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Prevalence and Associated Factors of Drug-Drug Interactions in Hospitalized Diabetic Patients: A Cross-Sectional Study Adil khan, Muhammad; Syafhan, Nadia Farhanah; Andrajati, Retnosari; Wispriyono, Bambang; Noor, Sidra
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.86-94.2024

Abstract

Diabetes mellitus is a chronic metabolic condition frequently associated with complications and comorbidities that often require hospitalization for effective management. Such patients are often prescribed multiple medications, which elevate the risk of potential drug-drug interactions (pDDIs). Hence, this study aims to determine the prevalence, severity, common interacting pairs, and factors associated with pDDIs among hospitalized diabetes patients. The study used a retrospective cross-sectional study design conducted at Universitas Indonesia Hospital. Lexicomp® Lexi-InteractTM software was used to analyze and classify possible drug interactions. Logistic regression analysis was used to identify different factors associated with potential DDIs. Of the 200 patients, 89.0% were observed to have pDDIs. A total of 966 interactions were found, of which 75.6% were moderate, 16.2% were minor, and 8.1% were of major severity. Meanwhile, in the risk rating C category, 71.0% were predominant, followed by B and D, 15.0% and 11.0%, respectively. Multivariate regression analysis showed a statistically significant association of pDDIs with 5–8 prescribed medicines (OR=22.8; 95% CI=5.5-94.7; p<0.001), >8 prescribed medicines (OR=64.4; 95% CI=11.3-336.5; p<0.001). The findings of this study revealed that pDDIs are highly prevalent in adult inpatients with diabetes. This emphasizes the critical need for appropriate monitoring and management strategies to reduce pDDIs and their adverse consequences.
Behaviour of Traders And Manufacturers In The Use Of Formalin In Wet Noodle And Tofu In Jakarta Galih Prima Arumsari; Tri Krianto; Bambang Wispriyono
Jurnal Kesehatan Masyarakat Andalas Vol 11 No 1 (2016): Jurnal Kesehatan Masyarakat Andalas
Publisher : Faculty of Public Health, Andalas University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24893/jkma.v11i1.261

Abstract

Formalin has been used widely in tofu and wet noodle as a preservative in Indonesia even it has been classified as a confirmed carcinogenic agent. The aim of this study is to analyze the behavior of traders and producers of tofu and wet noodle in the use of formalin in its products in DKI Jakarta. This study was conducted in March-June 2015 by using a qualitative method, descriptive study design, through literature study, interview and observation. The informants are producers and traders of wet noodles and tofu. Formalin was examined by Rapid Test Kit analysis. The results showed that knowledge, attitudes, perceptions of formalin; facilities and infrastructure, production and preservative; punishments, counseling, social support, income, and communication strategy played important roles in behavior of using of formalin. Communication and supervisory for public, traders, manufacturers are still limited. The distribution of formalin which is conducted by the government has not run optimally yet. Counseling and development to the community, traders and manufacturers are limited. Supervision of distribution of formalin has not worked optimally yet. As the recommendation to the number of parties to do research on safe preservatives, intensification of coaching traders and manufacturers as well as consumer empowerment should be done.
Vulnerability Mapping of Dengue Hemorrhagic Fever (DHF) Cases in West Java Province in 2023 Maramis, Arifanissa; Wispriyono, Bambang
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6720

Abstract

Dengue Hemorrhagic Fever (DHF) is one of the public health problems that needs serious attention, because this disease contributes a high mortality rate. Dengue disease related to environmental conditions, climate, population density, and community behavior. West Java is the highest province of dengue cases in Indonesia in 2023 that has 19,328 cases with the number of deaths due to dengue reaching 134 people. This study aims to map the spread of the disease by describing the distribution of dengue cases and describing the level of vulnerability through risk factors from dengue. The method used in this study is descriptive research with a Geographic Information System (GIS) approach. The data used is secondary data from the official website of the Central Statistics Agency (BPS) of West Java Province. Data analysis was carried out using QuantumGIS (QGIS) version 3.40.4 which is open-source software. The scoring results of 27 districts and cities in West Java Province show that the priority areas in handling of dengue cases are Bogor City, Bekasi City, and Bogor Regency which are the areas with the highest level of vulnerability. This study is expected to provide an overview of the distribution of cases and the level of dengue vulnerability based on districts/cities in West Java Province, so that studies can be carried out on dengue disease prevention and control programs, especially in areas with the highest level of vulnerability.
Tingkat Keamanan Konsumsi Residu Karbamat dalam Buah dan Sayur Menurut Analisis Pascakolom Kromatografi Cair Kinerja Tinggi Wispriyono, Bambang; Yanuar, Arry; Fitria, Laila
Kesmas Vol. 7, No. 7
Publisher : UI Scholars Hub

