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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Jurnal Silvikultur Tropika (JST) Hemera Zoa Jurnal Veteriner Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology Majalah Obat Tradisional JSFK (Jurnal Sains Farmasi & Klinis) ARSHI Veterinary Letters FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu dan Teknologi Kayu Tropis Britain International of Exact Sciences Journal (BIoEx Journal) Jurnal Kedokteran Hewan Jurnal Veteriner dan Biomedis Current Biomedicine Asian Journal of Social and Humanities
IETJE WIENTARSIH
Departement Of Veterinary Clinic Reproduction And Pathology Faculty Of Veterinary Medicine, Bogor Agricultural University, Jl. Raya Dramaga, Bogor, Jawa Barat 16680, Indonesia
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Journal : Hemera Zoa

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PF-18 Photomicrograph of Nanogel Andrographolide-Beta Cyclodextrine Inclusion Complex As Anti-Burns Bayu Febram Prasetyo; Ietje Wientarsih; Dondin Sajuthi; Vetnizah Juniantito
Hemera Zoa Proceedings of the 20th FAVA & the 15th KIVNAS PDHI 2018
Publisher : Hemera Zoa

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Abstract

Inclusion complex is a complex formed between drug molecules which act as guest or located inside the cavity of host molecule. Host molecules are commonly originated from the derivative group of cyclodextrin. Among cyclodextrin groups, beta cyclodextrin (BCD) is mostly used in formula development and drug delivery system [1].Andrographolide (AG) is a pure isolate chemically syntesized from sambiloto herbs (Andrographis paniculata Nees), in the form of needle cystal-like which is colorless and extremely bitter. AG has variety of medical properties, particularly as anti-inflamation to treat skin burns [2]. However AG has poor solubility in water. This will result in low abillity to solute, penetrate membrane, and distribute the drug when applied transdermally in burn skin. In burn skin, there is tendency to skin damage, especially in stratum corneum which acts as semipermeable barrier. The ability of drugs that applied transdermally tends to be high.Formation of inclusion complex using AG and BCD to increase the ability of AG in penetrating membrane should be done. Transmission Electron Microscope (TEM) is a fast technique to confirm the formation of drug or inclusion complex by  comparing the shape and particle size [3]. Study on percutaneous penetration of AG-BCD inclusion complex is produced through solvent evaporation method at mole ration 1:2 in viscolam gel preparation.
Co-Authors A.S. Satyaningtijas Agus saputra Ahmad Kurniawan Amrozi Andriyanto . ANGGARA ALDOBRATA Anita Esfandiari April Hari Wardhana April Hari Wardhana April Hari Wardhana Aswin Rahadian Aulia Andi Mustika Bambang Pontjo Priosoeryanto Bambang Purwantara Bayu Febram Bayu Febram Bayu Febram Prasetyo Bayu Febran Prasetyo Chandra Utami Wirawati Chatarina Umbul Wahyuni D R Agungpriyono Deded Sarip Nawawi Deni Noviana Denny Widaya Lukman Dian Firnanda Dodi Darmakusuma Dodi Darmakusumah Dondhin Sajuthi Dondin Sajuthi Dwi Utari Rahmiati Eko Agus Srihanto Erni H Purwaningsih Erni H Purwaningsih Esti Dhamayanti Eva Harlina Farra Sasmita Febryanto, Agung Fikri Hanifah Gunanati Soedjono Gunanti . Hadiyanti, Cresensia Rara Hr. Sjarif, Sulistyantie Huda Shalahudin Darusman I Nyoman Jaya Wistara I Putu Kompiang Ikrar Trisnaning Hardi Utami Iman, Bintang Nurul Indra Bachtiar Indra Bachtiar Irma Maulani Hamzah Istifharany Wahyudina Joko Pamungkas Khoirun Nisa L N Sutardi Lina Elfita Lina Elfita Lina Novianti Sutardi Lina Noviyanti Sutardi Lingga Surya Maret Daulay M. Rafi M. Yanuar J. Purwanto Madyastuti, Rini Maret Daulay, Lingga Surya Maulani Hamzah, Irma Meilisa Lidya Margarita Miranti Fardesiana Putri Mirnawati Sudarwanto MIRNAWATI SUDARWANTO Mokhamad Fakhrul Ulum, Mokhamad Muhammad Bintang Murtiningrum, Fitria Senja Nisa, Nunik Nida Choerun Nopen Meisaroh Nova P. Sulistyawati Nugroho, Radhitya Aryo Nuzul Asmilia Nuzul Asmilia Rahmawati Januar Rahminiwati, Min Rastina R, Rastina Rastina Rastina Rayendra, Raendi Rita Kartika Sari Rizal Arifin Akbari Ros Sumarny Sajuthi, Dondhin Sa’diah, Siti Sebayang, Shalina Setyo Widodo Setyo Widodo SILMI MARIYA Silmi Mariya Subangkit, Mawar Sudarwanto, Mirnawati Bachrum Sulistyantie Hr. Sjarif Sus Derthi Widhyari Tarigan, Ronald TATI NURHAYATI Tika Aryanti Trioso Purnawarman Tyas Ayu Lestari Upik Kesumawati Hadi Vetnizah Juniantito Wiwin Winarsih Yessa, Elma Yuliani