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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan E-Journal Obstetric & Gynecology Udayana WMJ (Warmadewa Medical Journal) Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Indonesian Journal of Obstetrics & Gynecology Science ISM (Intisari Sains Medis) : Jurnal Kedokteran Bioscientia Medicina : Journal of Biomedicine and Translational Research Babali Nursing Research Jurnal Syntax Transformation Jurnal Health Sains Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Social Service and Research Cermin Dunia Kedokteran Indonesian Journal of Perinatology Cermin Dunia Kedokteran
I Gde Sastra Winata
Departemen Obstetri Dan Ginekologi, Fakultas Kedokteran, Universitas Udayana
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Specific Histologic Type of Leiomyoma Related to Estrogen Receptor Expression Ni Wayan Armerinayanti; Desak Putu Oki Lestari; I Gde Sastra Winata
WMJ (Warmadewa Medical Journal) Vol 7 No 2 (2022): November 2022
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.7.2.4601.55-59

Abstract

Uterine Leiomyoma or fibroid is the most common gynecologic benign neoplasm which arising from monoclonal proliferation of smooth muscle cells in uterine wall. Some specific types of uterine leiomyoma, such ascellular leiomyoma, symplastic leiomyoma, mitotically active leiomyoma andmyxoid leiomyomahave different histomorphology from usual type leiomyoma. It also have wide variety of tumors size, but this study found that no correlation between type of leiomyoma and its size. Additional non-invasive therapy that predominantly developed in leiomyoma include many antagonist agents of estrogenic receptor. So, important to determine of estrogen receptor activity before that hormonal therapy prescription.Histopathology parameter that predict estrogen receptor activity in leiomyoma was not well understood. This study also try to correlate between specific histologic type of leiomyoma and estrogen receptor activity. This study was a retrospective crossectional study which analized by pearson chi-square test with p value < 0.05 and CI 95%. Result: There was significant correlation between specific histologic type of leiomyoma and estrogen receptor expression (p=0.007; p<0.05). Key Words: Leiomyoma, Estrogen Receptor
The role of antihypertensive drugs in patients with preeclampsia and how to prevent it I Gde Sastra Winata; I Wayan Agus Surya Pradnyana; Maria Septiana Parmonang Aroean
Majalah Obstetri & Ginekologi Vol. 30 No. 3 (2022): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V30I32022.146-153

Abstract

HIGHLIGHTS 1. Preeclampsia, or hypertension in pregnancy, remains a serious problem that has negative short and long-term consequences for the mother and the baby.2. The use of antihypertensive medications has its own precautions as it they may harm the fetus.3. Prophylactic measures with minimal or moderate impact may be beneficial for mothers with hypertension in pregnancy.   ABSTRACT Treatment of hypertension in pregnancy, such as preeclampsia (PE), is still a difficult issue with negative short and long-term consequences for both the mother and the baby. Screening for preeclampsia at 11-13 weeks' gestation using a combination of maternal demographic characteristics and medical history with biomarker measurements can identify approximately 75% of women who develop premature preeclampsia with delivery at 37 weeks gestation and 90% of those with early preeclampsia. Preeclampsia has a 10% positive screen rate at 32 weeks. Another important worry on the use of antihypertensive medications during pregnancy is the potential harm to the fetus. Methyldopa, hydralazine, labetalol, and nifedipine are some common antihypertensive medications. Aspirin use is frequently related to a decrease in the prevention of early preeclampsia, but it must be accompanied by medication adherence. Aspirin can be coupled with heparin. Recent investigations on the use of furosemide and nifedipine in preeclampsia have also revealed a new combination. 
PERBANDINGAN KURVA FRIEDMAN DAN PARTOGRAF WHO SEBAGAI MONITORING PERSALINAN DI ERA PANDEMI COVID 19 Sucitawati, Putu Devita; Winata, I Gede Sastra
JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 9 No. 2 (2021): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (96.078 KB) | DOI: 10.22437/jmj.v9i1.11486

