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Reza Safitri
Universitas Brawijaya
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Journal : Science and Technology Indonesia

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Ketoprofen-Tromethamine: Binary Phase Diagram of Multicomponent Crystal, Dissolution Rate, and Analgesic Activity Evaluation Hasanah, Uswatul; Badriyya, Elsa; Safitri, Reza; Yuliza, Sukma; Ihsan, Ikhwanul; Saafrida; Rosaini, Henni; Jessica, Adhitya; Zaini, Erizal
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.726-734

Abstract

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose formulation options are limited due to its low dissolution rate in aqueous media. This research aimed to enhance the solubility of ketoprofen in distilled water and to compare the anti-inflammatory and analgesic effects of its resulting multicomponent crystal with tromethamine. The binary phase diagram of ketoprofen-tromethamine was created across molar ratios ranging from 1:9 to 9:1. The multicomponent crystal comprising ketoprofen and tromethamine in the selected ratio was synthesized using a solvent drop grinding method and subjected to further characterization for thermal properties, crystallinity, chemical groups, and morphology. The dissolution rate assessments were evaluated in CO2-free distilled water. Pharmacological analyses examined the anti-inflammatory and analgesic effects of the multicomponent crystal. The binary phase analysis identified the 5:5 (1:1) molar ratio as optimal in forming a multicomponent crystal. Thermograms and diffractograms revealed crystalline alterations attributed to a new crystalline phase. The new multicomponent crystal exhibited approximately 2.7 times higher dissolution rate after 30 minutes, outperforming pure ketoprofen. Pharmacological assessments demonstrated superior analgesic effects of the multicomponent crystal. In summary, the ketoprofen-tromethamine cocrystal in 1:1 molar ratio offers enhanced dissolution rate and provides better analgesic activity than ketoprofen alone.
Co-Authors A.A. Ketut Agung Cahyawan W Airlangga, Muhammad Hafidz Daros Ansahnarmi, Annisa Arief, Muhammad Dimas Sulthan Astaningrum, Meita Dinar Atma Amanda Putri Avicenna, Fitria Azahar Kasim Bambang Dwi Prasetyo Budi Sawitri Chandra Sari, Rohmah Nia Darmawati, Surya Daros Airlangga, Muhammad Hafidz Darsono Wisadirana Edi Dwi Cahyono Eka Pradesti Eleonora Rumengan, Angelina Elsa Badriyya Erizal Zaini Febiola, Intri Fiaji, Noveria Anggraeni Firmannandya, Ade Fitri Avicenna Hanim, Faridha Hanindita Basmatulhana Hertanto, Dedy Iftita, Hasanatul Ihsan, Ikhwanul INDRAYANI INDRAYANI Ismi Aulil Wardani Jessica, Adhitya Kanto, Sanggar Kasim, Azahar Keppi Sukesi Keppi Sukesih Kliwon Hidayat kurniawan, jihan Kuswanto Kuswanto Lisda Veronika M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Mashita Putri Hatama Maulina Pia Wulandari Monica Trivena Nainggolan Muhammad Hafidz Daros Airlangga Muhammad Syukri Nainggolan, Monica Trivena Nanang Krisdinanto Nelci Batlolona Ningtias, Iin Nisa Alfira Noor Aziah Abdullah Norhadi Norhadi Normahfuzah Ahmad Noveria Anggraeni Fiaji Noviadhista, Ulwan Fakhri Oktaviani, Fitri Hariana Patricia Baliana Da Costa Pramesthi, Hanum Kanthi Prasetyo, Agus Subhan Purwandi, Edeliya Relanika Putri Nila Rahmataini Putri Sadayi, Delila Putri, Atma Amanda Rachmat Kriyantono Rachmat Kriyantono Rilo Pambudi Riski Amalia Rizky Trisna Putri Rohmah Nia Chandra Sari Rois, Aulia Nur Rosaini, Henni Saafrida Said, Moch Fauzie Saleh, Ahmad Muwafik Salsabila, Laluna Sandis Wahyu Prasetiyo Sari, Rohmania Chandra Satriawan, Pravasta Wahyu Sinta Swastikawara Siti Noer Tyas Tuti Sujoko, Anang Sundoko Sundoko Surya Darmawati Susanto, Amin Heri Sylvatri, Hapsari Dian Trida, Mutiara Tristania Puspa Kintani Tyas Tuti, Siti Noer Ulwan Fakhri Noviadhista Uswatul Hasanah, Uswatul Utomo, Pradita Eko Prasetyo Wahyuni, Silvia Santi Warda Firdausi Karimah Wijanarko, Wisnu Wisnu Widjanarko Yandi Aulia Rahman Yayuk Yulianti Yeni Pramita Yuliza, Sukma