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Abstract

Karbamat merupakan salah satu jenis pestisida yang banyak digunakan untuk membasmi hama buah dan sayur. Untuk menentukan bahwa residu karbamat dalam sayuran masih aman dikonsumsi manusia, telah dilakukan analisis beberapa residu karbamat seperti metomil, karbaril, karbofuran, dan propoksur. Sampel-sampel tomat, apel, selada air, kubis, dan sawi hijau dikumpulkan dari tiga supermarket dan satu pasar tradisional di Depok, Jawa Barat. Analisis dilakukan serempak untuk ke empat residu karbamat menggunakan kromatografi cair kinerja tinggi denganpereaksi o-ftalaldehida dan 2-merkaptoetanol dalam reaktor pascakolom dengan detektor fluoresensi. Dari sampel-sampel buah dan sayur yang dianalisis, hanya sawi hijau asal pasar tradisional yang positif mengandung propoksur dengan kadar 1,2 mg/25 gram berat basah (0,048 mg/g berat basah). Dengan Acceptable Daily Intake(ADI) propoksur 0,005 mg/kg berat badan/hari, konsumsi sawi hijau harian seberat 20 g/hari masih cukup aman dari gangguan kesehatan akibat pajanan kronik propoksur dengan margin of safety 298,7 (> 100 sebagai batas aman). Carbamat is a group of pesticides which is commonly used to control fruits and vegetables pests. To determine that carbamat residues in fruits and vegetables are safe for human consumption, carbamate residues such as methomyl, carbaryl, carbofuran, and propoxur in vegetables and fruits have been analyzed. Samples of tomato, apple, water lettuces, cabbage, and mustard greens were collected from three supermarkets and one traditional market in Depok, West Java. The analysis was carried out simultaneously for all four carbamate residues by high performance liquid chromatography using o-phtaladehyde and 2 mercaptoethanol reagents in post-column reactor with a fluorescence detector. Of fruits and vegetable samples analyzed, only mustard greens from traditional market positively containe propoxur at 1.2 mg/ 25 gram wet weight (0,048 mg/gram wet weight). With Acceptable Daily Intake (ADI) of 0.005 mg/kg body weight/day, mustard greens consumption of 20 g/day is safe from adverse health effect from chronic exposure to propoxur with Margin of Safety of 298.7 (> 100 as safe limit).
Public Perception and Obedience with Social Distancing Policies during the COVID-19 Pandemic in Jakarta, Indonesia Widyamurti, Widyamurti; Sitorus, Edwina Bernita; Susanna, Dewi; Wispriyono, Bambang; Kusuma, Aria; Mahkota, Renti
Kesmas Vol. 17, No. 1
Publisher : UI Scholars Hub

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Abstract

The Indonesian Government established a social distancing policy to prevent COVID-19 transmission. However, this implementation will be ineffective without the compliance of the people. This study aimed to analyze the relationship between public perception and obedience with social distancing in terms of the variables based on the Health Belief Model. This study used a cross-sectional design with a population of Daerah Khusus Ibukota (DKI) Jakarta’s indigenes within the productive age of 15-64 years. The sample comprised 408 participants, with the independent variables of sociodemographics (age, gender, occupation, and education) and health beliefs (perceived susceptibility, severity, benefits, barriers, and self-efficacy). Meanwhile, obedience to social distancing was the dependent variable. Data were obtained through an online questionnaire and evaluated with the bivariate and multivariate analysis using Chi-square and logistic regression tests. Gender (OR = 2.327; 95% CI = 1.404-3.857) and perceived self-efficacy (OR = 2.609; 95% CI = 1.726-3.945) were significantly related to social distancing obedience. Meanwhile, no statistical correlation (p-value>0.05) was found with sociodemographics, perceived susceptibility, severity, benefits, and barriers. The males with low self-efficacy were more likely to disobey the social distancing policies. The individual’s self-efficacy perception increased with their level of obedience to social distancing policies.
Ambient Particulate Matter with Blood Pressure in Adult Women Living in Urban City Aliyyah, Nurusysyarifah; Kusnoputranto, Haryoto; Wispriyono, Bambang; Fitria, Laila
Kesmas Vol. 19, No. 5
Publisher : UI Scholars Hub