Abstract

Saat ibu hamil memasuki rumah sakit di era pandemi COVID 19 maka penilaian terhadap ibu dan janin harus dilakukan secara lengkap. Pemeriksaan dan pemantauan ibu hamil saat persalinan juga dilakukan sesuai dengan standar nasional yaitu dengan menggunakan partograf. Partograf adalah alat pemantauan persalinan yang paling umum digunakan oleh tenaga kesehatan untuk memantau kemajuan persalinan dan memberikan intervensi tepat waktu jika diperlukan. Perkembangan dari pemantauan kemajuan persalinan didasari observasi yang dilakukan oleh Friedman pada tahun 1955. Barulah pada tahun 1994,WHO merancang partograf. Sejak pertama kali digunakan, partograf WHO telah dimodifikasi dan diadaptasi oleh banyak rumah sakit
Procedures to Reduce Haemorrhage during Myomectomy for Fibroids I Gede Sastra Winata; Nicholas Renata Lazarosony
Cermin Dunia Kedokteran Vol 49 No 10 (2022): Oftalmologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i10.312

Abstract

Uterine fibroids are the most common solid tumors in the female pelvis. Myomectomy is the first choice of treatment for woman who want to keep their uterus. Haemorrhage, uterine perforation, cervical injury, and metabolic problems from excessive absorption of the distension medium, such as glycine, are risks of hysteroscopic myomectomy. There are several procedures and techniques to reduce haemorrhage during myomectomy for fibroids. Some research demonstrated excellent outcomes with uterine artery ligation. Mioma uteri adalah tumor jinak yang paling sering dijumpai pada wanita. Tindakan miomektomi adalah salah satu pilihan terapi padawanita yang tetap ingin mempertahankan rahim. Perdarahan, perforasi uterus, cedera serviks, dan masalah metabolisme akibat penyerapan berlebihan media distensi, seperti glisin, adalah risiko prosedur histeroskopi miomektomi. Beberapa prosedur dan teknik dapat mengurangi perdarahan saat miomektomi pada kasus mioma uteri. Beberapa penelitian menunjukkan hasil yang sangat baik dengan ligasi arteri uterina.
ADMINISTRATION OF AUTOLOGOUS PLATELET RICH PLASMA ON THE IN VITRO FERTILIZATION ANTAGONIST PROTOCOL CAUSED HIGHER EXPRESSION OF INTEGRIN Β3 IN THE ENDOMETRIUM OF WISTAR STRAIN RATS THAN WITHOUT PRP AUTOLOGOUS ADMINISTRATION A.A.N. Anantasika; Putu Doster Mahayasa; I Nyoman Hariyasa Sanjaya; I Gde Sastra Winata; Endang Sri Widiyanti; IGN. Wiranta Permadi
Jurnal Health Sains Vol. 4 No. 6 (2023): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tujuan penentuan pemberian Autologous Platelet-rich plasma (PRP) pada protokol anthogonist In Vitro Fertilization menyebabkan ekspresi integrin β3 pada endometrium tikus galur wistar lebih tinggi dibandingkan tanpa pemberian Autologous PRP. Penelitian ini menggunakan desain eksperimen randomized posttest only control group design menggunakan 40 ekor tikus betina galur Wistar yang dibagi menjadi 2 perlakuan yaitu kelompok perlakuan dengan PRP dan kelompok tanpa PRP dengan simple random sampling. Prosedur penelitian terdiri dari stimulasi ovarium dengan Cetrotide (GnRH anatagonis), pemeriksaan imunohistokimia integrin ß3, dan analisis ekspresi integrin ß3 dengan mikroskop. Data kemudian diuji normalitas dan homogenitas dengan uji Shairo Wilk dan Levene, dan dilanjutkan dengan uji komparasi menggunakan uji Mann whittney dan Chi Square. Rata-rata H-score integrin ß3 diperoleh pada kelompok perlakuan 2,90 dan kelompok kontrol 1,54 dengan P<0,001. Pada kelompok perlakuan ekspresi integrin ß3 kuat – sangat kuat pada semua sampel, dibandingkan dengan kelompok kontrol didapatkan 18 lemah – sedang dan 2 kuat – sangat kuat (P<0,001). Kesimpulannya, pemberian Autologous Platelet Rich Plasma (PRP) pada protokol antagonis Fertilisasi In Vitro menyebabkan ekspresi integrin β3 yang lebih tinggi di endometrium tikus galur wistar. ekspresi integrin ß3 kuat – sangat kuat pada semua sampel, dibandingkan dengan kelompok kontrol diperoleh 18 lemah – sedang dan 2 kuat – sangat kuat (P<0,001). Kesimpulannya, pemberian Autologous Platelet Rich Plasma (PRP) pada protokol antagonis Fertilisasi In Vitro menyebabkan ekspresi integrin β3 yang lebih tinggi di endometrium tikus galur wistar. ekspresi integrin ß3 kuat – sangat kuat pada semua sampel, dibandingkan dengan kelompok kontrol diperoleh 18 lemah – sedang dan 2 kuat – sangat kuat (P<0,001). Kesimpulannya, pemberian Autologous Platelet Rich Plasma (PRP) pada protokol antagonis Fertilisasi In Vitro menyebabkan ekspresi integrin β3 yang lebih tinggi di endometrium tikus galur wistar.
Diagnosis and management of syphilis infection in pregnancy: a literature review I Gde Sastra Winata; William Alexander Setiawan; Ni Luh Wita Astari Widhusadi; DPG Jananuraga Maharddhika; Fenyta Christyani; Putu Bagus Darmayasa; Anthony Stephen Halim; Ernest TB Sianturi
Indonesian Journal of Perinatology Vol. 4 No. 1 (2023): (Available online: 1 June 2023)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i1.28

