Article Per Year (5 Year)
p-Index From 2021 - 2026
2.63
P-Index
This Author published in this journals
All Journal Paediatrica Indonesiana Pharmaceutical Sciences and Research (PSR) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Evy Yunihastuti
Departemen Ilmu Penyakit Dalam FK Universitas Indonesia-RSUP Nasional Dr. Cipto Mangunkusumo
Health Professions Medicine & Pharmacology

Published : 33 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 33 Documents
Search

 1   2   3   4 
Predictors of Virological Failure in HIV Patients Receiving FirstLine Antiretroviral Therapy with Good Adherence Kurniawan, Farid; Djauzi, Samsuridjal; Yunihastuti, Evy; Nugroho, Pringgodigdo
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Antiretroviral therapy (ART) effectively suppress HIV replication. Viral load (VL) measurement is better predictor than clinical or immunological criteria to evaluate success or failure of ART. However, in country with limited resources, viral load measurement is not easily accessible by HIV patients receiving ART. Therefore, it is necessary to know which factors that can predict virological failure. In previous studies, adherence was an important factor for suppression of HIV viral load. This study is aimed to know predictors of virological failure in HIV patients receiving recent first line ART regimen with good adherence in Indonesia. Methods. A retrospective cohort study was conducted among adult HIV patients in Out-patient Clinic of Cipto Mangunkusumo Hospital that started ART during periode of January 2011-June 2014. HIV patients with good adherence that had viral load data 6-9 months after initiation of ART were included in this study. Virological failure was defined as viral load ≥ 400 copies/ mL after minimum of 6 months therapy with good adherence. Age at starting ART, risk factor for HIV infection, HIV clinical stage, HIV-TB co-infection, baseline CD4 value, CD4 count increase, baseline hemoglobin level and body mass index, weight changes during therapy, and ART based regimen were analyzed in this study. Results. A total of 197 patients were included in this study. Virological failure was found in 21 patients (10,7%). CD4 increase /mm3 after minimum 6 months of ART was predictor of virological failure (p = 0,003; OR 5,802, 95%CI 1,842-18,270). Conclusion. CD4 increase /mm3 after minimum 6 months therapy can predict virological failure in HIV patients receiving first line ART with good adherence
Hiperimunoglobulin E, Atopi dan HIV Yunihastuti, Evy
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

HIV in Geriatrics Ainun, Nur; Yunihastuti, Evy; Roosheroe, Arya Govinda
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Through both prolonged survival and late acquisition of the disease, numbers of older adults with HIV are climbing. Along with ageing process is an accumulation of HIV-associated non-AIDS related comorbidities, creating a complex patient group affected by multi-morbidity along with polypharmacy, functional decline and social issues.
Predictors of Mortality in Hospitalized HIV/AIDS Patients Puspitasari, Estie; Yunihastuti, Evy; Rengganis, Iris; Rumende, Cleopas Martin
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) is a big problem that threatening in Indonesia and many countries in the world. The knowledge on the characteristics and prediction of outcome were important for patients management. There are no studies on the predictors of mortality in Indonesia. Methods. We performed a retrospective cohort study among hospitalized patients with HIV/AIDS in Cipto Mangunkusumo Hospital between 2011-2013. Datas on clinical, laboratory measurement, outcome (mortality) and causes of death during hospitalization were gathered from medical records. Bivariate analysis using Chi- Square test were used to evaluate seven prognostic factors (male sex, not came from referral hospital, never received/failed to continue antiretroviral therapy (ART), clinical WHO stage 4, hemoglobin level /dL, eGFR level /min/1.73 m2 and CD4+ count ≤200 cell/µL). Multivariate logistic regression analysis was performed to identify independent predictors of mortality. Results. Among 606 hospitalized HIV/AIDS patients (median age 32 years; 64.2% males), 122 (20.1%) were newly diagnosed with HIV infection during the hospitalization and 251 (41.5%) had previously received ART. Median length of stay was 11 (range 2 to 75) days. There were 425 (70.1%) patients being hospitalized due to opportunistic infection. In-hospital mortality rate was 23.4% with majority (92.3%) due to AIDS related illnesses. The independent predictors of mortality in multivariate analysis were clinical WHO stage 4 (OR=6.440; 95% CI 3.701-11.203), hemoglobin level /dL (OR=1.542; 95% CI 1.015- 2.343) and eGFR level /min/1.73 m2 (OR=3.414; 95% CI 1.821-6.402). Conclusions. In-hospital mortality rate was 23.4%. Clinical WHO stage 4, hemoglobin level /dL and eGFR level / min/1.73 m2 were the independent predictors of in-hospital mortality among hospitalized patients with HIV/AIDS.
