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All Journal Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Chemistry Proceeding of Mulawarman Pharmaceuticals Conferences Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan

Mirhansyah Ardana

Fakultas Farmasi Universitas Mulawarman, Samarinda, Indonesia

Author-ID : 4251542

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

Published : 43 Documents Claim Missing Document

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Pengaruh Jenis Gelling Agent terhadap Aktivitas Antibakteri Ekstrak Buah Libo (Ficus variegata, Blume) Novika Anggraini Putri Heryan; Viriyanata Wijaya; Mirhansyah Ardana
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 8 (2018): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Libo (Ficus variegata, Blume) merupakan salah satu tanaman yang telah diketahui memiliki metabolit sekunder berupa saponin dan alkaloid yang cukup dominan, dimana kedua senyawa tersebut memiliki aktivitas antibakteri. Tujuan dilakukannya penelitian ini adalah untuk mengetahui pengaruh penggunaan jenis gelling agent pada formulasi gel dalam mempengaruhi aktivitas ekstrak buah Libo (Ficus variegata, Blume) pada bakteri Staphylococcus aureus dan Propionibacterium acnes. Formula gel dibuat dengan memvariasikan jenis gelling agent yang akan digunakan yaitu HPMC dan Carbopol. Pengujian aktivitas antibakteri dilakukan dengan metode difusi sumuran, selanjutnya dilakukan pengamatan terhadap diameter zona bunuh dengan melihat adanya zona bening yang terbentuk disekitar area sumuran. Hasil penelitian menunjukkan bahwa adanya penggunaan jenis gelling agent HPMC tidak mempengaruhi aktivitas antibakteri dan Carbopol dapat mempengaruhi aktivitas antibakteri ekstrak buah libo.

Potensi Ekstrak Kulit Buah Pinang sebagai Antibakteri Propionibacterium acne Penyebab Jerawat Hendy Kesuma Pribady; Mirhansyah Ardana; Rolan Rusli
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Pinang (Areca catechu L.) merupakan tanaman yang memiliki banyak manfaat terutama pada bagian buahnya namun kulit buah pinang hanya dianggap sebagai limbah. Secara empiris suku dayaq benuaq memggunakan kulit buah pinang dalam pengobatan jerawat, namun belum ada data ilmiah mengenai hal tersebut. Penelitian ini bertujuan untuk menguji potensi antibakteri kulit buah pinang terhadap bakteri Propionibacterium acne penyebab jerawat dengan menggunakan metode Konsentrasi Hambat Minimum (KHM) dengan seri konsentrasi 5%, 10%, 30% dan 50%, serta dianalisis dengan uji T. Hasil penelitian menunjukkan bahwa kulit pinang tua memiliki daya hambat sebesar 2,3 mm (5%), 4,3 mm (10%), dan 5 mm (30%), serta 6,6 mm (50%). Sedangkan kulit pinang muda memiliki daya hambat sebesar 1 mm (10%), 1,3 mm (30%) dan 5,6 mm (50%). Kulit buah pinang memiliki potensi antibakteri terhadap Propionibacterium acne penyebab jerawat.

Ekstraksi Polifenol Total dari Umbi Bawang Dayak (Eleutherine bulbosa [Mill.] Urb.) Menggunakan Metode Citric Acid-Glucose based Microwave Assisted Extraction Selvy Jumiatul Astati; Mirhansyah Ardana; Islamudin Ahmad
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The use of environmentally friendly solvent-based expulsion methods today began to be widely used, one of which is a microwave-assisted extraction (MAE) using a citric acid-glucose acid solvent. The study aims to determine the influence of the use of citric acid-glucose based microwave-assisted extraction against the total extraction of polyphenols from Dayak onion bulbs (Eleutherine bulbosa [Mill.] Urb.).The dried samples were extracted using a solvent (green solvent) citric acid – glucose with a ratio of 4:1, 5:1 and 6:1 g/g with the extraction conditions in the form of microwave strength of 50% for 10 minutes with a sample and solvent ratio of 1:10 g/mL, then Extract solution obtained further determination of the total levels of polyphenols using Folin ciocalteu reagents, and its absorption was measured using a UV-vis spectrophotometer at a wavelength of 791 nm. Based on the results of the study, the total amount of polyphenols obtained from each of the solvent conditions used against the samples was 21.92 mgGAE/g samples, 13.86 mgGAE/g samples, and 14.38 mgGAE/g samples. From this study, it can be concluded that the concentration of citric acid in the microwave-based citric acid-glucose method is assisted by extraction according to the ability of the solvent in the competency of polyphenols from Dayak onion bulbs.

