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All Journal Jurnal Kesehatan Lingkungan indonesia Jurnal Ilmu Lingkungan Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Jurnal Kesehatan Melayu Jurnal Kesehatan Komunitas Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton Jurnal Respirasi (JR) Al-Tamimi Kesmas: Jurnal Ilmu Kesehatan Masyarakat (Journal of Public Health Sciences) Jurnal ABDINUS : Jurnal Pengabdian Nusantara Maspul Journal of Community Empowerment Indonesian Journal of Global Health research Unri Conference Series: Community Engagement Jurnal Zona Journal of Rural and Urban Community Empowerment Jurnal PkM (Pengabdian kepada Masyarakat) SEHATI: Jurnal Kesehatan Jurnal Ilmiah Kesehatan (JIKA) Dinamika Lingkungan Indonesia Journal of Community Engagement Research for Sustainability ETAM: Jurnal Pengabdian kepada Masyarakat International Journal of Public Health Excellence (IJPHE) Berita Kedokteran Masyarakat Jurnal Karya Abdi Masyarakat Jurnal Kedokteran Ibnu Nafis Indonesian Journal of Community Empowerment Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Zahtamal Zahtamal
Universitas Riau
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Downregulation of RGS2 Expression in Ovarian Cancer: A TCGA–GTEx Transcriptomic Analysis Annisa Abdi Ghifari; Marni Sianturi; Suyanto Suyanto; Zahtamal Zahtamal; Darmawi Darmawi
Jurnal Ilmiah Kesehatan (JIKA) Vol. 8 No. 2 (2026): Volume 8 Issue 2 August 2026
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v8i2.1604

Abstract

Regulator of G protein signaling 2 (RGS2), a negative regulator of G protein-coupled receptor signaling, is implicated in ovarian cancer. Given the disease's late-stage diagnosis and poor prognosis, identifying reliable molecular biomarkers is crucial. This study evaluated RGS2 gene expression in ovarian cancer and its clinicopathological and prognostic associations using public transcriptomic data. RNA-sequencing data from 419 The Cancer Genome Atlas (TCGA) tumor samples and 88 Genotype-Tissue Expression (GTEx) normal samples were compared using the Mann-Whitney U test. Additionally, 308 TCGA cases were analyzed for associations with tumor grade, clinical stage, and survival outcomes—including overall survival (OS), disease-specific survival (DSS), progression-free interval (PFI), and disease-free interval (DFI) using the Kaplan-Meier method and log-rank tests based on median RGS2 expression. Results demonstrated that RGS2 was significantly down-regulated in ovarian cancer tissues compared to normal tissues (p<0,001). However, RGS2 expression showed no significant correlation with tumor grade, clinical stage, or any evaluated survival metrics (all p>0,05). In conclusion, while RGS2 is consistently down-regulated at the transcript level in ovarian cancer, it is not significantly associated with patient survival. These findings suggest that although reduced RGS2 expression is a common molecular feature of ovarian cancer, its utility as a standalone prognostic biomarker is limited in unstratified transcriptomic analyses.
Co-Authors ., Yusdiana Adhisti Handarie Agung Adrianison Adrianison afdhal cahya pratama Agrina Aisyah Ratu Ikhsan Alida Widiawaty Amelinda Amelinda Aminuyati Anak Agung Istri Sri Wiadnyani Andini Fesya Putri Andry Wahyudi Agus Anisa Nur Eksanti Annisa Abdi Ghifari Annisa Salsabila Aprilia Zulinda Aras Mulyadi Ardilah Rahmadani Arizta Nanda Putri Arwina Pratiwi Kuswoyo Asmita Meilani Aulia Rizky Agita Nasution Bayhakki Besri Nasrul Carles, Carles Chairul Chairul Chairul, Chairul Dahlan Tampubolon Darmawi Darmawi Debby Febriani Dian Maulidawati Dwi Kurniawati R Dyah Siswanti Estiningsih ecy kartika sari Elda Nazriati Elda Nazriati Elvina Carolina Erni Setiawati Faisal Yunus Farah Diba Febrialismanto Febrialismanto Febrialismanto, Febrialismanto Fifia Chandra Fifia Chandra Fifiz Chandra Friska Meliana Putri Gebrina Reski Geovani Meiwanda Hafiko Andresni Hamida Sari Batubara Hamidah Batubara Hengki Firmanda Heni Pujiastuti Hery Widijanto Ibnu Daqiqil ID Imelda Pardede Indi Esha Indra Lesmana Indra Lesmana Indra Yovi Jadi Prasmadi Karnila, Rahman Karnila Khaiziana Syaputri Lasmaria, Rohani Lesi Kurnia Putri Lidya Novita Lientje K Setyawati Lientje Setyawati Lientje Setyawati Lientjie K. Setyawati Lilly Haslinda Lita Maliki Maliki Marni Sianturi Melfi Triani Siska Miftahul Kurniawan Mitra Mitra Mugen Adi Suryo Muhamad Nur Mahmudi Muhammad Adzan Ramadhan Muhammad Agus Setiawan Muhammad Khairani Muhammad Naufal Musyaffa Salim Muliyono Muliyono Nabillah Nastiti Wardhana Normalina Sandora Novita Rany Nurhapida Nurhapida Nurlisis, Nurlisis Palupi, Resti Paridah Paridah Pebryanty, Putri Putri, Fachriani Radith Mahatma Radith Mahatma RAHMI NOVALINA Resti Palupi Ridha Restila Ridha Restila Ridwan Manda Putra Rita Endriani Romi Kurniadi Rosadi, Tia Masita Santo Gwee Siregar, Fajri Marindra Sofyan Husein Siregar Sri Endang Kornita Sri Melati Munir Sri Melati Munir Sri Melati Munir Sri Retno Pramesti Sulistiawati, Mailinda Sulistiawati, Mailinda Sundari Sundari Sundari Suyanto Suyanto Syarifah Na’imi Aqila Syeptri Agiani Putri Sysca Priastiwi Teguh Santoso Tia Masita Rosadi Tuti Restuastuti Tuti Restuastuti Tuti Restuastuti Tuti Restuastuti Tuti Restuastuti Tuti Restuastuti Tuti Restuastuti Ulfa Raudha Viktor Amrifo Wasilah Rochmah Wasilah Rochmah Wasilah Rochmah Yanti Ernalia Yayi Suryo Prabandari Yayi Suryo Prabandari Yesi Hasneli Yesi Hasneli Yessi Alza Yessi Alza Yolazenia Yolazenia Yuni Eka Anggraini, Yuni Eka Yuni Eka. A Yunisman Roni Yusni Ikhwan Siregar Yuyun Priwahyuni Zarfiardy Aksa Fauzi Zulkarnain Umar Zulkarnaini Zulkarnaini Zulkifli Zulkifli