Faktor-Faktor yang Berperan terhadap Terjadinya Lipodistrofi pada Pasien HIV yang Mendapatkan Terapi Antiretroviral Lini Pertama Kusumayanti, Ratu Ratih; Yunihastuti, Evy; Purnamasari, Dyah; Witjaksono, F; Dewiasty, Esthika
Jurnal Penyakit Dalam Indonesia Vol. 2, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pendahuluan. Seiring dengan perkembangan antiretroviral, harapan hidup pasien HIV terus meningkat namun menjadi rentan terhadap efek samping pengobatan. Salah satu efek samping pengobatan adalah sindrom lipodistrofi, meliputi lipoatrofi, lipohipertrofi, atau gabungan keduanya. Faktor risiko yang dikaitkan dengan lipodistrofi pada HIV adalah usia, jenis kelamin, lama terapi antiretroviral, CD4 awal, Stadium HIV, dan pemakaian Stavudin. Belum ada publikasi di Indonesia yang meneliti kejadian lipodistrofi pada populasi pasien HIV yang mendapat terapi ARV lini pertama serta faktor-faktor yang memengaruhinya. Berdasarkan hal tersebut, penelitian ini dilakukan untuk mengetahui kejadian lipodistrofi pada pasien HIV dalam terapi ARV lini pertama berbasis Stavudin dan Zidovudin minimal 6 bulan serta faktor-faktor yang memengaruhinya yang berobat di Pokdisus RSCM. Metode. Penelitian dilakukan dengan desain potong lintang dan kasus kontrol untuk mengetahui prevalensi lipodistrofi pada pasien HIV dengan ARV lini pertama serta faktor-faktor yang memengaruhinya. Analisis statistik menggunakan uji chi square atau uji Kolmogrof Smirnoff untuk mendapatkan hubungan antara masing-masing faktor risiko dengan terjadinya lipodistrofi. Analisis multivariat dilakukan dengan regresi logistik. Hasil. Sebanyak 346 pasien terlibat dalam penelitian ini. Didapatkan prevalensi lipodistrofi sebesar 27,5%, dengan rincian 70,5% lipoatrofi, 8,4% lipohipertrofi, dan 21,1% gabungan keduanya. Lokasi lipoatrofi terbanyak di daerah wajah. Prevalensi lipodistrofi pada subjek yang menggunakan Stavudin sebesar 43.3%, dan Zidovudin sebesar 10,7%. Faktor yang berhubungan dengan kejadian lipodistrofi adalah penggunaan Stavudin [p= Simpulan. Didapatkan prevalensi Lipodistrofi pada pasien HIV yang mendapatkan terapi ARV lini pertama adalah 27.5%, dan didapatkan hubungan antara kejadian lipodistrofi pada pasien HIV dengan penggunaan Stavudin.
The Patterns of Primary Cotrimoxazole Prophylaxis in Adult HIVPatients in HIV Integrated Clinic Cipto Mangunkusumo HospitalJakarta in 2004-2013 Mastini, Ken Ayu; Djoerban, Zubair; Yunihastuti, Evy
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Low rate use of cotrimoxazole which is a standard of primary prevention against toxoplasmosis infection and Pneumocystis jirovecii pneumonia (PCP) in patients with CD4 <200 cell>/mm3 was found. This study aims to describe prescription pattern of cotrimoxazole primary prophylaxis in adult HIV patients in RSCM. Methods. A cohort retrospective study was conducted in HIV Integrated Clinic Cipto Mangunkusumo Hospital patients from 2004 to 2013. Individuals were eligible for this study if they were ≥18 years old and had indication of primary cotrimoxazole prophylaxis. Variable analyzed in this study were initiation, discontinuation, dosage, duration, duration percentage, and adverse events of primary cotrimoxazole prophylaxis. Results. A total of 3.818 patients had indication of primary cotrimoxazole prophylaxis. Initiation of primary cotrimoxazole prophylaxis was performed in 83% patients who met indication. Total od 99,8% patients used appropriate dose of cotrimoxazole. Frequent adverse events were increasing hepatic transaminase (38,1%), leucopenia (16,9%), anemia (16,5%), nausea (15,4%), vomiting (7,8%), thrombocytopenia (7,4%), and hypersensitivity (5,3%). Adverse event causing discontinuation were hypersensitivity (100%), anemia (2,4%), increasing hepatic transaminase (2,1%), vomiting (0,8%), and leucopenia (0,6%). Inappropriate discontinuation of cotrimoxazole was 61,6% with median duration percentage was 87,5% (IQR 39) and median of duration was 20 months (IQR 20). Duration in patients with CD4 ≤100 cell/mm3 and >100 cell/mm3 was 21 months (IQR 22) and 12,5 months (IQR 14,75) p <0,001. Conclusion. Although initiation of primary cotrimoxazole prophylaxis was done in 83% adult HIV patients with appropriate dosage, it was found that 61,6% discontinuation was inappropriate according with guideline.