Abstract

Treponema pallidum, which causes the infectious disease syphilis, has a high rate of vertical transfer from mother to kid. Untreated maternal infection increases the risk of perinatal morbidity and mortality and unfavorable pregnancy outcomes, notably congenital syphilis. It is necessary to check for gestational syphilis during the prenatal period, and its diagnosis is straightforward. Nevertheless, this illness still affects two million pregnant women globally, indicating its significant prevalence. Congenital syphilis clinical symptoms are regulated by gestational age, maternal syphilis stage, maternal therapy, and fetus immune response. Early and late congenital syphilis have historically been used to describe it. The direct identification of treponemes, serological tests, and clinical signs all contribute to the diagnosis of maternal infection. Penicillin is typically used in the treatment, which also includes sexual partners. Fetal infection can be treated and prevented from spreading from the mother to the fetus with proper maternal infection management. To lower the prevalence of congenital syphilis, screening, early detection, and appropriate care are crucial during pregnancy and the preconception period.
High Neutrophils to Lymphocytes Ratio in Maternal Blood Serum as Risk Factor for Preterm Premature Rupture of Membrane Nicholas Renata Lazarosony; I Wayan Artana Putra; Ryan Saktika Mulyana; I Made Darmayasa; Ida Bagus Gde Fajar Manuaba; I Gde Sastra Winata; I Nyoman Gede Budiana
International Journal of Social Service and Research Vol. 3 No. 9 (2023): International Journal of Social Service and Research (IJSSR)
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/ijssr.v3i9.518

Abstract

Introduction: Neutrophil-to-lymphocyte ratio (NLR) has been extensively studied as a prognostic factor for various diseases based on systemic inflammation. Premature rupture of membranes (PROM) is an obstetric problem that does not only occur in term pregnancies but can also occur in preterm pregnancies. One of the main etiologies for premature rupture of membranes is inflammation. Knowing the difference in the NLR between preterm prematurerupture of membranes (PPROM) and without PPROM is important to increase understanding of the crucial role of NLR in predicting the incidence of PPROM. Method: This analytic case-control study compared NLR values ??in maternal blood serum between PPROM and without PPROM. This research was conducted in the emergencydelivery room and obstetrics and gynecology outpatient clinic at Prof. dr. I.G.N.G. Ngoerah Hospital Denpasar from February to June 2022. Results: A high NLR in maternal blood serum may be a risk factor for PPROM. Patients with a high NLR had a 4.5 times greater likelihood of experiencing PPROM than those with a low NLR (OR = 4.5; 95% CI = 1.4 – 13.83; p = 0.007). Conclusion: A high NLR in maternal blood serum is a marker of inflammation with an increased risk of 4.5 times for the occurrence of PPROM.
Preoperative Level of Insulin-Like Growth Factor Binding Protein 2 Predicts The Suboptimal Outcome After Primary Debulking Surgery in Patients with Advance Ovarian Cancer Pande Kadek Aditya Prayudi; I Gde Sastra Winata; I Nyoman Gede Budiana; Kade Yudi Saspriyana; I Nyoman Bayu Mahendra; Ketut Suwiyoga
The Indonesian Biomedical Journal Vol 15, No 6 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i6.2722