Literatur Review: Aktivitas Antibakteri Terhadap Bakteri Penyebab Gangren Diabetik dari Minyak Atsiri Berbagai Tanaman Herbal Riska Novianti; Mirhansyah Ardana; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Diabetic gangrene is a complication caused by infection due to the presence of a bacteria or a wound inflammatory process associated with diabetes mellitus. One of the therapies given is by taking antibiotics and currently the problem of antimicrobial resistance is a problem that is often faced which makes people start using drugs from natural ingredients. This literature search aims to determine the antibacterial activity of essential oils of various herbal plants against bacteria that cause diabetic gangrene. The method used is literature review with journal searches on indexed journal databases. The results obtained from 12 literature show that the essential oil of a herbal plant that has antibacterial activity against bacteria that cause diabetic gangrene, namely Cymbopogon citratus essential oil, Juglans regia L, Zataria multiflora Boiss, Ocimum gratissimum L, Satureja spicigera, Cinnamomum osmophloeum, a combination of essential oils masoyi and cinnamon, citronella (Cymbopogon bernadus L), jeringau rhizome (Acorus calamus Linn), Piper gibbilimbum C, kaffir lime (Citrus hystrix DC) and clove flower essential oil (Syzygium arimaticum).

Aktivitas Antioksidan Tanaman Artocarpus Liza Kartika; Mirhansyah Ardana; Rolan Rusli
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Pengaruh Lama Penyimpanan Ekstrak Etanol Daun Sirih Hitam (Piper betle L. var Nigra) Terhadap Aktivitas Antibakteri: The Effect of Storage Time Extract Etanol Black Betel Leaf (Piper betle L. var Nigra) To Antibacterial Activity Falencia Ega Aprillia; Mirhansyah Ardana; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Black Betel Leaf (Piper betle L. var Nigra) contains compounds that act as antibacterials, namely alkaloids, flavonoids, saponins, tannins, steroids and phenolic compounds. Acne or acne vulgaris is an inflammatory reaction in the sebaceous follicles, which is caused by the Propionibacterium acnes bacteria. This study aims to prove that black betel leaf (Piper betle L. var Nigra) has antibacterial activity and has a long-lasting effect on the ethanol extract of black betel leaf against propionibacterium acne. The method includes sample extraction with 70% ethanol and then followed by antibacterial testing with the well method. In addition, the extract was prepared into a test solution and stored for 7 days at room temperature. The results of antibacterial testing using well diffusion can be concluded that the ethanol extract of black betel leaves with a concentration of 5%, 10%, 15%, 20% has the ability to inhibit the growth of propionibacterium acne bacteria. The effect of the extract storage time on day 7 had the largest inhibition zone.

Formulasi Sediaan Gel Masker Wajah Peel-Off dari Ekstrak Daun Melati (Jasminum Sambac L.) Sebagai Antibakteri Penyebab Jerawat: Formulation of Peel-Off Facial Mask Gel Preparations from Jasmine Leaf Extract (Jasminum sambac L.) as Antibacterial Causes Acne Andi Berbi Ollan Yunus; Mirhansyah Ardana; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.611

Formulasi Masker Clay Ekstrak Kelopak Bunga Rosella (Hibiscus sabdariffa L.) sebagai Antioksidan: Formulation of Clay Mask Rosella Flower Calyx Extract (Hibiscus sabdariffa L.) as an Antioxidant Ardella Safilla; Mirhansyah Ardana; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.612

Pengaruh Waktu Pengambilan Sampel Darah terhadap Pemeriksaan Testosteron Mirhansyah Ardana
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 1 (2015): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i1.84

The research about â€œThe Influence of Sampling Time to Testosterone for Medical Check Upâ€ had been develoved to 19 man aged 19 â€“ 25 years old. Sample was collected at 8 a.m. and 12 a.m. to determine testosterone serum level. Determining of testosteron serum level was done using Electrochemiluminescence Immunoassay(ECLIA). The result show that testosterone serum level mean at 8 a.m. (608.90 ng/dL) is slightly lower than testosterone serum level at 12 a.m. (647.95 ng/dL). The analysis of t test (Î±=0.05) show that there was not significantly difference between testosteron level mean at 8 a.m. and 12 a.m. So the sampling time to determine testosteron serum level to men can be done until 12.00 a.m. Keywords: Testosterone, Electrochemiluminescence, Immunoassay ABSTRAK Telah dilakukan penelitian mengenai â€œPengaruh Waktu Pengambilan Sampel Darah Terhadap Pemeriksaan Testosteronâ€. Sampel darah diambil dari 19 pria berumur 19 â€“ 25 tahun. Sampel darah dikumpulkan pada pukul 08.00 dan pukul 12.00 untuk pemeriksaan kadar testosteron. Penentuan kadar testosteron dilakukan menggunakan metode Electrochemiluminescence Immunoassay (ECLIA). Hasil penelitian menunjukan bahwa kadar testosteron rata-rata pada pukul 08.00 (608,90 ng/dL) sedikit lebih rendahdaripada kadar testosteron rata-rata pada pukul 12.00 (647,95 ng/dL). Hasil analisis uji t (Î± = 0,05) menunjukan bahwa tidak terdapat perbedaan yang signifikan antara kadar testosteron rata-rata pada pengambilan pukul 08.00 dan pukul 12.00. Sehingga pengambilan sampel darah untuk pemeriksaan kadar testosteron pada pria dewasa dapat dilakukan hingga pukul 12.00. Kata kunci: Testosteron, Electrochemiluminescence Immunoassay

