Sekar anissa, Siti nurul Annur, Isnaini Ardiyansyah, Roni Armon Fernando Armon Fernando Arsila, Sherly Putri Asmarani, Asmarani Aulia Fitri, Aulia Azzahra, Fayza Salwa A’dilah, Nur Burhan, Shafira Ilma Chehdimae, Hamdan Delvia, Sutri Delvia, Sutri Dwi Andreyas Elza, Bunga Emma Susanti Emrizal Enda Mora Eva Nurhasanah Fahri, Elifia Cahyani Faisya Abrari Lutrinda Fazira, Intan Febbyola, Flara Ferdy Firmansyah Feriansyah, Robby Fina Aryani, Fina Fitri Primawanty Furi, Mustika Haiyul Fadhli Haiyul, Fadhli Hanifa, Dhea Husnawati Ihsan Ikhtiarudin Ilham Nur Safitri Indah Puspita Sari Jumadila, Ikhsal Mukri M Almurdani Mahasri Shobabiya Masnun, Lidiatil Melzi Octaviani Miftahul Jannah Milianty, Jesy Mira Febriana Muhammad Wildan Shohib Mustika, Furi Musyirna Rahmah Nasution Musyirna Rahmah Nst Nasution, Musyirna Rahmah Nofri Hendri Sandi Nofriyanti Nofriyanti Novianti, Yetri Novriyenni Novriyenni Nur Rahmadani Fitri Nurul Asma Khoiriyah Oriendhini, Salsa Patmawati, Lilis Three Pitri, Siska Dian Pratama, Hafizh Yandi Pratiwi1, Tri Ningtiyas Putri Lestari, Putri Putri Zulnandita Putri, Lestari Rachmawati, Fatkur Rahayu, Adnin Rahma Dona Rahmayanı, Wıky rambe, Septy amelia rizki Rasihen, Sri Lidya Rifka, Zahira Rizki Wulandari Rizkia, Tiara Roscha Ulfa, Farsesa Rusmin Saragih, Rusmin Safitri, Rahtu Janese Safli, Fazza Aulia Salsabila, Helmaria Putri Septi Muharni Silalahi, Rizka Fitri Sirait, Indri Hotma Novida Siti Nurhaliza Syilfia Hasti Syilfia, Hasti T, Febry Sesilia Tambunan, Beatrix Evalin Ulandari, Bunga Ulfa, Rodia Utami, Adinda Abia Wahidah, Lutfiana Nurul Wira Noviana Suhery Yani, Halijah Putri Yanto, Rizki Dwi Yayuk Riana