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Abstract

Ambient air pollution, especially from fine particles, contributes to human mortality from cardiovascular and respiratory diseases, for which high blood pressure (BP) is a major modifiable risk factor. This study aimed to analyze the influence of ambient particulate matter (PM2.5) on the risk of high BP leading to hypertension. This study used a cross-sectional design on 118 adult women living in Central Jakarta, Indonesia. Participants were selected from a 1-km radius of the nearest air quality monitoring station with available data PM2.5. Linear regression was analyzed to examine the relationship between PM2.5 and systolic and diastolic BPs adjusted for potential confounders. The annual means of PM2.5 concentration was 36±5.74 μg/m3. The linear regression model showed that PM2.5 exposure was associated with systolic BP after controlling with age and body mass index (r = 0.408; R2 = 0.167). The second model showed that exposure to PM2.5 concentration could explain about 10.9% variation of diastolic BP after controlling with age, length of stay, body mass index, smoking status, and diabetes mellitus record. Ambient air PM2.5 has a risk of BP and hypertension among adult women in Central Jakarta.
Food Hygiene and Sanitation at the Jakarta Pondok Gede Hajj Embarkation Dormitory: Food Safety Efforts for the Hajj Pilgrims Hayati, Fauziah; Asyary, Al; Wispriyono, Bambang; Rashid, Harunor; Memish, Z
Kesmas Vol. 19, No. 3
Publisher : UI Scholars Hub

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Abstract

Several health risks are associated with performing Hajj pilgrimage. Food poisoning is a major cause of diarrhea and vomiting during Hajj. Food hygiene is an effort to control aspects of food, people, places, and equipment that could cause disease or health problems. This study aimed to describe food hygiene and sanitation efforts implemented in 2023 at the Jakarta Pondok Gede Hajj Embarkation Dormitory in Jakarta, implemented in 2023 to safeguard foods for the Hajj pilgrims. Using a descriptive qualitative design with a document analysis approach, this study examined activities during the pre-embarkation and embarkation periods. Pre-embarkation efforts included inspecting the kitchen environment and coaching the catering team, while during the embarkation period, activities involved checking the hygiene of catering services, inspecting foods brought by pilgrims, and assessing the quality of food and drink. This study found that the dormitory kitchen did not meet the necessary facilities and infrastructure requirements, affecting food safety. Additionally, food handlers did not fully comply with hygiene and sanitation standards. This study emphasized the necessity of meeting hygiene requirements in the kitchen, food handling, equipment, and ingredients since the pre-embarkation period.
Assessment of Free Drinking Water Facilities and Its Potential Health Risks: A Study in the University X Lumbantobing, Indah Actry Zane; Wispriyono, Bambang; Kurniasari, Fitri; Fauzia, Sifa; Ayyasy, Muhammad Nur Ihsan; Haura, Alissa Siti; Labibah, Ghina; Akmal, Muhammad Abiyyu; Heryadi, Kirana Mahadewi; Alfianti, Firda; Fauziyah, Nuranida
Kesmas Vol. 19, No. 4
Publisher : UI Scholars Hub

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Abstract

University X offers free drinking water facilities. However, it has a significant problem in accessing safe drinking water. This study aimed to examine the microbial and chemical parameters of the free drinking water facilities at University X. The microbial quality was assessed by evaluating the total coliform bacteria, and the chemical parameter assessment, substances such as nitrate, iron, manganese, hexavalent chromium, and fluoride were analyzed across 12 water samples from various locations within the university. Among these, only total coliform and fluoride levels exceeded the guidelines of the World Health Organization (WHO) and the Indonesian Ministry of Health. An Environmental Health Risk Assessment was also conducted to discern potential health hazards among the 112 respondents. This study found no potential non-carcinogenic health risks associated with consuming water from the facilities. However, a sample in one location tested positive for total coliform, and the nitrate and manganese concentrations in another location did not meet the Indonesian Ministry of Health standards. The findings suggested that the free drinking water provided by University X is safe for consumption. Nonetheless, regular maintenance of the treatment facilities is needed to ensure that water quality remains suitable and clean.
Upaya Pekerja Seks Komersial Lokalisasi Daerah Pesisir dan Perbatasan dalam Mencegah Penularan HIV AIDS: Studi Fenomenologi Parman, Dewy Haryanti; Waluyo, Agung; Yona, Sri; Wispriyono, Bambang
Faletehan Health Journal Vol 11 No 03 (2024): Faletehan Health Journal, November 2024
Publisher : Universitas Faletehan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33746/fhj.v11i03.747

Abstract

HIV AIDS cases continue to increase every year. In 2023, out of 1,414 HIV AIDS cases in North Kalimantan, Indonesia, 500 cases were in Tarakan region. This study aimed to reveal the situation of the extent of efforts of commercial sex workers (CSWs) in preventing HIV AIDS transmission in coastal and border areas of Tarakan. This research was qualitative with a descriptive phenomenological approach. This study involved 15 CSWs in the localization of Tarakan area as the participants. The data analysis used thematic analysis by Braun and Clarke. This study produced four themes, namely: (1) health checks were carried out on an irregular basis, (2) customers who refused to use condoms were still served, (3) the use of antibiotics to prevent HIV AIDS transmission, and (4) limiting customers. The prevention of HIV AIDS transmission by CSWs had not been maximized due to the limitations of economic background and negotiation skills and a lack of understanding of HIV AIDS. A more comprehensive educational approach was needed to raise awareness of the importance of self-prevention from infectious diseases to work, so that they can work for a long time.
Monitoring Resistensi Aedes aegepty Terhadap Cypermethrin 0,05% di Pelabuhan Telaga Punggur Kota Batam Tahun 2023 Adrianti, Zilfia; Wispriyono, Bambang; Pujawati, Dian Sapta Rahayu
Jurnal Cahaya Mandalika ISSN 2721-4796 (online) Vol. 3 No. 3 (2022)
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

