Article Per Year (5 Year)
p-Index From 2021 - 2026
6.203
P-Index
This Author published in this journals
All Journal Jurnal Penyuluhan Jurnal Ilmu Komunikasi Jurnal Ilmu Komunikasi Wacana, Jurnal Sosial dan Humaniora Journal of Innovation and Applied Technology Interaktif: Jurnal Ilmu-Ilmu Sosial AGRISE Habitat AGRIVITA, Journal of Agricultural Science Komunikator Nomosleca Jurnal PIKOM (Penelitian Komunikasi dan Pembangunan) Science and Technology Indonesia International Journal of Artificial Intelligence Research Jurnal Studi Komunikasi Jurnal Ilmiah Universitas Batanghari Jambi Jurnal SEPA (Social Economic and Agribusiness Journal) Syntax Literate: Jurnal Ilmiah Indonesia JEPA (Jurnal Ekonomi Pertanian dan Agribisnis) Sahafa Journal of Islamic Communication JURNAL EDUCATION AND DEVELOPMENT SANGKEP: Jurnal Kajian Sosial Keagamaan MEDIAKOM: Jurnal Ilmu Komunikasi Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton Jurnal Riset Komunikasi Bricolage : Jurnal Magister Ilmu Komunikasi LINIMASA: JURNAL ILMU KOMUNIKASI Communicare : Journal of Communication Studies AlphabetAlphabet: A Biannual Academic Journal on Language, Literary, and Cultural Studies Agro Bali: Agricultural Journal Musamus Journal of Public Administration Jurnal Riset Mahasiswa Dakwah dan Komunikasi (JRMDK) Devotion: Journal of Research and Community Service JURNAL ILMIAH GLOBAL EDUCATION International Journal of Science and Society (IJSOC) AGRIEKSTENSIA Ranah Research : Journal of Multidisciplinary Research and Development Jurnal Indonesia : Manajemen Informatika dan Komunikasi International Journal of Pedagogical Language, Literature, and Cultural Studies INJECT Interdisciplinary Journal of Communication
Reza Safitri
Universitas Brawijaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Physics Public Health Social Sciences Transportation Veterinary Other

Published : 61 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Science and Technology Indonesia

 1 
Ketoprofen-Tromethamine: Binary Phase Diagram of Multicomponent Crystal, Dissolution Rate, and Analgesic Activity Evaluation Hasanah, Uswatul; Badriyya, Elsa; Safitri, Reza; Yuliza, Sukma; Ihsan, Ikhwanul; Saafrida; Rosaini, Henni; Jessica, Adhitya; Zaini, Erizal
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.726-734

Abstract

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose formulation options are limited due to its low dissolution rate in aqueous media. This research aimed to enhance the solubility of ketoprofen in distilled water and to compare the anti-inflammatory and analgesic effects of its resulting multicomponent crystal with tromethamine. The binary phase diagram of ketoprofen-tromethamine was created across molar ratios ranging from 1:9 to 9:1. The multicomponent crystal comprising ketoprofen and tromethamine in the selected ratio was synthesized using a solvent drop grinding method and subjected to further characterization for thermal properties, crystallinity, chemical groups, and morphology. The dissolution rate assessments were evaluated in CO2-free distilled water. Pharmacological analyses examined the anti-inflammatory and analgesic effects of the multicomponent crystal. The binary phase analysis identified the 5:5 (1:1) molar ratio as optimal in forming a multicomponent crystal. Thermograms and diffractograms revealed crystalline alterations attributed to a new crystalline phase. The new multicomponent crystal exhibited approximately 2.7 times higher dissolution rate after 30 minutes, outperforming pure ketoprofen. Pharmacological assessments demonstrated superior analgesic effects of the multicomponent crystal. In summary, the ketoprofen-tromethamine cocrystal in 1:1 molar ratio offers enhanced dissolution rate and provides better analgesic activity than ketoprofen alone.
Co-Authors A.A. Ketut Agung Cahyawan W Airlangga, Muhammad Hafidz Daros Ansahnarmi, Annisa Arief, Muhammad Dimas Sulthan Astaningrum, Meita Dinar Atma Amanda Putri Avicenna, Fitria Azahar Kasim Bambang Dwi Prasetyo Budi Sawitri Chandra Sari, Rohmah Nia Darmawati, Surya Daros Airlangga, Muhammad Hafidz Darsono Wisadirana Dewi Kartika Ardiyani Edi Dwi Cahyono Eka Pradesti Eko Wahyudi, Lestari Eleonora Rumengan, Angelina Elsa Badriyya Erizal Zaini Febiola, Intri Fiaji, Noveria Anggraeni Firmannandya, Ade Fitri Avicenna Hanim, Faridha Hanindita Basmatulhana Hertanto, Dedy Iftita, Hasanatul Ihsan, Ikhwanul INDRAYANI INDRAYANI Ismi Aulil Wardani Jessica, Adhitya Kanto, Sanggar Kasim, Azahar Keppi Sukesi Keppi Sukesih Kliwon Hidayat Kriyantono, Rachmat Kriyantono kurniawan, jihan Kuswanto Kuswanto Lisda Veronika M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Mahanani, Sasanti Putri Mashita Putri Hatama Maulina Pia Wulandari Monica Trivena Nainggolan Muhammad Hafidz Daros Airlangga Muhammad Syukri Mulia, Yasmin Nainggolan, Monica Trivena Nanang Krisdinanto Nelci Batlolona Ningtias, Iin Nisa Alfira Noor Aziah Abdullah Norhadi Norhadi Normahfuzah Ahmad Noveria Anggraeni Fiaji Noviadhista, Ulwan Fakhri Oktaviani, Fitri Hariana Patricia Baliana Da Costa Pramesthi, Hanum Kanthi Prasetyo, Agus Subhan Primardiana Hermilia Wijayati Purwandi, Edeliya Relanika Putri Nila Rahmataini Putri Sadayi, Delila Putri, Atma Amanda Rachmat Kriyantono Rachmat Kriyantono Rilo Pambudi Riski Amalia Rizky Trisna Putri Rohmah Nia Chandra Sari Rois, Aulia Nur Rosaini, Henni Saafrida Said, Moch Fauzie Saleh, Ahmad Muwafik Salsabila, Laluna Sandis Wahyu Prasetiyo Sari, Rohmania Chandra Satriawan, Pravasta Wahyu Sharipudin , Mohamad-Noor Salehhuddin Sinta Swastikawara Siti Noer Tyas Tuti Sujoko, Anang Sundoko Sundoko Surya Darmawati Susanto, Amin Heri Swastika, Hanif Sylvatri, Hapsari Dian Trida, Mutiara Tristania Puspa Kintani Tyas Tuti, Siti Noer Ulwan Fakhri Noviadhista Uswatul Hasanah Utomo, Pradita Eko Prasetyo Vivit Novita Axviarani, Vivit Novita Wahyuni, Silvia Santi Warda Firdausi Karimah Wijanarko, Wisnu Wisnu Widjanarko Yandi Aulia Rahman Yayuk Yulianti Yeni Pramita Yuliza, Sukma Zayniddin, Zanakulov