Diagnosis and Treatment of Pneumocystis Carinii Pneumonia (PCP)/Pneumocystis Jirovecii Pneumonia in HIV patient: A Case Report Agustina, Dewi Rizki; Efiyanti, Christy; Yunihastuti, Evy
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pneumocystis carinii pneumonia (PCP) or pneumocystis jirovecii pneumonia is an opportunistic infection that can occur in immunocompromised patients. In patients with HIV, PCP is the most common opportunistic infection especially in patients with CD4 cell counts less than 200 cell /ul. To diagnose a PCP is very difficult because symptoms, blood tests, and thoracic radiography are not pathognomonic for PCP. However, untreated PCP is almost always fatal. Trimethroprimsulfamethoxazole (TMX-SMX) orally or intravenously for 21 days is the drug of choice for managing PCP with or without HIV. This article discusses a case with patients with symptoms of dyspneu, unproductive cough, diagnosed with PCP and finally improvement with TMX-SMX therapy
Coronavirus Disease 2019: Review of Current Literatures Susilo, Adityo; Rumende, C. Martin; Pitoyo, Ceva W; Santoso, Widayat Djoko; Yulianti, Mira; Herikurniawan, Herikurniawan; Sinto, Robert; Singh, Gurmeet; Nainggolan, Leonard; Nelwan, Erni J; Chen, Lie Khie; Widhani, Alvina; Wijaya, Edwin; Wicaksana, Bramantya; Maksum, Maradewi; Annisa, Firda; Jasirwan, Chyntia OM; Yunihastuti, Evy
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Factors Affecting Rapid Decline in Glomerular Filtration Rate in HIV/AIDS Patients Using Tenofovir Disoproxil Fumarate Yuriandro, Prima; Yunihastuti, Evy; Marbun, Maruhum Bonar H; Nugroho, Pringgodidgo
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Tenofovir disoproxil fumarate (TDF) treatment in HIV/AIDS patient has particular effect to the kidney, which is rapid decline in glomerular filtration rate (GFR) (> 5 cc/min/1.72 m2 one year after using the drug). The incidence rate for rapid decline in GFR and factors affecting it are still contradictive and not assessed completely. This study was done to identify cumulative incidence and factors affecting TDF related nephrotoxicity. Methods. A retrospective cohort study was conducted in HIV/AIDS outpatient clinic Cipto Mangunkusumo Hospital Jakarta. We included patients who start taking TDF as their medication from January 2010 until January 2015 with consecutive sampling method. Inclusion criterias were minimum one year of TDF treatment and baseline GFR > 60 cc/minute/1.72 m2. The study used secondary data from medical record, therefore subject with no GFR evaluation after one year was excluded. Logistic regression test was used to evaluate variabel that could potentially affect rapid decline in GFR. Results. 164 subjects were included for analysis and we found rapid decline in GFR after one year of TDF medication in 87 subjects (cumulative incidence 53%; 95% CI 45-60.4%). Factors affecting rapid decline in GFR were male gender (RR 4.0; 95% CI 1.1-4.8), CD4 cell count below 100 cell/mm3 (RR 3.7; 95% CI 1.7-8.1), weight increase above 20 % (RR 4.0; 95% CI 1.0-4.8), and baseline GFR above 90 cc/min/1.72 m2 (RR 9.8; 95% CI 2.3-42.1). Conclusion. The incidence rate for rapid decline in GFR after a year of TDF medication in HIV/AIDS patients in Cipto Mangunkusumo hospital was 53%. Risk factors that affecting this nephrotoxicity were male gender, CD4 cell count below 100 cell/mm3, weight increase above 20%, and baseline GFR above 90 cc/min/1.72 m2.