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Abstract

Di Indonesia Aedes aegepty adalah vektor penyakit Demam Berdarah Dengue (DBD). Salah satu Upaya untuk pencegahan DBD yaitu pengendalian vektor secara kimia yaitu fogging dengan menggunakan insektisida cypermethrin telah dilakukan di Pelabuhan Telaga Punggur . Penelitian ini bertujuan untuk mengetahui status resistensi nyamuk Aedes aegepty terhadap insektisida cypermethrine di Pelabuhan Telaga Punggur Kota Batam. Metode Penelitian ini merupakan deskriptif dengan menggunakan metode uji resistensi suscepbility test (WHO Standar) dengan menggunakan impregnated paper yang mengandung insektisida cypermethrin 0,05%. Nyamuk Aedes aegepty yang digunakan adalah nyamuk dari Pelabuhan telaga punggur dengan survey larva yang selanjutnya dilakukan rearing hingga menjadi nyamuk dewasa generasi pertama (F1) dan dilakukan identifikasi nyamuk . sampel nyamuk yang digunakan sebanyak 75 nyamuk, 60 nyamuk dipaparkan impregnated paper dan 15 nyamuk tidak dipaparkan dengan impregnated paper (kontrol) selama 60 menit dan di holding selama 24 jam pada suhu 27o c dan kelembaban 75% dan dihitung persentase kematian nyamuk. Hasil uji resistensi nyamuk Aedes aegepty Pelabuhan Telaga Punggur Kota Batam menggunakan suscepbility test (WHO Standar) yaitu rentan (susceptible) dengan persentase kematian nyamuk 100%.
Co-Authors Adil khan, Muhammad Adrianti, Zilfia Afrilia, Erza Nur Agung Waluyo Akmal, Muhammad Abiyyu Al Asyary Alfianti, Firda Aliyyah, Nurusysyarifah Amirah, Nada Annisa Ika Putri Ardhaneswari, Mutia Aria Kusuma Aria Kusuma Arif Sumantri Arry Yanuar Arsyina, Lia Athena Anwar Ayu Amalia Rahmi Ayudhia Rachmawati Ayyasy, Muhammad Nur Ihsan Bambang Teguh Prasetyo Batera, Same Desheila Andarini Dewi Rahayu Sudiman Dewi Susanna Djuria, Rachmawati Felani Dortua Lince Sidabalok Edwina Bernita Sitorus Eko Handoyo Ema Hermawati Evi Martha Fachrurozi Abdullah Gunawan Fatma Lestari Fauziyah, Nuranida Fety Fathimah Fitra N. Luthfiah Fitria Dewi Puspita Anggraeni Galih Prima Arumsari Glenzi Fizulmi Glenzi Fizulmi Hana Nika Rustia Haryoto Kusnoputranto Haura, Alissa Siti Hayati, Fauziah Heryadi, Kirana Mahadewi I Made Kariasa Iqbal Ardiansyah Isnatami Nurul Azni Kurniasari, Fitri Labibah, Ghina Laila Fitria Laura Dwi Pratiwi Lumbantobing, Indah Actry Zane Maramis, Arifanissa Meliana Sari Meliana Sari, Meliana Memish, Z Muhammad Ardi, Muhammad Mutia Ardhaneswari Nadia Arini Nadia Farhanah Syafhan Noor, Sidra Novrikasari Novrikasari, Novrikasari Nurcandra, Fajaria Nyamukondiwa, Melisa Ony Rosalia Parman, Dewy Haryanti Pujawati, Dian Sapta Rahayu Rachmawati Felani Djuria Rashid, Harunor Redi Yudha Irianto Renti Mahkota Retnosari Andrajati Retnosari Andrajati Rizki Amalia Salim Harris, Salim Sembiring, Rinawati Sifa Fauzia, Sifa Sitorus, Edwina Bernita Sri Yona Subekti Widodo Sudjianto Kamso Taufik Ashar Tri Krianto Tri Noviyanti Nurzanah Widyamurti Widyamurti Widyamurti, Widyamurti Yulianto S. Nugroho Zakianis Zakianis