Abstract

BACKGROUND: The need for clinically useful biomarkers which can predict the surgical outcome after primary debulking surgery (PDS) in patients with advance ovarian cancer (AOC) is really important. Insulin-like growth factor-binding protein 2 (IGFBP2) is the main binding protein expressed by ovarian cancer cells, which plays a prominent role in promoting proliferation, driving invasion, and suppressing apoptosis. This study was conducted to assess the performance of IGFBP2 in predicting the surgical outcome after PDS in patients with AOC.METHODS: Twenty-four subjects with AOC (Stage IIIc/IV) who underwent PDS were recruited consecutively. Clinicopathologic data were obtained from subjects' medical records. Blood samples were withdrawn form each subject and preoperative level of IGFBP2 were measured using enzyme-linked immunosorbent assay (ELISA). Multivariate analysis was employed to test the performance of multiple predictors of surgical outcome.RESULTS: Eighteen patients (75%) had suboptimal outcome after PDS. Mean IGFBP2 level was significantly higher in the suboptimal group (1157.5±359.9 ng/mL vs. 679.1±504.5 ng/mL, p=0.018). In bivariate model, higher preoperative level of IGFBP2 predict the suboptimal outcome with good accuracy (AUC: 0.796, sensitivity: 83.3%, specificity: 83.3%, p=0.033, optimal threshold level 870 ng/mL). Higher IGFBP2 level was associated with higher risk of suboptimal outcome, although IGFBP2 was not an independent risk factor (adjusted OR: 5.0, 95% CI: 0.43-57.9, p=0.198).CONCLUSION: IGFBP2 is a novel and promising biomarker for surgical outcome prediction following PDS in AOC patients. Since it is predictive for suboptimal outcome, patients with higher preoperative level of IGFBP2 needs more thorough preoperative evaluation as well as meticulous surgical technique to optimize the surgical outcome.KEYWORDS: IGFBP2, advance ovarian cancer, PDS, surgical outcome, predictor
Passive Smoking as a Significant Risk Factor of Cervical Dysplasia: A Novel Findings in Single Center Study in Denpasar, Bali, Indonesia Pradnyana, I Wayan Agus Surya; Mirani Ulfa Yusrika; I Gusti Bagus Mulia Agung Pradnyaandara; I Gde Sastra Winata
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1126

Abstract

Background: Colposcopy is a diagnostic procedure evaluating the cervix following an abnormal screening test. It aims to identify and treat cervical cancer precursors. Risk stratification at the end of colposcopy helps differentiate those who can return to regular screening from those needing more frequent screening or surveillance. The study examined the characteristics and risk factors of patients undergoing colposcopy for cervical dysplasia in Denpasar, Bali, Indonesia. Methods: This was a cross-sectional study of women who underwent colposcopy at BaliMed Hospital, Denpasar, Bali, Indonesia, from January 2021-December 2022. Data were derived from medical records. The gynecology oncologist performed a colposcopy examination with a biopsy sample, which was later checked by the pathologist. Bivariate and multivariate analyses were used to identify the risk factors associated with cervical dysplasia. Results: 142 patients underwent colposcopy with a mean age of 37.28+10.1 years. Seventy-eight patients (54.9%) had a low-grade cervical lesion, and 9 (6.3%) had a high-grade cervical lesion. After adjusting the employment status and education level, factors associated with cervical dysplasia were age at first intercourse <20 years (aOR [adjusted odd ratio] 2.44, 95% CI [1.04-5.69]) and history of smoking, either actively or passively (aOR 8.91, 95% CI [3.52-22.54]). From the biopsy result, patients with abnormal cervical lesions were associated with evidence of CIN (aOR 9.03, 95% CI [2.49-32.77]). Conclusion: Early age first sexual intercourse and history of smoking have been identified as significant risk factors for cervical dysplasia. Additionally, passive smoking has been shown to increase the risk. This research provides a foundational reference for future studies in this area.
Risk factors and characteristics of cervical cancer patients under 40 years old at Prof Dr I.G.N.G. Ngoerah Hospital Denpasar, Bali from January until December 2022 I Nyoman Gede Budiana; I Nyoman Bayu Mahendra; I Gde Sastra Winata; Kade Yudi Saspriyana; Kevin Agastya Duarsa; Pande Made Suwanpramana; Rayvany Uil; Dewi, Putu Pradnya Paramitha; Made Yudha Ganesa Wikantyas Widia; Eric Gradiyanto Ongko; I Gede Indra Kumara; Charles Richard Thene; Johan Qalaba; Made Ayu Prabawaty Indraswari; Ida Bagus Arjuna; Putu Harrista Indra Pramana; Ernest T. B. Sianturi
Indonesian Journal of Perinatology Vol. 4 No. 2 (2023): Available online : 1 December 2023
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v4i2.33