Pemeriksaan Bilasan Lambung: Alternatif Diagnostik Tuberkulosis pada Pasien HIV Dewasa? Yunihastuti, Evy
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Co-Authors . Andriansjah Achmad Fauzy, Achmad Ade Rosanti Adik Wibowo Adityo Susilo, Adityo Agnes Kurniawan Alvina Widhani, Alvina Amal C Sjaaf Andri Sanityoso Sulaiman Angga Pramudita Anggraini Alam Anggriani, Yusi Anna Rozaliyani Anna Ujainah Anna Ujainah, Anna Annisa, Firda Annisa, Rifka Ari F Syam Ari Fahrial Syam Arya Govinda Roosheroe Arya Govinda Roosheroe, Arya Govinda Astrid Citra Padmita Astrid Citra Padmita, Astrid Citra Bambang Sutopo Bramantya Wicaksana Budiman Bela C. Martin Rumende, C. Martin Ceva W. Pitoyo Chandra, Natasha Christy Efiyanti Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Chyntia Olivia MJ Cleopas Martin Rumende Cleopas Martin Rumende Cleopas Martin Rumende Cynthia Olivia Maurine Jasirwan Daldiyono Daldiyono Daldiyono Daldiyono Desi Salwani, Desi Dewi Mira Ratih Dewi Rizki Agustina Dewi Rizki Agustina, Dewi Rizki Dewi Sumaryani Soemarko Dhaneswara Adhyatama Wicaksono Djoerban, Zubair Dyah Purnamasari Dyah Purnamasari E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edwin Wijaya Edwin Wijaya, Edwin Elita, Dina Em Yunir, Em Endang Susalit Erni J Nelwan, Erni J Erni Juwita Nelwan, Erni Juwita Esthika Dewiasty Esthika Dewiasty, Esthika Estie Puspitasari Estie Puspitasari, Estie F Witjaksono F Witjaksono, F Faisal, Edward Farid Kurniawan Farid Kurniawan, Farid Firda Annisa Gita Aprilicia Gurmeet Singh H.M. Sjaifoellah Noer Hapsari, Aljira Fitya Harimurti, Kuntjro Harinda, Fadlika Hasan Maulahela Heri Wibowo Herikurniawan Herikurniawan Herikurniawan, Herikurniawan Herqutanto - Ikhwan Rinaldi Iris Rengganis Iris Rengganis Irsan Hasan Jasirwan, Chyntia Olivia Murine Jasirwan, Chyntia OM Julius R Samban Karmel Tambunan Ken Ayu Mastini Ken Ayu Mastini, Ken Ayu Khie Chen Kuntjoro Harimurti Kurniawan, Juferdy Kurniawan L A Lesmana Leonard Nainggolan Lestari, Regina Maksum, Maradewi Maradewi Maksum Marcellus Simadibrata Maruhum B.H. Marbun Masnjoer, Arif Mira Yulianti Mira Yulianti, Mira Mondrowinduro, Prionggo Murdani Abdullah Murdani Abdullah Nababan, Saut Horas Nasir, Ujainah Zaini Natali, Veritea Nia Kurniati Noto Dwimartutie Nugroho, Pringgodidgo Nunuk Mardiana, Nunuk Nur Ainun Nur Ainun Pane, Meivina Ramadhani Parhusip, Santi Sumihar Rumondang Pramita Gayatri Praptini, Mirna Nurasri Pratama, Metra Adi Prima Yuriandro Prima Yuriandro Pringgodigdo Nugroho Pringgodigdo Nugroho, Pringgodigdo Ratih, Dewi Mira Ratu Ratih Kusumayanti Ratu Ratih Kusumayanti Regina Lestari Reise Manninda Rifka Annisa Rino A Gani Rino A Gani Rino Alvani Gani Rino Alvani Gani Rino Alvani Gani Robert Sinto Robert Sinto Rosanti, Ade Rudi Putranto Rudy Hidayat Sabrina Munggarani Yusuf Samsuridjal Djauzi Samsuridjal Djauzi Samsuridjal Djauzi Siti Taqwa Fitria Lubis, Siti Taqwa Fitria Sri Wahdini Sukamto Koesnoe Sukamto Koesnoe Sulaiman, Andri Andri Syahrani, Aisyah Teguh Harjono Karjadi, Teguh Harjono Tito Ardi Ujainah Zaini Nasir Unggul Budihusodo Virnanda Amu, Ivan Wardoyo, Elizabeth Y Wicaksana, Bramantya Widayat Djoko Santoso Widayat Djoko Santoso, Widayat Djoko Wiraguna, Andrian Yulia Trisna Yulia Trisna, Yulia Yulidar Yulidar Yulidar Yulidar Yusi Anggriani Zakiudin Munasir Zubairi Djoerban Zubairi Djoerban Zubairi Djoerban