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All Journal Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Chemistry Proceeding of Mulawarman Pharmaceuticals Conferences Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Mirhansyah Ardana
Fakultas Farmasi Universitas Mulawarman, Samarinda, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline Nurul Khotimah; Agung Rahmadani; Dewi Rahmawati; Mirhansyah Ardana
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 4 (2018): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v4i4.183

Abstract

Pyrazoline is a five-ring heterocyclic compound having 3 carbon atoms and 2 nitrogen atoms known to have some biological activity. This study aims to synthesize 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) pyrazoline using 2’,4’-dichloro-4-hydroxy-3-methoxy chalcone and hydrazine. Synthesis was performed by reflux method at 80oC for 7 hours. The synthesis compounds were characterized by structural elucidation techniques. From the synthesis results obtained compound 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) Pyrazoline is pale yellow powder with 84%yield. The result of antioxidant activity test by 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that the compound had very strong antioxidant activity, Antibacterial test by diffusion method to use paper disk showed that the compound had antibacterial activity against Gram positive bacteria (S.aureus) and Gram negative bacteria (E.coli) and toxicity test by Brine Shrimp Lethality Test (BSLT) showed that the compound had toxicity.
Optimization of Gelling Agents and Emulsifiers in Emulgel Bases, and Physical Evaluation of Emulgel containing Sepabang (Melastoma malabathricum L.) Leaves Extract Nur Mita; Mirhansyah Ardana; Muhammad Arifuddin; Noor Linda Febrianie; Sofa Farida
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 2 (2020): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sepabang (Melastoma malabathricumshot L.) leaf contains a group of phenolic compounds and has a very strong antioxidant activity so it is potentially to be developed in the form of pharmaceutical preparations. The purpose of this research is to optimize and formulate an emulgel containing Sepabang leaf extract that physically stable. Emulgel preparations are formulated using carbopol and hydroxyprophylmethylcellulose as gelling agents and Tween 60 – Span 60 and combination of triethanolamine and stearic acid as emulsifiers, with a concentration of methanol extract of Sepabang leaves of 0.25%. Physical characteristics of emulgel preparations include pH value, viscosity determination, and spreadability test evaluated at room temperature for 4 weeks. The physical stability test is done by the Freeze Thaw method for 6 cycles, of which 1 cycle consists of 48 hours at 4°C and 48 hours at 40°C. The results showed that the Sepabang emulgel that meet physical characteristic and stability parameters are F1 with HPMC as gelling agents and Tween 60-Span 60 3% as emulsifiers.
Pengaruh Penambahan Ekstrak Aloe vera Terhadap Karakteristik Fisik Basis Polietilen Glikol Sediaan Suppositoria: The Effect of Aloe vera Extract Addition to Physical Characteristic of Polyethylene Glycol Suppository Base Mirhansyah Ardana; Wilujeng Cahya Arundina; Sabaniah Indjar Gamma
Jurnal Sains dan Kesehatan Vol. 4 No. 3 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i3.1177

Abstract

Ekstrak Aloe vera berpotensi untuk dikembangkan menjadi sediaan suppositoria karena terbukti memiliki aktivitas laksatif. Pada penelitian ini sejumlah ekstrak yang dosisnya telah dikonfersi dicampurkan dengan basis suppositoria polietilen glikol (PEG). Kemudian dilakukan evaluasi karakteristik fisik meliputi kekerasan, disolusi, dan titik leleh terhadap basis dan sediaan suppositoria yang mengandung ekstrak. Hal ini bertujuan untuk melihat pengaruh penambahan ekstrak terhadap karakteristik basis PEG suppositoria yang telah dioptimasi komposisinya, sehingga akan mempermudah formulator untuk melakukan penyesuaian komposisi basis terhadap persyaratan sediaan suppositoria yang baik. Hasil pengujian menunjukan bahwa ekstrak tidak mengubah kekerasan basis suppositoria, tetapi mempengaruhi disolusi dan titik leleh basis. Ekstrak Aloe vera mempercepat disolusi basis dari 37,163 menit menjadi 36,933 menit dan meningkatkan titik leleh basis dari 62,967 °C menjadi 80,467 °C. Dari data yang diperoleh dapat disimpulkan bahwa basis PEG yang ditambahkan ekstrak Aloe vera tidak memerlukan penyesuaikan komposisi karena perubahan yang terjadi masih sesuai dengan persyaratan dan tidak mempengaruhi performa sediaan dalam hal pelepasan zat aktif.
Co-Authors Abdul Rahim Adam M. Ramadhan Andi Berbi Ollan Yunus Ardella Safilla Arsyik Ibrahim Asri Dwi Endah Dewi Pramesthi Bohari Yusuf Dewi Rahmawati Dewi Rahmawati Dwi Elfira Kurniati Eka Widiya Wati Falencia Ega Aprillia Farida Anggraeni Fika Aryati Firzan Nainu Fitri Eka Giuliana Fritlyanti Mappapa Gayuk Kalih Prasesti Hadi Kuncoro Hana Luthfiani Hariati Hariati Hendy Kesuma Pribady Herman Herman HUSNUL KHOTIMAH Ida Yuliani Islamudin Ahmad Jaka Fadraersada Laode Rijai Leny Munawwarah Liza Kartika Muhamad Etsya Putra Muhammad Akbar MUHAMMAD AMIR MASRUHIM Muhammad Arifuddin Muhammad Hafidz Assaufi Muhammad Satyo Pradana Niken Indriyanti Noor Linda Febrianie Nor Zuraidah Novika Anggraini Putri Heryan Novita Dwi Sulistiani Nur Mita Nur wahidah Nurul Annisa Nurul Khotimah Rachma Nadya Utami Rahmadani, Agung Riska Harfiani Junaid Riska Novianti Risna Agustina Rizki Duratul Hikma Sambiri Rolan Rusli Sabaniah Indjar Gamma Selvi Jumiatul Astati Selvy Jumiatul Astati Siti Sulaeha Sofa Farida Sri Indah Mulyawan Dewi Sulton Ulfadha Tina Dwi Rahayu Triska Gea Ambasalu Uswatun Hasanah Vebry Aeyni Wahyu Widayat Welinda Dyah Ayu Wijaya, Viriyanata Wilujeng Cahya Arundina Wisnu Cahyo Prabowo Yulita Seja Yurika Sastyarina Yuriska Yudistia Ningrum