Abstract

Background: Cervical cancer is the main cause of death for women worldwide. 500.000 new cases and 250.000 deaths are reported each year. In Indonesia, women as young as 25 are being diagnosed with this disease. The study will be conducted at Prof.Dr.I.G.N.G Ngoerah Hospital from January to December 2022 to analyze cervical cancer patients under 40. This study aimed to see the profile and the distribution of 40 year-old women with cervical cancer at our hospital. Methods: This descriptive study was conducted using medical records that were centered around female patients who were below 40 years of age and had been diagnosed with cervical cancer in Prof.Dr.I.G.N.G Ngoerah hospital in January - December 2022. Purposive sampling was done, and the samples were selected according to the inclusion criteria. The resulting data was presented in a table format. Results: Fifty-one cervical cancer patients aged under 40 years were included, with most of the age group being 30 – 39 years (88.2%). Twenty-eight patients (54.9%) were in the two-to-three parity group. The most dominant stage of cervical cancer is stage IIIB, with a total of 20 people (39.2%). Non-keratinizing squamous cell carcinoma (NKSCC) was the most common histopathological appearance (64.7%).  Conclusions: The study found that cervical cancer commonly affects those between 30-39 years old, particularly in the form of NKSCC. Many patients are diagnosed in advanced stages of the disease. Early screening, education, and vaccination programs are crucial in preventing cervical cancer.
Co-Authors A.A.N. Anantasika Anak Agung Gede Putra Wiradnyana Anak Agung Ngurah Anantasika Anthony Stephen Halim Arlando Martino Anapaku Charles Richard Thene Clara Amanda Daniel Hadinata Susanto Desak Putu Oki Lestari Dewi, Putu Pradnya Paramitha Dolesgit, Ni Made Garnis DPG Jananuraga Maharddhika Endang Sri Widiyanti Eric Gradiyanto Ongko Ernest T. B. Sianturi Ernest TB Sianturi Felyanto, Felyanto Fenyta Christyani FLORENCIA Florencia Desiree I Gede Indra Kumara I Gede Mahendra Adiguna Dira I Gede Mega Putra I Gusti Ayu Putri Kartika, I Gusti Ayu I Gusti Bagus Mulia Agung Pradnyaandara I Ketut Surya Negara I Ketut Suwiyoga I Made Darmayasa I Nyoman Bayu Mahendra I Nyoman Gede Budiana I Nyoman Gede Budiana I Nyoman Hariyasa Sanjaya I Wayan Agus Surya Pradnyana I Wayan Artana Putra I Wayan Megadhana I Wayan Parsa Ida Bagus Arjuna Ida Bagus Gde Fajar Manuaba IGN. Wiranta Permadi Ika Widi Astuti, Ika Widi Ines Kurniaty Hartono Johan Qalaba Kade Yudi Saspriyana Kade Yudi Saspriyana Ketut Suwiyoga Kevin Agastya Duarsa Lazarosony, Nicholas Renata Made Ayu Prabawaty Indraswari Made Bagus Dwi Aryana Made Yudha Ganesa Wikantyas Widia Maria Septiana Parmonang Aroean Mirani Ulfa Yusrika Musa Taufiq Musa Taufiq Ngakan Ketut Darmawan Ni Luh Wita Astari Widhusadi Ni Wayan Armerinayanti Nicholas Renata Lazarosony Nicholas Renata Lazarosony Nyoman Bayu Mahendra Ongko, Eric Gradiyanto Pande Kadek Aditya Prayudi Pande Kadek Aditya Prayudi Pande Made Suwanpramana Paskarani, Putu Erika Piere Emanuel Yoltuwu Piers Andreas Noak Pradnyana, I Wayan Agus Surya Putu Bagus Darmayasa Putu Doster Mahayasa Putu Harrista Indra Pramana Rayvany Uil Ryan Saktika Mulyana Sitohang, Elisa Laura Oktrinita Sucitawati, Putu Devita Tjokorda Gde Agung Suwardewa Wibawa, I Gusti Ngurah Agung Satria William Alexander Setiawan Yuliantini, Sang Ayu Putu