Formulasi dan Optimasi Basis Gel HPMC (Hidroxy Propyl Methyl Cellulose) dengan Berbagai Variasi Konsentrasi Mirhansyah Ardana; Vebry Aeyni; Arsyik Ibrahim
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 2 (2015): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i2.95

Ideal gel formulation can be obtained by formulating some kind of gelling material, but the most important thing to note is the selection of a gelling agent. HPMC (Hidroxy Propyl Methyl Cellulose) is a gelling agent that is commonly used in the production of cosmetics and drugs, because it can producea gel that is clear, easily soluble in water, and has a low toxicity. This study aimed to obtain the concentration of HPMC as a gelling agent that has the physical stability in accordance with the stipulated requirements. Gel formulations made with HPMC concentration variation of 3%, 5% and 7%, further evaluation of physical properties include organoleptic test, homogeneity, dispersive power, pH, and viscosity. Evaluation gel base done for 3 weeks. The results of stability tests show the base gel with a concentration of 7% HPMC has a good standard for viscosity, pH, dispersive power, homogeneity and organoleptic.Key words: Gel, HPMC (hidroxy propyl methyl cellulose), gelling agent.ABSTRAKSediaan gel yang baik dapat diperoleh dengan cara memformulasikan beberapa jenis bahan pembentuk gel, namun yang paling penting untuk diperhatikan adalah pemilihan gelling agent. HPMC (Hidroxy Propyl Methyl Cellulose) merupakan gelling agent yang sering digunakan dalam produksi kosmetik dan obat, karena dapat menghasilkan gel yang bening, mudah larut dalam air, dan mempunyai ketoksikan yang rendah. Penelitian ini bertujuan untuk memperoleh konsentrasi HPMC sebagai gelling agent yang memiliki kestabilan fisika yang sesuai dengan persyaratan yang telah ditetapkan. Formulasi gel dibuat dengan variasi konsentrasi HPMC 3%, 5% dan 7%, selanjutnya dilakukan evaluasi sifat fisika yang meliputiuji organoleptis, homogenitas, daya sebar, pH, dan viskositas. Evaluasi basis gel dilakukan selama 3 minggu. Hasil yang diperoleh dari uji stabilitas menunjukan basis gel dengan konsentrasi HPMC 7% memiliki standar yang baik untuk viskositas, pH, daya sebar, homogenitas dan organoleptis.Kata Kunci : Gel, HPMC (Hidroxy Propyl Methyl Cellulose), gelling agent.

Co-Authors Abdul Rahim Adam M. Ramadhan Andi Berbi Ollan Yunus Ardella Safilla Arsyik Ibrahim Asri Dwi Endah Dewi Pramesthi Bohari Yusuf Dewi Rahmawati Dewi Rahmawati Dwi Elfira Kurniati Eka Widiya Wati Falencia Ega Aprillia Farida Anggraeni Fika Aryati Firzan Nainu Fitri Eka Giuliana Fritlyanti Mappapa Gayuk Kalih Prasesti Hadi Kuncoro Hana Luthfiani Hariati Hariati Hendy Kesuma Pribady Herman Herman HUSNUL KHOTIMAH Ida Yuliani Islamudin Ahmad Jaka Fadraersada Laode Rijai Leny Munawwarah Liza Kartika Muhamad Etsya Putra Muhammad Akbar MUHAMMAD AMIR MASRUHIM Muhammad Arifuddin Muhammad Hafidz Assaufi Muhammad Satyo Pradana Niken Indriyanti Noor Linda Febrianie Nor Zuraidah Novika Anggraini Putri Heryan Novita Dwi Sulistiani Nur Mita Nur wahidah Nurul Annisa Nurul Khotimah Rachma Nadya Utami Rahmadani, Agung Riska Harfiani Junaid Riska Novianti Risna Agustina Rizki Duratul Hikma Sambiri Rolan Rusli Sabaniah Indjar Gamma Selvi Jumiatul Astati Selvy Jumiatul Astati Siti Sulaeha Sofa Farida Sri Indah Mulyawan Dewi Sulton Ulfadha Tina Dwi Rahayu Triska Gea Ambasalu Uswatun Hasanah Vebry Aeyni Wahyu Widayat Welinda Dyah Ayu Wijaya, Viriyanata Wilujeng Cahya Arundina Wisnu Cahyo Prabowo Yulita Seja Yurika Sastyarina Yuriska Yudistia Ningrum

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